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PubMed1977

Measurement of intrarenal anatomic distribution of krypton-85 in endotoxic shock in dogs.

Renal blood flow distribution was measured in control dogs and dogs in endotoxic shock by utilizing a modification of 85Kr washout. Kidneys, injected with 85Kr via a renal arterial cannula, were removed at several specific intervals after injection, rapidly frozen, and sectioned transversely so that pieces of tissue could be isolated and counted for radioactivity. Control outer cortical blood flow was 462 ml/min per 100 g tissue wt, but 122 ml/min per 100 g during shock. Control inner cortical outer medullary flow was 396 ml/min per 100 g, but 166 ml/min per 100 g in shock. Control flow in the inner stripe of the outer zone of the medulla was 130 ml/min per 100 g and 134 ml/min per 100 g in shock. In shock the initial volume of radioactivity distributed to outer cortex was smaller, to inner cortex the same, and to inner stripe outer zone of the medulla larger than in controls. This study delineates renal washout of 85Kr from specific areas of the kidney and indicates the alterations in extent and magnitude of this washout in endotoxic shock.

Animals↗
PubMed1978

Regional distribution of VA/Q in man at rest and with exercise measured with krypton-81m.

The regional distribution of ventilation-perfusion ratio (VA/Q) in the lung was obtained from the continuous inhalation and infusion of 81mKr. With this short half-life isotope (13 s) serial measurements were made in six young normal subjects during spontaneous breathing, with minimal radiation exposure. At rest in the upright position the apical zone had a high VA/Q, but over the lower two thirds VA/Q distribution was relatively homogeneous. There was a slight increase towards the base. During exercise at 50 and 100 W the distribution became more uniform but there was more obvious than at rest. These distributions are consistent with a zone of reduced basal blood flow (zone IV) which becomes more marked on exercise. Apical blood flow was followed during the transition from rest to exercise and recovery. There was a large (40-150%) increase within 30 s of starting to pedal at 50 W, but little change thereafter.

Adult↗
PubMedDate not supplied

Continuous measurement of regional cerebral blood flow using krypton-81m.

We have developed a new method for taking continuous measurements of rCBF by means of continuous infusion of 81mKr. Using this method, it is possible to follow the sequential changes in blood flow of various brain regions continuously. The method makes it possible to observe the sequential changes in CBF following drug administration, motor activation and various kinds of stimulation, and, furthermore, to observe the CO2 reactivity and autoregulation of cerebral vessels. It will undoubtedly prove useful in the investigation of various pathological states.

Adult↗