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Results for “tumor development”

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At least 37 records · Page 2Linked to original sources
PubMed1977

Pathology of tumors developed in guinea pigs given intraperitoneal injections of N-methyl-N-nitrosourea.

The carcinogenic effects of N-methyl-N-nitrosourea after repeated intraperitoneal administration in inbred strain NIH 13 guinea pigs were studied. 50% of the animals that survived beyond 22 weeks, after intraperitoneal injection of MNU at a dose of 10 mg/kg body weight/week for 18 weeks, developed a broad spectrum of tumors: these included adenocarcinoma of pancreas in 2 animals, fibrosarcoma of the mesentery in 2 animals, angiosarcoma of mesentery in 2 animals, mesothelioma of the peritoneum in 1 animal and tumors of small intestine in 3 animals. These studies indicate the susceptibility of different types of tissue to the local effects of MNU after intraperitoneal administration.

Adenocarcinoma↗
PubMedDate not supplied

[Immune response dynamics during malignant tumor development].

Several mathematical models for the development of immune reaction during cancer diseases were plotted. The models describe both stimulation of the immune system by the tumor and its suppression. Non-specific inhibition was considered which resulted from glucose deficiency accompanying the development of a malignant tumor. The inhibiting effect of antitumour antibodies on toxic influence of limphocytes-killers was taken into account. The qualitative and quantitative study of the models showed the limits for the description of real interactions between tumour and organism by the mechanisms stated.

Animals↗
PubMed1977

Relationship of surface immunoglobulin-bearing cells, plasma cells, and tumor development in anaplastic carcinoma-bearing A/J mice.

Since the humoral immune response has been shown to be associated with immunological enhancement of tumor growth, the study of surface immunoglobulin-bearing cells and plasma cell antigen (PCA)-bearing cells during neoplastic development may provide new approaches to the study of tumor immunology. Peripheral blood was collected every other day from normal and carcinoma-bearing mice. Lymphocytes obtained by Ficoll-Hypaque density centrifugation were assayed for immunoglobulin-bearing cells and PCA-bearing cells using either fluorescein-conjugated goat anti-mouse immunoglobulin or rabbit anti-mouse plasma cell serum and fluorescein-conjugated goat anti-rabbit immunoglobulin. A marked increase in immunoglobulin-bearing cells from tumor-bearing mice was observed by Day 6 and peaked at Day 10. An increase in PCA-bearing cells followed the immunoglobulin-bearing cells increas by 2 to 4 days. The immunoglobulin-bearing cells declined by Day 12, whereas PCA-bearing cells remained elevated through Day 20. Using rabbit anti-mouse plasma cell serum as an immunosuppressive agent, a 4-day prolongation of the mean survival time was observed in rabbit anti-mouse plasma cell serum-treated tumor-bearing mice. This suggests that tumor growth in this model may be related to an active humoral immune response and that suppression of the plasma cell population may prove to be beneficial in the treatment of certain tumors.

Animals↗
PubMed1979

[Stimulation of induction or inhibition of crown-gall tumor development by RNA-fragments U2. Interference by auxin].

RNA-fragments U2 obtained by mild degradation with RNase U2 of ribosomal RNA containing A and G nucleotides in excess are capable of exhibiting either a stimulatory effect on the induction of Crown-gall tumors or an inhibitory action on their subsequent development. These different effects are dependent on the moment at which RNA-fragments were introduced into wounded Pea seedlings infected by Agrobacterium tumefaciens B6. The results obtained in vitro and in vivo suggest that an interaction between auxin and RNA-fragments U2 may take place, either increasing the tumor induction or inhibiting the proliferation of tumourous cells.

Cell Transformation, Neoplastic↗
PubMed1976

[Effect of early thymectomy on the growth of transplanted mammary gland tumors developing in mouse line C3Hf].

Mammary tumours which developed in factorless C3Hf mice when transplanted to MTV-S+ and MTV-S- recipients were found to grow at the same rate' early thymectomy failed to influence their growth. The observed accelerated growth of mammary tumour transplants from C3H/He mice to MTV-S+ recipients, as compared to the MTV-S- ones, and inhibition of the tumour growth after early thymectomy seemed to be connected with the peculiarities of the immunological reaction to the virus-induced antigens.

Animals↗
PubMed2026

The Hematological Variations and Effect of Cadmium Induced Toxicity on Mammary Tumors Development in Albino Mice. A Comparative Model Study on the Effect of Heavy Metals in Human Breast Cancer.

INTRODUCTION: Breast cancer develops in breast tissues, in ducts and lobules. It affects both genders, though it is uncommon in men. Hematological variations are important considerations and deficiencies in metals can negatively impact human health. Cadmium is highly toxic and plays role in breast cancer progression. This study was designed for hematological variations and cadmium induced toxicity in mice and humans causing breast cancer. METHODS: Mice, obtained from local supplier, housed at university laboratory for 11 weeks, exposed to cadmium. Following dissection, blood and organs were harvested for examination. Histological analysis of liver and mammary gland tissues was conducted. RESULTS: Affected mice had higher Hb, RBC, HCT, MCV, and MCH, while humans showed lower Hb, HCT, and MCV but similar RBC and MCH. Other blood values also show changes. Histopathology revealed changes in mammary glands (higher cadmium led to increased fat deposition, degeneration of alveolar epithelial cells, and a reduction in alveolar milk lumen size, indicating compromised glandular function) and liver damage (vacuolation, lipid accumulation, fibrosis, and collagen deposition, was noticeable with prolonged cadmium). These changes causes liver fibrosis and impaired mammary gland function. DISCUSSION: The cadmium exposure induces distinct hematological alterations and severe tissues damage, reflecting species-specific responses. The observed liver fibrosis and mammary gland dysfunction emphasize cadmium's potential to compromise critical organ functions over time. CONCLUSION: Significant effects of cadmium exposure in mice were observed. Histological damage was seen in mammary glands and liver. Further research on protective measures and dose-response relationships for cadmium exposure is needed.

Animals↗