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PubMed2005

Dominant-submissive behavior as models of mania and depression.

This review examines the ways in which dominant-subordinate behavior in animals, as determined in laboratory studies, can be used to model depression and mania in humans. Affective disorders are mood illnesses with two opposite poles, melancholia (depression) and mania that are expressed to different degrees in affected individuals. Dominance and submissiveness are also two contrasting behavioral poles distributed as a continuum along an axis with less or more dominant or submissive animals. The premise of this article is that important elements of both mania and depression can be modeled in rats and mice based on observation of dominant and submissive behavior exhibited under well defined conditions. Studies from our own research, where dominance and submissiveness are defined in a competition test and measured as the relative success of two food-restricted rats to gain access to a feeder, have yielded a paradigm that we call the Dominant Submissive Relationship (DSR). This paradigm results in two models sensitive to drugs used to treat mood disorders. Specifically, drugs used to treat mania inhibit the dominant behavior of rats gaining access to food at the expense of an opponent (Reduction of Dominant Behavior Model or RDBM), whereas antidepressants counteract the behavior of rats losing such encounters; Reduction of Submissive Behavior Model (RSBM). The validation of these models, as well as their advantages and limitations, are discussed and compared with other animal paradigms that utilize animal social behavior to model human mood disturbances.

Animals↗
PubMedDate not supplied

Aminergic neuron systems of lobsters: morphology and electrophysiology of octopamine-containing neurosecretory cells.

In the American lobster (Homarus americanus) the biogenic amines serotonin and octopamine appear to play important and opposite roles in the regulation of aggressive behavior, in the establishment and/or maintenance of dominant and subordinate behavioral states and in the modulation of the associated postural stances and escape responses. The octopamine-containing neurosecretory neurons in the thoracic regions of the lobster ventral nerve cord fall into two morphological subgroups, the root octopamine cells, a classical neurohemal group with release regions along second thoracic roots, and the claw octopamine cells, a group that selectively innervates the claws. Cells of both subgroups have additional sets of endings within neuropil regions of ganglia of the ventral nerve cord. Octopamine neurosecretory neurons generally are silent, but when spontaneously active or when activated, they show large overshooting action potentials with prominent after-hyperpolarizations. Autoinhibition after high-frequency firing, which is also seen in other crustacean neurosecretory cells, is readily apparent in these cells. The cells show no spontaneous synaptic activity, but appear to be excited by a unitary source. Stimulation of lateral or medial giant axons, which excite serotonergic cells yielded no response in octopaminergic neurosecretory cells and no evidence for direct interactions between pairs of octopamine neurons, or between the octopaminergic and the serotonergic sets of neurosecretory neurons was found.

Animals↗
PubMed2006

Production supervisor impacts on subordinates' safety outcomes: an investigation of leader-member exchange and safety communication.

PROBLEM: Supervisors are increasingly important to the functioning of manufacturing operations, in large part due to their role as leaders. While supervisors' relations and communication with their subordinates are known to be important in influencing subordinates' behavior, little is known about how these two factors will impact subordinates' safety. This study investigated how much each factor contributes to safety-related outcomes for blue-collar production employees. METHOD: Production employees at five Pennsylvania wood manufacturers completed a survey during their work shift. Five hundred and ninety eight employees provided data on leader-member exchange (LMX), safety communication, and safety-related events. Archival data on OSHA recordables were also obtained from the producers' human resources database. RESULTS: Analyses found that the influence of LMX was greater than that of safety communication in predicting safety-related events. Neither LMX nor safety communication was significantly related to OSHA recordables. Results also demonstrated that employee job satisfaction and demographic variables such as gender and age have safety implications. IMPACT ON INDUSTRY: Results from this study further emphasize the importance of production supervisors and illustrate the potential role of leader-member exchange in enhancing workplace safety. Specifically, organizations should foster positive social exchange between their employees and supervisors and enhance the leadership qualities of supervisors to help reduce workplace injuries.

Accidents, Occupational↗
PubMed1986

Hand-rearing baboons for laboratory investigations.

