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PubMed1979

Late results of congenital cataract surgery.

Generally speaking, it can be said, when considering all operated bilateral congenital cataracts, that a visual acuity of over 20/100 is found in approximately 50% of patients. In this study, 230 eyes were followed; of these 100 (43%) had an acuity of 20/60 or better and 130 (57%) had 20/100 or less. In conclusion the functional prognosis is better for incomplete cataracts than for total congenital cataracts. The main reason for this is the fact that total cataracts are often associated with cerebroretinal lesions or anomalies. The patient's age at operation and the surgical technique chosen are secondary factors. When considered from the standpoint of visual acuity, the results of congenital cataract surgery are discouraging, at least in the eyes with complete cataract. The visual prognosis could be better for total congenital cataracts if we operate on them at birth or immediately after birth.

Adult↗
PubMed1977

Reversibility of corticosteroid-associated cataracts in children with the nephrotic syndrome.

We reexamined the eyes of 39 nephrotic children to investigate further the relationship between oral corticosteroid therapy and posterior subcapsular cataract formation. The corticosteroid dosage was proportional to each patient's weight. Six children had posterior subcapsular cataracts an average of 16 months after the first examination. Nine patients had complete regression of their posterior subcapsular cataracts. We found no correlation between the age at onset of the nephrotic syndrome, the dosage or duration of corticosteroid therapy, or the renal biopsy findings and posterior subcapsular cataract formation. Cushingoid manifestations were significantly more common in the patients with posterior subcapsular cataracts. These patients may be more sensitive to the effects of corticosteroids than those who never had cataracts and those whose cataracts regressed.

Adolescent↗
PubMed1979

Nonenzymatic glycosylation, sulfhydryl oxidation, and aggregation of lens proteins in experimental sugar cataracts.

The formation of sugar-cataracts has been hypothesized to involve the nonenzymatic glycosylation, sulfhydryl oxidation, and aggregation of lens proteins. Cataractous lenses of diabetic and galactosemic rats were analyzed for glycosylated lysine residues in crystallins. A five- and a ten-fold increase in glycosylated lysine residues was measured in galactose and diabetic cataracts, respectively. The modification was predominant in the insoluble fraction of the lens homogenate. The proteins were further examined for the presence of disulfide bonds and high molecular weight aggregates. After careful disruption of the lens in a nitrogen environment, a cloudy solution was obtained from cataractous lenses whereas a clear solution was obtained from normal lenses. The absorbance at 550 nm of the solution of both the galactosemic and the diabetic cataracts could be decreased by approximately 50% with the addition of dithioerythritol (50 mM). The presence of high molecular weight aggregates was ascertained by sucrose gradient centrifugation and gel filtration chromatography. The proteins were heterogenous in size and showed a mol wt range of 36 to greater than 176 million daltons. Treatment with dithioerythritol induced a marked decrease in the amount of high molecular weight proteins. These data suggest that sugar cataracts of experimental animals have, in common with human cataracts, the presence of high molecular weight aggregates which are in part linked by disulfide bonds.

Alloxan↗
PubMed1979

Variations of lens thickness in relation to biomicroscopic types of human senile cataract.

The results are reported of 38 ultrasonographic in vivo mensurations of intraindividual differences in axial thickness between a cataractous lens in one eye and a biomicroscopically clear or slightly cataractous lens (incipient deep cortical opacity) in the other. Obviously intumescent cataractous lenses were excluded. In general, the cataractous lens was thinner than the contralateral clear or slightly cataractous lens. Large decreases in lens thickness appeared in lenses with the capsule-near opacities of posterior subcapsular cataract (PSC) + anterior capsular/subcapsular opacity (ACSCO). PSC was more closely correlated to lens thinning than was ACSCO. Nuclear cataract very often occurred in thin lenses, but did not appear to cause lens thinning per se. Deep cortical opacity was not associated with lens thinning. The present results contributed to our argumentation that the decrease in lens thickness is due to a leak of lens material through the "lens membrane" beside a possible cessation of growth of the lens fibres.

Age Factors↗
PubMed1976

Experimental studies on cataract.

I have discussed five aspects of lens metabolism and their possible relationship to cataract in man, and this has left me with five fundamental questions to be answered. 1. Are the fluorescent tryptophan derivatives, found only in the lens of man and higher primates, involved in the development of brown nuclear cataract? 2. Is naphthalene cataract in rabbits a model for any type of cataract in man--i.e., are quinones ever formed in the human eye? 3. Is diabetes the only cataract in which osmotic swelling is important? 4. Does self-digestion of protein in the human lens contribute to cataract development? 5. Are the consequences of the abnormal maturation of lens fibers, which occurs in tryptophan deficiency cataract in rats, ever seen in man?

