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PubMed2000

Changes in serum copper level during detoxification of acutely poisoned drug addicts.

Although it is known that drug addicts are a high-risk group for disruption of many homeostatic processes, little is know about changes in serum trace elements concentrations after taking the psychoactive substances. The aim of the study was to check the influence of the taking homemade heroin on serum level of copper. Blood samples were taken from 30 opiate addicts, and copper concentrations were measured by the means of atomic absorption spectrophotometry. The result of the study show that in the examined group, copper serum concentrations (1.35 mg/L) upon admission to the clinic were higher than in the control group (1.11 mg/L) but decreased during hospitalization (1.18 mg/L). There was no correlation between duration of stay at the hospital and changes in serum copper concentration.

Adolescent↗
PubMed1996

[Anti-tumor effects of an angiogenesis inhibitor, TNP-470 (AGM-1470) alone and in combination with cisplatinum, and changes in serum copper levels in liver cancer bearing rats].

Effects of a newly developed angiogenesis inhibitor, TNP-470 (AGM-1470) alone and in combination with cisplatinum on tumor-bearing rats were investigated. Wistar-King A male rats were subcutaneously inoculated with 10(7) cultured syngeneic liver cancer cells that had been induced by oral intake of 3'-methyl-4-dimethylaminoazobenzen, and were used as tumor-bearing rats. Tumor sizes and changes in serum copper levels were measured after administration of TNP-470. Administration of TNP-470 (5, 10, 20 or 30mg/kg, s.c., daily for 7 days) inhibited tumor growth in a dose-dependent manner. The suppressive effects were the same in the rats which were administered TNP-470 (20mg/kg, s.c., daily for 7 days) and cisplatinum (0.5 mg/kg, s.c., daily for 7 days) simultaneously, and rats administered cisplatinum (0.5mg/kg, s.c., daily for 7 days) following TNP-470 (20mg/kg, s.c., daily for 7 days). These inhibitory effects were almost the same as that of cisplatinum (0.5mg/kg, s.c., daily for 7 days) alone. While, administration of TNP-470 (20mg/kg, s.c., daily for 7 days) following cisplatinum treatment (0.5 mg/kg, s.c., daily) showed markedly higher anti-tumor effects, compared with these groups. Administration of TNP-470 caused elevation of serum copper levels in normal rats as well as tumor-bearing rats with the same degree. Serum copper levels remained normal after discontinuation of TNP-470 in normal rats, while in tumor-bearing rats, it decreased during the first week and re-elevated in 2 to 3 weeks after discontinuation of TNP-470. This re-elevation of serum copper levels was related to rapid tumor growth after discontinuation of TNP-470. Furthermore, there was also a positive correlation between serum copper levels and capillary density in the tumor. In conclusion, TNP-470 had anti-tumor effect in a dose-dependent manner against a rat liver cancer, with markedly higher effects when it was administered following cisplatinum. Serum copper levels after discontinuation of TNP-470 treatment might indicate re-proliferation of the capillaries in the tumor tissue.

Animals↗
PubMed1990

Serum copper levels in elderly patients with femoral-neck fractures.

The serum copper levels of 46 elderly patients with fractures of the femoral neck were assayed and found to be significantly lower than those of a group of controls matched for age and sex. These findings are consistent with nutritional copper deficiency which may contribute to the development of fractures by reducing bone strength.

Age Factors↗
PubMedDate not supplied

Plasma antioxidant potency and serum copper levels in atherosclerosis.

Blood plasma of patients with arteriosclerosis obliterans and diabetes showed a higher antioxidant potency as compared with plasma of healthy volunteers. Serum copper level in those patients was also elevated, but on the contrary to healthy subjects no correlation between serum copper level and plasma antioxidant potency was found. Similar changes were observed in rabbits fed four weeks with atherogenic diet. Administration of vitamin E increased plasma antioxidant potency, however, only in the patients suffering from arteriosclerosis obliterans with high regime of dosage of vitamin E (3 X 200 mg daily p.o.). N-ethylmaldimide-stimulated (malondialdehyde (MDA)) generation by washed platelets was suppressed by addition of homologous plasma to washed platelet preparation. Preincubation of rat aortic tissue with plasma from healthy volunteers resulted in an increase in PGI2-biosynthesis b 75%. We were not able to demonstrate the antioxidant activity of aortic endothelial cell homogenates. We conclude that antioxidant properties of plasma may play an important role in protection of serum lipids against autooxidation. Antioxidant ability of plasma is not exclusively correlated with plasma copper or ceruloplasmin level.

