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PubMed1991

[Comparison of screening methods for diabetes mellitus, based on fasting glucose, HbA1C and fructosamine levels].

Screening methods for diabetes mellitus, based on fasting glucose (FPG), HbA1C and fructosamine (FRA) levels were compared with regard to their screening power. The subjects studied were 699 health examinees. A significant elevation of the mean level of each screening index was observed in diabetic subjects, but not in borderline cases compared with that of normal subjects. The FPG, HbA1C and FRA levels in diabetic subjects distributed over a wide range overlapping largely with the distributions of non-diabetic subjects. No appreciable difference in the screening power was observed between FPG and HbA1C but specificity was low in FRG for the comparable sensitivity level. In the screening methods based on the combination of two or more indices, elevation of the sensitivity was noted, but the specificity declined, resulting in an increase of re-examination rate. Among them, the combination of FPG and HbA1C indicated the highest sensitivity.

Adult↗
PubMedDate not supplied

Serum fructosamine and lipid profile in type I diabetic children in Turkey.

Serum levels of total cholesterol (TC), triglycerides (TG), lipoprotein cholesterol fractions (HDL-C and LDL-C) and fructosamine (FA) were determined in twenty-three children with Type I diabetes and twenty healthy children aged 4-14 years. Mean serum TC and HDL-C did not differ significantly between diabetic and nondiabetic children. Mean serum TG and FA showed a statistically significant increase in the diabetic group compared to healthy children. It is interesting to note that extremely high FA values had never been reported in the literature before were obtained for the Turkish diabetic children. Although we have observed relatively higher values for LDL-C/HLD-C ratio in diabetics, the difference between two groups was not statistically significant.

Adolescent↗
PubMed1990

[The fructosamine test for the determination of nonenzymatic glycosylated serum proteins. A critical inspection of the method].

A modification of the original method of R.A. Johnson et al. for nonenzymatically glycated serum proteins (fructosamine test) is described. Problems of performance and optimization of the method as well as of calibration and the influence of protein composition on the results are discussed. Measuring is manually performed after a 8 min preincubation interval over a 1 min's period using the spectrophotometer "Spekol 220". Interserial precision was 3.2%. First clinical results demonstrate the possibility to assess glycemic control in type 1 diabetic patients over a integrated time interval.

Blood Proteins↗
PubMed1990

[Fructosamine reference ranges for pregnant patients and children determined using an improved NBT method].

Reference values for fructosamine in pregnancy show a decrease with progressing pregnancy, which can be explained by pregnancy-associated hemodilution. A normalization to 7.0 g/dl total protein leads to values independent of gestational age. For children and adolescents age-dependency of the reference range is abolished if values are related to total protein. More plausible values are obtained in longitudinal profiles if fluctuations of protein concentration are taken into account.

Adolescent↗
PubMed1990

Performance and clinical significance of the new fructosamine assay in diabetic patients.

The performance of the assay and the clinical usefulness of a new short-term index (Fructosamine Plus: FP) of metabolic control in diabetes was evaluated. The FP concentration was determined with the Hitachi 704, Cobas Mira, and Cobas Fara analyzers. The "within run" and "between run" CVs were less than 2.67% and less than 4.26%, respectively. The reference interval (determined from data on 125 blood donors) was 191 to 288 mumol/l (mean 240 mumol/l). In poorly controlled diabetic patients FP was significantly higher than in the well controlled ones. Moreover FP was significantly correlated with HbA1c and blood glucose levels. Our preliminary data seem to demonstrate that relating FP to total protein does not improve the clinical value of the new index.

Adult↗
PubMed1990

[Serum fructosamine assay in the evaluation and follow-up of diabetics].

Fructosamine (FRA) levels were determined in diabetic and nondiabetic patients. A normal mean of 2.38 mmol/L +/- 0.21 (SD), and range of 2.0-2.8, was found in 156 nondiabetic subjects. A highly significant correlation was found between FRA and glycosylated hemoglobin, and between FRA and fasting glucose and 2-hour postprandial glucose in the 163 diabetics. The mean FRA in 60 diabetics receiving oral hypoglycemic agents was 3.05 +/- 0.34. It ranged from 3.28 +/- 0.65 in patients with NIDDM receiving insulin to 3.50 +/- 1.03 in those with IDDM. Over 60% of the latter were inadequately controlled, as assessed by FRA levels. FRA repeated during 4-12 months in 68 patients showed no improvement in 45%, despite determined attempts to control blood glucose. However, fasting blood glucose in diabetics with normal FRA was 134 +/- 51 mg/dl. Therefore, a consistently normal level of FRA does not indicate normoglycemia. The FRA assay is rapid, simple, economical and of significant aid in the control of diabetes.

