Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “ZIRCONIUM”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed1976

Colorimetric determination of zirconium in antiperspirant aerosols.

A rapid direct dilution procedure for the estimation of soluble zirconium and a fusion procedure for the determination of total zirconium (soluble and insoluble forms) in cream base concentrates prepared from antiperspirant aerosols are described. The direct dilution procedure involves extraction of soluble zirconium with HCl (55 + 45). The filtered extract is reacted with alizarin red S to form a stable colored complex which is measured spectrophotometrically. The fusion procedure involves ashing the aerosol concentrate followed by fusion of the ash with potassium pyrosulfate to form an acid-soluble melt. Zirconium is precipitated from solution as the hydroxide and washed to eliminate interfering ions, particularly sulfate. After redissolving in HCl (55 + 45) and reacting with alizarin red S, total zirconium is measured. Zirconyl chloride octahydrate, assayed gravimetrically by hydroxide precipitation and conversion to the oxide, is used as the zirconium reference standard. Concentration range of zirconium measured was 200-500 mug/100 ml. Recoveries of standard zirconium added to commercial aerosols labeled to contain aluminum and zirconyl hydroxychlorides ranged from 97 to 101% by the fusion procedure. Analysis of these aerosols by direct dilution gave generally slightly lower results than by fusion. It is recommended that the procedures be collaboratively studied after further testing of their general applicability to a variety of drugs and cosmetics.

Aerosols↗
PubMed2006

Inflammatory infiltrate, microvessel density, nitric oxide synthase expression, vascular endothelial growth factor expression, and proliferative activity in peri-implant soft tissues around titanium and zirconium oxide healing caps.

BACKGROUND: The aim of the present study in humans was to conduct a comparative immunohistochemical evaluation of vascular endothelial growth factor (VEGF) and nitric oxide synthase (NOS) expression, inflammatory infiltrate, proliferative activity expression, and microvessel density (MVD) in peri-implant soft tissues of titanium and zirconium oxide healing caps. METHODS: Five patients, three men and two women (aged 30 to 66 years; mean: 49 years), participated in this study. All patients received dental implants that were 3.8 mm in diameter and 11 mm in length. All implants were left to heal in a non-submerged (single-stage) mode. Healing caps (3.8 mm in diameter and 3.0 mm in height) were inserted in all implants. Half of the implants were supplied with standard, prefabricated caps of commercially pure titanium, whereas the other half were provided with test zirconium oxide caps. After a 6-month healing period, a gingival biopsy was performed with a circular scalpel (5.5 mm in diameter) around the healing caps of both groups, without unscrewing or removing the healing caps. The dimensions of the gingival biopsies were 1.7 mm (5.5-3.8 mm) in thickness and 3 mm in height. RESULTS: Statistically significant differences were found in the microvessel density between titanium and zirconium oxide healing caps and group II (P < or = 0.0001). Statistically significant differences were likewise found in the low and high intensities of NOS1, NOS3, and VEGF (P < or = 0.0001). In conclusion, the high intensity of NOS1, NOS3, and VEGF were mostly expressed in the titanium group, whereas the low intensity of NOS1, NOS3, and VEGF were mostly expressed in the zirconium oxide group. CONCLUSIONS: In our specimens, the inflammatory infiltrate was mostly present in the titanium specimens. Their extension was much larger than that of the zirconium oxide specimens. Higher values of MVD were observed in the titanium specimens (29.1 versus 15.8). In addition, a higher expression of VEGF intensity was observed in the peri-implant tissues of titanium healing caps, whereas predominantly lower expressions of VEGF intensity were noted around the zirconium oxide healing caps. The Ki-67 expression was higher in the titanium specimens. All these data revealed that the tissues around titanium healing caps underwent a higher rate of inflammation-associated processes, most probably correlated to the higher inflammation processes observed in these tissues. A higher intensity expression of NOS1 and NOS3 was recorded in the tissues around titanium, whereas, on the contrary, a lower intensity of expression was found in the tissues around zirconium oxide specimens. These latter data indicate that the higher expression of these two mediators could be correlated to the higher amount of bacteria present around the titanium samples.

