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PubMed1987

Pediococci and biotechnology.

Nomenclature changes of pediococci postdate the publication of Bergey's Manual. Pediococci possess both a "group" and a "type" antigen. They are gram positive, asporogenous, nonmotile, generally catalase negative, but may possess catalase-like activity. The pediococci may have either a cytochrome or a flavoprotein enzyme system. Anaerobically they are homofermentative using the PEP:PTS and the EMP pathway. Catalase positive strains utilize glucose aerobically and anaerobically while lactose and glycerol are only used aerobically. Some pentoses are fermented to lactate and acetate. Absolute requirement for folinic acid and nearly all amino acids is observed. Pediococci grow luxuriously in All Purpose Tween (APT) broth and are isolated on Rogosa SL agar. Detection can be done by electrical impedance and fluorescent antibody techniques. The Arrhenius concept was utilized in selecting metabolically efficient strains. Antibiotics, antioxidants, some chloride salts and some spices are detrimental to the pediococci. On the other hand, some chloride salts, manganese, and some spices are stimulant. Dialysis-fermentation and immobilization of pediococcal cells were recorded. Some strains decarboxylate histidine to histamine. The resting cell metabolism and the production of bacteriocin have been utilized in antibiosis. An intra and intergeneric genetic transfer system of plasmids from pediococci was by a conjugation-like mechanism. Formation of bacteriocin and fermentation of carbohydrates were linked to plasmids. Lytic bacteriophages to pediococci have not yet been identified. Industrial cultures are mainly frozen concentrates. Linear equations were developed to model the fermentative activity of pediococci and the effects of environmental factors.

Antibiosis↗
PubMed2005

Intergenerational transmission of subthreshold autistic traits in the general population.

BACKGROUND: Autistic disorder (AD) is a disabling oligogenic condition characterized by severe social impairment. Subthreshold autistic social impairments are known to aggregate in the family members of autistic probands; therefore, we conducted this study to examine the intergenerational transmission of such traits in the general population. METHODS: The Social Responsiveness Scale (SRS), a quantitative measure of autistic traits, was completed on 285 pairs of twins (by maternal report) and on their parents (by spouse report). RESULTS: Correlation for social impairment or competence between parents and their children and between spouses was on the order of .4. In families in which both parents scored in the upper quartile for social impairment on the SRS, mean SRS score of offspring was significantly elevated (effect size 1.5). Estimated assortative mating explained approximately 30% of the variation in parent SRS scores. CONCLUSIONS: Children from families in which both parents manifest subthreshold autistic traits exhibit a substantial shift in the distribution of their scores for impairment in reciprocal social behavior, toward the pathological end. As has been previously demonstrated in children, heritable subthreshold autistic impairments are measurable in adults and appear continuously distributed in the general population.

Adolescent↗
PubMed2002

Perceived attributes of health-promoting laughter: a cross-generational comparison.

A small but growing body of empirical data support the popular belief that laughter benefits health. However, there are many varieties of laughter and no reason to assume all varieties should be, or would be, perceived as equally beneficial. The authors examined which types of laughter and which characteristics of laughter people associate with health and whether there are generational differences in this perception. Young adults and older participants rated 12 laughter terms (e.g., chuckle, giggle, belly laugh) on their contribution to health and assessed various aspects of each laughter type on 11 scales. The young adults characterized health-promoting laughter as strong, active, uninhibited, and involving movement; the older participants characterized it as socially appropriate. Both groups associated health-promoting laughter strongly with positive emotion and absence of malice. Implications for placebo effects in laughter interventions are discussed. Differences between humor and laughter and among the proposed mechanisms by which they affect health are clarified.

Affect↗
PubMed2002

Health of grandmothers: a comparison by caregiver status.

