Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Foundation model”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 361 records · Page 20Linked to original sources
PubMedDate not supplied

Getting the most out of the clinical encounter: the four habits model.

Medical interviewing is the foundation of medical care and is the clinician's most important activity. A growing body of evidence suggests that clinicians use distinctive, describable behaviors to conduct medical interviews. This article describes four patterns of behavior that we term Habits and reviews the research evidence that links each Habit with both biomedical and functional outcomes of care. The Four Habits are: Invest in the Beginning, Elicit the Patient's Perspective, Demonstrate Empathy, and Invest in the End. Each Habit refers to a family of skills. In addition, the Habits bear a sequential relationship to one another and are thus interdependent. The Four Habits approach offers an efficient and practical framework for organizing the flow of medical visits. It is unique because it concentrates on families of interviewing skills and on their inter-relationships.

Empathy↗
PubMed1999

Inferring tree models for oncogenesis from comparative genome hybridization data.

Comparative genome hybridization (CGH) is a laboratory method to measure gains and losses of chromosomal regions in tumor cells. It is believed that DNA gains and losses in tumor cells do not occur entirely at random, but partly through some flow of causality. Models that relate tumor progression to the occurrence of DNA gains and losses could be very useful in hunting cancer genes and in cancer diagnosis. We lay some mathematical foundations for inferring a model of tumor progression from a CGH data set. We consider a class of tree models that are more general than a path model that has been developed for colorectal cancer. We derive a tree model inference algorithm based on the idea of a maximum-weight branching in a graph, and we show that under plausible assumptions our algorithm infers the correct tree. We have implemented our methods in software, and we illustrate with a CGH data set for renal cancer.

Chromosome Aberrations↗
PubMed1997

Fractal modeling and segmentation for the enhancement of microcalcifications in digital mammograms.

The objective of this research is to model the mammographic parenchymal, ductal patterns and enhance the microcalcifications using deterministic fractal approach. According to the theory of deterministic fractal geometry, images can be modeled by deterministic fractal objects which are attractors of sets of two-dimensional (2-D) affine transformations. The iterated functions systems and the collage theorem are the mathematical foundations of fractal image modeling. In this paper, a methodology based on fractal image modeling is developed to analyze and model breast background structures. We show that general mammographic parenchymal and ductal patterns can be well modeled by a set of parameters of affine transformations. Therefore, microcalcifications can be enhanced by taking the difference between the original image and the modeled image. Our results are compared with those of the partial wavelet reconstruction and morphological operation approaches. The results demonstrate that the fractal modeling method is an effective way to enhance microcalcifications. It may also be able to improve the detection and classification of microcalcifications in a computer-aided diagnosis system.

Algorithms↗
PubMed2006

Incisal orientation and biting efficiency.

Broad-edged 'spatulate' upper and lower incisors are distinctive of catarrhines and platyrrhines who use them in various ways to peel fruits, remove bark, and strip leaves from branches. The incisors of modern humans not only control the bite size of foods during ingestion, but often grip items in a number of non-food related tasks. Such uses have long been implicated for Neandertals as well. Despite the evolutionary importance of incision and the fact that the incisors feature prominently in clinical dentistry (via orthodontic practices designed both to correct incisal misalignments and adjust their orientation), little is known about what affects their functional efficiency. Few mechanical analyses of incisal action have been published and none that seem to take note of the mechanisms of both fracture and friction at the tooth-food interface. Here, we modeled the incisal tip as a wedge, finding that the efficiency of biting foods that fracture elastically is strongly dependent on both the apex angle of the incisor and the coefficient of friction. Based on apex angle measurements from a small sample of human central incisors, the overall efficiency of upper central incisors is predicted to be greatest when the angle between the apex bisector and the direction of applied force is zero. However, this is complicated greatly by friction, particularly for the lower incisors. The analysis probably applies not only to the use of incisors by humans, but also to some extent to frugivorous primates. This model should clarify the mechanics behind incision and can provide a basic foundation upon which more advanced models can be built on in the future.

Animals↗
PubMed2004

Reflective learning with drama in nursing education--a Swedish attempt to overcome the theory praxis gap.

It is obvious that the gap between theory and praxis in nursing education affects the students' ability to develop understanding and professional knowledge that stems both from theory and practice. Appropriate didactic methods are thus needed in nursing education. In a project we developed and practised a didactic model with the intention of encouraging a reflective attitude within the student, considering caring science in theory as well as in praxis. The didactic model, based on educational drama, was implemented during three terms of the nursing education programme. In this paper we present the educational model and its theoretical foundation. We also present the preliminary outcomes of the project.

Drama↗
PubMed1990

Design optimization of a prosthesis stem reinforcing shell in total hip arthroplasty.

