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Results for “ovarian development”

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At least 37 records · Page 2Linked to original sources
PubMed2025

Celastrol modulates IRS1 expression to alleviate ovarian aging and to enhance follicular development.

Ovarian aging significantly contributes to the decline of the female reproductive system, adversely affecting fertility and endocrine homeostasis. To address the challenges posed by reproductive aging, natural products have shown promising preventive and therapeutic effects. Here, we investigated the beneficial effects of natural compound celastrol on ovarian development and aging, together with its underlying mechanisms. We found that celastrol administration at a concentration of 3 mg/kg promoted follicle development in young mice and enhanced porcine oocyte maturation, while regulating granulosa cell proliferation and apoptosis. In 12-month-old mice (equivalent to middle-aged adults), celastrol exhibited similar beneficial effects. Transcriptomic analysis revealed that differentially expressed genes post-celastrol treatment were associated with steroid biosynthesis, estrogen signaling pathways, type 2 diabetes, insulin secretion, meiosis, and apoptosis. Additionally, insulin receptor substrate 1 (IRS1), an adapter protein in insulin signaling, was shown to advance puberty in young mice and to facilitate oocyte maturation. Overexpression of IRS1 in oocytes promoted follicular development and oocyte maturation, resulting in enhanced steroid hormone levels, whereas IRS1 knockdown inhibited these processes. Our findings indicate that celastrol may regulate ovarian development and aging by modulating IRS1 expression and its related pathways, suggesting celastrol as a novel small-molecule compound targeting IRS1, and offering new perspectives for potential therapeutic strategies against reproductive aging and infertility.

Animals↗
PubMed1979

[Kinetics of morphological and histochemical changes in the spleen under conditions of ovarian neoplasms developing in same and of administration of anticollagen serum].

Experimentally, on the Biskind model it was shown that the development of ovarian tumors transplanted into the spleen is proceded by a progressive reduction in the amount of active splenic cell elements, containing serotonin and hydrolytic enzymes, and by the increased changes in the structure and chemical composition of non-cellular elements of its connective tissue framework with catecholamines accumulated in the latter and the remaining cells. The injection of anticollagen serum (ACS) would increase the terms of tumors arising with the resultant predominance of their benign forms.

Animals↗
PubMed1979

The association of parity and marital status with the development of ovarian carcinoma: clinical implications.

Three hundred twenty-seven patients with ovarian carcinoma were compared with matched controls to determine the association of parity and marital status with the development of ovarian cancer. Nulliparous women were found to have 2.31 times the risk of developing ovarian cancer as parous women. Unmarried women had 3 times the risk of developing ovarian cancer, but marital status was not established as a variable independent of parity. Almost 8% of patients with ovarian carcinoma had had hysterectomies when they were over 40 years of age. This study indicates that parity is an important consideration when determining whether a patient is at high risk for the development of ovarian carcinoma. Other epidemiologic variables are discussed in an effort to facilitate the judicious selection of patients for elective oophorectomy at the time of hysterectomy.

Adult↗
PubMed1977

Ovarian actinomycosis developed during the use of a plastic intrauterine contraceptive device.

The case of a primary ovarian actinomycosis developed during the use of a Szontágh--Szereday type plastic IUD is presented. After a radical operation the patient was discharged in a good condition but 40 days later had to be readmitted because of a pelvic and abdominal wall abscess. After local surgery and massive penicillin treatment she is free of complaints. It is assumed that the IUD had a pathomechanical role.

Actinomycosis↗
PubMed1977

Binding of human chorionic gonadotrophin to rat ovary during development.

Ovarian tissue of prenatal, newborn, and 5-day-old rats does not specifically bind 125I-labelled HCG. Specific binding of HCG was first observed in ovaries of 10-day-old animals and binding increased with age. These results indicate that, contrary to rat testis, the HCG receptor in the rat ovary is not present during foetal and early postnatal development. Thus, the insensitivity of the ovary to endogenous and exogenous LH or HCG during this developmental period is due to the lack of specific receptors.