Adult↗
PubMed1984

The value of serum copper levels in non-Hodgkin's lymphoma.

A study of 306 serum copper levels (SCL) determinations in 115 patients with non-Hodgkin's lymphoma indicates a positive correlation between SCL and the state of disease. Patients with advanced disease (Stages II, III and IV) before treatment, those with active disease while under treatment, or in a relapse had a significantly higher SCL than patients in Stage I or those with no evidence of disease (NED). The mean SCL of patients with Stage I was similar to that of patients with NED. The mean values of these two groups did not differ significantly from that of healthy controls. Histological subtypes, according to the Rappaport classification, has no influence on SCL. Grouping into nodular versus diffuse lymphoma, histiocytic versus lymphocytic lymphoma and favorable versus unfavorable histology failed to demonstrate a difference between the groups. Within each subset a wide range of SCL was evident. However, good correlation was observed with the degree of disease activity. SCL may provide a useful parameter for patient monitoring. In this series, however, SCL was not useful for the prediction of an early relapse.

Adult↗
PubMed2003

Difference of baseline serum copper levels between groups of patients with different one year mortality and morbidity and chronic heart failure.

BACKGROUND: Serum copper concentrations as indicators of non-specific inflammatory response are higher in patients with severe heart failure than in patients with mild to moderate cardiac insufficiency and correlate with acute phase protein concentrations. The aim of this study was to find out if baseline serum copper concentrations are higher in patients with chronic heart failure and higher one year mortality and morbidity and whether serum copper concentrations correlate with prognostic indicators. METHODS AND RESULTS: Baseline serum copper concentrations were determined in 64 patients with chronic heart failure, functional classification NYHA II-IV (NYHA - New York Heart Association), caused by ischemic heart disease, with severe left ventricular dysfunction (ejection fraction < or = 35%). 30 patients died or were admitted to the hospital because of worsening heart failure (group A) within 12 months since their examination. 34 patients did not die and hospitalisation was not necessary within 12 months (group B). Retrospectively the presence of differences in serum copper concentrations and in prognostic indicators was assessed between both groups. Statistically significant differences between both groups were found in these parameters: baseline serum copper concentrations (p < 0.001), ejection fraction of left ventricle (p < 0.05), baseline heart rate (p < 0.01) and cardiothoracic ratio (p < 0.01). Serum copper concentrations significantly correlate with heart rate (p < 0.01), inverse correlation with left ventricular ejection fraction and positive correlation with cardiothoracic ratio are not statistically significant. CONCLUSIONS: Baseline serum copper concentrations are significantly higher in patients with chronic heart failure, also correlating with higher one-year mortality and morbidity. Serum copper levels significantly correlate with baseline heart rate. Relation of serum copper concentrations with left ventricular ejection fraction and cardiothoracic ratio is not statistically significant.

Aged↗
PubMed1982

Serum copper levels in relation to sex and age.

For a reliable assessment of the copper status the determination of several copper parameters has necessarily to be differentiated as to sex and age. In this paper we studied serum copper levels in relation to sex in ten different age groups with use of the flameless atomic absorption technique. Only 50 microliters of serum or even less is required and the method is quite suitable for large scale population surveys. Statistical analyses of the serum copper levels in six different male age groups and four different female age groups showed that the ten age groups can be divided in three larger groups: male 18--60 years, males above 60 years and females of 18 years and older, with different normal values for each group.

Adolescent↗
PubMed2025

Host genetics predominates over gut microbiota in serum copper levels in boars.

Copper is an essential trace element in numerous biological processes; maintaining its homeostasis is crucial for pig health and productivity. In this study, we employed a mixed-effects model to investigate the contributions of host genetics, gut microbiota, and their interactions with serum copper levels in pigs. We further explored potential candidate genes and microbiota associated with copper metabolism. The results demonstrated that host genetics exert a dominant influence on serum copper regulation compared to the effects of the gut microbiota. Furthermore, genome-wide association analysis identified 4 candidate genes, CPHL1, CP, NCEH1, and PDE10A, strongly linked to copper metabolism. By applying multiple association approaches, 10 bacterial genera, such as Blautia, Lachnospiraceae UCG-008, and Ruminococcaceae UCG-007 were found to be significantly correlated with serum copper levels. This research offers novel insights into the genetic and microbial determinants of copper variation in pigs, establishing a foundation for future genetic and microbiota-based strategies aimed at enhancing copper homeostasis and overall livestock health.