Blood Glucose↗
PubMedDate not supplied

Home blood glucose monitoring, glycosylated hemoglobin and fructosamine: their relationships in diabetic patients with and without residual C-peptide secretion.

HbA1c and fructosamine (F) were determined at monthly intervals in insulin-treated diabetic outpatients with (n = 25; C-peptide [+]) and without (n = 30; C-peptide [-]) residual B-cell function (post-prandial C-peptide: 0.76 +/- 0.33 and less than or equal to 0.09 pmol/ml, respectively; mean +/- SD), performing home blood glucose monitoring (HBGM) (40 determinations/month; memory containing reflectometer) during 4 months. Mean monthly blood glucose did not change with time and was equivalent in both groups (9.3 +/- 3.3 and 9.4 +/- 2.0 mmol/l). The magnitude of glycemic excursions was lower in C-peptide [+] than C-peptide [-] patients (mean intra-individual coefficients of variation: 31% and 47%, respectively; P less than 0.001). Overall mean HbA1c was of 7.12 +/- 1.32 and 7.30 +/- 1.06% and F levels were of 44 +/- 6 and 48 +/- 7 mumol/g protein (P less than 0.001) in the C-peptide [+] and [-] groups, respectively. In C-peptide [+] patients, HbA1c strongly correlated with prior mean monthly blood glucose at all visits (range of r valeurs = 0.71-0.84; P less than 0.001); the relation between F and mean monthly blood glucose was always significant but weaker (r = 0.48-0.62; P less than 0.05-0.001). In C-peptide [-] patients, HbA1c correlated weakly with mean blood glucose, only when averaged over 8 weeks (r = 0.40-0.59; P less than 0.05-0.001) but F did not correlate with blood glucose, whether averaged over 1-8 week periods.(ABSTRACT TRUNCATED AT 250 WORDS)

Biomarkers↗
PubMed1988

Effect of nitroblue tetrazolium concentration on the fructosamine assay for quantifying glycated protein.

Experiments with nitroblue tetrazolium (NBT) at 0.25, 0.50, and 0.75 mmol/L confirmed that reactivity of 1-deoxy-1-morpholino-D-fructose, the standard, was more sensitive to reagent concentration than was protein ketoamine and demonstrated why an increase in NBT or a decrease in sample volume yields lower values for serum fructosamine. Analyses of clinical samples from diabetic and nondiabetic patients and from healthy subjects indicated that, with NBT at 0.25 mmol/L, discrimination between diabetics and other subjects was improved by changing the sample:reagent volume ratio from the usual 1:10 to 1:25 (9- to 12-min reading time). Discrimination improved further with NBT at 0.75 mmol/L and a 1:25 ratio but a later reading time (18-21 min); these conditions may minimize the effects of some but not all interferents.

Adult↗
PubMed1987

Effect of nifedipine on glucose tolerance, serum insulin, and serum fructosamine in diabetic and nondiabetic patients.

The hypothesis that nifedipine may cause an insidious but reversible change in glucose tolerance, similar to that associated with thiazide therapy, was studied in six nondiabetic and six noninsulin-dependent diabetic patients with hypertension. After medium-term nifedipine therapy (mean duration, 11.5 months) was stopped for one month and then resumed for a month, values for fasting blood glucose, fasting serum insulin, serum fructosamine, glucose tolerance, and insulin release in response to oral glucose were unchanged in both groups. These findings suggest that nifedipine in conventional doses does not have important effects on glucose handling in either diabetic or nondiabetic patients.

Blood Glucose↗
PubMed1988

[Fructosamine determination as a screening test for diabetes mellitus in patients with acute coronary heart disease].

Plasma fructosamine was determined in 41 patients with acute coronary heart disease (acute myocardial infarction and instable angina) to assess its usefulness as a screening method for diabetes mellitus. The results (11/15 true positive and 23/26 true negative) were comparable to those for glycated hemoglobin (14/15, 22/26). Discriminant analysis was performed to extract additional information from further laboratory data (glucose and albumin).

Coronary Disease↗
PubMed1987

[The serum fructosamine test in the control plan of glucose homeostasis].

A new method to measure serum glycosylated proteins as index of diabetic control is evaluated. Precision, recovery and interference tests have been evaluated. A good correlation of fructosamine values with glycosylated haemoglobin and glucose in normal and diabetic patients was found. The analytical performance and its simple application to automated instruments make this test suitable for monitoring diabetes mellitus and for assessing intermediate-term control of blood glucose.

Blood Proteins↗
PubMed1995

[Changes of fructosamine content and their effects on platelet aggregation of glycosylated modification of low density lipoprotein in vitro].