The use of a perforated, titanium funicular shell to support the proximal femoral cortex in total hip arthroplasty was evaluated with the aid of both analytical and numerical techniques. The principal interactions between the femoral cortex, the metal shell, the implant stem and the acrylic bone cement were modeled using beam on elastic foundations theory and two-dimensional elasticity theory. Subsequent formulation of this model as a nonlinear design optimization problem enabled the determination of the dimensions of the implant and reinforcing shell which minimized an objective function based on a simplified material failure criterion. Two cases were examined, each with two cervico-diaphyseal angles: case A: with a rigid contact between a proximal prosthesis collar and the calcar femorale and case B: no collar contact (a collarless prosthesis or post-operative loosening). Case A achieved an optimal solution at a stem diameter 11-23 percent of the cortex inner diameter, a stem length to diameter ratio of 12-40, shell diameter 22-53 percent and thickness 0.2-7.2 percent of the cortex inner diameter and thickness, respectively. Case B achieved an optimal solution at a stem diameter 67-92 percent of the cortex inner diameter, length to diameter ratio of 4-6, and no shell. In case A the collar support makes the type of internal fixation unimportant, while in the more realistic case B, the shell is not recommended.

Elasticity↗
PubMed2004

A neuroendocrine-based regulatory fatigue model.

PURPOSE: To provide an overview of select existing fatigue models and propose a neuroendocrine-based regulatory fatigue model that can serve as a foundation for interventions to manage fatigue. CONCEPTUAL FRAMEWORK: Biobehavioral systems based on a neuroendocrine regulatory framework. METHODS: Empirical data and literature review to develop a fatigue model to serve as a foundation for interventions to manage fatigue. CONCLUSIONS: The proposed model will facilitate testing of interventions based on the premise that common neuroendocrine transmitters provide the mechanisms of fatigue in patients diagnosed with chronic illnesses, such as with cancer treatment-related fatigue. The model may also be used to identify predictors of fatigue in specific patient populations, provide guidance for clinicians in their selection of precise interventions to be implemented, and identify the effects of treatments captured in these populations. By clearly identifying the mechanisms of fatigue, we can discover which interventions are effective for particular types of fatigue.

Circadian Rhythm↗
PubMed2004

Can we prevent a second 'Gulf War syndrome'? Population-based healthcare for chronic idiopathic pain and fatigue after war.

In the 1991 Gulf War less than 150 of nearly 700,000 deployed US troops were killed in action. Today, however, over 1 in 7 US veterans of the war has sought federal healthcare for related-health concerns, and fully 17% of UK Gulf War veterans describe themselves as suffering from the 'Gulf War syndrome', a set of poorly defined and heterogeneous ailments consisting mainly of chronic pain, fatigue, depression and other symptoms. Even though over 250 million dollars of federally funded medical research has failed to identify a unique syndrome, the debate regarding potential causes continues and has included oil well smoke, contagious infections, exposure to chemical and biological warfare agents, and posttraumatic stress disorder. Historical analyses completed since the Gulf War have found that postwar syndromes consisting of chronic pain, fatigue, depression and other symptoms have occurred after every war in the 20th century. These syndromes have gone by a variety of names such as Da Costa's syndrome, irritable heart, shell shock, neurocirculatory asthenia, and battle fatigue. Though the direct causes of these syndromes are typically elusive, it is clear that war sets in motion an undeniable cycle of physical, emotional, and fiscal consequences for war veterans and for society. These findings lead to important healthcare questions. Is there a way to prevent or mitigate subsequent postwar symptoms and associated depression and disability? We argue that while idiopathic symptoms are certain to occur following any war, a population-based approach to postwar healthcare can mitigate the impact of postwar syndromes and foster societal, military, and veteran trust. This article delineates the model, describes its epidemiological foundations, and details examples of how it is being adopted and improved as part of the system of care for US military personnel, war veterans and families. A scientific test of the model's overall effectiveness is difficult, yet healthcare systems for combatants and their families are already being put to pragmatic tests as troops return from war in Iraq and Afghanistan and from other military challenges.

Chronic Disease↗
PubMedDate not supplied

Classical and quantum dynamics on p-adic trees of ideas.

We propose mathematical models of information processes of unconscious and conscious thinking (based on p-adic number representation of mental spaces). Unconscious thinking is described by classical cognitive mechanics (which generalizes Newton's mechanics). Conscious thinking is described by quantum cognitive mechanics (which generalizes the pilot wave model of quantum mechanics). The information state and motivation of a conscious cognitive system evolve under the action of classical information forces and a new quantum information force, namely, conscious force. Our model might provide mathematical foundations for some cognitive and psychological phenomena: collective conscious behavior, connection between physiological and mental processes in a biological organism, Freud's psychoanalysis, hypnotism, homeopathy. It may be used as the basis of a model of conscious evolution of life.

