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Data are presented on the dermatoglyphics of a group of cancer patients showing that they differ from those of groups suffering from certain other diseases and from those of reported mixed English samples. The differences are much more marked in males than in females. It is suggested that the genes which produce these differences may predispose the cancer patients to their malignancy.
The morphological features of the palmar, plantar and digital areas of the rat were studied and compared to the corresponding human traits. The location and the timing of appearance of the volar pads and flexion creases of human and rat fetuses were investigated to determine the feasibility of using rats as an experimental model for studying the factors influencing early development of the dermatoglyphics in humans. Comparisons between analogous developmental stages of human and rat fetuses demonstrate striking similarities in overall fetal development. However, marked differences between human and rat fetuses were found in the timing of developmental milestones and in some morphological features. Provided that these differences are taken into consideration, rats can serve as a useful experimental model in studies of the utility of the epidermal ridge configurations and flexion creases in medical disorders.
The dermatoglyphic (fingerprint) patterns of 288 patients with biliary atresia (117 males and 171 females) were compared to those of normal Japanese. Arches and radial loops were seen more frequently than the normal distribution on thumb, ring- and little-fingers. Nineteen percent of the patients had abnormal fingerprint patterns.
Dermatoglyphic characteristics, both quantitative and qualitative, of fingers and palms of 19 46,XY propositae with the complete form of the testicular feminization syndrome, derived from 28 index kinships, have been analysed in detail. The results reveal trends which allow the tentative conclusions to be reached that in normal circumstances, and insofar as the sex chromosome influence is concerned, aspects of the development of the palmar patterns of loops and triradii may be directly influenced by the sex chromosomal complement of the fetus; by contrast the digital ridges, and, secondarily, the digital patterns, may be influenced to an extent by testicular androgens.
Fluctuating asymmetry has been used frequently, especially in the experimental literature, as a measure of developmental stability. However, the relationship between asymmetry and the ability of the genotype to produce an adaptive phenotype is far from clear. In this paper we evaluate the relationship between asymmetry and the mean of a quantitative trait in humans. The trait used is the a-b ridge-count, the count between the a and b triradius in the second interdigital area of the palm. The extremes of both ends of the a-b count distribution exhibit greater asymmetry than values closer to the mean. This evidence suggests that dermatoglyphic asymmetry does reflect to some extent the degree to which the developing phenotype is controlled.
With very few exceptions, dermatoglyphic methodology either refers to shape (pattern) or to size (quantitative value). In this study, an attempt is made to consider simultaneously these two basic components of morphology in the analysis of the third palmar interdigital area. For this purpose, three criteria of shape and bc ridgecount (size) were studied in 150 male and 150 female Viennese pupils, and were each classified according to whether they could be interpreted as showing strong reduction, slight reduction or no reduction. Their frequencies alone and in combination were calculated. Their interrelation with the mean ridge counts and their comparison with the traditional reduction types of c-triradius or mainline C strongly suggest that the traditional notation is not sufficiently precise to evaluate criteria of reduction which are thought to indicate different embryonic growth patterns.
Digital dermatoglyphics of a sample from the Basque Valley of Salazar, situated in the West of the Pyrenees, were analysed. The results showed bimanual differences in both sexes, and also sexual differences for both hands. The comparative study with other Basque valleys showed that, in spite of their supposed common origin, the geographic barriers and the isolation have generated a genetic/dermatoglyphic and linguistic differentiation.
Genetic and environmental prenatal factors influencing the fluctuating asymmetry of the a-b interdigital ridge count are examined. From the results obtained we can conclude that fluctuating asymmetry of the a-b interdigital ridge count is poorly influenced by genetic factors. We suggest that fluctuating asymmetry of dermatoglyphics provides a good measure of developmental stability in humans, especially for males. The results also indicate that random environmental factors, acting before the 19th week of embryonic development, could be related to the differential timing of maturation of the sexes.
The present report deals with digital and palmar dermatoglyphics of a sample of 98 Chorote indians, collected in the north of Argentina, in the Gran Chaco region. Bimanual dimorphism was observed in males and females, both in finger and in palmar variables. Significant differences between sexes appear only in digital ridge counts and in the combined incidence of the four pattern types the Chorote, in general, show low sexual dimorphism. Univariate comparisons carried out with other tribes of the Gran Chaco (Chiriguano, Pilagá, Mataco, and Toba) indicate statistically significant differences between these and the Chorote, both in males and females. The greatest differences were found in relation to the Mataco, who belong to the same linguistic family as the Chorote. Probable explanations for these differences are proposed.
Inheritance of dermatoglyphic configurations was studied on the palmar III interdigital pad of the rat (Rattus norvegicus). Four rats from each of the WKS and ACI/N inbred strains were mated with each other, and 54 F1 and 88 F2 hybrids were obtained. In addition, 52 offspring were produced by backcross mating between F1 hybrids and WKS and ACI/N parents. Whorls were the predominant pattern in the WKS strain and triradial patterns characterized the ACI/N strains. The F1 hybrids showed a wide range of pattern types, consisting of whorls, loops, cusps, arches, and triradial patterns. These patterns were intermediate in size between the two inbred strains. The F2 hybrids presented a distribution of patterns with a similar range as the F1, but the frequencies of some types were different. Patterns in the offspring of each backcross demonstrated a slight shift towards the characteristic pattern of the parental inbred strain. No sex difference was observed. Generally, the bilateral differences were striking, with a radial direction predominating on the left palm, and an ulnar one on the right palm, respectively. This study suggests that the dermal patterns are genetically determined, but also are influenced by environmental factors, especially in the hybrids.