Animals↗
PubMed1989

[Serum copper levels and pathologic changes in the fetal membranes in cases of premature rupture of the membranes].

140 samples of serum and amnionic membrane collected from 60 patients with premature rupture of membranes (PROM) and 20 controls were assayed for levels of essential trace elements by inductively coupled plasma atomic emission spectrometry (ICPAES). 72 samples of amnionic membranes were examined by pathologist with HE. Van Gieson's and Wright's strain. The serum copper level in PROM cases was significantly lower (23.438 8 +/- 3.292 4 mumol/L) as compared with that of the controls (30.044 1 +/- 4.416 1 mumol/L), P less than 0.01. The serum and tissue level of essential trace elements (Cr, Mn) showed no difference. The collagen and elastin in the amnionic membranes were sparse and weak. It is pointed out that the low copper level and the sparse and weak collagen and elastin in amnionic membranes may be related to PROM.

Copper↗
PubMed1978

Value of serum copper levels and erythrocyte sedimentation rates as indicators of disease activity in children with Hodgkin's disease.

Initial and serial serum copper levels (SCL) and erythrocyte sedimentation rates (ESR) of 29 children with Hodgkin's disease were reviewed to determine the relationship of these features to disease activity. Only six of 10 patients who relapsed had SCL greater than adult upper normal levels. Although correction for age increased this to 7, it also increased the number of patients with false positive results to 9 of 19. Although 9 of the 10 patients at relapse had an increase in SCL over the preceding value, almost one-fifth of patients in remission had increases in consecutive SCL greater than the average increase of patients who relapsed. We conclude that SCL, even when age corrected and consecutively followed, are not useful as indicators of disease activity in children with Hodgkin's disease. Although the ESR increased to greater than 20 mm/hour in 9 of 10 patients who relapsed, this determination could not be considered a useful early indicator of disease recurrence since it was so frequently elevated in patients who were free of disease (62 of 109 determinations). The extremely nonspecific nature of SCL and ESR in childhood renders these tests unreliable, particularly in the individual child.

Adolescent↗
PubMed1978

The diagnostic value of serum copper levels and other hematochemical parameters in malignancies.

An increase in the serum copper (Cu++) level has been described as a sensitive index of disease activity in several hematologic and nonhematologic malignancies. In order to explore the diagnostic value of Cu++ compared to other hematochemical parameters frequently abnormal in malignancies, Cu++, serum alpha2 globulin (alpha2), plasmatic fibrinogen (Fibr), the erythrocyte sedimentation rate (ESR), and serum iron (Fe++) have been detected and evaluated in 267 patients affected with the following diseases: Hodgkin's lymphoma (HL), non-Hodgkin's Lymphomas (NHL), Acute Leukemias (AL), Chronic Myeloid Leukemia (CML), Chronic Lymphocytic Leukemia (CLL), Myeloma (MM), and Breast Cancer (BC). The best correlation between Cu++ increase and disease activity has been found in HL, NHL, AL, and BC. In these diseases, when the considered parameters were compared, Cu++ and ESR showed a similar pattern, i.e., a high frequency of abnormalities in active disease. It is concluded that Cu++ represents a good complement to some other aspecific parameters in evaluating the activity and diffusion of neoplasias and the therapeutic results, particularly in HL, NHL, AL and BC.

Alpha-Globulins↗
PubMed2004

Serum copper levels among quartz stone crushing workers: a cross sectional study.

The present cross sectional study was carried out among 134 workers of quartz stone crushing units to assess the serum Cu activity among quartz stone workers without disease. Demographic and occupational details of the subjects were recorded on the predesigned proforma. Standard diagnostic criteria were used for diagnosing silicosis and tuberculosis. The pulmonary functions of the subjects were measured using Spirovit SP-10. The mean age for male was found to be 26.63 +/- 6.28 years while that for female was 21.93 +/- 4.29 years and for the whole group was 26.13 +/- 6.26 years. In the present study only one case of silicosis and seven cases of tuberculosis were found. The mean serum Cu levels of those having respiratory disease was found to be 91.5 +/- 19.8 microg/dl while mean serum Cu level of those free from respiratory disease was 86.8 +/- 21.3 microg/dl The difference was found to be statistically non-significant (t = 0.64, df= 1, P > 0.05). Thus, in the present study, though the elevated level of serum Cu was found in solitary case of silicosis, no association could be established between the silica exposure and serum copper levels as suggested by non-significant effect of duration of exposure (P = 0.53).

