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[Evaluation of the contribution of the importance of neuroimaging for the diagnostics of dementias--comparison to the psychological diagnostics].

OBJECTIVE: While psychology is accepted as a necessary component of the dementia diagnostics, the extended clinical diagnostics with neuroimaging is differently estimated. The goal of the study is the quantification of the individual contribution of the two different methods. METHODS: Of 100 patients the diagnosis of entrance, the neurological, the psychological, and the final clinical diagnosis were documented. For both imaging and psychology the sensitivity, specificity, and the positive predictive value were computed. The diagnostic of each method was determined from the change of the final in relation to the initial clinical diagnosis. The neuroradiological investigation took place with MRI, the psychological examination used both usual power and special speed tests. RESULTS: The extended clinical diagnostics led for 26 % of the patients to the change of the clinical diagnosis. Imaging and psychology supplied different own but supplementing contributions. In the case of annihilation imaging contributed with 73.3 %, psychology with 54.1 % to the diagnosis of a neurodegenerative dementia, whereas the contributions to the diagnosis of a vascular dementia were 83.3 % and 70.8 %, respectively. However psychology diagnosed and quantified the dementia. The contribution of neuroimaging consisted in the differential diagnosis of the dementias. Organic causes of symptomatic dementias and vascular encephalopathy without dementia but with consequences for a secondary prophylaxis were additional information also. CONCLUSION: Psychology improves the diagnostic accuracy of dementias. Neuroimaging improves the differential diagnosis of dementias and supplies additional clinically relevant findings. In the qualified diagnostics and differential diagnostics of the dementias both methods are indispensable.

Aged↗

[Ultrasound examination of the breast with 7.5 MHz and 13 MHz-transducers: scope for improving diagnostic accuracy in complementary breast diagnostics?].

AIM: Complementary diagnostic methods in early diagnosis of breast cancer are used to increase diagnostic accuracy and minimize unnecessary invasive diagnostic procedures. Aim of the following prospective, open multicenter clinical study was to define the value of high-frequency breast ultrasound with 13 MHZ transducers compared to standard breast ultrasound with 7.5 MHz. METHOD: Data of 810 female patients, aged 45 to 60 years, with 819 suspicious breast lesions evaluated by four participating centres between October 1996 and December 1997. Standardised breast ultrasound was performed uniformly using a AU4 IDEA diagnostic ultrasound system by Esaote-Biomedica in addition to a standardised procedure of clinical examination and standard-2view-mammography. Analysis of all aquired data and the correlating histopathological findings was done by means of descriptive statistics on the basis of an access datafile (Version 2.0). RESULTS: The histopathological evaluation showed 435 benign and 384 malignant findings. Overall sensitivity and specificity of the clinical examination were 71.1 % and 88.9 % and for mammography 84.7 % and 76.5 %, respectively. Standard ultrasound with 7,5 MHz reached a sensitivity of 82,6 % and a specificity of 80.8 % high-frequency ultrasound with 13 MHz came to 87.2 % and 78.4 %, respectively. Regarding tumour size, mammography gave the highest sensitivity in detection of pre-invasive cancers (DCIS). High-frequency breast ultrasound (13 MHz) proved to have a higher diagnostic accuracy compared to standard breast ultrasound (7,5 MHz) regardless of tumour size. Sensitivity was especially improved in case of small invasive tumours (pT1a) with 78 % versus 56 %, respectively. CONCLUSIONS: We conclude that high-frequency ultrasound is a valueable additive tool especially in the diagnosis of small tumours, improving diagnostic safety and reducing unnecessary invasive diagnostic procedures.

Breast Diseases↗

Somatization disorder in the community. A study of diagnostic concordance among three diagnostic systems.

Somatization disorder, the presentation of multiple somatic complaints in multiple organ systems, can be diagnosed by three roughly comparable diagnostic systems: the Washington University Feighner criteria, the Research Diagnostic Criteria, and DSM-III criteria. This study evaluates diagnostic concordance for somatization disorder in these three diagnostic systems using data gathered in the National Institute of Mental Health-sponsored Epidemiologic Catchment Area Program at four sites. Data gathered through use of the Diagnostic Interview Schedule at the Duke, Johns Hopkins, Washington, and Yale University sites indicate that each criterion set identifies a somewhat different group of respondents. Feighner criteria identify the fewest number of respondents, followed by DSM-III criteria and the Research Diagnostic Criteria. Demographic, symptomatic, health utilization, and other severity indices indicate that the respondents identified by each group are very similar and that all diagnostic groups are clearly distinguishable from the normal population.

