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Pesticide exposure and risk of breast cancer: a nested case-control study of residentially stable women living on Long Island.

We conducted a nested case-control study of women in the New York State cohort who lived on Long Island. We estimated the historical environmental exposure to pesticides in 105 women diagnosed with breast cancer between 1980 and 1992 and 210 age and race-matched controls in this cohort of long-term residentially stable women who completed a short mailed questionnaire in 1980. Prior agricultural land use was assessed from aerial photographs taken in 1947 and 1950. Pesticides detected in drinking water were estimated from measures taken between 1977 and 1992. Geographic information system software was used to calculate the distance between residences and hazardous waste sites (HWS) containing pesticides. We found an increased breast cancer risk for women residing within 1 mile of HWS containing organochlorine pesticides (odds ratio [OR]=2.8; 95% confidence interval [CI], 1.1-7.1), after adjusting for other risk factors. A significant interaction was shown for women residing on land that was previously used for agriculture and women who were either nulliparous or had an older age at first birth (> or =26 yr old), compared to women who did not live on previously agricultural land and with a younger age (<26 yr old) at first birth (OR=6.4; 95%CI, 2.2-18.2). Study power was limited and confidence intervals were wide. Our findings suggest that exposure to pesticides in the environment needs to be more comprehensively investigated in relation to breast cancer risk.

Adult↗

CC chemokine concentrations increase in respiratory distress syndrome and correlate with development of bronchopulmonary dysplasia.

Inflammation is one of the primary processes underlying respiratory distress syndrome (RDS) and its evolution into bronchopulmonary dysplasia (BPD). Recruitment and subsequent activation of macrophages in the lung are mediated by CC chemokines. The role of CC chemokines has not been extensively studied in the course of RDS. Serial tracheal aspirates (TA) were obtained from 56 mechanically ventilated infants with birth weights less than 1,500 g during intervals in the first 21 days of life. Tracheal aspirate concentrations of monocyte chemoattractant proteins-1,2,3 (MCP-1,2,3) and macrophage inflammatory proteins-1alpha and -1beta (MIP-1alpha, MIP-1beta) were determined by enzyme-linked immunosorbent assay (ELISA). Tracheal aspirate concentrations of MCP-1, MCP-2, MCP-3, and MIP-1beta increased during the first week of life in infants with RDS, whereas MIP-1alpha concentrations did not increase appreciably. Increased TA cytokine concentrations were associated with the development of BPD. Maximal TA concentrations of MCP-1, MCP-2, MCP-3, MIP-1alpha, and MIP-1beta were significantly higher in infants who were oxygen-dependent at 28 postnatal days compared to infant who were not. Similarly, maximal TA MCP-1, MCP-2, and MCP-3 but not MIP-1alpha and MIP-1beta concentrations were significantly higher in infants who were oxygen-dependent at 36 weeks of postconceptional age (PCA) than those who were not oxygen-dependent at 36 weeks PCA. Histologic chorioamnionitis and isolation of Ureaplasma urealyticum from the airways were associated with higher maximal TA concentrations of MIP-1alpha and MIP-1beta. Pulmonary hemorrhage was associated with increased maximal concentrations of MCP-1, MCP-2, and MCP-3. These data suggest a role for CC chemokines in the development of BPD in the newborn infant.

Bronchopulmonary Dysplasia↗

Metabolic DNA in the hepatocyte nuclei in newborn rats.

The behaviour in time of labelled nuclear DNA in the hepatocytes of newborn rats was studied using autoradiographic and biochemical techniques in two groups of experiments. In the first group H-3-thymidine was injected to the mothers at the 16th day of pregnancy and the amount of labelled DNA was evaluated in the newborns after delivery. In the second group H-3-thymidine was injected to the newborns two hours after birth and the labelled DNA was studied at the same time intervals as the first group. The amount of labelled thymidine incorporated into the first group of animals remains constant for the first three days of life, thereafter a reduction in specific activity of DNA is observed concomitant with an increase of the percentage of labelled nuclei and a decrease of the number of grains per nucleus. These results show that mitotic divisions, which are absent during the first three days of life, take place between the third and sixth days of life. The decrease of the specific activity is therefore due to dilution and not to loss of labelled DNA. In the second group of experiments the DNA labelled with H-3-thymidine shows a decrease by about 30--40% per day during the first three days of life accompanied by a decrease in the number of grains per nucleus without changes in the percentage of labelled nuclei. These data show that DNA synthesized during the first day after birth is metabolically unstable, unlike that synthesized during foetal life.