OBJECTIVES: In this cross-sectional study, stress, coping, social support, and health were compared in 86 primary caregiver grandmothers, 85 partial/supplemental caregiver grandmothers in multigenerational homes, and 112 noncaregiver grandmothers. Whether support and coping reduced effects of stress on the physical and mental health of grandmother caregivers, including mediating and moderating effects, was examined. METHODS: A convenience sample completed a mailed questionnaire that included measures of stress, health, support, and coping. RESULTS: Primary caregivers reported worse self-assessed health, but partial/supplemental caregivers reported a tendency toward more depression and more instrumental support. Noncaregivers reported the least stress and less active and avoidant coping. Coping and subjective support added to the variance of depression and self-rated health. Subjective support and avoidant coping mediated between stress and health, and active coping moderated the effects of stress on health. DISCUSSION: Implications of these findings relative to the health of grandmothers by caregiver status are discussed.

Adaptation, Psychological↗
PubMed1995

The intergenerational relationship between mother's birthweight, infant birthweight and infant mortality in black and white mothers.

The relationship between the birthweight of white and black mothers and the outcomes of their infants were examined using the 1988 National Maternal and Infant Health Survey. White and black women who were low birthweight themselves were at increased risk of delivering very low birthweight (VLBW), moderately low birthweight (MLBW), extremely preterm and small size for gestational age (SGA) infants. Adjustment for the confounding effects of prepregnant weight and height reduced the risks of all these outcomes slightly, and more substantially reduced the maternal birthweight associated risk of moderately low birthweight among white mothers. There was little effect of maternal birthweight on infant birthweight-specific infant mortality in white mothers; however, black mothers who weighed less than 4 lbs at birth were at significantly increased risk of delivering a normal birthweight infant who subsequently died. Although the risks for the various outcomes associated with low maternal birthweight were not consistently higher in black mothers compared with white mothers, adjustment for prepregnant weight and height had a greater effect in white mothers than in black mothers. We suggest that interventions to reduce the risks for adverse pregnancy outcomes associated with low maternal birthweight should attempt to optimise prepregnant weight and foster child health and growth.

Adult↗
PubMed2002

[Importance of family for quality of life of the elderly in a social and cultural comparison].

This paper explores the role of the family and its contribution to quality of life in old age under a comparative perspective, looking at different European welfare states (Norway, Germany, Spain and Israel). The literature demonstrates a consistent association between well-being and social networks in old age. Intergenerational family relations seem to be of special relevance in their contribution to health and well-being of older family members. Key features of intergenerational relationships include association, help, and support. However, in modern welfare states, certain tasks traditionally performed by families are covered by services. To assess the relative impact of families and the welfare state and to understand the interaction between them both a comparative perspective is needed analyzing diverse cultures and welfare regimes. Cultural and societal contexts are of central importance in exploring and understanding the complex association between family relations and the quality of life of the elderly. It is hypothesized that there is an interaction between family structure and welfare state transfers. This hypothesis states that the relationship between family structure and quality of life depends on the type of welfare state and welfare state transfers and services. Hence, the relationship between quality of life and family support should be strong only in those cases where welfare state transfers are low. The empirical results partly confirm the theoretical assumptions of welfare state regime dependence of the children's effect on the elder's quality of life. Three out of the four analyzed countries show results that strongly support the hypothesis of an intervening effect of welfare state systems on the connection between family and overall quality of life in old age. However, further analyses are needed. First, more sensitive indicators of parent-child relations have to be used. Second, needs and their intervening effects on the direct linkages between children and quality of life have to be taken into account in more complex analyses. Third, more elaborated indicators of "quality of life" should be used in future analyses.

Aged↗
PubMed1992

Sponsorship for adolescents with diabetes.

In this intervention, teenagers with diabetes were introduced to insulin-dependent adults who served as their sponsors. The study used an experimental design with 54 adolescents randomized into experimental and control groups. Data were collected from biochemical markers, psychometric instruments, and interviews. Analysis of hemoglobins showed no differences between groups, although means for the intervention group declined. Intervention adolescents were less likely to agree that "I wish I could run away" and "I wish I didn't have diabetes" and showed higher self-esteem with regard to social acceptance and romantic appeal. Interview data showed that the adolescent-sponsor relationship provided a vital source of support that helped the adolescents develop awareness of their potential, contributing to feelings of validation and responsible regimen management. This study provides an evaluation of an innovative strategy for improving compliance in a high-risk population. The effectiveness of the intervention for black and Hispanic teenagers suggests that the program would be particularly viable in medical centers in minority communities.

