Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Taste modeling”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed1989

A theoretical model for perceived intensity in human taste and smell. II. Temporal integration and reaction times.

The theoretical model for perceived intensity in human taste and smell published previously was extended by incorporating the concept of signal detectability and temporal integration phenomena at low and high stimulus levels. The processes involved in human taste and smell perception are divided into three stages: a) An "internal meter" registers outside signals. Adaptation occurs at this stage. b) The meter is read for two possible purposes: to detect a weak signal or to estimate the signal's intensity. Both tasks require the smoothing of noise, which is accomplished by integration of the meter over time. c) The internal estimate is expressed through the use of a scaling method.

Humans↗
PubMed1989

Alternative genetic models for the inheritance of the phenylthiocarbamide taste deficiency.

Pedigree segregation analysis was used to examine several one- and two-locus models of the inheritance of phenylthiocarbamide (PTC) taste deficiency that extend the traditional one-locus recessive model by the addition of either another allele or another locus, and in some cases predict two types of nontasters. These models allow nontaster by nontaster matings to produce taster offspring, consistent with our data and several previous studies which use the Harris and Kalmus [Annals of Eugenics 15:24-32, 1949] dilution method. The models fit our data set of 1,152 individuals from 120 families significantly better than the one-locus recessive model. The best fit was obtained with a two-locus model in which one locus controls PTC tasting and the other locus controls a more general taste ability. This model is consistent with research on the physiology of PTC tasting and with results from genetic linkage studies. Further study is suggested to evaluate better the accuracy of the proposed model.

Alleles↗
PubMed1976

A model for the stimulation of taste receptor cells by salt.

A taste cell mucosal surface is regarded as a planar region containing bound anionic sites and openings to ionic channels. It is assumed that the bulk aqueous properties of the exterior phase are not continuous with the surface but terminate at a plane near the surface. The region between the (Stern) plane and the membrane is regarded as having a lower dielectric constant than bulk water. This fact admits the possibility of ion pair formation between fixed sites and mobile cations. Mobile ion pairs entering the region may also bind to a fixed anionic site. Thus, it is assumed that mobile cations and ion pairs are potential determining species at the surface. Binding cations neutralizes surface charges, whereas binding mobile ion pairs does not. This competition accounts for the observed anion effect on stimulation of tast receptors by sodium salts. The potential profile is constructed by superimposing the phase boundary potentials with an ionic diffusion potential across the membrane. The model accounts for the anion effect on receptor potential, pH effects, the reversal of polarity when cells are treated with FeCl3, and the so-called "water reponse," depolarization of the taste cell upon dilution of the stimulant solution below a critical lower limit. The proposed model does not require both bound cationic and anionic receptors, and further suggests that limited access to a Stern-like region continuous with membrane channels may generally serve to control transport of ions.

Acetates↗
PubMed1972

Taste stimuli: time course of peripheral nerve response and theoretical models.

The responses of a taste nerve in rats to sodium chloride were integrated over successive 10-millisecond intervals and averaged. The time course of the mean responses consisted of a 30-millisecond latency, a rapid rise to a maximum, and a slower decline to a sustained level. The chemoreceptor theories of Beidler and Paton failed to predict the relation between phasic response and time or concentration.

Animals↗
PubMed1976

Physicochemical studies of taste reception. III. Interpretation of the water response in taste reception.

The model membrane composed of a Millipore filter paper and the total lipids from bovine tongue epithelium or phosphatidylcholine from egg yolk simulated well the water response of a living taste cell, The water response observed with the model membrane adapted to various salt solutions was interpreted in terms of changes in electric potential at the membrane-solution interface, i.e. the water response was attributed to the e.m.f. change produced by diffusion of the electrolytes dissolved in (or adsorbed on) the membrane surface into the bulk solution. The water response of the frog tongue was also investigated by measuring the neural response of the glossopharyngeal nerve. The results obtained were consistent with the mechanism proposed in the present paper. The response of the frog to Ca2+ was examined under the condition where the water response was suppressed, and it was concluded that the water response of the frog is different from the response to Ca2+.

Animals↗
PubMed1987

Morphological evidence of innervation of taste buds of rat fungiform papillae after acute X-ray irradiation.