Animals↗

Ontogeny of circadian dentinogenesis in the rat incisor.

Periodic growth increments are found universally in the dentine of animals. The goal here was to determine when and how circadian dentine growth increments develop ontogenetically. A total of 97 rat pups, obtained from 13 mothers of the Wistar strain, were injected with nitrilotriacetato lead at appropriate intervals to chronologically label the dentine. Labelled rat pups were killed 5-50 days after birth. Histological transverse sections of the demineralized dentine were obtained from the maxillary incisors of the pups and stained with haematoxylin. Two types of increments were observed in the circumpulpal dentine. The first type was a deeply stained circadian band which appeared at intervals of about 16-24 microns. The other was a faintly stained, narrow, ultradian increment, at intervals of approx. 6-8 microns. The circadian increments were first detected during the second to third week after birth and were observed consistently afterwards. Before the circadian increments developed, the ultradian increments were predominant. These two rhythms seemed to be independent of each other and sometimes coexisted in one section. Thus, the two types of dentine increments may be due to two independent mechanisms.

Activity Cycles↗

Anthropometric indices in relation to mammographic patterns among peri-menopausal women.

The relationship between body height, weight and body mass index and mammographic patterns was examined among 3,208 Norwegian women, aged 40-56 years, participating in the Third Tromsø study. Standardized measurements of height and weight were recorded. Epidemiologic data were obtained through questionnaires. Mammograms were categorized into 5 groups based on anatomic-mammographic correlations. For analysis, patterns I-III were combined into a low-risk group and patterns IV and V into a high-risk group. Odd ratios (ORs), adjusted for menopausal status, age, parity, age at first birth, age at menarche and anthropometric measures, with 95% confidence intervals (CIs), were calculated. Body height was associated positively with high-risk patterns, while weight and body mass index were associated inversely with high-risk patterns. Women in the highest tertile of height were twice as likely (OR = 2.0, 95% CI 1.6-2.6) to have high-risk patterns compared with those in the lowest tertile, and women in the highest tertile of weight were 70% less likely (OR = 0.3, 95% CI 0.2-0.4) to have high-risk patterns compared with those in the lowest tertile. Associations with body mass index were similar to those with weight. All associations were present when stratified by menopausal status. Among post-menopausal women, the inverse associations between body weight and body mass index and high-risk patterns decreased with increasing number of years since menopause. Our results indicate that body height and weight are independently associated with the mammographic pattern among peri-menopausal women. We suggest that body height and weight are related to mammographic patterns through different mechanisms.

Adult↗

Misoprostol in second and early third trimester for termination of pregnancies with fetal anomalies.

OBJECTIVES: To assess the effectiveness of a prostaglandin E1 analog, misoprostol, using different regimens compared with dinoprostone in termination of pregnancies in second and early third trimester complicated by either congenital fetal anomalies or intrauterine fetal demise. METHODS: A retrospective review of 59 pregnancies between 15 and 30 weeks was performed which were terminated due to congenital fetal anomalies or intrauterine fetal demise. In group 1 (n=29) 400 microg oral and 600 microg vaginal misoprostol, in group 2 (n=12) 600 microg vaginal misoprostol and in group 3 (n=18) 0.5 mg dinoprostone gel were given for the termination of the pregnancies. All these groups were evaluated for demographic characteristics and delivery findings. Statistical analysis were performed by one-way ANOVA, Kruskal-Wallis and chi(2)-test. RESULTS: No significant statistical difference was observed in terms of age, gravidity, parity, previous abortion, gestational week, frequency of prostaglandin usage, and birth weights among the three groups. The time intervals between the first administration and delivery were 20.3 h for oral vaginal misoprostol, 17.3 h for vaginal misoprostol and 22.5 h for the dinoprostone group (P=0.594). Evacuation rates after single doses were similar in all groups (83%, 73% and 72%, respectively). Uterine tachysystole was the only major side effect encountered in the oral-vaginal misoprostol group. CONCLUSIONS: All three regimens yielded similar results for termination of pregnancies in second and third trimester. The major advantage of misoprostol was the cost.

Abortifacient Agents, Nonsteroidal↗

Home visiting by paraprofessionals and by nurses: a randomized, controlled trial.

