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Results for “Vitamin B Complex”

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PubMed1950

The effect of deficiency of the B vitamin complex (except thiamine) on the blood pressure of the rat.

Certain diets essentially identical with those previously reported as causing an elevation of the blood pressure of rats have failed to produce any elevation. Examination of micro sections from the kidneys of these rats, with the aid of special stains, has failed to demonstrate any vascular lesions similar to those previously described by Calder. Evidence of tubular atrophy was present to a minor degree in sections of the kidneys of rats fed diets deficient in the B vitamins (except thiamine) and in those fed diets low in choline. This finding has been noted previously by others, but examples of this type of lesion were found as well in animals fed the control diets of our experiments. It should be emphasized that these control diets were nutritionally inadequate. Deposits of intracellular granules of hemosiderin were prominent in the convoluted tubules of the kidneys in rats fed the diets deficient in the B vitamin complex.

Animals↗
PubMed1976

Interactions between malnutrition and primaquine studied on Wistar rats. II. Complex vitamin B deficiency and thiamine deficiency.

The action of primaquine was investigated on male Wistar rats depleted on the vitamin B complex (approximately 50% of their requirement for optimal growth), on thiamine (approximately 50% of their requirement for optimal growth), and pair-fed control animals. There was only a marginal increase in adverse primaquine reactions in the malnourished, especially in the thiamine deficient rats.

Animals↗
PubMed1999

Characterization of the potentiation of the antinociceptive effect of diclofenac by vitamin B complex in the rat.

The role of vitamin B complex preparations as an analgesic adjuvant is controversial. Therefore, the purpose of the present study was to characterize the potentiation of the antinociceptive effect of diclofenac by a vitamin B complex preparation and its individual components by using the pain-induced functional-impairment model in the rat (PIFIR). Pain was produced by the intraarticular injection of uric acid in the right hind limb. Oral administration of diclofenac resulted in a dose-dependent antinociceptive effect. Oral administration of a vitamin B complex preparation containing thiamine (vitamin B(1)), pyridoxine (vitamin B(6)), and cyanocobalamin (vitamin B(12)) in a 1:1:0.01 proportion did not produce any antinociception by itself, but it significantly potentiated the effect of diclofenac. Coadministration of diclofenac with either thiamine or pyridoxine resulted in an antinociceptive effect similar to that of diclofenac alone. On the other hand, coadministration of cyanocobalamin significantly increased diclofenac-induced antinociception. It is concluded that the potentiation of diclofenac-induced antinociception in the PIFIR model is due to cyanocobalamin.

Animals↗