An acute dose of 2000 Roentgens (R) of x-ray was delivered to the head and neck area of Sprague-Dawley rats. Groups of rats were sacrificed at 0, 3, 7, 14, 21 and 30 days after x-ray irradiation. Both general nerve staining and localization of cholinergic nerves by special staining of fungiform papillae were performed. No apparent change in number and distribution of nerve fibres were observed light microscopically within the fungiform papillae containing normal, degenerating and regenerating taste buds. Similarly, cholinesterase activity was present in all control and experimental groups. These preliminary findings do not support the theory that taste bud degeneration is due to x-ray irradiation causing damage to related nerve fibres. A theoretical model of taste bud degeneration after acute x-ray irradiation is proposed.

Animals↗
PubMed1981

Drugs and taste aversion.

The literature on the effects of drugs on the acquisition and the magnitude of taste aversion is reviewed and discussed. Then, the results of a series of experiments on the effects of phenobarbital and related drugs on taste aversion are reported. A standard taste aversion model was used in all experiments; test drugs were injected prior to drinking in a one bottle situation on the first test day following the taste aversion treatment. Phenobarbital in doses ranging from 20 to 80 mg/kg significantly attenuated taste aversion induced by lithium chloride (LiCl) and x-radiation, the maximal effect occurred with the 60 mg/kg dose. The attenuating effect was found to be dependent upon the magnitude of the aversion to the sapid solution. Phenobarbital completely abolished aversion produced by 0.375 mEq LiCl while the attenuation effect decreased linearly with higher doses of LiCl. Results also indicate that phenobarbital's attenuating effect cannot be solely attributed to its dipsogenic characteristic or to its state dependent learning effect. Attenuation of LiCl aversion to a saccharin solution was also observed following single doses of amobarbital, 30 mg/kg, pentobarbital, 15 mg/kg, and chloropromazine, 0.75 mg/kg. Taste aversion was not affected by other doses of those drugs or by hexobarbital, barbital, and chlordiazepoxide. Phenobarbital's attenuating effect on taste aversion is discussed in relation to other known behavioral and neurophysiological effects of the drug.

Animals↗
PubMed1992

A review of sweet taste potentiation brought about by divalent oxygen and sulfur incorporation.

The plethora of high-potency sweetener research has allowed the construction of important structure-taste relationships. In light of new structure-taste relationships, it is instructive to review sweet taste potentiation brought about by divalent oxygen and sulfur incorporation. The taste of sulfur-containing organic compounds was reviewed in Japanese by Yasuo Ariyoshi in 1977. Several new representative examples of sweet taste potentiation and taste dichotomy (sweet and bitter) found within similar classes of oxygen- and sulfur-containing organic compound: amides, dipeptides, ureas, sulfamates, sulfonamides, oximes, sugars, dihydroisocoumarins, and others are reviewed. Special attention is given to the thioethers and thioureas in sulfamates, dipeptides, aryl ureas, and hybrid dipeptide ureas. The most notable contributions have arisen from the work of Nofre and Tinti at Université Claude Bernard in Lyons, France. A common trend emerges with certain sweeteners when a carbon atom is strategically replaced by sulfur or oxygen atoms. The net result is an increase in the sweetness two- to tenfold. With saccharins, the usual bitter, metallic taste is removed. Sweet taste receptor models that have been published are mainly based on the original Shallenberger and Acree model of the glucophores AH-B with contributions from Kier (AH-B-X). AH is a proton donor group, B is a proton acceptor group, and X is some hydrophobic group. All of the models have overlooked the contributions of divalent sulfur (often in place of oxygen) in bringing about sweetness potentiation. There is no precedence for localizing the energy-minimized structures of sulfur-containing sweeteners in a binding mode that includes sulfur. These sulfur potentiation loci are analyzed and illustrated in a computer-generated sweetener model to show the specific region in which sulfur is being "recognized" as a potentiating feature.

Humans↗
PubMed1982

Modelling the evolution of heterogeneity in residential mobility.

Migration probabilities are known to vary over the population (heterogeneity) and over time (nonstationarity). It is shown that if the heterogeneity is represented by an SB mixing distribution and the nonstationarity by a set of arbitrary logistic scaling functions, then not only may all sources of heterogeneity, including tastes, be modelled, but heterogeneity at different points in time may be readily compared. The model is calibrated using data previously published by Clark et al. (1977, 1979) for a sample of 1,176 older renters and is found to fit well. The changing heterogeneity over the ten-year period of observation is represented graphically.