OBJECTIVE: To examine the effectiveness of home visiting by paraprofessionals and by nurses as separate means of improving maternal and child health when both types of visitors are trained in a program model that has demonstrated effectiveness when delivered by nurses. METHODS: A randomized, controlled trial was conducted in public- and private-care settings in Denver, Colorado. One thousand one hundred seventy-eight consecutive pregnant women with no previous live births who were eligible for Medicaid or who had no private health insurance were invited to participate. Seven hundred thirty-five women were randomized to control, paraprofessional, or nurse conditions. Nurses completed an average of 6.5 home visits during pregnancy and 21 visits from birth to the children's second birthdays. Paraprofessionals completed an average of 6.3 home visits during pregnancy and 16 visits from birth to the children's second birthdays. The main outcomes consisted of changes in women's urine cotinine over the course of pregnancy; women's use of ancillary services during pregnancy; subsequent pregnancies and births, educational achievement, workforce participation, and use of welfare; mother-infant responsive interaction; families' home environments; infants' emotional vulnerability in response to fear stimuli and low emotional vitality in response to joy and anger stimuli; and children's language and mental development, temperament, and behavioral problems. RESULTS: Paraprofessional-visited mother-child pairs in which the mother had low psychological resources interacted with one another more responsively than their control-group counterparts (99.45 vs 97.54 standard score points). There were no other statistically significant paraprofessional effects. In contrast to their control-group counterparts, nurse-visited smokers had greater reductions in cotinine levels from intake to the end of pregnancy (259.0 vs 12.32 ng/mL); by the study child's second birthday, women visited by nurses had fewer subsequent pregnancies (29% vs 41%) and births (12% vs 19%); they delayed subsequent pregnancies for longer intervals; and during the second year after the birth of their first child, they worked more than women in the control group (6.83 vs 5.65 months). Nurse-visited mother-child pairs interacted with one another more responsively than those in the control group (100.31 vs 98.99 standard score points). At 6 months of age, nurse-visited infants, in contrast to their control-group counterparts, were less likely to exhibit emotional vulnerability in response to fear stimuli (16% vs 25%) and nurse-visited infants born to women with low psychological resources were less likely to exhibit low emotional vitality in response to joy and anger stimuli (24% vs 40% and 13% vs 33%). At 21 months, nurse-visited children born to women with low psychological resources were less likely to exhibit language delays (7% vs 18%); and at 24 months, they exhibited superior mental development (90.18 vs 86.20 Mental Development Index scores) than their control-group counterparts. There were no statistically significant program effects for the nurses on women's use of ancillary prenatal services, educational achievement, use of welfare, or their children's temperament or behavior problems. For most outcomes on which either visitor produced significant effects, the paraprofessionals typically had effects that were about half the size of those produced by nurses. CONCLUSIONS: When trained in a model program of prenatal and infancy home visiting, paraprofessionals produced small effects that rarely achieved statistical or clinical significance; the absence of statistical significance for some outcomes is probably attributable to limited statistical power to detect small effects. Nurses produced significant effects on a wide range of maternal and child outcomes.

Female↗

Nutritional supplementation during two consecutive pregnancies and the interim lactation period: effect on birth weight.

The study consisted of 169 mothers enrolled during two consecutive pregnancies and the intervening lactation period in the Guatemalan Nutritional Supplementation Study. Women were grouped for this analysis according to the levels of caloric supplementation that they received (high or low) during two consecutive pregnancies and the period between them. The supplement also contained minerals and vitamins. Data were analyzed adjusting for maternal height, birth interval, parity, length of lactation, socioeconomic status, birth weight of the first offspring, gestational age of the second offspring, and caloric supplementation, expressed either in continuous fashion (total intake) or as caloric supplementation per week. The adjusted mean birth weights of the second offspring of women with high supplementation during two pregnancies (about an extra 180 kcal/d), and the in-between lactation period (about an extra 245 kcal/d), were up to 301 g greater than that of the low supplementation group. Women with high supplementation while breast-feeding their first offsprings and during their second pregnancies had babies up to 150 g heavier than the reference group; those mothers with high supplementation only during the second pregnancy had infants about 124 g heavier than those of the low supplementation group. Therefore, high supplementation during two consecutive pregnancies and their intervening lactation period among chronically, yet moderately, malnourished women was capable of increasing the mean birth weight to levels closer to those reported for industrialized populations. The mean birth weight increase is between two and three times greater than the effect shown in almost all of the previous studies of this topic.