To conduct laboratory studies in unsedated animals that were similar anatomically and physiologically to man, five full term baboons (four Papio cynocephalus anubis, one Papio cynocephalus cynocephalus) were hand-reared. These infants were used as unsedated animal models in short-term lung clearance studies conducted from birth to 2 years of age. The hand-rearing techniques described here encouraged the formation of an infant-human rearer bond that permitted us to control the level of expressed aggressive behavior as the infant matured. These techniques resulted in baboons which displayed subordinate behavior, showed positive reception to human contact (without evidence of negative stereotypic behavioral anomalies) and remained cooperative subjects for our investigations of short-term pulmonary clearance. The baboons generally were above average in weight in comparison to conspecifically-reared baboons of similar age, sex and species. Representative lung retention curves presented on one baboon demonstrate the feasibility of lung clearance studies in these hand-reared animals. Due to its suitability for unsedated studies, this baboon model may be considered for other types of laboratory investigations.

Aging↗
PubMed1986

Does intermale mounting function as a dominance demonstration in rhesus monkeys?

The relationship between dominance and intermale mounting was analyzed in two troops of captive rhesus monkeys (Macaca mulatta). The data did not support the assumption that mounting among males functions as a dominance demonstration as described in the literature because mounting commonly (63% of 65 dyads) occurred in a bidirectional fashion, and mounting not only was performed by dominant males but also was shown with regularity (36% of 521 cases) by subordinate males. Intermale mounting was often (37% of 521 cases) associated with amicable interactions--commonly preceding them--but it was only rarely (2%) associated with dominance-subordination behaviors. It was concluded that intermale mounting may serve as a socially cohesive behavior in rhesus monkeys by promoting nonagonistic contact.

Animals↗
PubMed2004

Social factors and individual vulnerability to chronic stress exposure.

The stress-response is adaptive in the short-term, but it can be maladaptive if sustained levels of its mediators are chronically maintained. Furthermore, not all individuals exposed to chronic stress will progress to disease. Thus, understanding the causes of individual differences and the consequences of variation in vulnerability is of major importance. The aim of this review is to shed light on this issue by presenting a new naturalistic model of chronic psychosocial stress in male mice. Resident/intruder pairs of mice lived in continuous sensory contact and physically interacted daily. Four categories were identified: Resident Dominant, Resident Subordinate (RS), Intruder Dominant, and Intruder Subordinate. Behavior, autonomic and immune functions, hypothalamic-pituitary-adrenocortical responses, brain cytokine expression and cardiac histology were investigated in stress-exposed mice. Certain stress-induced alterations were present in all mice independent of their social status, while others clearly differentiated dominants from subordinates. RS mice showed a unique profile of alterations suggesting that the loss of relevant resources, such as the territory, is the key factor determining why only certain stress-exposed individuals ultimately show malignancy and psychopathologies.

Aggression↗
PubMed1983

Behavioral studies in spontaneously hypertensive rats.

In the present study we examined some behavioral patterns in spontaneously hypertensive (SHR) male rats as compared with Wistar (W) rats. The following methods were employed: open field test, two-way active avoidance, passive avoidance, shock-induced fighting, shock-induced suppression of drinking (conflict test), and dominant-subordinate behavior in rats competing for water. Spontaneously hypertensive rats showed higher level of locomotor activity, lower emotionality, lower anxiety level, increased acquisition of avoidance tasks, and enhanced dominance behavior. In addition, hypertensive rats were less aggressive in shock-induced fighting test. It is concluded, that spontaneously hypertensive rats seem to be hyperactive in terms of locomotor activity while their emotionality appears to be paradoxically reduced.

Aggression↗
PubMedDate not supplied

Organization of brainstem behavioral systems.

A review of recent literature suggests that the brainstem may play a more fundamental role in the elaboration of adaptive behaviors than has often been assumed. This view is indicated by current reports documenting the substantial behavioral repertoire of decerebrate animals and by the recent findings that electrical stimulation of localized areas in all major levels of the brainstem can induce complex and coordinated behaviors, including eating, grooming and attack. Indeed, behaviors elicited from sites in the caudal brainstem evidence unexpected goal specificity and stimulus control over response topography. Additional neuroanatomical and behavioral data are reviewed which further implicate caudal brainstem networks in process of reward and aversion. From these and other findings it is argued that integrating mechanisms for the expression of many aspects of species-characteristic behaviors are intrinsic to the brainstem. In line with this view, rostral hypothalamic-limbic mechanisms, while perhaps contributing refinement to the integration of behaviors, may best be viewed as phylogenetically newer control mechanisms making the expression of species-characteristic behaviors subordinate to additional class of exteroceptive and interoceptive stimuli.

Aggression↗
PubMed2005

Social status does not predict responses to Seoul virus infection or reproductive success among male Norway rats.