Adult↗
PubMed2006

Zirconium implant abutments: fracture strength and influence of cyclic loading on retaining-screw loosening.

OBJECTIVE: The purpose of this study was to determine the fracture strength of zirconium implant abutments and the torque required to unfasten the retaining screw before and after applying cyclic loading to the implant-abutment assembly. The dynamic behavior and stress distribution pattern of zirconium abutments were also evaluated. METHODS AND MATERIALS: Static and cyclic loading of 7 XiVE implants with straight Cercon zirconium abutments were simulated under worst-case conditions. Cyclic loading tests were performed via a servohydraulic dynamic testing machine at loads between 100 and 450 N, for up to 5 million loading cycles, at 15 Hz. The dynamic behavior of the zirconium abutments was analyzed by finite element modeling and Pro/Mechanica software, comparing van-der-Mises and maximum stress levels. RESULTS: Cercon zirconium-ceramic abutments exhibited a maximum fracture strength of 672 N during static loading and 269 N at 800,000 to 5 million cycles runout point, and 403 N at 10,000 cycles runout point during cyclic loading. The mean torque value required to unfasten the abutment retaining screws after (initial) tightening was 21 Ncm +/- 1 and 20 Ncm +/- 1 (measurement accuracy +/- 2 Ncm) after loading with up to 5 million cycles respectively. Torque values decreased minimally and screw loosening did not occur. Within the limited number of test specimens (7), the difference was statistically significant (P = .015). FEM analysis displayed higher stress peaks up to 800 MPa at the cervical aspect of the zirconium abutment and at the apical third of its retaining screw at an external load of 250 N. CONCLUSION: Within the limitations of this study, zirconium implant abutments exceeded the established values for maximum incisal bite forces reported in the literature and tightly fit into the titanium implant after several millions of loading cycles.

Bite Force↗
PubMed1977

Collaborative study of the colorimetric determination of zirconium in antiperspirant aerosols.

A previously published method for determining zirconium in antiperspirant aerosols was collaboratively studied by 7 laboratories. The method consists of 2 procedures: a rapid dilution procedure for soluble zirconium compounds or a lengthier fusion procedure for total zirconium (soluble and insoluble compounds), followed by colorimetric determination. The collaborators were asked to perform the following: Spiking materials representing 4 levels of soluble zirconium were added to weighed portions of a zirconium-free cream base concentrate and the portions were assayed by the dilution procedure. Spiking materials representing 4 levels of zirconium in either the soluble or the insoluble form (or as a mixture) were also added to portions of the same concentrate and these portions were assayed by the fusion procedure. They were also asked to concentrate and assay, by both procedured, 2 cans each of 2 commercial aerosol antiperspirants containing zirconyl hydroxychloride. The average per cent recoveries and standard deviations for spiked samples were 99.8-100.2 and 1.69-2.71, respectively, for soluble compounds determined by the dilution procedure, and 93.8-97.4 and 3.09-4.78, respectively, for soluble and/or insoluble compounds determined by the fusion procedure. The average per cent zirconium fouund by the dilution procedure in the 2 commercial aerosol products was 0.751 and 0.792, respectively,with coefficients of variation of 2.94 and 2.53%, respectively. Insufficient collaborative results were received for the fusion procedure for statistical evaluation. The dilution procedure for statistical evaluation. The dilution procedure has been adopted as official first action.

Aerosols↗
PubMed2003

Volatile beta-ketoiminato- and beta-diketiminato-based zirconium complexes as potential MOCVD precursors.