Adolescent↗

Accuracy of clinical operational diagnostic criteria for Alzheimer's disease in relation to different pathological diagnostic protocols.

In this study we analysed the accuracy of two sets of clinical diagnostic criteria, the NINCDS/ADRDA and DSM-III-R, in relation to the currently used pathological diagnostic criteria for Alzheimer's disease (AD), the Khachaturian criteria, the Tierney A3 criteria and the CERAD protocol. The sensitivity of the individual clinical diagnostic criteria, NINCDS/ADRDA and DSM-III-R, is poor (34-58%) irrespective of the pathological diagnostic criteria applied for the definite diagnosis of AD. The combination of the NINCDS/ ADRDA 'possible' and 'probable dementia of the Alzheimer type' (DAT) categories has a high sensitivity (91-98%). However the combination resulted in very poor specificity (40-61 %). Thus, none of the clinical diagnostic criteria is satisfactory. We found similar results when we analysed the predictive value of these clinical diagnostic criteria. The positive predictive value of NINCDS 'probable DAT' category and that of the DAT diagnosis by DSM-III-R is very high (89-100%). This makes the use of these categories suitable for research purposes. However, the negative predictive value of both diagnoses is poor (33-63%), making these criteria unsuitable for diagnostic purposes in clinical practice.

Aged↗

Towards complete and accurate reporting of studies of diagnostic accuracy: the STARD initiative. The Standards for Reporting of Diagnostic Accuracy Group.

OBJECTIVE: To improve the accuracy and completeness of reporting of studies of diagnostic accuracy in order to allow readers to assess the potential for bias in a study and to evaluate the generalizability of its results. METHODS: The Standards for Reporting of Diagnostic Accuracy (STARD) steering committee searched the literature to identify publications on the appropriate conduct and reporting of diagnostic studies and extracted potential items into an extensive list. Researchers, editors, and members of professional organizations shortened this list during a 2-day consensus meeting with the goal of developing a checklist and a generic flow diagram for studies of diagnostic accuracy. RESULTS: The search for published guidelines about diagnostic research yielded 33 previously published checklists, from which we extracted a list of 75 potential items. At the consensus meeting, participants shortened the list to a 25-item checklist, by using evidence whenever available. A prototype of a flow diagram provides information about the method of recruitment of patients, the order of test execution and the numbers of patients undergoing the test under evaluation, the reference standard, or both. CONCLUSIONS: Evaluation of research depends on complete and accurate reporting. If medical journals adopt the checklist and the flow diagram, the quality of reporting of studies of diagnostic accuracy should improve to the advantage of clinicians, researchers, reviewers, journals, and the public.

Advisory Committees↗

An investigation of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder construct as a prototype category and the psychometric properties of the diagnostic criteria.

This study investigated several aspects of the validity of the Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition avoidant personality disorder (APD) construct, with emphasis on the psychometric properties of the diagnostic criteria and the prototype nature of the construct. A sample of 1,058 patients from the Norwegian Network of Psychotherapeutic Day Hospitals was examined by means of exploratory factor analysis, correlation, and diagnostic efficiency statistics, chi(2) analysis, and frequency distribution. The results indicated that APD is a 1-dimensional construct with good internal consistency. The criteria had acceptable diagnostic efficiency; criterion 3 performed poorest. Number of APD criteria showed no distinct threshold between No-APD and patients with APD. Sixty-two different combinations of any 4 APD criteria occurred. It can be concluded that the prototype model fitted the data well and that the APD diagnostic criteria perform well in the current classification system. The Diagnostic and Statistical Manual of Mental Disorders, Fourth Edition hierarchy of criteria was not supported.

Adult↗

Inpatient diagnostic assessments: 3. Causes and effects of diagnostic imprecision.

