Teratogenic effects in early chick embryos of solanine and glycoalkaloids from potatoes infected with late-blight, Phytophthora infestans.
Solanine or a preparation of mixed glycoalkaloids from potatoes naturally infected with the late-blight fungus, Phytophthora infestans, was injected into fertile chicken eggs between 0 and 26 h of incubation, before formation of the neural tube. The embryos were examined after a total of 72 h of incubation. Various abnormalities were found, the most conspicuous being absence of the tail or trunk below the wing bud (rumplessness). A statistically significant proportion of the abnormal embryos showed malformations that seemed to be related to this condition; these included fluid- or blood-filled vesicles in the lower trunk or tail region on one or both sides of the neural tube. Such abnormalities were not observed in control embryos.
Abnormalities, Drug-Induced↗