Demography↗
PubMed1983

The construction and prediction of psychophysical power functions for the sweetness of equiratio sugar mixtures.

Psychophysical taste mixture models describe the relationship between the perceived intensities of the unmixed components and the intensity of the mixture. Three of these models are discussed. As all of these appear either to be internally inconsistent or lack sufficient generality, a simple alternative model has been developed especially for the prediction of the intensity of equiratio mixtures. This model was experimentally tested with glucose-fructose mixtures. On the basis of the data obtained it is shown that a psychophysical equiratio mixture function can be constructed in the same way as a power function for a single compound. The results show that the new mixture model can predict the functions for equiratio mixtures with great precision. Implications for mixture interaction phenomena are discussed.

Adult↗
PubMed1979

Concept of neuron types in gustation in the rat.

1. In taste neurophysiology, from Pfaffmann's (49, 50) pioneering work until the present, the possibility of types of neurons corresponding in some sense with the "primary" taste qualities of Henning (33) has been entertained: recently types of gustatory neurons in peripheral nerves have been established according to which of the four classical stimuli is the "best stimulus." However, considerable variation occurs in the response profiles within neurons classified as belonging to the same type. The purpose of this research is to determine, using mathematical techniques where appropriate, if the within-type variation is spurious or, instead, indicates the absence of a typology of taste neurons. The data used were counts of the spike discharges of 50 individual taste neurons in the nucleus of the solitary tract of the rat, evoked by 32 diverse chemical stimuli. 2. Using as input the matrix of Pearson r correlation coefficients calculated for the responses of all pairings of neurons to all stimuli, multidimensional scaling analysis revealed a two-dimensional space in which no clear groupings of neurons occurred. 3. In a hierarchical cluster analysis of the neuron response profile similarities, no evidence of grouping was found, suggesting a more-or-less continuous variation among neurons. 4. When the organization of the 32 stimuli utilized was studied by the same techniques, no clear evidence for stimulus types was found, although the possibility of two stimulus types--"sweet" and "nonsweet"--was raised. 5. Construction of a joint neuron-stimulus space supported a spatial model of taste neuron-stimulus interaction, while analysis of the number and pattern of high correlations among neurons--even after allowance for attenuation due to measurement error--failed to support the notion of types of taste neurons with identical response profiles. 6. Aspects of the logical role of types of neurons in gustatory coding were discussed, and the results and methods of the present investigation were related to classification schemes for neurons in general. Suggestions for a formal taxonomy of neurons were given. 7. It should be emphasized that the present study and conclusions are of second-order, CNS neurons, whereas the studies advocating the presence of neurons types were of peripheral neurons. Taken together, the implication to be drawn from these studies is that if neural types do exist in peripheral taste nerves, the typology is lost at the first synapse and is thus unavailable to the CNS for coding purposes, at least in the rat.

Animals↗
PubMed1981

Supported work for ex-addicts: an exploration of endogenous tastes.

The expected impact of Supported Work on former drug addicts' employment, crime, and drug use are derived from two models: the human capital model and a model of endogenous tastes. Empirically, Supported Work is found to increase the earnings of at least some ex-addicts, primarily due to increases in hours worked rather than wage rates. The program also reduced ex-addicts' crime, producing the greatest impact on the robbery and drug-related crimes and changing relationship between crime and employment. The program did not affect ex-addicts' recidivism to drugs. The pattern effects only partially supports the human capital model, and there is also some support for the model of endogenous tastes.

Employment↗
PubMed1987

Sapid savvy in sucklings: the effect of quinine hydrochloride on intraoral negative pressure and intake by 11-13-day-old rat pups.

Three experiments describe the consummatory behavior of 11-13-day-old rat pups during and following experience with a model aversive taste, quinine hydrochloride. Pups were observed while away from the dam and while suckling. Results show that pups actively reject quinine adulterated solutions in both situations. They do so by spitting the solution from the mouth when away from the nipple and by leaving the nipple and/or decreasing their sucking effort when with the dam.

Animals↗