An amine elimination pathway has been used to produce a number of homo- and heteroleptic zirconium complexes, starting from tetrakis(dialkylamido)zirconium complexes and beta-diketimine or, alternatively, Schiff Base compounds. Reaction of 2 equiv of the bidentate beta-diketimine (2Z,4E)-N-methyl-4-(methylimino)pent-2-en-2-amine with Zr(NR(2))(4) (R = Me, Et) affords the six-coordinate heteroleptic compounds bis(N-methyl-4-(methylimino)pent-2-en-2-amido)bis(dialkylamido)zirconium 1 (alkyl = Me) and 2 (alkyl = Et). The dynamic behavior of these two compounds in solution has been investigated. Reaction with the isopropyl-substituted beta-diketimine (2Z)-N-isopropyl-4-(isopropylimino)pent-2-en-2-amine gives the five-coordinate mono(diketiminato)-substituted compound (N-isopropyl-4-(isoropylimino)pent-2-en-2-amido)tris(dimethylamido )zirconium, 3. With employment of the Schiff base (3Z)-4-(methylamino)pent-3-en-2-one, it was also possible to prepare the six-coordinate bis(4-(methylamino)pent-3-en-2-onato)bis(diethylamido)zirconium compound 4. When the bidentate ligand bearing hydrogen as substituent on the imino-nitrogen atom was employed, homoleptic tetrakis(beta-ketoiminato)- and tetrakis(beta-diketiminato)zirconium compounds 5 and 6 can be obtained. Complexes 1 and 5 have been tested for their air stability with reference to Zr(NMe(2))(4). The stability order turned out to be 1 > 5 >> Zr(NMe(2))(4). The thermal properties and volatility of all the compounds are discussed in view of their potential application in metal-organic chemical vapor deposition processes (MOCVD) of zirconium nitride.

Journal Article↗
PubMed2006

Synthesis of bis(indenyl)zirconium dihydrides and subsequent rearrangement to eta5,eta3-4,5-dihydroindenediyl ligands: evidence for intermediates during the hydrogenation to tetrahydroindenyl derivatives.

Exposure of eta9,eta5-bis(indenyl)zirconium sandwich complexes to 4 atm of H2 resulted in facile oxidative addition to furnish the corresponding zirconocene dihydrides, (eta5-C9H5-1,3-R2)2ZrH2 (R = SiMe3, SiMe2Ph, CHMe2). Continued hydrogenation completed conversion to the tetrahydroindenyl derivatives, (eta5-C9H9-1,3-R2)2ZrH2. Deuterium labeling studies established that dihydrogen (dideuterium) addition to the benzo rings is intramolecular and stereospecific, occurring solely from the endo face of the ligand, proximal to the zirconium. In the absence of dihydrogen, the bis(indenyl)zirconium dihydrides rearranged to new zirconium monohydride complexes containing an unusual eta5,eta3-4,5-dihydroindenediyl ligand, arising from metal-to-benzo ring hydrogen transfer. Mechanistic studies, including a normal, primary kinetic isotope effect measured at 23 degrees C, are consistent with a pathway involving regio- and stereoselective insertion of a benzo C=C bond into a zirconium hydride. The stereochemistry of the insertion reaction, and hence the eta5,eta3-4,5-dihydroindenediyl product, is influenced by the presence of donor ligands and controlled by the preferred conformation of the indenyl rings. Exposure of the zirconium hydrides containing the eta5,eta3-4,5-dihydroindenediyl rings to 1 atm of dihydrogen afforded the tetrahydroindenyl zirconium dihydride complexes, establishing the intermediacy of this unusual coordination environment during benzo ring hydrogenation.

Journal Article↗
PubMed2006

New zirconium (IV) complexes of coumarins with cytotoxic activity.