Trade-offs exist among life history strategies that are used to increase survival and reproduction; such that, males that engage in more competitive behaviors may be more susceptible to infection. Hantaviruses are transmitted horizontally between rodents through the passage of virus in saliva during wounding and male rodents are more likely to be infected with hantaviruses than females. To determine whether a trade-off exists between dominance and susceptibility to Seoul virus infection, male Long Evans rats were group housed (3/cage) with a female rat and aggressive and subordinate behaviors were monitored during a 10 day group housing condition. After behavioral testing, males were individually housed, inoculated with Seoul virus, and blood, saliva, and fecal samples were collected. Dominant males initiated more aggressive encounters than subordinate males. Dominant and subordinate males, however, had similar steroid hormone concentrations, anti-Seoul virus IgG responses, and weight gain over the course of infection. A similar proportion of dominant and subordinate males shed virus in saliva and feces during infection. Using microsatellite DNA markers paternity was assigned to pups derived during the group housing period. In contrast to our initial hypothesis, dominant and subordinate males sired a similar percentage of pups. Taken together, host social status may not predict reproductive success or susceptibility to hantaviruses in rodent reservoir populations.

Analysis of Variance↗
PubMed1994

[Neurochemical correlates of dominant behavior in mice].

The influence of genetic factors on the activity of a key catecholamine-synthesizing enzyme and the relationship between the synthesis parameters in catecholaminergic systems and the predisposition of male mice of inbred lines to dominate in a population were studied. It was determined that the interline variability of tyrosine hydroxylase activity in the cortex, hippocampus, hypothalamus, striatum, and hindbrain exceeded the intraline one. PT line and CBA/Lac males were characterized respectively by maximum and minimum enzymatic activity in the majority of brain regions and also by dominant and subordinate behavior determined by genotype. Significant rank interline correlations of noradrenaline levels in the striatum, hippocampus and hindbrain, tyrosine hydroxylase activity in the striatum and hindbrain, and the percentage of dominant males among the examined genotypes were found. It was concluded that a genetically determined relationship exists between biosynthetic processes in the noradrenergic neurons of the brain and a dominant behavior phenotype.

Animals↗
PubMed1998

Whole-body cortisol concentrations and ontogeny of aggressive behavior in yellowtail (Seriola quinqueradiata Temminck & Schlegel; Carangidae).

Ontogenetic changes in whole-body immunoreactive cortisol concentrations (IRC) and aggressive behavior were examined in yellowtail Seriola quinqueradiata (Temminck & Schlegel; Carangidae). Baseline IRC significantly increased during the transition from larval to juvenile stage and was correlated with the onset of aggressive behavior. Handled fish (13.1 +/- 2.6 ng/g tissue) showed an IRC level about three times higher than unhandled fish (4.7 +/- 1.4 ng/g tissue), indicating that whole-body immunoreactive cortisol level may be an indicator of stress in juvenile yellowtails. Behaviorally subordinate fish (8.6 +/- 1.6 ng/g tissue, n = 4) showed IRC levels significantly higher than dominant fish (0.6 +/- 0.3 ng/g tissue, n = 4). Whole-body immunoreactive cortisol levels may thus reflect stress and social status in juvenile yellowtails, and the inverse relationship between social rank and IRC may result from agonistic interactions.

Aggression↗
PubMed2006

Social suppression of cortisol in female marmosets: role of luteinizing hormone/chorionic gonadotropin.

Behaviorally subordinate female common marmosets (Callithrix jacchus) undergo suppression of ovulation and chronic reductions in basal plasma cortisol concentrations. Indirect evidence suggests that hypophyseal chorionic gonadotropin (CG; the major pituitary luteinizing gonadotropin in marmosets) may elevate cortisol concentrations in female marmosets, and therefore that social suppression of CG may contribute to diminution of cortisol in subordinates. To test this hypothesis, we determined whether pharmacological inhibition of pituitary CG release decreases basal and adrenocorticotropin (ACTH)-stimulated cortisol secretion. We characterized cortisol and reproductive hormone concentrations in six ovary-intact and six ovariectomized marmosets during long-term treatment with leuprolide acetate, a gonadotropin-releasing hormone (GnRH) agonist, and vehicle. Leuprolide suppressed basal plasma CG concentrations, abolished the CG response to exogenous GnRH, and, in intact animals, blocked ovarian cyclicity. During treatment with vehicle, plasma cortisol concentrations were elevated during the periovulatory phase in intact females, compared to the follicular phase, the luteal phase, and ovariectomized females. Leuprolide suppressed basal cortisol concentrations of intact females as compared to the periovulatory phase, but did not affect basal cortisol in ovariectomized animals and did not alter responses to exogenous ACTH. These findings suggest that elevations in circulating CG concentrations are associated with elevated cortisol concentrations in female marmosets, and that this relationship requires simultaneous increases in ovarian hormones that occur only during the periovulatory period. Thus, suppression of CG release in anovulatory subordinate females may not play an important role in socially induced diminution of cortisol.