Adaptation, Psychological↗
PubMed1995

Tinkering with the tinkerer: pollution versus evolution.

Pollutants can act as powerful selective forces by altering genetic variability, its intergenerational transfer, and the size, functional viability, adaptability, and survival of future generations. It is at the level of the cell and the individual that meiosis occurs, that genetic diversity is maintained, and behavior, reproduction, growth, and survival occur and are regulated. It is at this level that evolutionary processes occur and most pollutants exert their toxic effects. Chronic exposure to chemicals contributes to the cumulative stress on individuals and disrupts physiological processes and chemically mediated communication thereby threatening the diversity and long-term survival of sexually reproducing biota. Regional or global effects of pollution on the atmosphere, hydrosphere, and lithosphere have indirectly altered Earth's life-support systems, thereby modifying trace metal balance, reproduction, and incidence of UV-B-induced DNA damage in biota. By altering the competitive ability and survival of species, chemical pollutants potentially threaten evolutionary processes and the biodiversity and function of intercepting ecosystems.

Animals↗
PubMed1984

Alternate generation education: a developmental curriculum for secondary schools.

This article addresses the development, implementation, and evaluation of a high school curriculum intervention designed to promote the psychological development of students enrolled in a course on life history interviewing. The curriculum, based on the Deliberate Psychological Education practicum-seminar model, included field interviewing of older people about their lives, plus a class seminar to teach appropriate skills, discuss pertinent issues related to aging, and integrate the field experience. Students assumed the responsible role of life history interviewer, conducting at least three hours of interviews with one older person, thus counter-acting both adolescent egocentrism and generational isolation. The curriculum was designed to foster adolescents' understanding of older people in a manner which also stimulated the younger people's psychological development. A total of fifty-one tenth, eleventh, and twelfth graders at a public high school in a large midwestern city during the fall of 1979 were the subjects for the study. The multiple quantitative and qualitative measures indicated that the curriculum had a positive effect on the experimental students' psychological development. ANOCOVA procedures revealed that attitudes toward older people were significantly more positive, pre to post, for the experimental group (p less than .001), while those of the comparison group showed no change. Implications of the study for increased emphasis on responsible role-taking by adolescents in school programs, on intergenerational programming with a lifelong developmental focus, and on further time perspective research are discussed in the article.

Adolescent↗
PubMed2026

Fetal hypoxia causes oocyte oxidative stress damage via the Sirt3/Sod2 pathway and can be alleviated by nicotinamide mononucleotide.

Environmental hypoxia exerts detrimental effects on the reproductive capabilities of both humans and animals. A fetal hypoxia model was established in which fetal mice were kept in a high-plateau hypoxic setting from embryonic day (E) 0 to 16.5. In our previous research, we found that fetal hypoxia exposure perturbs the methylation of imprinted genes in adult sperm and causes intergenerational placental impairments in male offspring. However, the specific impacts of fetal hypoxia on the female reproductive system, particularly regarding oocyte maturation, remain poorly understood. First, we found that fetal hypoxia mice exhibited a significant reduction in the average number of pups per litter. We conducted a comprehensive analysis of the transcriptome in oocytes from the hypoxic group and investigated the metabolic alterations within the follicular microenvironment. Fetal hypoxic stress contributed to cleavage and blastocyst rate reduction and induced early apoptosis and DNA damage triggered by mitochondrial dysfunction, oxidative stress aggravation and Sirt3/Sod2 downregulation. Additionally, administration of nicotinamide mononucleotide (NMN) has been shown to prevent oocytes from mitochondrial dysfunction and developmental impairment by increasing the expression of Sirt3/Sod2 and autophagy. The number of pups per litter in fetal hypoxia mice was reduced by 57.7% compared to the control group, while NMN intervention could restore it to 73.1% of the control group. These results indicate that fetal hypoxia exposure exerts multiple potential damages to adult female reproduction, while highlighting the clinical potential of NMN supplementation as a targeted intervention to alleviate such hypoxia-associated female reproductive impairment.