Age Factors↗
PubMed1976

Ovarian follicular development in the rat: hormone receptor regulation by estradiol, follicle stimulating hormone and luteinizing hormone.

The effects of estradiol, FSH and LH on ovarian follicular development and granulosa cell differentiation were examined in the immature rat hypophysectomized on day 24 of age. Administration of estradiol to hypophysectomized rats for 4 days stimulated the growth of large preantral follicles with a concomitant 1.5-fold increase in FSH receptor content and a 4-fold decrease in LH receptor content in the granulosa cells. When highly purified hFSH was administered alone, receptor content for FSH increased progressively for 4 days while receptor for LH remained essentially unchanged. However, when rats were pretreated with estradiol, the response of follicles to FSH was markedly enhanced as indicated by the appearance of large, antral follicles and elevated receptor content for both FSH and LH. Receptor content for FSH increased markedly in response to hFSH following only one day of estradiol pretreatment, while receptor content for LH increased most rapidly in response to hFSH after 3 days of estradiol pretreatment. LH administered to rats possessing large preovulatory follicles caused luteinization of granulosa cells and a marked decline in receptor content for both gonadotropins within 24 h. Receptor content remained low even 48 h after LH administration when granulosa cells were fully luteinized. These results indicated that follicular development and granulosa cell differentiation are dependent on steroid-protein hormone regulation of hormone specific receptors.

Animals↗
PubMed1978

The histological effect of an ovarian growth factor on ovarian follicle development in immature mice.

The effect of an ovarian growth factor (OGF) purified from bovine pituitary glands was tested in vivo in immature mice from twelve to nineteen days old. Differential count of ovarian follicles was taken as a morphologic parameter for OGF effect upon ovarian maturation. Results obtained suggest that OGF injection increases the number of small secondary follicles which leave the pool of non-growing follicles, but does not promote follicle cell luteinization nor present follicle degeneration.

Animals↗
PubMedDate not supplied

[Regularity in the extreme character of the ontogenetic development of ovarian activity in the reproductive function self-regulation system].

Opposite conclusions were drawn depending on the sex hormones which different authors used to assess the functional condition of the ovaries at various age periods. A new index--reception coefficient (RC)--is suggested proceeding from the systemic approach to find the way out from this inconsistency. This coefficient represents the ratio of the peripheral hormone value and the gonadotropin level inducing it. Regularities of the extreme character in the ontogenetic development of the ovarian activity were established by means of RC: the maximum ovarian function under normal conditions fell on the age group of 20--29 years, and the minimum--on the age groups of under 7 and over 50 years. A sharp decline of the ovarian function began in the age group of 40--49 years.

Adolescent↗
PubMed1978

Follicular growth in fetal and prepubertal ovaries of humans and other primates.

Follicular growth begins in the fetal ovary as soon as the first follicles are formed. Although orderly follicular growth is found in the fetal ovary, many of the early growing follicles show abnormalties. Follicles with irregular granulosa layers, with hypertrophied or with underdeveloped theca layers, are characteristic. Such follicles are rarely seen after birth. The ovary during childhood is an active organ in which follicular growth and follicular atresia normally take place. Follicles begin to grow at all ages, differentiate to preantral and antral follicles, but degenerate at various stages of their development before they reach pre-ovulatory sizes. Follicular growth in the fetus and children is dependent on hormones. Fetal gonadotrophins are necessary to ensure normal and sequential follicular growth before birth. During childhood a close correlation between follicle growth, hormone response and hormone production seems to exist. Certain diseases and treatment with cytotoxic agents or radiation to the abdomen influence ovarian development and follicular growth. Chromosome abnormalities, especially Turner's syndrome, trisomy 18 or 21, alter normal ovarian development by reducing the pool of available follicles and inhibiting follicular growth. Treatment with cytotoxic drugs inhibits follicular growth, while abdominal irradiation in childhood unless the ovaries are adequately shielded causes permanent damage by destroying the small follicles.

Abdominal Neoplasms↗