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Results for “Gatekeeping”

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PubMed2006

Regulation of PTEN function as a PIP3 gatekeeper through membrane interaction.

PTEN, one of the most frequently mutated genes in human cancer, acts as a tumor suppressor by dephosphorylating the plasma membrane lipid second messenger phosphoinositide-3,4,5-trisphosphate (PIP3) generated by the action of PI3Kinases. PTEN activity to prevent elevated levels of PIP3 and tumorigenesis depends on its interaction with the lipid bilayer. PTEN binds dynamically to the plasma membrane through a complex mix of protein-lipid and protein-protein interactions and the translocation is regulated by several mechanisms including C-terminal tail phosphorylations. Here we have summarized our current view of the interaction of PTEN with the plasma membrane and what the implications are for cancer biology.

Cell Membrane↗
PubMed1994

Gatekeepers of capitation.

As CFOs walk the financial tightrope in the move from fee-for-service to capitated delivery, their roles are changing. They're now being charged with providing the data, systems and strategies needed to stretch fixed treatment dollars.

Capitation Fee↗