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At least 361 records · Page 20Linked to original sources
PubMed1984

Immunologic dysfunction during viral oncogenesis. II. Inhibition of cellular immunity to viral antigens by malignant rabbit fibroma virus.

The ability of two related viruses--Shope fibroma virus (SFV) and malignant rabbit fibroma virus (MV)--to induce virus-specific immune responses in lymphocytes of recipient animals was studied. SFV produces a benign local tumor which regresses in 12-14 days. Using an assay for virus-induced lymphocyte blastogenesis lymphocytes reactive to SFV were detected, both in rabbits bearing SFV-induced tumors and in rabbits whose SFV-induced tumor had regressed. These virus-reactive cells were detected in peripheral blood and spleen, and in lymph nodes draining the primary tumor. In contrast, MV produces a disseminated tumor and eventual death. MV does not induce detectable blastogenic responses in lymphocyte populations. SFV and MV are antigenically cross reactive: rabbits immune to SFV do not develop MV-induced tumors, and antisera to each virus neutralize both equally. Lymphocytes from SFV-infected rabbits proliferate in vitro in response to MV that has been inactivated by ultraviolet light (uv/MV) but not to infectious MV. In contrast, lymphocytes from rabbits infected with MV do not respond to uv-inactivated MV or to SFV. Thus, infectious MV inhibits the development of normal blastogenic responses in vivo and prevents the expression of those responses in lymphocytes from MV-resistant, SFV-immune rabbits in vitro. The relevance of this impairment to the differences in the clinical courses of SFV- and MV-induced tumors is discussed.

Animals↗
PubMed1978

Desmoplastic fibroma (fibromatosis) of the jawbones. Report of a case and review of the literature.

Desmoplastic fibroma (fibromatosis) is rarely seen as a primary tumor of bone. Its occurrence as a central lesion in the jaws is even more uncommon. The case of a 26-year-old woman with a central desmoplastic fibroma of the body of the mandible is described. The lesion manifested as a painless swelling and radiographically appeared as a well-delineated radiolucency. On exploration, the tumor was found to have infiltrated through the lingual cortex. Microscopic examination revealed invasion of muscle. The clinicopathologic features of this case and of the twenty-five similar lesions previously described in the literature are analyzed and discussed.

Adult↗
PubMed1990

Contiguous enlarged dental follicles with histologic features resembling the WHO type of odontogenic fibroma.

Defective odontogenesis and/or retarded eruption of teeth can be associated with histologic features akin to odontogenic fibroma in the dental follicles. Unerupted mandibular premolar and molar teeth of a 24-year-old man were surgically exposed, yet the teeth failed to erupt. About a year and a half later, radiographs indicated further enlargement of the follicle of the premolar, and both teeth were subsequently surgically removed. Histologically, the follicles were composed of mature collagenous tissue among which epithelial islands and numerous clusters of calcified bodies were present. Indirect immunofluorescence showed positive staining for type I and type III collagen, which exhibited a sparse distribution, but not for the aminoterminal propeptide of type III procollagen. The hamartomatous nature of the lesions is discussed with emphasis on their histologic resemblance to the WHO type of odontogenic fibroma.

Adult↗
PubMed1991

Fibromatous epulis in dogs and peripheral odontogenic fibroma in human beings: two equivalent lesions.

This article compares the clinical and histopathologic features of the peripheral odontogenic fibroma in human beings and the fibromatous epulis in dogs. They are apparently equivalent lesions. Both are odontogenic tumors of limited growth potential that do not recur if adequately excised; both occur in middle and late adulthood of the species concerned. The one difference is that the peripheral odontogenic fibroma is a rare condition, whereas the canine fibromatous epulis is common.

Animals↗
PubMed1983

Physical characterization and molecular cloning of the Shope fibroma virus DNA genome.

DNA from several independent strains of Shope fibroma virus, a tumorogenic leporipoxvirus of rabbits, was isolated and analyzed by restriction endonuclease digestion and Southern blotting. The restriction profiles indicated a high degree of sequence conservation among the isolates but blotting under standard stringencies revealed no detectable cross homology with a member of the orthopoxvirus group, vaccinia. The genome of the fibroma virus was calculated to be in excess of 160 kilobases and shown to possess two features analogous to the orthopoxvirus group: (1) the terminal restriction fragments possess covalently closed hairpin structures; and (2) the terminal sequences are present as inverted repeats of greater than 10 kilobases. The terminal 3.6 kilobase BamHI restriction fragment was cloned in pBR322 after removal of the hairpin structure with mung bean single strand-specific endonuclease and addition of BamHI linkers. SFV sequences within this terminal region were shown, using 32P SFV cloned terminal probe, to have none of the sequence heterogeneity characteristic of vaccinia DNA termini. The remaining 20 internal SFV BamHI restriction fragments were propagated in bacterial plasmids either as intact fragments, or after secondary digestion with HindIII, and together constitute the complete cloned SFV sequence library.