Aging↗
PubMed1976

Protein changes in the human lens during development of senile nuclear cataract.

Senile nuclear cataractous lenses were divided into three groups of increasing nuclear color. These groups were considered as successive stages in the development of senile nuclear cataract. The cortex and the nucleus of normal and cataractous lenses were separated into water-soluble, urea-soluble and urea-insoluble fractions. Fractionation on a Sephadex G-200 column of the water-soluble components revealed five protein fractions for both cortex and nucleus. Only minor quantitative differences in polypeptide chain composition were found by isoelectric focusing between corresponding protein fractions isolated from normal and cataractous lenses. The weight percentages of the water-soluble, urea-soluble, and urea-insoluble fractions of cortex and nucleus from the normal and cataractous lenses were determined. A decrease of the amounts of the water-soluble and urea-soluble fractions and a concomitant increase of the urea-insoluble fraction were observed in the nucleus as a function of cataract development. Lens wet weight and protein content did not change significantly. The carbohydrate content of the urea-soluble fractions increased, that of the urea-insoluble fraction decreased. A striking decrease of the phospholipid content in the urea-insoluble fraction was found.

Aged↗
PubMed1976

Concentrations of some ribonucleotides, L-lactate, and pyruvate in human senile cataractous lenses with special reference to anterior capsular/subcapsular opacity.

The concentrations of some ribonucleoside tri- and diphosphates, adenosine-5'-monophosphate, L-lactate and pyruvate were determined in human senile cataractous lenses removed during cataract operations. Pyruvate concentrations were found to be negligible (median = 56 mumol/kg lens wet weight) in 15 human senile cataractous lenses. On the basis of correlations between the biomicroscopic appearances of the senile cataractous lenses (N = 80) and the concentrations and ratios of the metabolites in question, the following classification was found to be justified: 1. Immature cataractous lenses without anterior capsular/subcapsular opacity: high levels of ribonucleoside triphosphates (RTP), high sums of RTP, ribonucleoside diphosphates (RDP), and adenosine 5'-monophosphate (AMP) as well as high levels of L-lactate and high ratios of L-lactate in the lens/L-lactate in the aqueous. 2. Immature cataractous lenses with anterior capsular/subcapsular opacity; intermediate levels of RTP, intermediate values for the sums of RTP, RDP, and AMP, high L-lactate levels, and intermediate values of the ratios of L-lactate in the lens/L-lactate in the aqueous. 3. Totally opaque lenses, which all had extensive anterior capsular/subcapsular opacity; low values for the concentrations of lens RTP, for the sums of RTP, RDP and AMP, and for lens L-lactate. Low ratios of L-lactate in the lens/L-lactate in the aqueous.

Adenosine Diphosphate↗
PubMed1978

Experimental cataract production by high frequency ultrasound.

In vivo animal experiments were performed to study the cataractogenic effects of high-frequency, high-intensity ultrasound. A series of anesthetized rabbits was insonified with quantified exposures of ultrasound using a 9.8 MHz focused ultrasonic beam. Ophthalmoscopic and slit lamp examinations revealed small haze cataracts as the first stage of lenticular damage. Larger exposures produced totally opaque cataracts. These first appeared as fine white threads surrounded by haze cataracts. The intensity-exposure time conjugates required to produce haze cataracts were determined over times ranging from 35 msec to 5 sec. At short times (under 100 msec) a relatively constant amount of energy was needed for cataract production. At longer times, the requried energy progressively increased. This observation, together with the physical appearance of these cataracts, suggests that those lesions are the result of thermal phenomena.

Animals↗
PubMed1977

Massive cataract relief in eye camps.

The concept of "eye camp" represents a revolutionary approach to the massive problem of cataract-related blindness and visual disability. The "eye camp" involves comprehensive cooperative relief efforts on a large scale to combat the widespread incidence of cataract as it affects residents of rural areas, especially in developing nations. We worked in an eye camp in Johilpatti, India, in the rural province of Tamil Nadu. On this site, 216 cataract operations were performed in one morning by 8 doctors and 16 nurses. In this province alone, an estimated 700,000 persons have cataract requiring operation. However, presently existing facilities are equipped to handle a maximum of only 20,000 cases annually. But from June 1972 to June 1973, approximately 50,000 cataract operations were performed in the eye camps. Evidently, the eye camp idea has great potential to significantly reduce the incidence of untreated cataract in rural areas where there are chronic shortages of treatment facilities and medical personnel.

Adult↗
PubMed1979

[Operation on a congenital cataract in a Siberian Tiger].