The changes of fructosamine (FA) in low density lipoprotein (LDL) incubated in different durations and concentrations of glucose, electrophoretic mobility of different degrees of glycosylated modification of LDL, and the effects on platelet aggregation by glycosylated LDL were observed. The results revealed that FA content increased in LDL incubated with glucose and induced glycosylated modification of LDL, and FA content in LDL correlated to the duration of LDL incubated with glucose and also correlated to different concentrations of glucose. There was a positive correlation between electrophoretic mobility and FA content in LDL. The higher of FA content in LDL the higher of platelet aggregation. This study indicated that FA content in LDL reflected the degree of glycosylated modification of LDL, in which the physical, chemical and biological properties were changed.

Fructosamine↗
PubMed1993

[Efficacy of hemoglobin-Alc, fructosamine, and 1,5-anhydroglucitol in community screening for diabetes mellitus].

To evaluate the efficacy of hemoglobin-Alc, fructosamine, and 1,5-anhydroglucitol tests in screening for diabetes mellitus in communities, the sensitivity and the specificity of these tests were observed on the island of Ojika, Goto islands, Nagasaki prefecture Japan. A 75 gram glucose tolerance test was performed simultaneously on every participant, and WHO diabetes mellitus criteria were used to classify individuals. A total of 554 males and 820 females, older than 34 years, participated in the examination, representing a response rate of 42% and 52% respectively, and 86 were classified as diabetic. The sensitivity and the specificity of several screening levels were determined for each test. Each of the tests attained greater than 70% sensitivity and specificity simultaneously, but could not achieve greater than an 80% level simultaneously. If screening levels are selected for a sensitivity of as low as 50%, it is possible to produce a high specificity of 97-98%. These results provide valuable information for the planning of efficient diabetes mellitus detection programs in communities.

Adult↗
PubMed1995

[Respective value of glycated hemoglobin and fructosamine assays in the care of diabetes mellitus].

The monitoring of metabolic balance in diabetes mellitus involves the assay of cumulative markers of protein glycation. Glycated hemoglobin, particularly the major component HbA1c, and fructosamine, which reflects glycated plasma protein levels, are the most commonly used parameters. Nevertheless, their utilization is still under discussion with respect to methodologies used, as well as to their respective interest in clinical diabetology. This review shows current opinion concerning the analytical and physiopathological use of these biological indicators.

Chromatography, Ion Exchange↗
PubMed1995

[Fructosamine determination as a tool in the prognosis of diabetes mellitus in dogs].

It is difficult to give the prognosis of diabetes mellitus after castration of the bitch. An algorithm using the blood glucose and fructosamine level is suggested to evaluate the prognosis of diabetes: While the algorithm classifies 19 bitches with good prognosis 18 (95%) are cured. 18 are classified with poor prognosis and all of them undergo a long difficult insulin-therapy or are not treated with success. 6 bitches are classified as indifferent, 2 of them are cured by castration, 2 are managed with insulin and 2 are treated without success. The limits can be described by the following equations: lower limit y = 5.04x + 321, upper limit y = 7.74x + 433. If blood glucose is available only in mg/dl, the equations are: lower limit y = 0.28 + 321, upper limit y = 0.43x + 433. The algorithm is statistical high significant but it should be verified by calculation of a larger number of patients.

Algorithms↗
PubMed1995

[The concentration of glucose, glycosylated hemoglobin and fructosamine in blood of patients with cerebral hemorrhage in the acute stage of the disease].

The level of glucose, fructosamine (FA), glucosylated hemoglobin (HbA1) was determined for 21 patients with cerebral haemorrhage at an early stage of their illness. The correct level of FA and HbA1 shows that in the period of 2-3 weeks and 2-3 months before the stroke the average level of glucose in blood was normal. No significant differences of glucose concentration with respect to patients with a good prognosis and patients with a bad prognosis were found.

Aged↗
PubMed1996

[Value of glucose, glycosylated hemoglobin and fructosamine in blood of patients with ischemic cerebral infarction without diabetes during the early stage of the disease].

Fasting blood glucose level, glycosylated haemoglobin (HBA1) and fructosamine (FA) were measured in 37 non-diabetic patients with a recent (48 h) brain infarction of the carotid territory. The severity of hemiparesis was assessed on admission, and in the 2nd week and 1st month. The functional outcome and fatality rate was estimated after 1 month. On the basis of elevated the HBA1 concentration the group of 54% patients was diagnosed to have prestroke hyperglycemia. Hyperglycemia predating cerebral infarction did not influence fasting glycemia during the few days after stroke. Fasting blood glucose concentration but not the preceding 2-3 months and 2-3 weeks glycemia correlated strongly with the severity of hemiparesis and predicted stroke outcome. Measurement of HBA1 seems to be useful as a screening test for mild, clinically silent diabetes in patients without other risk factors for cerebral stroke.

Aged↗