Base Sequence↗
PubMed1987

Tumorigenic poxviruses: transcriptional mapping of the terminal inverted repeats of Shope fibroma virus.

A composite transcriptional map for the entire 12.4-kb terminal inverted repeat (TIR) region of the Shope fibroma virus (SFV) genome has been determined. Northern blotting and S1-nuclease mapping were used to determine the regions which are transcribed, their temporal relationships, as well as the transcriptional initiation sites. Sequences representing the entire TIR are transcribed into poly(A)+ mRNA at both early and late times in the infection. Fifteen transcriptional initiation sites were mapped, 12 within the TIRs and 3 within the unique sequences close to the junction between the right TIR and the unique internal sequences. Ten of the 12 transcriptional initiation sites within the TIR and 2 of the 3 sites outside the right TIR correspond to the 5'-ends of the major open reading frames (ORFs) T1 to T9 plus the SFV growth factor gene. The 3 other initiation sites map within ORFs but near potential start codons for shorter polypeptides. All the expressed ORFs are tandemly arranged and transcribed toward the hairpin terminus. At early times during SFV infection of cultured rabbit cells, transcription of each ORF gives rise to a transcript of distinct size, while at late times termination of transcription is imprecise and substantial read-through into downstream sequences occurs. These results are discussed in light of recent observations on the related recombinant leporipoxvirus, malignant rabbit fibroma virus, which suggest that one or more gene products from this region of the SFV genome are implicated in viral tumorigenicity.

Base Sequence↗
PubMed1990

Myxoma virus and malignant rabbit fibroma virus encode a serpin-like protein important for virus virulence.

The leporipoxviruses Shope fibroma virus (SFV), the myxoma virus (MYX), and the SFV/MYX recombinant malignant rabbit fibroma virus (MRV) are closely related yet induce profoundly different diseases in the European rabbit. SFV, which produces a benign tumor at the site of inoculation, is cleared by the immune system after approximately 2 weeks whereas MYX and MRV induce a rapidly lethal systemic infection characterized by generalized suppression of host immune functions. DNA sequencing studies reveal that MRV and MYX possess homologous gene members of the T6/T8/T9 family originally described in the terminal inverted repeat (TIR) of SFV. We also describe a gene present in both MYX and MRV genomes, but which has apparently evolved in the SFV genome into a fragmented pseudogene that appears to contribute to the aggressive nature of MYX and MRV infections. Translation of this open reading frame, designated MYXOMA SERPIN 1 (SERP1), reveals a protein sequence with highly significant homology to the super-family of serine protease inhibitors (serpins) which also includes a number of other poxviral proteins. In the MYX genome the SERP1 gene lies entirely within the TIR sequences and is thus present as two copies, while in the MRV genome SERP1 is present in the unique sequences adjacent to the TIR boundary and hence is a single copy. The amino acid homology between the putative active site of SERP1 and those of other serpins predicts that the target enzyme will be different from the known catalog of serine antiprotease substrates. Deletion of this gene from MRV significantly attenuates the disease spectrum induced by the normally lethal virus. Although the MRV-S1 deletion construct (MRV with SERP1 gene deleted) grows in all tissue culture cells tested in a fashion identical to the MRV parent, the majority of rabbits infected with MRV-S1 are able to mount an effective immune response and totally recover from the virus infection to become resistant to subsequent challenge by MRV or MYX.

Amino Acid Sequence↗
PubMed1990

Tumorigenic poxviruses: characterization of the expression of an epidermal growth factor related gene in Shope fibroma virus.

The transcription and translation of an epidermal growth factor (EGF) related gene in the Leporipoxvirus Shope fibroma virus (SFV), termed the Shope fibroma growth factor (SFGF), have been characterized. Three early RNA transcripts complimentary to an anti-SFGF oligonucleotide were detected by Northern blot analysis, while no late transcripts were expressed. The activity of the SFGF early promoter was measured using a transient gene expression assay in SFV-infected cells using the bacterial choloramphenicol acetyltransferase as a reporter gene. Deletion analysis showed that the functional SFGF promoter domain is an AT-rich sequence contained within 30 bp of the major transcriptional initiation site as is typical of early poxvirus promoters. An intracellular form of the SFGF gene product was immunoprecipitated from infected lysates using rabbit antisera raised against a synthetic SFGF (amino acids 26-80). A 16-kDa product was detected, while in cells infected in the presence of tunicamycin, the immunoprecipitated product had a mobility on SDS-polyacrylamide gels of approximately 6 kDa, indicating that the SFGF gene product is extensively post-transcriptionally modified. The intracellular 16-kDa form can be pulse-chased to a 14-kDa form but the secreted form of SFGF could not be detected in the medium using this anti-peptide antiserum.

