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Effect of respiratory rate on respiratory patterns in patients with chronic obstructive pulmonary disease.

We enrolled 22 patients with chronic obstructive pulmonary disease (COPD) and 20 normal subjects as controls. Using a hot-wire flow meter, we obtained tidal volume (VT), duty ratio (Ti/Ttot), and mean inspiratory flow (VT/Ti) as measures of respiratory pattern at two different respiratory rates; 0.5 Hz and 1.5 Hz. At 0.5 Hz, there were significant differences in Ti/Ttot and VT/Ti. At 1.5 Hz, patients with COPD had significantly lower values of VT and VT/Ti. Furthermore, we calculated the change ratios from 0.5 Hz to 1.5 Hz in these parameters as new parameters of respiratory pattern change by respiratory rate. VT0.5/1.5 and VT/Ti0.5/1.5 significantly correlated with FEV1.0/FVC. The findings suggest that the parameters of the respiratory pattern may change depending on respiratory rates, and that the ratios of those parameters obtained at two different rates could be helpful in diagnosing airflow obstruction.

Aged↗

The effects of stress in response to mirror drawing test trials on the electrogastrogram, heart rate and respiratory rate of human subjects.

Electrogastrograms (EGGs), heart and respiratory rates were recorded simultaneously from human subjects and analyzed spectrally by the maximal entropy method. The stress of the mirror drawing test (MDT) significantly increased both the heart and respiratory rates with an associated increase in LF/HF ratios. MDT stress, however, increased (excited groups) or decreased (inhibited groups) the power amplitude and the power ratio, (peak power during MDT)/(peak power during rest), of the 1-cpm (0-2.4 cpm), 3-cpm (2.5-4.9), 6-cpm (5.0-7.4), 8-cpm (7.5-9.9) and 10-cpm (10.0-12.9) spectral group components of the EGG recording of the electrical activity of the gastrointestinal tract. The depression scores of the subjects in the MDT stress excited group were higher and their resting frequencies were significantly lower than those of the MDT stress inhibited groups in each of the epigastric, supra-umbilical and infra-umbilical 6-cpm frequency groups but not in the epigastric 1-cpm frequency group. Anxiety scores of the MDT stress excited groups were significantly higher and their power ratios were also significantly higher than those of the inhibited groups in each of the epigastric 10-cpm, the supra-umbilical 6-cpm and the infra-umbilical 1- and 3-cpm frequency groups. Therefore, depression scores appeared to have inhibitory effects on the resting EGG frequencies, while anxiety scores appeared to have facilitatory effects on the EGG power ratio during MDT stress. It is suggested that analysis of EGG under MDT stress would provide a measure of the stress sensitivity of the electrical activity of the human gastrointestinal tract.

Adult↗

Correlations between the responses of electrogastrograms, heart rate and respiratory rate to the stress of the mirror drawing test in human subjects.

An electrogastrogram (EGG) recorded on the skin is believed to reflect the electrical activity of the gastrointestinal tract. In this study, linear correlations were calculated for the EGG spectral frequencies and the power ratios, changes in heart and respiratory rate before and during mirror drawing test (MDT) stress and after having meals, with the changes in the sympathetic tone indicator (LF/HF) and HADS anxiety and depression scores in human subjects (n=48). Depression scores had a negative linear correlation with the EGG resting frequencies of the epigastric and supraumbilical 6 cpm groups (5.0-7.4 cpm). Anxiety scores had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 6 cpm groups (6 cpm area during MDT/that during fasting rest). The resting LF/HF had a positive linear correlation with the EGG area power ratio of the resting to MDT stress responses of the epigastric and infraumbilical 3 cpm groups (2.5-4.9 cpm). The resting LF/HF ratio had a negative correlation with the area power ratio of the resting to postprandial responses (postprandial power/resting power) in the epigatric, supraumbilical and infraumbilical 6 cpm groups. The resting LF/HF ratio had a positive linear correlation with the heart rate at rest and during MDT-stress. In contrast, the resting LF/HF ratio had a negative linear correlation with the respiratory rate at rest and during MDT-stress. EGGs of the surface electrical activities of the gastrointestinal tract were influenced by acute MDT-stress and their frequencies and their response power ratios were correlated linearly with anxiety scores, depression scores and the sympathetic tone indicator, the LF/HF ratio.

Adult↗

Effect of xylazine and ketamine on blood pressure, heart rate and respiratory rate in rabbits.

New Zealand white and New Zeland white-Dutch Belted cross rabbits of both sexes were anesthetized using xylazine and ketamine alone and in combination while blood pressure, heart and respiratory rates were monitored. Blood pressure effects were measured from the aortic arch by a cannula implant through the left carotid artery. