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PubMed1990

[Computed tomography and ultrasonography of lymphoma involving urogenital systems].

Fourteen cases of lymphoma involving urogenital systems (10 kidney, 1 bladder and 3 female genital system) were studied as to their image manifestations. In all 10 kidney cases of diffuse non-Hodgkin's lymphomas, multiple parenchymal nodules were found in 4, single mass in 3, perirenal involvement (Halo sign) with multiple nodules in the kidney in 2 and diffuse infiltration in the other one. The main ultrasonographic findings were hypoecho solid lesions without sharp margins. On pre-contrast CT scans, most of the lesions had similar attenuation as the normal renal parenchyma. After contrast, the normal parenchyma was enhanced much more than the lesion. The lesion may be missed if scan was performed without contrast enhancement. In the 3 cases with involvement of the female genital organs, the involved uterus and cervix were obviously enlarged and vaginal wall became thickened as hypoecho in B-ultrasound. Multi-planned scanning ultrasound is very helpful in showing the relation between pelvic mass and uterus.

Adolescent↗
PubMed1992

Morphological and physiological correlates of unilateral agenesis of the urogenital system in young ovariectomized ACI rats.

ACI rats are distinguished by a polygenic trait resulting in unilateral agenesis of the urogenital system in 20-30% of animals of both sexes. This report details additional features, both morphological and physiological, which distinguish ACI rats with unilateral agenesis of the reproductive and urinary tracts from the majority of ACI rats that have intact urogenital systems. Young female ACI rats were ovariectomized at 34 days of age and sacrificed 19 days later. A preliminary determination of the urogenital morphology was made at the time of ovariectomy and then confirmed by careful abdominal inspection at necropsy. Data on the time of vaginal opening were obtained at selected intervals prior to sacrifice. At necropsy, the mammary glands were removed and were prepared as stained whole mounts for morphological evaluation; the remaining portions of the reproductive tracts were excised, weighed, fixed, and sectioned for microscopic examination. A majority of animals with unilateral agenesis had mammary glands that had higher degrees of glandular proliferation than the mammary glands of intact rats. Unilateral agenesis animals also possessed significantly thicker and heavier uterine horns, despite having been ovariectomized. Furthermore, rats with unilateral agenesis were found to have an earlier time of vaginal opening than that of their intact counterparts. These features of ovariectomized ACI rats with unilateral agenesis are consistent with an active, extra-ovarian source of endogenous estrogen. Further investigation of the endocrinological state of animals with unilateral agenesis of the urogenital tract is warranted.(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed2001

Diagnostic procedures for the urogenital system.

In making clinical decisions concerning the urogenital system, the emergency department physician has many different diagnostic tools at his or her disposal. Choosing the appropriate diagnostic study can often be difficult. For well over a thousand years, the initial step in assessing almost any urologic condition has been to examine the urine. Thankfully, this has progressed from a gustatory approach to the modern urinalysis. There is certainly a great deal of information that may be gleaned from the urinalysis, but the physician must also be mindful of its limitations. Overuse of the urinalysis can result in unwanted and unhelpful information. Although IVP is still the study of choice in assessing the functional status of the kidney, the introduction of CT and ultrasound technology to clinical medicine has revolutionized the emergency department assessment of the urogenital tract. CT and ultrasound can help differentiate between the urologic emergencies and the various surgical conditions that can mimic them.

Diagnostic Imaging↗
PubMed1988

Morphology of urogenital system in female Echinopardalis atrata (Acanthocephala).

Four major areas of the urogenital system of Echinopardalis atrata are examined: (1) capsular protonephridial system, (2) uterine bell complex, (3) uterus, (4) vagina. Photomicrographs of cross sections from wax preparations depict morphological changes along the length of this system. Diagrammatic illustrations show relationships between excretory ducts and oviducts in the uterine bell complex. Relative positions of dorsal and ventral ligament accessory cells, median wall cells, and sheathing syncytium are also shown in this complex. The common oviduct and excretory canal join to form a ciliated urogenital canal that empties into the lumen of the uterus along the latter's anterior mid-dorsal surface. The excretory bladder is located on the inside mid-dorsal surface of the bell wall and is serviced by 2 nephridial canals--1 from each of 2 capsular protonephridia. The vagina affixes the posterior terminus of the uterus to the tegument and consists of an internal and external sphincter surrounding a hypodermal lining.

Acanthocephala↗
PubMed2006

Expression profiles of high voltage-activated calcium channels in sympathetic and parasympathetic pelvic ganglion neurons innervating the urogenital system.

Among the autonomic ganglia, major pelvic ganglia (MPG) innervating the urogenital system are unique because both sympathetic and parasympathetic neurons are colocalized within one ganglion capsule. Sympathetic MPG neurons are discriminated from parasympathetic ones by expression of low voltage-activated Ca2+ channels that primarily arise from T-type alpha1H isoform and contribute to the generation of low-threshold spikes. Until now, however, expression profiles of high voltage-activated (HVA) Ca2+ channels in these two populations of MPG neurons remain unknown. Thus, in the present study, we dissected out HVA Ca2+ channels using pharmacological and molecular biological tools. Reverse transcription-polymerase chain reaction analysis showed that MPG neurons contained transcripts encoding all of the known HVA Ca2+ channel isoforms (alpha1B, alpha1C, alpha1D and alpha1E), with the exception of alpha1A. Western blot analysis and pharmacology with omega-agatoxin IVA (1 microM) confirmed that MPG neurons lack the alpha1A Ca2+ channels. Unexpectedly, the expression profile of HVA Ca2+ channel isoforms was identical in the sympathetic and parasympathetic neurons of the MPG. Of the total Ca2+ currents, omega-conotoxin GVIA-sensitive N-type (alpha1B) currents constituted 57 +/- 5% (n = 9) and 60 +/- 3% (n = 6), respectively; nimodipine-sensitive L-type (alpha1C and alpha1D) currents made up 17 +/- 4% and 14 +/- 2%, respectively; and nimodipine-resistant and omega-conotoxin GVIA-resistant R-type currents were 25 +/- 3% and 22 +/- 2%, respectively. The R-type Ca2+ currents were sensitive to NiCl2 (IC50 = 22 +/- 0.1 microM) but not to SNX-482, which was able to potently (IC50 = 76 +/- 0.4 nM) block the recombinant alpha1E/beta2a/alpha2delta Ca2+ currents expressed in human embryonic kidney 293 cells. Taken together, our data suggest that sympathetic and parasympathetic MPG neurons share a similar but unique profile of HVA Ca2+ channel isoforms.

Animals↗
PubMed1993

Contrast studies of the urogenital system.

Traditional contrast radiographic techniques for evaluation of the urogenital system are reviewed. Specific procedural protocols are suggested. The indications, limitations, and interpretation of the studies are discussed.

Animals↗
PubMed2003

[Results of treatment of isolated and combined trauma of urogenital system].

Retrospective analysis of treatment results of 608 patients with trauma of organs of urogenital system (UGS) was carried out. Beating was the cause of trauma in 55% cases, fall from height--in 17%, transport trauma--in 14.3%, knife wound--in 4.4%, gunshort wound--in 1.3%. Isolated trauma of UGS was in 481 (79.1%) patients. In other patients combined injury of UGS with injury of skeleton's bones (53), cranium and brain (25), abdominal organs (20) was diagnosed. In 29 patients severe combined trauma of UGS, abdominal organs, skeleton bones and cranium was seen. Surgeries were performed in 267 patients. Surgeries on kidney and urinary bladder due to their disruption predominated. In 44 patients these surgeries were combined with ones on abdominal organs. Surgery was performed in two stages in 25 patients with combined trauma of UGS and other organs. From 608 patients 552 (90.2%) cured. Lethal outcome was in 56 (9.2%) patients due to progressive traumatic shock.

Accidents↗
PubMed2005

CD2-associated protein in human urogenital system and in adult kidney tumours.

We studied expression of CD2-associated protein (CD2AP) in human urogenital system and in adult kidney tumours. In the cortex of normal kidney, CD2AP was expressed in all types of tubules and in the glomeruli. Labelling was more intense in cytokeratin 7- and in Tamm-Horsfall-positive tubules than in proximal tubules. In the medulla, expression was observed in the collecting ducts. Urothelium and the epithelium of prostatic acini, seminal vesicles, seminiferous tubules, epididymal ducts, Fallopian tube, endometrium and endocervix as well as granulosa cells showed moderate to strong CD2AP positivity. In syncytiotrophoblast, the expression was weaker than in cytotrophoblast. Endometrial stroma was negative, but decidualised stroma was weakly positive. Clear cell renal cell carcinoma (RCC) (n=63) showed a weak expression. Type-I papillary RCCs (n=4) and papillary adenomas (n=3) were negative. The epithelium lining the cysts in multilocular cystic RCCs (n=3) and in cystic nephroma (n=1) was strongly positive. Chromophobe RCCs (n=2), oncocytomas (n=3) and urothelial carcinomas (n=2) were moderately positive. The results show that CD2AP displays a specific expression pattern in human urogenital organs and that distinct expression is shown in several types of kidney tumours but not in type-I papillary RCCs or in papillary adenomas.

Adaptor Proteins, Signal Transducing↗
PubMed1979

[Total body computer tomography or the urogenital system (author's transl)].

Computer tomography cannot only produce transversal sections of the body, but also evaluate the x-ray absorption values of various organs and tissues. It was first used in the investigation of the brain and has influenced the use of traditional neuroradiological techniques. Computer tomography can be used in special cases of diseases of the urogenital system. It is especially helpful in the diagnosis of primary or secondary retroperitoneal processes and also for tumors of the kidney. It allows effective frequent follow up of various therapies and has no side effects. Also in the follow up of various tumors, this noninvasive technique can demonstrate possible recurrences. It appears however that the total body computer tomography will not replace traditional radiological technique. During treatment and follow up of malignant tumors of the urogenital system however it appears very helpful.

Adenocarcinoma↗
PubMed1989

Effect of prenatal ethanol administration on the urogenital system of mice.

The purpose of the present series of studies was to determine whether an obstruction in the urogenital system or vesicoureteral reflux (reflux, the retrograde passage of urine from the bladder into the kidney) existed in mice prenatally exposed to ethanol which might account for the high incidence of hydronephrosis and hydroureter observed. In order to examine these possibilities, indigo carmine was injected into the bladder of 19-day fetuses previously exposed to ethanol on Day 10 of gestation and the presence of hydronephrosis and/or reflux determined. As expected, we found a greatly increased incidence of hydronephrosis and hydroureter. In addition, there was a significant increase in reflux in the ethanol-treated mice. The incidence of reflux appeared to be related to the severity of the hydronephrosis observed, though cases of hydronephrosis without reflux and reflux without hydronephrosis were found. These data suggest both hypotheses may be salient and that a multiplicity of urogenital abnormalities are found following prenatal ethanol exposure.

Animals↗
PubMed1976

Spontaneous tumors and common diseases in two colonies of Syrian hamsters. III. Urogenital system and endocrine glands.

The frequency of spontaneously occuring neoplasms in the urogenital system and endocrine organs was examined in two Syrian hamster colonies [Eppley colony (EC); Hannover colony (HC)]. With the exception of a renal adenoma in an EC female, the urinary systems of animals in both colonies were free of neoplastic growths. A single epididymal adenoma of the male fenital system (EC) was found. However, incidences of female genital tract tumors were 10 (EC) and 3.5% (HC) and accounted for 34 and 11%, respectively, of all tumors in females. Among all genital tract tumors, 3 (EC) and 57% (HC) were ovarian, 14% (HC) were in the fallopian tubes, 81 (EC) AND 29% (HC) were uterine, and 16% (EC), vaginal. The overall incidence of endocrine organ tumors was similar in both colonies (EC, 22%; HC, 19%). The distribution of these tumors was as follows: pituitary gland; EC, 3%, HC, 0; thyroid gland: EC, 28%, HC, 31%; parathyroid gland: EC,11%, HC, 18%; adrenal cortex: EC, 42%, HC, 31%; adrenal medulla: EC, 7%, HC, 0; and endocrine pancreas: EC, 10%, HC, 31%. The morphology of these neoplasms is described and the incidence compared with those reported in other colonies.

Adrenal Gland Neoplasms↗