Cognition↗
PubMed1990

Wives, husbands, and daughters caring for institutionalized and noninstitutionalized dementia patients: toward a model of caregiver burden.

The primary purposes of this article are to clarify some of the inconsistencies in the previous research studies done on factors associated with caregiver burden; to identify specific sets of variables that best explain the differential burden levels among caregivers; and to provide a substantial foundation for developing a model of caregiver burden useful for both research and clinical interventions. The caregiver's gender, relationship to the patient, and the residential location of the patient (same house, community, or institution) are major considerations in our analyses. This study is also unique, because it uses a relatively large national sample of caregivers, which is necessary to accomplish the study's objectives. Mailed questionnaires were completed by 409 caregivers identified by fifty local support groups in sixteen different states in the United States. Generally, the primary correlates of burden were factors related to the levels and types of impairment in patient functioning, caregiver life satisfaction, and social support. Each category of caregiver circumstances had a unique set of three to five correlates with the total amount of variance explained in burden ranging from 25 percent (husbands living with the patients) to 68 percent (husbands with spouses in nursing homes). Implications for future research and interventions are discussed.

Alzheimer Disease↗
PubMed1993

Caring perspectives in nursing education: liberation, transformation and meaning.

The author's personal journey through many years of nursing education as both a student and faculty member lead to a theoretical exploration of a caring pedagogy between students and teachers. The author places this exploration in a historical context and examines education, feminist and nursing literature to evolve common themes in describing caring pedagogy within nursing. Finally, the author suggests a model that forms the foundation for nursing curricula based on caring values.

Attitude of Health Personnel↗
PubMed1987

Cognitive rehabilitation: a model for occupational therapy.

A theoretical model that provides a foundation for understanding function and dysfunction in cognition and perception is needed as a prerequisite for the development of effective assessment and treatment tools to be used with the brain-injured adult. Such a model and clear definitions are absent in the occupational therapy literature on adult brain function and dysfunction. This paper represents a cognitive rehabilitation model adapted for occupational therapy from the fields of neuropsychology and cognitive psychology. Differentiation of terms, an overview of the model's theory, and evaluation principles are discussed. Cognitive rehabilitation is presented from an information processing perspective. Three other treatment approaches identified in the literature are discussed and compared with cognitive rehabilitation.

Activities of Daily Living↗
PubMed2007

The Work Compatibility Improvement Framework: an integrated perspective of the human-at-work system.

The industrial revolution demonstrated the limitations of a pure mechanistic approach towards work design. Human work is now seen as a complex entity that involves different scientific branches and blurs the line between mental and physical activities. Job design has been a traditional concern of applied psychology, which has provided insight into the interaction between the individual and the work environment. The goal of this paper is to introduce the human-at-work system as a holistic approach to organizational design. It postulates that the well-being of workers and work outcomes are issues that need to be addressed jointly, moving beyond traditional concepts of job satisfaction and work stress. The work compatibility model (WCM) is introduced as an engineering approach that seeks to integrate previous constructs of job and organizational design. The WCM seeks a balance between energy expenditure and replenishment. The implementation of the WCM in industrial settings is described within the context of the Work Compatibility Improvement Framework. A sample review of six models (motivation-hygiene theory; job characteristics theory; person-environment fit; demand-control model; and balance theory) provides the foundation for the interaction between the individual and the work environment. A review of three workload assessment methods (position analysis questionnaire, job task analysis and NASA task load index) gives an example of the foundation for the taxonomy of work environment domains. Previous models have sought to identify a balance state for the human-at-work system. They differentiated between the objective and subjective effects of the environment and the worker. An imbalance between the person and the environment has been proven to increase health risks. The WCM works with a taxonomy of 12 work domains classified in terms of the direct (acting) or indirect (experienced) effect on the worker. In terms of measurement, two quantitative methods are proposed to measure the state of the system. The first method introduced by Abdallah et al. (2004) identifies operating zones. The second method introduced by Salem et al. (2006) identifies the distribution of the work elements on the x/y coordinate plane. While previous efforts have identified some relevant elements of the systems, they failed to provide a holistic, quantitative approach combining organizational and human factors into a common framework. It is postulated that improving the well-being of workers will simultaneously improve organizational outcomes. The WCM moves beyond previous models by providing a hierarchical structure of work domains and a combination of methods to diagnose any organizational setting. The WCM is an attempt to achieve organizational excellence in human resource management, moving beyond job design to an integrated improvement strategy. A joint approach to organizational and job design will not only result in decreased prevalence of health risks, but in enhanced organizational effectiveness as well. The implementation of the WCM, that is, the Work Compatibility Improvement Framework, provides the basis for integrating different elements of the work environment into a single reliable construct. An improvement framework is essential to ensure that the measures of the WCM result in a system that is adaptive and self-regulated.

Employment↗