Base Sequence↗
PubMed1992

Ossifying fibroma of the thoracolumbar spine: a case report and review of the literature.

A 43-year-old woman with ossifying fibroma of the thoracolumbar vertebrae was presented with a 6-month history of progressive radiculomyelopathy. The symptoms were successfully treated by laminectomy and partial resection of the lesion. This is the first reported case of ossifying fibroma involving the thoracolumbar spine. The clinical significance and management of this rare lesion are discussed with a review of the literature.

Adult↗
PubMed1992

Sequence and analysis of the BamHI "D" fragment of Shope fibroma virus: comparison with similar regions of related poxviruses.

Differences observed in the virulence of two related leporipoxviruses are closely tied to a particular region of their genomes. For the virulent poxvirus of this pair, malignant rabbit fibroma virus (MV), this region is the BamHI "C" fragment, which is 10.7 kb. For the avirulent poxvirus, Shope fibroma virus, SFV, this region is the corresponding BamHI "D" fragment, which is 13.1 kb. As part of our attempt to understand the virulence of these two viruses, we sequenced these two DNA fragments. The sequence for the BamHI "C" fragment of MV is reported elsewhere (Strayer et al., 1991). We report here the sequence for SFV's BamHI "D" fragment and resultant open reading frames, and compare both DNA and open reading frame structures to those of MV and other known poxviruses. The BamHI "D" fragment of SFV contains 12 open reading frames of 100 amino acids or more, arranged similarly to orf's in MV and vaccinia. Striking similarities between SFV and MV are seen in certain parts of this restriction fragment, including substantial stretches of DNA in which the two viruses are identical. Clear homologies exist between these leporipox virus genomes and those of other related poxviruses. To understand the pathogenesis of virus infection, one must appreciate the structure of those viral genes that play important roles in infection.

Base Sequence↗
PubMed1989

Non-osteogenic fibroma of the mandibular condyle.

Non-osteogenic fibroma is a lesion most commonly seen within the metaphyseal region of the tibia or femur presenting during the second decade. Few cases have been reported in the jaws and all occurred in the mandible. This report documents an 18-year-old female with a non-osteogenic fibroma in the condyle.

Adolescent↗
PubMed1985

Aggressive ossifying fibroma of the mandible.

A case of aggressive ossifying fibroma has been presented, and emphasis has been placed on the importance of evaluating multiple parameters before a specific diagnosis is assigned. The unique histologic appearance of this particular lesion demonstrates a close relationship between the aggressive ossifying fibroma and a well-differentiated osteogenic sarcoma and advocates the need for more defined microscopic criteria to properly identify such lesions as either benign or malignant. It is suggested that proper surgical management of the aggressive forms of fibro-osseous lesions be dictated by the surgical judgement of the operator, in conjunction with what is best for the patient.

Child↗
PubMed1995

Ossifying fibroma of the occipital bone.

A case of occipital ossifying fibroma in a 13-year-old girl is presented. Ossifying fibroma is a rare, benign, primary bone tumour that occurs most commonly in the mandible. Cranial vault location is extremely rare. To our knowledge, our patient is the second case of occipital location reported. Total surgical excision is the treatment of choice.

Adolescent↗
PubMed1994

Fibroma of tendon sheath in the hand.

Seven cases of fibroma of tendon sheath in the hand are reviewed. These tumors are common enough to be considered in the differential diagnosis of a soft tissue tumor in the hand, as they comprised 7 of our series of 208 soft tissue hand tumors excised over a 15-year period. A marginal excision was performed in each case, and no tumor recurred after a mean follow-up interval of 8 years. The fibromas were adherent to tendons, tendon sheaths, and neurovascular structures, and thus were more difficult to excise without morbidity than other soft tissue hand tumors.

Adolescent↗
PubMed1993

Desmoplastic fibroma of the maxillary alveolus.

Desmoplastic fibroma is an uncommon tumour of bone and has only exceptionally been reported in the jaws. This case report describes only the second example of a desmoplastic fibroma which involved the maxillary alveolus.

Adult↗
PubMed2006

Left ventricular fibroma mimicking an acute coronary syndrome.

Cardiac fibromas are exceedingly rare neoplasms. We report the case of a 21-year-old woman who presented with symptoms that were initially misinterpreted as an acute coronary syndrome. Radical surgical resection was undertaken and was considered curative, as the mass histology was consistent with a benign fibroma.

Adult↗