Preceding studies found that clinicians using the Traditional Diagnostic Assessment (TDA, the standard of clinical practice) often made imprecise diagnoses, compared with gold standards. Those same studies found excellent diagnostic agreement (kappa>0.75) between Computer Assisted Diagnostic Interview (CADI) and gold standards, thus warranting CADI's use as the standard for data collection and diagnosis in this study. When TDA and CADI users independently examined 106 inpatient-subjects, TDA users agreed only 45.3% (48/106) with CADI's primary diagnosis and found only 50.5% as many total diagnoses. This study searched for the causes and effects of those differences. To test the hypothesis that insufficient data collection was the cause, the 106 TDA write-ups were analyzed word-by-word. Only 46.2% (49/106) of the TDA write-ups listed enough symptom criteria (e.g. hallucinations, depression) to meet DSM-IV requirements for diagnosis, a likely cause of TDA's inaccuracy. TDA write-ups evaluated only 52.9% of the 18 Key Criteria necessary to screen for 10 diagnostic groups, a likely cause of TDA's incompleteness. TDA's diagnostic imprecision had effects on (1) length of stay (LOS) for hospitalized patients and (2) associated costs. Patients evaluated with TDA had a mean LOS of 12.5 days versus 7.7 days for CADI patients, a reduction of 4.8 days (12.5-7.7). If CADI replaced TDA, then annual savings of 3,000,000 dollars system-wide could be projected for inpatient care. Remedies for TDA's diagnostic imprecision are proposed.

California↗

Identifying relevant diagnostic studies in MEDLINE. The diagnostic value of the erythrocyte sedimentation rate (ESR) and dipstick as an example.

OBJECTIVE: We aimed to examine sensitivity and positive predictive value of MEDLINE searching for diagnostic studies, relevant for the primary health care setting. METHOD: Results of MEDLINE searches were compared with a reference standard collection of studies on two subjects, the diagnostic value of ESR in discriminating between 'pathology' and 'no pathology', and the dipstick method in diagnosing urinary tract infections. The main outcome measures were sensitivity (proportion of the total number of reference standard diagnostic studies that could be identified by the search) and positive predictive value (proportion of the total number of publications retrieved by MEDLINE that were incorporated in the reference standard). RESULTS: The combined MeSH and freetext search was more sensitive than MeSH term searching only, for both the ESR and the dipstick search. With this combined search sensitivities of 0.91 and 0.98 and predictive values of 0.10 and 0.68 were found for ESR and dipstick respectively. By restricting the search with keywords describing the primary health care setting the predictive values increased to 0.72 and 1.00 but sensitivity dropped to 0.10 and 0.07 (ESR and dipstick respectively). CONCLUSION: Combining freetext and MeSH term searching, without restriction to the primary health care setting, is a valuable strategy in systematically searching for available evidence on the value of a diagnostic test in the scope of a specific disease. The predictive value seems to depend on the breadth of the disease area. MEDLINE should provide a term such as 'diagnostic evaluation study' to be used in the limit field Publication Type to specify diagnostic studies.

Blood Sedimentation↗

Sources of diagnostic inaccuracy of conventional versus new diagnostic criteria for myocardial infarction in an unselected UK population with suspected cardiac chest pain, and investigation of independent prognostic variables.

OBJECTIVE: To assess the degree and sources of current diagnostic inaccuracy of serial conventional cardiac markers and ECGs compared with the new diagnostic criteria for myocardial infarction, with specific reference to physician specialty and the prognostic value of troponin T. DESIGN: Prospective, blinded observational study. SETTING: University hospital. PATIENTS AND INTERVENTIONS: All suspected cardiac chest pain admissions for six months, with additional blinded measurement of CK-MB mass and troponin T. World Health Organization and new criteria myocardial infarction diagnoses were made by an expert panel. MAIN OUTCOME MEASURES: Diagnostic adjustment by expert panel; completeness of serial measurements; six months prognosis. RESULTS: A complete set of serial cardiac markers was not taken in 38.7% of patients, this being twice as likely when managed by non-cardiologists than by cardiologists (p < 0.0001). The WHO myocardial infarction diagnosis was adjusted by the expert panel in 4% of cases, this being 90% more likely in patients admitted under non-cardiologists (p = 0.026). The new criteria for myocardial infarction identified an additional 27.3% of infarcts, with a diagnostic alteration in 12.0% of the cohort; 45.2% of these cases had a potentially preventable cause for diagnostic adjustment. Only troponin T (p = 0.0004), ST depression (p = 0.003), and heart failure (p = 0.016) were independently predictive of prognosis. CONCLUSIONS: Chest pain patients appear less likely to be fully and accurately assessed by non-cardiologists than by cardiologists. The new criteria for myocardial infarction identify approximately 25% of additional patients as MI, with potential additional advantages related to simplicity of diagnostic protocols. Troponin T was the most potent predictor of six month prognosis in an unselected cohort of chest pain admissions.