Complexes of zirconium (IV) with some bis-coumarin ligands have been synthesized. The zirconium (IV) complexes with bis-coumarins were characterized by different physicochemical methods-elemental analysis, IR-, and (1)H-NMR-spectroscopies and mass spectral data. The spectral data of zirconium (IV) complexes were interpreted on the basis of comparison with the spectra of the free ligands. The results of the ligands and their complexes, based on spectral data are informative and useful for suggestion of the metal-ligand binding mode. Cytotoxic screening by MTT assay was carried out. In the present study we performed comparative evaluation of the cytotoxic effects of the three newly synthesized zirconium complexes against the acute myeloid leukemia derived HL-60 and the chronic myeloid leukemia LAMA-84. The preliminary cytotoxicity screening program revealed that the investigated zirconium complexes induced 50% inhibition of the cell viability of HL-60 and LAMA-84 cells at micromolar concentrations and thus could be considered as biologically active. Independently of the tumor test system evaluated the complex of bis(4-hydroxy-2-oxo-2H-chromen-3-yl)-(1H-pyrazol-3-yl)-methane proved superior to the remaining agents with respect to the IC(50) values obtained. The complexes of both the other coumarins evaluated proved to be less potent than the corresponding free ligands, as evidenced by the IC(50) values obtained. Thus the zirconium complexes with coumarin ligands represent a novel class of antiproliferative agents, which deserve further attention in search of anticancer lead compounds.

Antineoplastic Agents↗
PubMed1997

Tribological evaluation of oxidized zirconium using an articular cartilage counterface: a novel material for potential use in hemiarthroplasty.

Problems with total joint replacement that have surfaced in recent years have made reconsideration of more conservative hip reconstructive procedures compelling. Moreover, procedures such as hemiarthroplasty might benefit from newly developed materials that could provide more favourable tribological performance when employed as a counterface for articulation with articular cartilage. The objective of this study was to evaluate the tribology of a new biomaterial, oxidized zirconium, with articular cartilage in a laboratory test apparatus. Oxidized zirconium components are produced by oxidizing the zirconium alloy to form a relatively thick (7 microns), adherent, abrasion-resistant ceramic surface. We found that the coefficient of friction of bovine articular cartilage rubbed against oxidized zirconium was lower than with cobalt-chromium alloy control surfaces, and that there was a trend toward less wear with oxidized zirconium. A defined layer of degraded tissue was found on the surface of the articular cartilage specimens, providing some indication of the mechanism of wear. Results of this study warrant further investigation of oxidized zirconium as the bearing surface for hemiarthroplasty.

Alloys↗
PubMed2006

Carbon-oxygen bond cleavage with eta9,eta5-bis(indenyl)zirconium sandwich complexes.

Treatment of the eta9,eta5-bis(indenyl)zirconium sandwich complex, (eta9-C9H5-1,3-(SiMe3)2)(eta5-C9H5-1,3-(SiMe3)2)Zr, with dialkyl ethers such as diethyl ether, CH3OR (R=Et, nBu, tBu), nBu2O, or iPr2O resulted in facile C-O bond scission furnishing an eta5,eta5-bis(indenyl)zirconium alkoxy hydride complex and free olefin. In cases where ethylene is formed, trapping by the zirconocene sandwich yields a rare example of a crystallographically characterized, base-free eta5,eta5-bis(indenyl)zirconium ethylene complex. Observation of normal, primary kinetic isotope effects in combination with rate studies and the stability of various model compounds support a mechanism involving rate-determining C-H activation to yield an eta5,eta5-bis(indenyl)zirconium alkyl hydride intermediate followed by rapid beta-alkoxide elimination. For isolable eta6,eta5-bis(indenyl)zirconium THF compounds, thermolysis at 85 degrees C also resulted in C-O bond cleavage to yield the corresponding zirconacycle. Both mechanistic and computational studies again support a pathway involving haptotropic rearrangement to eta5,eta5-bis(indenyl)zirconium intermediates that promote rate-determining C-H activation and ultimately C-O bond scission.

Carbon↗
PubMed1995

Mechanical properties of the binary titanium-zirconium alloys and their potential for biomedical materials.

Mechanical properties of titanium-zirconium binary alloys were investigated in order to reveal their possible use for new biomedical materials and to collect useful data for alloy design through a hardness test, a tensile test, and optical microscopy. The hardness of the alloy containing 50% zirconium was approximately 2.5 times as large as the hardness of pure titanium and pure zirconium. Tensile tests showed a similar tendency. No changes between hardness of as cast specimens and as homogenized specimens were observed, nor were changes in microstructures noted. Comparisons between the Ti-6Al-4V alloy and the Ti-Zr-6Al-4V alloy indicated that a titanium-zirconium alloy could provide a base material for a new biomedical alloy. From these results, it was concluded that new alloys for biomedical materials should be designed as titanium-zirconium base alloys.

Alloys↗
PubMed2006

Effect of zirconium-oxide ceramic surface treatments on the bond strength to adhesive resin.

STATEMENT OF PROBLEM: Surface treatment methods used for resin bonding to conventional silica-based dental ceramics are not reliable for zirconium-oxide ceramics. PURPOSE: The aim of this study was to compare the effects of airborne-particle abrasion, silanization, tribochemical silica coating, and a combination of bonding/silane coupling agent surface treatment methods on the bond strength of zirconium-oxide ceramic to a resin luting agent. MATERIAL AND METHODS: Sixty square-shaped (5 x 5 x 1.5 mm) zirconium-oxide ceramic (Cercon) specimens and composite resin (Z-250) cylinders (3 x 3 mm) were prepared. The ceramic surfaces were airborne-particle abraded with 125-microm aluminum-oxide (Al(2)O(3)) particles and then divided into 6 groups (n = 10) that were subsequently treated as follows: Group C, no treatment (control); Group SIL, silanized with a silane coupling agent (Clearfil Porcelain Bond Activator); Group BSIL, application of the adhesive 10-methacryloyloxydecyl dihydrogen phosphate monomer (MDP)-containing bonding/silane coupling agent mixture (Clearfil Liner Bond 2V/ Porcelain Bond Activator); Group SC, silica coating using 30-microm Al(2)O(3) particles modified by silica (CoJet System); Group SCSIL, silica coating and silanization (CoJet System); and Group SCBSIL, silica coating and application of an MDP-containing bonding/silane coupling agent mixture (Clearfil Liner Bond 2V/Porcelain Bond Activator). The composite resin cylinders were bonded to the treated ceramic surfaces using an adhesive phosphate monomer-containing resin luting agent (Panavia F). After the specimens were stored in distilled water at 37 degrees C for 24 hours, their shear bonding strength was tested using a universal testing machine at a crosshead speed of 0.5 mm/min. Debonded specimen surfaces were examined with a stereomicroscope to assess the mode of failure, and the treated surfaces were observed by scanning electron microscopy. Bond strength data were analyzed using 1-way analysis of variance and the Duncan test (alpha = .05). RESULTS: The bond strengths (mean +/- SD; MPa) in the groups were as follows: Group C, 15.7 +/- 2.9; Group SIL, 16.5 +/- 3.4; Group BSIL, 18.8 +/- 2.8; Group SC, 21.6 +/- 3.6; Group SCSIL, 21.9 +/- 3.9; and Group SCBSIL, 22.9 +/- 3.1. The bond strength was significantly higher in Group SCBSIL than in Groups C, SIL, and BSIL (P<.001), but did not differ significantly from those in Groups SC and SCSIL. Failure modes were primarily adhesive at the interface between zirconium and the resin luting agent in Groups C and SIL, and primarily mixed and cohesive in Groups SC, SCSIL, and SCBSIL. CONCLUSION: Tribochemical silica coating (CoJet System) and the application of an MDP-containing bonding/silane coupling agent mixture increased the shear bond strength between zirconium-oxide ceramic and resin luting agent (Panavia F).

Air Abrasion, Dental↗
PubMed2004

Oxidized zirconium femoral components reduce polyethylene wear in a knee wear simulator.