Birth Weight↗

[The quantitative passage of immunoglobulins from the intestine into the blood vessels in newborn lambs].

A trial with 69 lambs examined the effect of the feeding regime on the transfer of colostral immunoglobulins from the intestinal lumen to the circulating blood. The lambs received 125 ml of bovine colostral milk per kg birth weight at each feeding in the first 24 hours after birth. There were four experimental groups. Feeding intervals were either 2 or 6 hours and the milk was administered with or without doubling the fluid volume by addition of tap water. Serum concentrations of IgG1, IgG2, IgM and IgA were measured during the experimental period and the transport efficiency index for each isotype was calculated. The transport efficiency index represents the relationship between the amount of immunoglobulin administered in colostral milk and the concentration measured in the blood. Feeding in 2 hour intervals produced maximum immunoglobulin concentrations at 30 hours, while 6 hour feeding intervals achieved the same maximal levels at 24 hours. The relative proportions of the four immunoglobulin isotypes measured in the blood were unaffected by the feeding interval. Doubling the fluid volume administered while holding the absolute amount of colostral milk constant, resulted in a disproportionate increase in blood IgG1 concentration as compared to the other isotypes. Concentrations for IgG2, IgM and IgA remained essentially the same as those achieved with undiluted colostral milk. The feeding regimes tested did not affect endogenous immunoglobulin synthesis, growth rate or the health of the lambs.

Animals↗

Breastfeeding experience and breast cancer risk among postmenopausal women.

Results of studies of breastfeeding and postmenopausal breast cancer risk have been inconsistent, with many investigators concluding that breastfeeding does not influence risk. We examined whether breastfeeding reduces postmenopausal breast cancer risk as well as the details of this relationship, including possible modification in risk by the age that a woman first breastfed a child and the number of children she breastfed. This population-based case-control study compared 974 women who were residents of Los Angeles County and newly diagnosed with breast cancer to 973 women with no history of breast cancer who were matched to patients by age (within 3 years) and neighborhood of residence. Subjects were parous and postmenopausal. Breast cancer patients were ages 55-64 years at diagnosis. Women who breastfed at least 16 months experienced a reduced odds of breast cancer relative to women who never breastfed (odds ratio, 0.73; 95% confidence interval, 0.52-1.01). Risk decreased as the number of children breastfed increased, but the association was attenuated after accounting for lifetime duration of breastfeeding. Breast cancer risk was 30% lower among women ages 20-24 years at first breastfeeding than women who had never breastfed (odds ratio, 0.69; 95% confidence interval, 0.54-0.88), independent of the effect of age at first birth. This study provides some evidence that the protective effect of breastfeeding persists into the postmenopausal years. The potential for nondifferential error in recall of breastfeeding habits among postmenopausal patients and controls may explain the inconsistent results observed across studies and underscores the need for careful assessment of this relationship.

Adolescent↗

Perinatal mortality in first- and second-born twins in the United States.

OBJECTIVE: To evaluate the prevailing mortality paradox that second-born twins are at higher risk of perinatal mortality than first-born twins. METHODS: We used the 1995-1997 United States "matched multiple birth" data files assembled by the National Center for Health Statistics, for analysis of risk of perinatal mortality in first- and second-born twins (293788 fetuses). Perinatal mortality was defined to include stillbirths after 20 weeks of gestation and neonatal deaths (deaths within the first 28 days). Gestational age-specific risk of perinatal mortality (per 1000 total births), stillbirth (per 1000 total births), and neonatal mortality (per 1000 livebirths) by order of twin birth were based on the fetuses-at-risk approach. Associations between order of birth and mortality indices were evaluated by fitting multivariable logistic regression models based on the method of generalized estimating equations. These models were adjusted for several potential confounding factors. RESULTS: Perinatal mortality was 37% higher in second-born (26.1 per 1000 total births) than in first-born (20.3 per 1000 total births) twins (adjusted relative risk [RR] 1.37; 95% confidence interval [CI] 1.32, 1.42). The increased risk of perinatal mortality in second-born twins was chiefly driven by a 2.46-fold (95% CI 2.29, 2.63) increase in the number of stillbirths. However, the risk of neonatal mortality was very similar between first- and second-born twins (RR 0.99, 95% CI 0.95, 1.04). CONCLUSIONS: The increased risk of perinatal death in second-born twins is driven chiefly by increased rates of stillborn second twins. Thus, the increased mortality in second-born over first-born twins probably is an artifact of mortality comparisons.