Adolescent↗
PubMed2001

[Dynamics of serum copper level in patients in the acute phase of hepatitis B and in early convalescence].

OBJECTIVE: Analysis of serum copper (Cu) level dynamics during the acute phase of hepatitis acute B and the early convalescence in compliance with gravity of the acute disease course. METHODS: The study included 39 patients (12 men and 27 women), aged 18 to 76 years. They were hospitalised in the Department of Infectious Diseases of Medical Academy in Lublin because of the hepatitis acute B, without coexisting diseases. The diagnosis was based on the epidemiologic anamnesis, clinical symptoms, biochemical and serological examinations. The studied group was divided in respect to sex and the course of the disease as: light, medium-weighty and weighty. In all examined patients, the serum Cu level was determined according to the following scheme: at the first, tenth, twentieth and the last day of the hospitalisation and additionally one time at four weeks after discharging from the clinic. The serum Cu level was made by atomic absorption spectrometry (AAS) at the wave length of 324.8 nm. The received data were subjected to statistical analysis according to t-Student's test and in cases of significant differences according to the variants of c-Cochran and Cox's tests. According to the SI Unit Conversion Guide, the values 11.22 to 23.58 mumol/l were taken as the normal range. The values derived from the control group of 24 healthy persons (13 men and 11 women) aged 22 to 69 years. RESULTS: The significant increase of serum Cu level in comparison with the control values was found both in the acute phase of hepatitis B and the early convalescence. It could be observed a correlation between serum Cu level and the course of hepatitis viralis acuta B.

Acute Disease↗
PubMed2002

Elevation of serum copper levels in Alzheimer's disease.

OBJECTIVE: To determine whether serum trace metals and oxidative species are related to abnormal cognition in AD. METHODS: The authors studied serum peroxides, copper, iron, transferrin, and antioxidant capacity in 79 patients with AD (mean age 74.3 years; 25 men, 54 women) and in 76 cognitively normal individuals (mean age 70.1 years; 33 men, 43 women). The relation of these oxidative and trace metals to APOE epsilon4 allele frequency, neuropsychological performance, and cerebrovascular or atrophic burden, as estimated by brain MRI and ultrasonography of cerebral vessels, was evaluated. RESULTS: Copper level was higher (p < 0.001) in subjects with AD than control subjects (specificity = 95%, sensitivity = 60%) with a cutoff serum level of 16 micro mol/L (1.02 mg/L). An increase of 1 micro mol/L in serum copper accounted for 80% of the risk of having AD and correlated with poor neuropsychological performance and medial temporal lobe atrophy (p < 0.03). Antioxidant capacity decreased and correlated with medial temporal lobe atrophy (p < 0.009) and with APOE epsilon4 allele (p = 0.004). CONCLUSIONS: Copper may play a role in neurodegenerative processes in AD, and serum copper measurement may prove to be a peripheral diagnostic marker for AD.

Aged↗
PubMed1986

Whole blood and serum copper levels in relation to sex and age.

The copper content in whole blood and serum was determined in healthy human subjects (240 males and 217 females) by atomic absorption spectrophotometry. The mean level of copper obtained in whole blood was 104.8 +/- 20.5 micrograms/100 ml in males and 117.1 +/- 20.1 micrograms/100 ml in females. The mean level of copper in serum was 102.3 +/- 21.7 micrograms/100 ml and 123.9 +/- 30.4 micrograms/100 ml, in males and females respectively. The copper concentration in whole blood and serum in females proved to be significantly higher than in males (p less than 0.001). With respect to age, the copper level showed a slightly negative correlation which is only statistically significant in whole blood in females (p less than 0.05).

Adolescent↗
PubMed1985

[Serum levels of copper and zinc in patients with lung cancer].

Serum copper levels (SCL) and serum zinc levels (SZL) were measured in two groups of lung cancer patients divided according to disease extension. SCL was higher, SZL was lower and SCL/SZL ratio was more raised in patients extensively affected by the disease. It is confirmed that SCL, SZL and the SCL/SZL ratio play an important role in indicating the stage of lung cancer development.

Adult↗