Polyethylene wear remains a major problem that can jeopardize the long-term durability of prostheses used in total knee arthroplasty. Oxidized zirconium is a material that combines the strength of a metal with the wear properties of a ceramic. This study evaluated the wear rates of polyethylene inserts against oxidized zirconium femoral components. Three oxidized zirconium femoral components and three Co-Cr femoral components of identical geometry used in total knee arthroplasty were articulated against standard tibial components with modular tibial inserts made of noncross-linked ultra-high molecular weight polyethylene. Gravimetric and volumetric polyethylene wear rates were calculated after 5 million gait cycles on an AMTI knee wear simulator. Oxidized zirconium reduced polyethylene wear by 42% compared with Co-Cr alloy. This study shows that oxidized zirconium can reduce polyethylene wear substantially when used for fixed-bearing total knee arthroplasty.

Biocompatible Materials↗
PubMed2002

Apatite formation on bioactive zirconium metal prepared by chemical treatment.

Bioactive metallic materials, which can directly bond to living bone, are badly needed in dental and orthopedic implants for better long-term results. Forming a layer of bone-like apatite on the surface of the metal is one of the most promising methods to increase its bioactivity. This study creates a new chemical treatment for zirconium metal to induce apatite formation in a simulated body fluid (SBF), and analyzes the apatite layer by using scanning electron microscopy (SEM), energy dispersive X-ray spectroscopy (EDS), and Fourier transform infrared spectroscopy (FTIR). Zirconium samples were soaked in 10% CuCl2 aqueous solution at 80 degrees C for 72 hours, heat-treated at 500 degrees C for one hour and soaked in SBF for various periods. An apatite-like layer appeared on the zirconium surface as early as three days in SBF, and increased with immersion time. EDS and FTIR confirmed that the deposited layer was apatite. This implies that bioinert zirconium metal can become bioactive by forming an apatite layer in a simulated body fluid after a suitable chemical treatment. The ZrOOH+ hydrogel layer produced on the zirconium surface by CuCl2 and heat-treatments is thought to induce the apatite formation.

Apatites↗
PubMedDate not supplied

Versatility of transmucosal implants with zirconium ring. Case report.

Utiling zirconium characteristics, a biomaterial with high affinity with bone and gum, we have positioned in the same patient 2 transmucosal implants in titanium with a coronal ring in zirconium in 2 different manners. The first fixture was positioned with the ring in zirconium at the same level of the gum in order to obtain a good periodontal healing and esthetic without metallic transparencies. The second postestractive implant was positioned with the zirconium ring at the level of the crestal bone in order to reduce the gap between the fixture and the alveolar bone and to avoid the use of a resorbable barrier relying on the osteointegrative properties of zirconium.

Dental Implantation↗
PubMed1991

Zirconium compound-induced pulmonary fibrosis.

Despite suspicion that inhalation of zirconium should be capable of causing human pulmonary disease, documentation of zirconium pneumoconiosis in humans has been lacking. We studied a likely case of zirconium compound-induced pulmonary fibrosis. The diagnosis was based on the following: (1) a history of gradual increase in symptoms and slowly progressing pulmonary fibrosis by chest roentgenogram compatible with a pneumoconiosis; (2) an appropriate history of exposure and a latency period of about 15 years before the onset of dyspnea and of roentgenographic changes; (3) analysis of open lung biopsy material revealing end-stage fibrosis and honeycombing, a moderate number of birefringent particles, and extremely high levels of a variety of zirconium compounds; and (4) no other potential cause of fibrosis. We conclude that zirconium should be considered a likely cause of pneumoconiosis and that appropriate precautions should be taken in the workplace.

Humans↗
PubMed1994

Simulated knee wear with cobalt chromium and oxidized zirconium knee femoral components.

