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PubMedDate not supplied

Inhibition of murine intestinal inflammation by anti-substance P antibody.

Several neuropeptides have recently been shown to affect various aspects of the inflammatory process. Among these, the neuropeptide substance P possesses a host of immune modifying actions, which include the enhancement of lymphocyte activity, macrophage function, and neutrophil chemotaxis. The role of substance P during inflamed states has, as yet, not been fully described. Here, in T. spiralis-infected mice, we parallel increased levels of substance P both locally, (the gut) and peripherally (serum) with decreased lymphocyte responsiveness. Upon the introduction of in vivo antisubstance P antibody during the infection, levels of substance P, gastrointestinal inflammation, and lymphocyte proliferation are significantly restored to baseline (noninfected) levels. These findings suggest that the neuropeptide substance P plays an important role in promoting inflammation. It also offers the basis for future pharmacological interventions.

Animals↗
PubMed1993

[Hepatobiliary disorders in chronic nonspecific intestinal inflammation].

In 1977-1992 chronic inflammatory bowel disease was diagnosed in the gastroenterological department at the Clinic of Pediatrics in 31 children. Idiopathic proctocolitis was diagnosed in 16 children--mean age at the time of diagnosis was 13 years and 9 months. Fifteen children were treated for the diagnosis of Crohn's disease. Their mean age was 12 years and 9 months. During the investigation period all patients were examined regularly with special attention to hepatobiliary disease. Elevated aminotransferase values were observed in four children, three of these children have had permanent elevation of aminotransferase. Percutaneous liver biopsy revealed chronic persistent or active hepatitis. The authors investigated the course of the liver disease in relation to GIT disease. In the discussion they analyze the incidence, etiopathogenesis and type of liver lesions in inflammatory bowel disease with regard to the case-histories of their three patients.

Adolescent↗
PubMed1993

[New developments in the treatment of non-specific intestinal inflammation].

This term comprises idiopathic proctocolitis (IPC) and regional enteritis (RE, Crohn's disease). Despite a number of similarities (similar age, symptoms, immunology, drugs), the two conditions differ substantially (site, pathology, surgery) and thus from a practical aspect it is essential to differentiate them. The term "ulcerative colitis" comprises also other inflammations, e.g. recently identified infections with causal agents which are difficult to diagnose. There are also several types of regional enteritis which differ as to their course and sequelae. As regards medical treatment, in both conditions in particular corticosteroids are used and 5-aminosalicylic acid. An important novelty are 5-aminosalicylic acid tablets with prolonged action; different types are used depending on the site of the disease. Surgical treatment differs not only as to its frequency but also by the type of operation. In regional enteritis operations confined to the affected site are used, while in idiopathic proctocolitis standard operations are available: proctocolectomy, colectomy with an ileorectal anastomosis, with continent ileostomy or with an ileoanal anastomosis and reservoir. The latter is preferred nowadays.

Humans↗