A cataract operation in a young Siberian tiger is reported. This 5-month-old tiger, presenting with blindness, showed bilateral residual pupillary membranes and anterior polar cataracts combined with nuclear cataracts. After unilateral intracapsular extraction of the lens, the tiger adapted well to the improvement in sight and behaved almost like an animal with normal vision. The animal died 3 months post-operatively from unknown cause. Histological examination of the aphakic eye showed, at the site of operation on the cornea, an intact epithelium with discrete infiltration of the stroma together with low-grade vascularisation. In the eye not treated operatively, both an anterior polar cataract with adherent pupillary membrane strands and a central cataract were seen. Of particular note, when comparing this large wild cat with the domestic cat, was the marked development of the tapetum lucidum (up to 30 cell layers).

Animals↗
PubMed2026

KLF5 promotes proliferation, migration, and autophagy-/EMT‑associated molecular changes in lens epithelial cells via transcriptional activation of THBS1 in traumatic cataract.

PURPOSE: Traumatic cataract is a common blinding eye disease after ocular trauma, and its pathogenesis is closely related to lens epithelial cell dysfunction, while the definite molecular regulatory mechanism between upstream transcription factor and downstream target gene remains poorly clarified. This study aimed to clarify the role and molecular mechanism of the krüppel-like factor 5 (KLF5)/ thrombosponin 1 (THBS1) axis in regulating proliferation, migration, epithelial-mesenchymal transition and autophagy of lens epithelial cells in traumatic cataract, and to explore its potential clinical therapeutic value. METHODS: The GSE295383 dataset in the gene expression omnibus (GEO) database was downloaded, and the differentially expressed genes (DEGs) were screened by linear models for microarray data (limma) package of R language. Combined with Weighted gene co-expression network analysis (WGCNA), the gene co-expression network was constructed and the key modules were screened. Gene ontology (GO), kyoto encyclopedia of genes and genomes (KEGG) and gene set enrichment analysis (GSEA) combined with human transcription factor target (hTFtarget) and JASPAR databases were used to predict the upstream transcription factors of THBS1. Subsequently, SRA01/04 cells were induced with transforming growth factor-beta 2 (TGF-β2) to construct a cataract cell model. RESULTS: THBS1 and KLF5 were highly expressed in LECs exposed to TGF-β2. KLF5 could activate THBS1 transcription by binding to THBS1 promoter - 174 to -165 sites. Knockdown of THBS1 inhibited TGF-β2-induced viability, proliferation, migration, and altered the expression of epithelial-mesenchymal transition (EMT)- and autophagy-related markers in LECs. Knockdown of KLF5 downregulated THBS1 expression and produced a similar inhibitory effect, while overexpression of THBS1 reversed the effect of KLF5 knockdown. CONCLUSIONS: This study demonstrated that KLF5 promoted the proliferation, migration, and EMT‑associated molecular changes of LECs in traumatic cataract through transcriptional activation of THBS1, and regulated the expression of autophagy‑related markers in LECs, suggesting that KLF5/THBS1 axis might be a potential target for the treatment of traumatic cataract.

Cataract↗
PubMed2024

A lipidomic study on the lens epithelial cells of patients with age related cataracts.

Age related cataracts (ARC) represent the main reason for blindness globally. The lens epithelial cells (LECs) participate not only in the metabolism of many substances in the lens but also in maintaining lens transparency. This study used lipidomics to investigate the metabolic differences in LECs of ARC patients with different severity, aiming at identifying potential metabolic biomarkers of ARC. Patients diagnosed with ARC and underwent cataract surgery at Shanghai Tongren Hospital were selected to participate in this study, which were classified as mild ARC group and severe ARC group. During their cataract surgery, anterior lens capsules(LCs) containing LECs were obtained. The lipidomics of LECs were analyzed using the liquid chromatography‑mass spectrometry (LC-MS). Potential pathways of lipids were searched for using databases such as the Kyoto Encyclopedia of Genes and Genomes (KEGG) and MetaboAnalyst platform. In LEC lipids, 26 lipids have been identified as potential biomarkers between mild ARC and severe ARC, with AUC values of 0.67-0.94. The pathway analysis results revealed that the Glycerophospholipid (GPL) metabolism was significantly influenced, indicating that these metabolic markers contribute significantly to regulating this pathway. The LEC metabolic spectrum demonstrates a proficient ability to differentiate between patients with varying levels of cataracts. Herein, we have successfully identified potential metabolic biomarkers and pathways that have proven to be valuable in enhancing our understanding of ARC pathogenesis. The finding has translational value for developing new cataract treatment methods in the future.

Humans↗
PubMed1977

[The prognostic value of the laser-interference-fringe-test with cataract patients (author's transl)].