Adrenocorticotropic Hormone↗
PubMed2004

Social suppression of cortisol in female marmoset monkeys: role of circulating ACTH levels and glucocorticoid negative feedback.

Behaviorally subordinate female common marmoset monkeys (Callithrix jacchus) exhibit pronounced, chronic reductions of circulating cortisol levels. Cortisol suppression in these animals is mediated in part by adrenocortical hyporesponsiveness to adrenocorticotropic hormone (ACTH). In addition, we hypothesized that social subordination may activate a central, neurally mediated mechanism to further inhibit hypothalamo-pituitary-adrenal function. In this study, therefore, we evaluated basal plasma cortisol and ACTH concentrations, as well as cortisol and ACTH responses to dexamethasone (DEX), in dominant and subordinate females to initially characterize such a mechanism. Morning plasma cortisol and ACTH levels were determined before, and 1, 2, and 3 days following administration of DEX (0.5, 1.0, or 5.0 mg/kg, IM) or saline. Baseline cortisol concentrations prior to DEX treatment were significantly lower in subordinate females than in dominants, as previously reported. However, ACTH concentrations in the same blood samples did not differ between the two groups. Furthermore, dominant and subordinate females showed similar cortisol and ACTH responses to DEX. These results indicate that reduced circulating cortisol levels in subordinate females are not associated with either altered circulating ACTH concentrations or enhanced responsiveness to glucocorticoid negative feedback. However, the finding that basal ACTH levels are not elevated in subordinate females as compared to dominants, in spite of low circulating cortisol concentrations, suggests that ACTH secretion in subordinate females is restrained by a steroid-independent inhibitory mechanism operating at the level of the brain or pituitary.

Adaptation, Physiological↗
PubMed2003

Serotonin modulates the electric waveform of the gymnotiform electric fish Brachyhypopomus pinnicaudatus.

The gymnotiform electric fish Brachyhypopomus pinnicaudatus communicates with a sexually dimorphic electric waveform, the electric organ discharge (EOD). Males display pronounced circadian rhythms in the amplitude and duration of their EODs. Changes in the social environment influence the magnitudes of these circadian rhythms and also produce more transient responses in the EOD waveforms. Here we show that injections of serotonin produce quick, transient, dose-dependent enhancements of the male EOD characters similar to those induced by encounters with another male. The response to serotonin administered peripherally begins 5-10 min post injection and lasts approximately 3 h. The magnitude of the response to serotonin is tightly associated with the magnitude of the day-to-night swing of the circadian rhythm prior to injection. Taken together these findings suggest that the male's social environment influences his response to serotonin by altering the function of some part of the downstream chain between the serotonin receptors and the ion channels involved in control of the EOD waveform. Although chronic activation of serotonin circuitry is widely known to elicit subordinate behavior, we find that 5-HT initially increases a dominance signal in these fish. These findings are consistent with the emerging view that serotonin facilitates different adaptive responses to acute and chronic social challenge and stress.

Animal Communication↗
PubMed1998

Status and cockpit dynamics: a review and empirical study.

One of the most troublesome dynamics evident in the airplane cockpit is related to patterns of authority relations between the captain and the first officer: Too often, captains fail to listen and first officers fail to speak. The authors propose that many instances of superordinate and subordinate behavior in the cockpit--the captain's tendency to reject input from other team members and the first officer's hesitancy to question the captain--represent cases of status generalization. First, the authors describe the theory of status generalization and show support for the operation of the theory by presenring examples of flightcrew behavior that the theory predicts. Second, an initial empirical test was conducted to instantiate the claim that captain-first officer differences can be seen as status differences. Finally, the significance and implications of this perspective are discussed.

Accidents, Aviation↗
PubMed1989

[The effects of planning leadership behavior on the subordinates' person perception].