Adult↗

'Diagnostic orphans' among young adult cannabis users: persons who report dependence symptoms but do not meet diagnostic criteria.

OBJECTIVE: To examine the characteristics of 'diagnostic orphans' among cannabis users-those who report one or two symptoms of DSM-IV dependence but do not meet diagnostic criteria for DSM-IV abuse or dependence. METHOD: Data were collected from a representative population cohort of 1601 young adults aged 20-21 years. Those who reported that they had used cannabis at least weekly at some point within the past year were assessed for symptoms of DSM-IV cannabis abuse and dependence using the Composite International Diagnostic Interview. RESULTS: Approximately 2.8% of the cohort could be classified as diagnostic orphans, with another 3.0 and 7.5% meeting criteria for abuse and dependence, respectively. Diagnostic orphans were: similar to those who met criteria for cannabis abuse or dependence in terms of demographic characteristics; similar to those who met criteria for cannabis abuse in terms of cannabis use patterns; and similar to those who met criteria for abuse and dependence in their rates of heavy alcohol use and DSM-IV alcohol dependence. However, they did not appear to have elevated rates of illicit drug use or mental health problems compared to non users. CONCLUSIONS: Diagnostic orphans reported using cannabis in a manner similar to persons meeting criteria for cannabis abuse, and had similar rates of alcohol dependence and other illicit drug use. Strict adherence to DSM-IV diagnoses of abuse and dependence may overlook a substantial proportion of young persons who experience cannabis-related problems. There is a need to consider (a) subthreshold levels of cannabis-related problems among those seeking treatment for other problems; and (b) interventions for this group to prevent escalation of such problems.

Adult↗

Toward an understanding of diagnostic teleconsultations and their impact on diagnostic confidence.

This paper describes a four-stage model of the medical diagnostic process, and provides the results of an initial test of this emerging knowledge management theory. A study of the diagnostic teleconsultations between primary care physicians located in remote communities and specialists at the Medical College of Georgia was conducted. The study involved an analysis of the video recordings of teleconsultations and postteleconsultation telephone interviews with the specialists and physicians conducting diagnostic teleconsultations. The study revealed that the number of hypotheses generated by specialists, the overall duration of teleconsultations, and physicians' change in diagnostic confidence depended on the diagnostic stage of the specialty teleconsultation. This study demonstrated that the diagnostic stages have different behavioral and cognitive characteristics. Designers of telemedicine programs can complement these characteristics to increase the productivity of health care providers.

Clinical Competence↗

[Diagnostics and differential diagnostics of bronchial asthma and chronic obstructive pulmonary disease].

The subjects of the study were 14 patients with bronchial asthma (BA) and 11 patients with chronic obstructive pulmonary diseases (COPD). A special diagnostic approach, including spirography with a broncholytic test after inhalation loading (IL), was developed and applied to these patients in order to optimize diagnostics and differentiation diagnostics of BA. IL included the use of hypertonic sodium chloride solution inhalation. The control group consisted of 10 patients with non-obstructive chronic bronchitis and 22 healthy individuals. The results show that bronchial reaction to IL is different in patients with BA and COPD, and demonstrate that this diagnostic approach is appropriate when evaluating the peculiarities of bronchial patency. This allows more accurate diagnostics and differential diagnostics of BA and COPD, optimization of patient grouping for scientific studies, including genetic ones, and is interesting from the perspective of therapy prediction in patients with these diseases.

Asthma↗

Diagnostic sensitivity, diagnostic specificity and predictive value of the determination of tumour markers.