Animals↗
PubMed2002

Psychological reactions to redress: diversity among Japanese Americans interned during World War II.

The psychological reactions of 2nd-generation (Nisei) Japanese Americans to receiving redress from the U.S. government for the injustices of their World War II internment were investigated. The respondents, all of whom had been interned during the war, rated the degree to which the receipt of redress nearly 50 years after their incarceration was associated with 8 different areas of personal impact. Results indicated that redress was reported to be most effective in increasing faith in the government and least effective in reducing physical suffering from the internment. Women and older respondents reported more positive redress effects. In addition, lower levels of current income, an attitudinal preference for Japanese Americans, and preredress support for seeking monetary compensation each increased the prediction of positive redress effects. Findings are discussed in relation to theories of social and retributive justice.

Adaptation, Psychological↗
PubMed2002

Identification of ter94, Drosophila VCP, as a modulator of polyglutamine-induced neurodegeneration.

We have successfully generated a Drosophila model of human polyglutamine (polyQ) diseases by the targeted expression of expanded-polyQ (ex-polyQ) in the Drosophila compound eye. The resulting eye degeneration is progressive and ex-polyQ dosage- and ex-polyQ length-dependent. Furthermore, intergenerational changes in repeat length were observed in homozygotes, with concomitant changes in the levels of degeneration. Through genetic screening, using this fly model, we identified loss-of-function mutants of the ter94 gene that encodes the Drosophila homolog of VCP/CDC48, a member of the AAA+ class of the ATPase protein family, as dominant suppressors. The suppressive effects of the ter94 mutants on ex-polyQ-induced neurodegeneration correlated well with the degrees of loss-of-function, but appeared not to result from the inhibition of ex-polyQ aggregate formation. In the ex-polyQ-expressing cells of the late pupa, an upregulation of ter94 expression was observed prior to cell death. Co-expression of ter94 with ex-polyQ severely enhanced eye degeneration. Interestingly, when ter94 was overexpressed in the eye by increasing the transgene copies, severe eye degeneration was induced. Furthermore, genetical studies revealed that ter94 was not involved in grim-, reaper-, hid-, ced4-, or p53-induced cell death pathways. From these observations, we propose that VCP is a novel cell death effector molecule in ex-polyQ-induced neurodegeneration, where the amount of VCP is critical. Control of VCP expression may thus be a potential therapeutic target in ex-polyQ-induced neurodegeneration.

Adenosine Triphosphatases↗
PubMed2004

Maternal calcium intake and offspring blood pressure.

BACKGROUND: Few data exist on the intergenerational influence of calcium intake during pregnancy on offspring blood pressure. METHODS AND RESULTS: As part of the ongoing US prospective cohort study Project Viva, we analyzed 4091 Dinamap blood pressure measurements from 936 six-month-old infants whose mothers had completed food frequency questionnaires during the second trimester of pregnancy. We used mixed models to estimate effects of maternal calcium intake on offspring systolic blood pressure. Mean+/-SD daily total maternal calcium intake was 1494+/-523 mg, consisting of 1230+/-486 mg from foods and 264+/-191 mg from supplements. Mean+/-SD 6-month blood pressure was 89.9+/-12.9 mm Hg. From bottom to top quartile of dietary calcium from foods adjusted for energy intake and measurement conditions, mean infant systolic blood pressures were 91.0, 90.2, 90.9, and 90.2 mm Hg (trend P=0.62). From calcium supplements only, the values were 91.5, 90.2, 90.4, and 88.4 mm Hg (trend P=0.006). After further adjustment for demographic, anthropometric, dietary, social, and economic variables, the decrease in 6-month systolic blood pressure was -3.0 mm Hg (95% CI, -4.9 to -1.1) for each 500-mg increment of maternal supplemental calcium intake during pregnancy. We did not find evidence of effect modification by maternal vitamin D or potassium intake or by infant body mass index. First-trimester calcium intake was not associated with offspring blood pressure. CONCLUSIONS: These observational data suggest that supplementing maternal midgestational calcium intake may lower offspring blood pressure, thus helping to prevent hypertension in the next generation.

