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PubMed1989

Efficacy of a new Hoffmann-La Roche compound (Ro 15-5458) against Schistosoma mansoni (Gezira strain, Sudan) in vervet monkeys (Cercopithecus aethiops).

Some compounds of the class 9-acridanone-hydrazones have recently been developed by Hoffmann-La Roche (Basel-Switzerland) and were shown to have antischistosomal effects. One of these compounds (RO 15-5458/000) was administered at two dose levels (25 mg and 15 mg/kg body-weight) to S. mansoni (Gezira strain-Sudan) infected vervet monkeys. The faecal egg-output was terminated, worm-burden killed and tissue egg-counts were greatly reduced as compared with the untreated control monkey. Severe necrotic changes were seen around dead worms in sections from treated animals' livers. The efficacy of this compound as an antischistosomal is encouraging and deserves further studying.

Acridines↗
PubMed1977

Effect of oral estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey (Cercopithecus aethiops sabaeus).

We studied the effects of estramustine phosphate on pituitary, gonadal, and adrenal function in the green monkey. A 2-week course of estramustine phosphate (75 mg per day) reversibly suppressed the luteinizing hormone and testosterone response to luteinizing hormone-releasing hormone but did not affect pituitary-adrenal function assessed by the 11-deoxycorticosterone response to metyrapone. Treatment with oral estramustine phosphate also resulted in a significant increase in corticosteroid-binding globulin but did not affect a series of liver enzymes nor hematology. The results are consistent with a pure estrogen effect produced by hydrolysis of the carbamate-ester bona at a site distant from estrogen target tissues and could explain most of the reported in vivo effects of this compound.

Administration, Oral↗