The retinal visual acuity of 198 cataractous eyes was tested with interference-fringes and compared with the post-operative visual acuity. A new method of creating interference-fringes was used. The interference-fringe technique showed its special clinical value with immature cataracts. It is of certain value also with premature cataracts. With mature and hypermature cataracts no results of clinical value could be obtained. The method seems to have its value with congenital and juvenile cataracts.

Cataract↗
PubMed1977

Cataract operations in a retina centre.

The position of the cataract surgeon in a retinal surgical centre is a particular one. Close collaboration with the retinal specialist obliges him never to lose sight of the judgement of the latter. The retinal surgeon does not judge the success of a cataract operation by the consequent visual acuteness obtained, but must wait to see the fundus of the eye, and in particular the retinal periphery. This is a problem with which we are occupied. We have studied from the point of view of the cataract specialist the modifications and retinal complications occurring in 2000 cataract operations. In addition, we have tried to make, from the point of view of the retina specialist, an analysis of detachments of the aphakia which occurred in relation to the cataract operations during the same period of time.

Cataract↗
PubMed1977

Results in cataract extraction after retinal detachment surgery.

Out of 58 eyes in which a cataract extraction followed a successful detachment operation, only 8, or 15.5%, developed a detachment of the retina after the cataract operation and, of these 8 eyes, 7 were cured with further retinal detachment operation. Thus, in 58 healed detachment eyes, only 1 (1.7%) lost useful vision because of incurable retinal detachment following cataract extraction. Therefore, one may conclude that, in a patient definitely handicapped by poor vision due to a cataract in an eye with a healed retinal detachment, extraction of this cataract is justified and carries a good prognosis.

Adolescent↗
PubMed1977

Visual results following infantile cataract surgery.

Aspiration and its modifications have been shown to be a superior operative procedure for neonatal, congenital, infantile, and acquired cataracts. However, the visual results obtained in the infantile cataractous eye, whether the opacity is complete or partial, still remain within the same range as the results of other operative techniques reported over the last 3 decades. Adequate visual results often cannot be obtained because of the associated systemic and/or ocular defects or failure of optical and amblyopia treatment. Perhaps increased efforts should be made to perform surgery at even earlier ages in those patients with complete, or in some cases, partial, cataracts in which surgery is contemplated. In children with partial cataracts who are able to function well, the lens should be allowed to remain in place and conservative measures of visual preservation should be undertaken for as long as possible. This allows the eye more time to develop normal visual functions with an intact lens and accommodative mechanisms. It should be stressed again that the sole success or failure of surgery for infantile cataracts cannot always be the visual acuity. The real measure is the child's ability to function successfully in his environment for the remainder of his life.

Adult↗
PubMed1977

Oxidative changes in human lens proteins during senile nuclear cataract formation.

1. Proteins from the cortex and nucleus of the human lens were studied to determine if any changes could be detected in their amino acids during senile cataract formation. 2. Senile nuclear cataract formation was found to be accompanied by a progressive oxidation of cysteine and methionine. The oxidation of methionine and changes in the distribution of the nuclear proteins did not appear to start until about 60% of the cysteine had been oxidized. 3. In the advanced nuclear cataractous lens, about 90% of the cysteine has been oxidized and 45% of the methionine is present as the sulphoxide in the nuclear proteins. The levels of other amino acids appeared to remain constant. 4. Similar, but smaller, changes were found in the cortical proteins in advanced nuclear cataractous lenses, suggesting that the oxidation spreads from the nucleus to the cortex. 5. These changes were discussed with regard to current views on cataract formation and it was concluded that they are probably the result of simple oxidation of the proteins with O2 or H2O2.

Adult↗
PubMed1978

Association of presenile cataracts with heterozygosity for galactosaemic states and with riboflavin deficiency.

Red cells and the lens of the eye are non-nucleated cells; moreover, they have metabolic similarities. Cataracts develop in childhood in homozygotes for galactosaemic abnormalities, which can be detected by biochemical measurements in red blood-cells. It has not been determined whether heterozygotes for these defects are at greater risk for cataract development later in life. Similarly, riboflavin deficiecy for which the erythrocyte is a sensitive indicator, has been associated with cataracts in animals. Red-cell studies were carried out in 22 patients, aged under 50, with cataracts. Heterozygosity for galactokinase deficiency was detected in 5 patients, for galactose-uridyl transferase in 2, and evidence of an erythrocytic deficiency of riboflavin in 8. Even when Black subjects were excluded from analysis because of their high incidence of polymorphism for galactokinase, these findings are significantly different from those expected from population surveys and suggest that many patients with presenile cataracts have a biochemical abnormality which can be detected by examination of red blood-cells and which may be corrected by dietary restrictions or supplements.

Adolescent↗