Adult↗

Birth interval and the sex of children in a traditional African population: an evolutionary analysis.

Birth interval is a major determinant of rates of fertility, and is also a measure of parental investment in a child. In this paper the length of the birth interval in a traditional African population is analysed by sex of children. Birth intervals after the birth of a boy were significantly longer than after the birth of a girl, indicating higher parental investment in boys. However, in women of high parity, this differential disappeared. Birth intervals for women with no son were shorter than for those with at least one son. All these results are compatible with an evolutionary analysis of reproductive decision-making. First born sons have particularly high reproductive success, daughters have average reproductive success and late born sons have low reproductive success. The birth interval follows a similar trend, suggesting that longer birth intervals represent higher maternal investment in children of high reproductive potential.

Adult↗

Reproductive and hormonal factors associated with mammographic breast density by age (United States).

OBJECTIVES: We determined the association of certain reproductive and hormonal factors with breast density over decades of life. METHODS: Subjects were women age 20-79 years who had a screening mammogram between 1 June 1996 and 1 August 1997, in Seattle, Washington. Women with increased breast density (upper two categories of BI-RADS terminology) (n = 14,432) were compared to those with fatty breasts (lower two categories (n = 14,552). Unconditional logistic regression was used with adjustment for age at mammogram, parity, age at first birth, menopausal status, current use of hormone replacement therapy (HRT), and body mass index. RESULTS: The association of nulliparity with density was evident for women at all ages (odds ratio (OR) and 95% confidence interval (CI) = 1.5 (1.3-1.7) and 1.6 (1.4-1.9) for women age < or = 45 and > 65, respectively). Older age at first birth was more strongly associated with density among women > 55 than among younger women. The association of current use of HRT with density, but not of former use, increased with age when compared to never users (OR = 1.4 (1.2-1.7) and 2.2 (2.0-2.5) for women age 46-55 and > 65, respectively). CONCLUSIONS: Results suggest that pregnancy at an early age has a permanent beneficial association with density, while HRT has a transitory adverse association.

Adipose Tissue↗

The impact of pregnancy on the long-term weight gain of primiparous women in England.

OBJECTIVES: To investigate the impact of pregnancy on long-term weight gain of primiparous mothers in England, and to identify potential risk factors for maternal obesity. DESIGN: A retrospective, repeat-pregnancy study which examined the change in maternal body weight from the beginning of the first successful pregnancy to the beginning of the second. SUBJECTS: Two hundred and forty-three mothers, all of whom had been weighed during the first trimester of their first and second pregnancies, and none of whom had fallen pregnant less than 12 months after the birth of their first child. MEASUREMENTS: Sociodemographic, behavioural, medical, obstetric and perinatal data, together with antenatal measurements of maternal body weight and height, were extracted from each mother's obstetric notes. A comprehensive survey of weighing scales used at all antenatal clinics was undertaken. RESULTS: After accounting for the effect of ageing, there was no significant long-term increase in mean maternal body weight following the first pregnancy (95% Confidence Intervals: -0.82-0.28kg). While most mothers (70.8%) gained 1.0 kg or less, 24.7% gained more than 1.54 kg. Even after accounting for the maximum error in clinic scales, 14.8% of the mothers gained 1.54 kg or more in association with their first pregnancy. Mothers with higher BMIs at the beginning of their first pregnancy, who gained more weight during pregnancy, gave birth to heavier babies and had longer intervals between their pregnancies, gained significantly more weight from one pregnancy to the next. CONCLUSIONS: Pregnancy has little impact on the mean weight gain of primiparous women from England, who have a low prevalence of obesity (BMI > or = 26.0, 25.5%). Nevertheless, pregnancy may be associated with a permanent increase in maternal body weight simply because it is a period of positive energy balance during which some women gain excessive weight. Other factors, such as prepregnant BMI, determine whether long-term weight gain actually occurs.

Adult↗

Properties of thyroid-stimulating hormone and cortisol secretion by the human newborn on the day of birth.