According to the two factor theory of leadership, leaders were instructed to behave both gently and strictly. However, how can be achieved such behavior? Here, a solution to this problem is suggested by an analysis of subordinates' person perception. Yamada (1987) analyzed the data of PM leadership surveys, and found three factors; Maintenance [M.] (corresponds to "Consideration" in the Ohio Study) Planning (Initiating Structure), and Pressure (Production Emphasis). It was found that High Planning supported the independence of M. from Pressure. The purpose of this experimental study was to test the effect of Planning behavior on cognitive structure. Sixty-four female subjects performed a maze task using computer simulation. In the high Planning condition, the leader displayed direction signs, whereas no sign was displayed in the low Planning condition. Each condition was further subdivided into two Pressure conditions (High or low) by the amount of linguistic behavior. The result of the survey data was supported. M. cognition decreased by increasing Pressure cognition in the low Planning condition, but no correlation was found between M. and Pressure in the High Planning condition.

Adult↗
PubMed2006

Conditioning properties of social subordination in rats: behavioral and biochemical correlates of anxiety.

To develop a socially based model of anxiety, the contextual fear conditioning properties of social defeat were examined in rats. Social threat consisted of exposing intruders to aggressive residents in resident home cage, separated by a partition. During 3 daily encounters, intruders were either defeated or threatened by residents, providing the defeated-threatened (DT) and threatened-threatened (TT) groups respectively. On Day 4, both DT and TT animals were subjected to a social threat only. Additional animals received a 4-day exposure to a novel empty cage (EC group). Further DT, TT, and EC rats were confronted to a different context on Day 4. DT rats exhibited a robust and context-specific anxiety-like response, characterized by significant behavioral and biochemical alterations. DT rats showed increased risk assessment and decreased exploration compared to TT and EC rats that in turn were not different towards each other. DT and TT rats exhibited increased ACTH levels, while only DT rats showed enhanced corticosterone and decreased testosterone levels compared to EC. These differences were context-specific since they were absent confronting animals to a different context and since they were not long lasting. Overall, these data demonstrate the induction of an anxiety-like state in rats through a context conditioning process based upon social factors. The social basis of this paradigm offers good face validity with anxiety disorders, which in humans are mainly related to social factors and associated with HPA axis deregulations. The present procedure may provide a useful experimental model to further investigate the neurobiological mechanisms underlying anxiety-related disorders.

Adrenocorticotropic Hormone↗
PubMed2001

Chronic subordination stress in male tree shrews: replacement of testosterone affects behavior and central alpha(2)-adrenoceptors.

Subordination stress induced by social defeat in male animals is known to inhibit gonadal functions and it has been discussed whether the resulting deficit in testosterone might play a role in subordination behavior. One of the major transmitter systems involved in regulation of behavior is the noradrenergic system. To analyze whether a testosterone replacement can alter subordination behavior and whether this might be related to changes in the brain noradrenergic system, we quantified alpha(2)-adrenoceptors (alpha(2)-ARs) in the central nervous system of male tree shrews. Animals were submitted to chronic subordination stress and received testosterone at the same time. Behavior was monitored during all phases of the experiment: the control period of 10 days, the period of social stress lasting 10 days when subordinates were confronted daily with a dominant male, and, subsequently, the stress and treatment period of 18 days when in parallel to the stress, animals received either injections of testosterone or vehicle. Brain alpha(2)-ARs were quantified by in vitro receptor autoradiography using the antagonist ligand (3)H-RX821002. Locomotor activity decreased significantly during the stress period and was not re-normalized by testosterone. In contrast, testosterone re-normalized scent marking behavior and autogrooming, parameters that had both been reduced due to the subordination stress. Vehicle injections improved none of these behaviors. In 8 of 10 brain regions that were analyzed, numbers of alpha(2)-adrenergic binding sites were increased in stressed animals that received vehicle injections, but a difference between testosterone and vehicle injected animals was only observed in five regions. These brain regions are all known to be involved in emotional behavior (anterior hypothalamus, medial nucleus of the amygdala, cingulate cortex) or autonomic regulation, respectively (solitary tract nucleus, dorsal motor nucleus of vagus). Therefore, our data show that testosterone influences behavior of male subordinates and modulates alpha(2)-AR expression in their brains. Androgen-mediated alterations in receptors occur in brain regions that are known to be involved in emotionality, e.g., in the anterior hypothalamus which regulates aggressive behavior. One can therefore conclude that alpha(2)-ARs contribute to neuronal functions that are responsible for subordination of stress behavior, and that testosterone-induced receptor changes are related to the partial restoration of normal behavior.

Animals↗