Adult↗
PubMed1991

The place of IVF in infertility care.

In vitro fertilization has become standard treatment for infertility without the benefit of thorough evaluation. Today, the effectiveness of IVF is the subject of ongoing debate, the medical and non-medical risks of treatment are not adequately understood, and there is great concern about the true costs of care both for individuals and society. Added to this debate are ethical dilemmas which have changed the way we think about reproductive rights, the family, parenthood, intergenerational responsibilities, and the legal status of children and embryos. In order to address these issues, the World Health Organization Regional Office for Europe held a meeting in June 1990 on the Place of In Vitro Fertilization in Infertility Care. The recommendations from the meeting are presented.

Adoption↗
PubMed2002

Reflections on the meritocracy debate in Britain: a response to Richard Breen and John Goldthorpe.

A paper by Breen and Goldthorpe recently claimed to have exposed 'fatal flaws' in my work on meritocracy in Britain. This paper responds to their criticisms. The results of their re-analysis of the NCDS data set are shown to be consistent with my earlier findings and arguments. Furthermore, re-running some of my earlier models using measures that they favour and a method designed to privilege their position, the results once again demonstrate that, while class origins have some effect on class destinations (in particular, for those born into the middle class), ability and effort exert a much greater effect. Based on these results, the paper identifies three core propositions about meritocracy in Britain on which all parties to this debate should now be able to agree.

Achievement↗
PubMed1996

Coaggregation of Candida albicans with oral Actinomyces species.

Eight strains of Actinomyces were examined for their ability to coaggregate in vitro with four strains of Candida albicans. The Actinomyces coaggregated to various degrees with all of the Candida strains. Exposure of the Candida but not the Actinomyces to heat, trypsin, proteinase K, amphotericin B or trichodermin abolished coaggregation. All sugars tested did not inhibit any of the reactions. All coaggregating pairs were disaggregated by the addition of SDS, but nonionic detergents had no effect. The addition of urea or EDTA completely reversed coaggregation. Actinomyces strains were sensitive to periodate oxidation, whereas the Candida strains were unaffected. These data suggest that the coaggregations involve a protein on the Candida surface that may interact with carbohydrates or carbohydrate-containing molecules on the surface of the Actinomyces. These observations expand the known range of intergeneric coaggregations occurring between human oral microbes and indicate that coaggregation of C. albicans and Actinomyces may be an important factor in oral colonization by this yeast.

Actinomyces↗
PubMed1996

Japan's financing system for health care of the elderly.

The multiplicity of Japan's health insurance system fails to achieve equality among the different insurance groups of the sharing of the financial burden. This "horizontal" inequality is effectively offset by a unique redistribution mechanism established in 1982. However, there is no reserve fund so that savings can be accumulated for the greater financial need in the future. This will inevitably lead to a heavier financial burden for the future working generation or more utilization of the personal assets of the elderly. How to achieve "vertical" or intergenerational equality in financing the cost of health care for the elderly is the biggest social policy challenge for Japan.

Aged↗
PubMed2003

Validation of multigenerational interconnectedness scale among Arab adolescents.

This study intends to validate the Multigenerational Interconnectedness Scale among Arab adolescents. The Arabic version of the scale was administered to 224 male and 294 female Arab students in Grades 10 and 12. Principal factor analysis with a priori three factors and varimax rotation was conducted. This showed good convergence of the items into three subscales: Emotional, Financial, and Functional. Coefficient alpha was .80, indicating good internal consistency. Adolescent girls scored significantly higher on Connectedness to their families than the boys. Given the restricted age range, the effect of age was not significant. Further validation studies are needed with an external criterion for construct validity and a larger sample to cover the older age range of adolescence.

Adolescent↗