Fingerprints were obtained from 46 patients with celiac disease and compared with those of 46 control subjects matched for sex and ethnic origin. Whorls were more frequent and ulnar loops were less frequent, significantly, in celiac patients than in controls. A digital pattern of four or more whorls was present in 69% of celiac patients, but in only 28% of controls (p less than 0.001). As a diagnostic test, the fingerprint's sensitivity, specificity, and positive and negative predictive values were 66, 73, 67, and 71%, respectively. Similarly, a pattern of four or less ulnar loops was evident in 44% of celiac patients as opposed to only 19% of controls (p less than 0.005). Sensitivity, specificity, and positive and negative predictive values were 46%, 81%, 62%, and 63%, respectively. We conclude that particular dermatoglyphic patterns are significantly more common in patients with celiac disease than in controls. We therefore suggest that this marker be used as a diagnostic clue, indicating the need for further investigation.
In a dermatoglyphic study of 101 patients with dermatitis herpetiformis, comparison was made with their normal relatives and several random normal series. The results of the several comparisons are quite consistent, considering the nature of the data, for the all point to an attenuation of qualitative and quantitative digital and palmar traits in the patients. It is argued that these differences are associated with the disease itself, and that some of the female relatives have an inherited tendency to the disorder, but do not express it. The findings suggest the involvement of genetic factors in the aetiology, and possibly intrauterine environmental influences as well.
We have reported the dermatoglyphic findings on the soles of eighty Japanese Klinefelter's syndrome patients (47,XXY). As compared with normal Japanese males and females, three statistically different traits were observed: (1) Distal loops in the hallucal area are smaller, (2) pattern intensity is higher, and (3) the frequency of triradius p is elevated.
In this study a new method for description of fingerprints was used on plain ulnar loops of Down's syndrome individuals of both sexes. The results of the patients were compared with those of their parents, siblings and unrelated control samples, all of the matching sex. Higher variability within the dermatoglyphics was seen among patients. The results were supported by higher correlation figures between the parameters studied in the control samples. The TRC showed no difference between Down's syndrome individuals and controls. Several causes for the results are discussed. Investigations by other authors are presented.
The proposition that finger print variability between individuals might be reduced by the absence of an X-chromosome in Turner's syndrome was rejected. In the present study of 58 XO patients, aged 15-50 years, relatives of several cases, unrelated female control samples and three unrelated male samples were investigated. The higher mean value of the TRC among patients supported the hypothesis forwarded by Penrose that an added X- or Y-chromosome reduces the TRC and a missing one increasing it. The figures do not speak against the hypothesis that genes affecting the TRC are located on the X-chromosome. A summary of the major dermatoglyphic investigations in Turner's syndrome is presented.
One hundred probands of vitiligo were studied for palmar dermatoglyphics, both qualitatively and quantitatively, and were compared with those of 100 phenotypically normal control subjects. Ulnar loop pattern was the most common digital pattern observed in both probands and controls. An increased incidence of whorls and arches in men and women probands, respectively, was found to be statistically significant when compared with those of controls. Simian crease and Sydney line also have been observed in the present study, which has not been previously reported. A statistically highly significant reduction has been observed in total finger ridge count (TFRC) and a-b ridge count in both sexes of vitiligo cases when compared with those of controls. No significant changes was observed in the values of atd angle and position of axial triradius.
To determine whether quanitative dermal indices are useful in ascertaining the liability for or severity of mosaic Down's syndrome (DS), dermatoglyphics of 107 subjects with proven 46/47,+21 DS were scored by four quantitative dermal indices. The distribution of mosaics by weighted mean percentage of +21 cells ranged from 1 to 95 and was bimodal. Mean maternal age at birth of mosaics (32.9 +/- 7.5 years) was elevated when compared with control maternal ages in the literature. The distribution of quantitative dermal indices for the total mosaic population fell roughly midway between those in the literature for normal and full DS individuals: 73% of mosaics were classified as definitively DS, 21% were in the intermediate range, and 6% were normal. For mosaics who were minimally affected, 24% were DS, 53% intermediate, and 23% normal. One can conclude: (1) For any suspect mosaic, a dermal score in the DS range is highly suggestive of karyotypic pathology. (2) The high prevalence of intermediate scores in normal subjects severely restricts their diagnostic value in screening for mosaics in the general population. For a selected population, such as parents of +21 children, the screening value of quantitative dermal indices remains an open question. Weighted regression analyses demonstrate a highly significant correlation (P less than 0.001) of dermal index score with the weighted mean proportion of +21 cells transformed to the logit scale. One may exploit this correlation to predict the ratio of +21/normal cells in infants, in whom early karyotype evolution can preclude an estimate of the ultimate syndrome based on initial degree of mosaicism. Furthermore, this correlation provides additional indirect evidence that dermal microsymptoms in DS are a reflection of the presence of +21 cells.
The dermatoglyphics of 33 Japanese (20 females and 13 males) with Cri du Chat syndrome were compared with 544 male and 129 female controls. In these cases, 18 cases were described only with regard to simian crease and distal axial triradius. It was found that these patients showed high frequencies of certain characteristics such as whorl pattern, arch pattern, thenar pattern, bilateral simian creases and distally displaced axial triradii on both palms (t').