The meaningful use of tumour markers for cancer diagnosis depends on the nature of the diagnostic problem, on an adequate definition of positive and negative test results, and on the correct choice of the patient group. Potential diagnostic applications lie in screening studies, diagnosis in patients with symptoms, staging and prognosis, diagnosis of local recurrence and distant metastases, and the monitoring of radio- and chemotherapy. In quantitative tests, a positive or negative test result may be obtained by the establishment of reference ranges in control groups, or by longitudinal studies in single patients. Usually, the monitoring of therapy and the diagnosis of tumour progression are performed by following the concentration pattern of the marker. When tumour marker determinations are performed in conjunction with other diagnostic tests, the diagnostic sensitivity or specificity may be increased, depending on the particular test combination. The determination of tumour markers with limited diagnostic specificity should be performed in groups of patients with a high prevalence of the disease, e.g. in the postoperative follow-up of patients with a high risk of tumour recurrence. Tumour markers with high diagnostic specificity are also useful in differential diagnosis.

Antigens, Neoplasm↗

Organized quantitative pathology. Short review of the activities of the Committee for Diagnostic Quantitative Pathology from 1981 to the foundation of the International Society of Diagnostic Quantitative Pathology in 1994.

The Committee for Diagnostic Quantitative Pathology (CDQP), known originally as the Committee for Diagnostic Morphometry, ceased to exist under the original title and was converted to the International Society for Diagnostic Quantitative Pathology (ISDQP) in Amsterdam, September 14, 1994. The history of this society started in 1981 in a conference < > held at Koli, Finland. Since the original meeting the group of quantitative pathologists organized yearly gatherings: Symposia on Diagnostic Quantitative Pathology (earlier known as Symposia on Morphometry in Morphological Diagnosis) every other year, and meetings in association with the European Society of Pathology Congresses in the intervening years. In 1981, the symposium had 23 participants, in 1994, the International Society for Diagnostic Quantitative Pathology had over 300 members from six continents. During the short period of its existence the society has witnessed a steadily growing trend in educational courses on quantitative pathology. The general policy of the Committee, now Society, has willingly supported all activities which can be expected to lead to valuable results in quantitative microscopy and associated fields either through development of education, methodology or practical applications. By arranging a course of Diagnostic Quantitative Pathology the society participates in the activities of the European School of Pathology in Torino. The next symposia of the Society will be arranged in Heidelberg, October 1995 and in Sendai, Japan, October/November 1996.

Europe↗

[Effect of diagnostic imaging on pre-mortem diagnostic reliability].

BACKGROUND: Between 1972 and 1984 the diagnostic arsenal has much changed due to wide application of endoscopy, sonography and computed tomography. PATIENTS AND METHOD: Using the data from patients undergoing autopsy in the years 1972, 1977, 1981, and 1984, it was assessed how many of the diagnostic techniques had been used and to what extent the premortal diagnosis of abnormalities found at autopsy improved during this period. RESULT: While the number of autopsies declined from 113 in 1977 to 66 in 1984, the number of diagnostic techniques used increased continuously (94, 107, 118, and 140, amounting to 0.83, 1.34, 1.76 and 2.12 per patient). The premortal detection of abdominal abnormalities increased globally from 16.8 to 32.5%. This increase was largely due to better diagnosis of liver and gallbladder abnormalities which were in most cases of little relevance. CONCLUSION: Thus, the massive increase of the application of technical diagnostic tools leads only to a limited premortal diagnostic gain while costs are significant.

Abdomen↗

[Basic principles of selection and use of diagnostic tests: analysis of the results of diagnostic studies].

In clinical practice, in order to design and implement a specific therapeutic plan, as well as communicating an appropriate prognosis, the doctor needs to establish a precise diagnosis of the condition. Sometimes all one needs is a clinical impression. More often, however, the definition of an accurate diagnosis will need the interpretation of specific diagnostic tests as well. The rational use of diagnostic tests in cardiology--whether laboratorial or imagiologic--should be based on three factors: 1) validity of the study results about the test; 2) diagnostic properties of the test and 3) applicability of the test in the clinical setting. The rational use and correct interpretation of diagnostic tests are based on these three factors. In this article we present the basic principles concerning the validity of the results from the study that defined the specific test, and what level of evidence that constitutes. Other articles will address diagnostic properties of tests (sensitivity, specificity, positive and negative predictive values, likelihood ratios) as well as the applicability of the test in clinical practice.

Diagnostic Techniques, Cardiovascular↗