A knee simulator that mimics the plowing/rolling wear mechanisms of the knee was used to compare wear properties of cobalt chromium and oxidized zirconium femoral components. The simulator flexes and extends the knee so that the femoral components travels from 0 degrees to 30 degrees while applying axial loads from 130 to 1300 lb. Three oxidized zirconium and 3 cobalt chromium femoral components were tested with 10-mm tibial polyethylene components. The oxidized zirconium femoral components caused significantly less ultra high molecular weight polyethylene wear than cobalt chromium femoral components. Tibial inserts that were articulated against the cobalt chromium components had evidence of scratching, burnishing, and delamination, but none of the surfaces that were articulated against oxidized zirconium components had evidence of delamination. Cobalt chromium surface roughness significantly increased during the 2,000,000 cycle test, but oxidized zirconium surface roughness was not affected. Polyethylene wear was correlated to a significant degree with the surface roughness of the femoral components. The improved wear characteristics of the ceramic articular surfaces can be explained by the wettability of the ceramic surface, which minimized adhesive wear, and the resistance of the hard, ceramic surface to roughening.

Chromium Alloys↗
PubMed2004

Structure of the hydrated, hydrolysed and solvated zirconium(IV) and hafnium(IV) ions in water and aprotic oxygen donor solvents. A crystallographic, EXAFS spectroscopic and large angle X-ray scattering study.

The tetrameric hydrolysis products of zirconium(IV) and hafnium(IV), the zirconyl(IV) and hafnyl(IV) ions, [M(4)(OH)(8)(OH(2))(16)(8+)], often labelled MO(2+).5H(2)O, are in principle the only zirconium(IV) and hafnium(IV) species present in aqueous solution without stabilising ligands and pH larger than zero. These complexes are furthermore kinetically very stable and do not become protonated even after refluxing in concentrated acid for at least a week. The structures of these complexes have been determined in both solid state and aqueous solution by means of crystallography, EXAFS and large angle X-ray scattering (LAXS). Each metal ion in the [M(4)(OH)(8)(OH(2))(16)](8+) complex binds four hydroxide ions in double hydroxo bridges, and four water molecules terminally. The M-O bond distance to the hydroxide ions are markedly shorter, ca. 0.12 A, than to the water molecules. The hydrated zirconium(IV) and hafnium(IV) ions only exist in extremely acidic aqueous solution due to their very strong tendency to hydrolyse. The structure of the hydrated zirconium(IV) and hafnium(IV) ions has been determined in concentrated aqueous perchloric acid by means of EXAFS, with both ions being eight-coordinated, most probably in square antiprismatic fashion, with mean Zr-O and Hf-O bond distances of 2.187(3) and 2.160(12) A, respectively. The dimethyl sulfoxide solvated zirconium(IV) and hafnium(IV) ions are square antiprismatic in both solid state and solution, with mean Zr-O and Hf-O bond distances of 2.193(1) and 2.181(6) A, respectively, in the solid state. Hafnium(IV) chloride does not dissociate in N,N'-dimethylpropyleneurea, dmpu, a solvent with good solvating properties but with a somewhat lower permittivity (epsilon= 36.1) than dimethyl sulfoxide (epsilon= 46.4), and an octahedral HfCl(4)(dmpu)(2) complex is formed.

Journal Article↗
PubMed1990

Subcellular localization of zirconium in nodular lymphatic cells after administration of soluble salts. Study by electron microprobe.

In the literature two elements, beryllium and zirconium, have been described as inducing identical tissular lesions consisting of granulomas, which some authors have related to an immunological process. Intracellular lesions induced by beryllium sulphate have been studied previously. These lesions were essentially characterized by intranuclear inclusions rich in beryllium. In this work we have studied intracellular concentration sites of zirconium after injection of low doses of zirconium sulphate. Results show that the intracellular concentration sites are very different between both elements, as zirconium is uniquely localized in the lysosomes of the lymph node macrophages where it is associated with phosphorus.

Animals↗