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At least 37 records · Page 2Linked to original sources
PubMed1989

Serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) levels in diabetes mellitus.

The activities of serum glutamic oxaloacetic transaminase (GOT) and glutamic pyruvic transaminase (GPT) in 72 Libyan diabetic patients were determined. The respective mean values were 24 +/- 1.1 U/L and 23.03 +/- 0.87 U/L. Significant correlations were found between the activities of GOT or GPT and fasting blood glucose, age, body mass index, heart rate and blood pressure levels. The mean values of GOT and GPT in diabetic patients with secondary complications were significantly higher than those without complications. On the other hand, patients with family history of diabetes have higher mean values of GOT and GPT when compared with those without diabetes in the family.

Age Factors↗
PubMed1986

Serum levels of aspartate transaminase, alanine transaminase and worm burden in mice infected with Ancylostoma caninum larvae.

Aspartate transaminase and alanine transaminase levels showed considerable increase during initial (1 to 9 days) period of infection in all the experimental groups of mice and their level reached higher values than in the controls. The increase of enzymes was influenced by the degree of retention of worm load and the immunological damage caused by Ancylostoma caninum larvae within the host system.

Alanine Transaminase↗
PubMed1973

[Changes in lactate dehydrogenase, glutamate-cxaloacetate transaminase and glutamate-pyruvate transaminase in several muscular atrophies. I. Changes following tenotomy].

The activites of lactic dehydrogenase (LDH), glutamicoxalactic transaminase (GOT) and glutamic-pyruvic transaminase (GPT) are investigated within variable periods following tenotomy of m. gastrocnemius in the rat. A gradual fall of total activities is established, mostly significant for LDH, and least - for GPT. The specific activities undergo similar alterations. Experiments with dialysates show that the changes found are due to a reduced enzyme molecules' synthesis, and not to altered ratios between enzyme activators and inhibitors.

Alanine Transaminase↗
PubMedDate not supplied

The effect of natural training and electrostimulation on changes of alanine transaminase and aspartate transaminase activity in rat skeletal muscles.

Wistar rats were trained on a moving track or/and had stimulation of the crural muscles with electric current of 50 Hz frequency for 14 days. Dramatic changes were observed in the activity of alanine transaminase (AlAT) and aspartate transaminase (AspAT), which was particularly pronounced during 16 days of follow-up after completion of training and stimulation. Persisting high activity of the enzymes in the white muscle fibres exceeding 2-3 times the control values showed a significant effect of electrostimulation on the metabolism of amino acids enabling the muscles to obtain energy for contraction from non-glycolytic source.

Alanine Transaminase↗
PubMed1980

Liver glutamate-oxalate transaminase and glutamate-pyruvate transaminase activity in pigs as influenced by dietary methionine and lysine levels.

Four trials involving 192 Large White X Landrace pigs were conducted to investigate the effect of wide variation of dietary methionine, lysine and caloric density on the activity of hepatic glutamate-oxalate ad glutamate-pyruvate transaminases. Results of the study show that: The activities of the two transaminases were influenced by the nutritional treatments. GOT and GPT activity exhibited significant positive and negative quadratic relationship respectively with dietary methionine levels. Both GOT and GPT activities decreased with increasing caloric density or palm oil level of the diet. In weanling pigs, both GOT and GPT exhibited significant negative quadratic relationship with dietary lysine levels and were also significantly influenced by the sex of the animals. In older pigs, only GOT activity was significantly affected by dietary lysine levels. The correlation of GOT and GPT activities to dietary essential amino acids shows that hepatic enzymatic activities could be good indices of essential amino acid utilization.

Alanine Transaminase↗
PubMed1993

Effects of dietary vitamin E on clinical course and plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities in hereditary hepatitis of LEC rats.

Long-Evans Cinnamon (LEC) rats are autosomal recessive mutants that develop hepatitis and hepatocellular carcinoma. Because copper accumulates in the livers of these rats, and some of their clinical and pathological features are similar to those of patients with Wilson's disease, LEC rats are proposed as an animal model of Wilson's disease. It has been thought that unbound copper generates free radicals, which act as hemolytic and hepatocytotoxic agents. To examine the effects of vitamin E as an antioxidant on hereditary hepatitis in LEC rats, we fed 3-week-old rats for 25 weeks either vitamin E-deficient, control, or vitamin E-supplemented diets which contained < 0.01 mg of total tocopherols, 2 mg of d,l-alpha-tocopheryl acetate (2 I.U.), and 58.5 mg of d,l-alpha-tocopheryl nicotinate (50 I.U.), respectively, per 100 mg of feed. In males, body weight loss was first observed in the vitamin E-deficient group, and mean ages at which jaundice occurred were in the order: deficient younger than control younger than supplemented groups. The ages when plasma glutamic oxaloacetic transaminase and glutamic pyruvic transaminase activities began to increase sharply and peaked followed the same order. Thus, it is likely that free radicals are involved in jaundice and hepatitis in LEC male rats, and they are a model for studying the relationship of copper, free radicals, and hepatitis. Conversely, in females, no apparent differences in clinical and biochemical changes were observed among the three groups. Causes for the discrepancy between the sexes remain to be clarified.

Alanine Transaminase↗
PubMed1983

Glutamic-oxalacetic transaminase (SGOT) and glutamic-pyruvic transaminase (SGPT) in newborns in relation to the gestational age.

The transaminase enzymatic activity (SGOT-SGPT) was measured in the first 72h. of life, within the 7th day and on the 30th day of life in two groups of new borns i.e. full-term and premature ones with a gestational age less than or equal to 37 weeks. The premature babies were divided into two sub-groups: babies with a gestational ager less than or equal to 32 and greater than 32 weeks. Our results on the SGOT and SGPT activity in healthy full-term newborns agree with literature data, but indicate a lowering of the SGOT mean values at the 30th day of life. A similar lowering occurs at the 7th day of life; in premature newborns; these have lower SGOT values during the first 72h. of life than full-term newborns. Newborns with a gestational age of less than or equal to 32 weeks have higher SGOT values than newborns with a gestational age of greater than 32 weeks. The mean values of SGPT during the first days of life are higher in full-term than in premature newborns; there are no significant differences in the sub groups with different gestational age.

Aging↗