Secretory activation of the thyroid and adrenal glands is a hallmark of the neonatal adaptation to extrauterine life. TSH and cortisol play key roles in these axes. The highest serum concentrations of TSH attained over the full span of human life are normally found shortly after birth. Serum cortisol is also known to be elevated in the immediate postnatal period. However, the dynamics of TSH and cortisol secretion have hitherto not been documented on the day of birth. To study the properties of neonatal TSH and cortisol secretion, we obtained arterial blood at regular intervals (every 20 min for 6 h) from nine polycythemic newborns (gestational age, 34-41 weeks) on the first and/or fourth days after birth during a therapeutic, standardized, isovolumetric, partial exchange transfusion. One premature infant had received betamethasone antenatally. The serum TSH level of an infant with congenital hyperthyroidism of transplacental origin was also measured at the postnatal age of 1 h. Deconvolution analysis of the profiles revealed that all infants displayed a combination of basal and pulsatile TSH release. Bursts of TSH secretion occurred at a median interval of 133 min. The median serum TSH half-life was 75 min. On the day of birth, basal TSH secretion and the amplitude of pulsatile TSH secretion were higher than 3 days later. Cortisol was secreted exclusively in a pulsatile fashion. Bursts of cortisol release occurred at a median interval of 69 min. The median serum cortisol half-life was 60 min. Cortisol secretion appeared to shift gradually from a high frequency, low amplitude pattern early on the first day toward a lower frequency, higher amplitude pattern 3 days later. TSH and cortisol secretion were low in the infant who received betamethasone prenatally. Serum TSH was undetectable in the infant with congenital hyperthyroidism. In conclusion, serum TSH concentrations in the human newborn appear to be elevated on the day of birth as a result of amplified basal and pulsatile TSH release, then fall rapidly through a mechanism that decreases the amplitude of TSH secretion and are affected by modulation of the fetal thyroid axis. From the day of birth onward, cortisol was found to be released in an exclusively pulsatile mode, with characteristics that appear to depend on postnatal age and prenatal glucocorticoid exposure.

Aging↗

Outcomes of pregnancies complicated by early vaginal bleeding.

The association between early gestational bleeding and suboptimal pregnancy outcome was examined. Postpartum women were interviewed during January-October 1998 at the two main obstetric hospitals in Alexandria, Egypt. Of 1503 singleton deliveries, 10.6% reported bleeding; 63.5% and 36.5% during first and second trimesters respectively. Bleeding was more frequent among women of age > 33 years, with history of low-birth-weight babies or previous miscarriage. Suboptimal outcomes occurred more often among women reporting bleeding than among those who never bled and the risk of such outcomes significantly increased with second trimester bleeding. Risk of a low-birth-weight baby, preterm delivery and perinatal death significantly decreased with increasing interpregnancy interval for women with first trimester or second trimester bleeding.

Adult↗

Recurrence risk in hyperemesis gravidarum.

OBJECTIVES: To compare the risk of hyperemesis gravidarum in second pregnancies in women with and without hyperemesis in their first pregnancy, and to determine if this risk changes with changes in paternity or with the interval between deliveries. DESIGN: Cohort study. SETTING: Data from the population-based Medical Birth Registry of Norway, 1967-1998. Sample All women in the registry with records of their first and second singleton delivery, a total of 547,238 women. METHODS: The relative risk of hyperemesis in the second delivery was estimated as odds ratios (ORs) in logistic regression models, controlling for potential confounding factors. MAIN OUTCOME MEASURES: The main outcome measure was the risk of hyperemesis in the second pregnancy according to hyperemesis in the first pregnancy, interval between deliveries and change in paternity. RESULTS: The risk of hyperemesis was 15.2% in the second pregnancy in women with and 0.7% in women without previous hyperemesis [OR=26.4, 95% confidence interval (CI) 24.2, 28.7]. The OR did not change after adjustment for maternal age, change in paternity, period of the first delivery and time interval between deliveries. After a change in paternity, the risk of recurrent hyperemesis was 10.9% compared with 16.0% in women without a change in paternity [adjusted OR (aOR)=0.60, 95% CI 0.39, 0.92]. The risk of hyperemesis in the second pregnancy increased with increasing time interval between deliveries, but only in women with no previous hyperemesis. CONCLUSIONS: The primary finding was the high risk of recurrence observed in women with hyperemesis in the first pregnancy. The risk was reduced by a change in paternity. For women with no previous hyperemesis, a long interval between births slightly increased the risk of hyperemesis in the second pregnancy. Further studies are needed to explore the relative impact of genetic and environmental factors and their possible interactions in hyperemesis gravidarum.

Adult↗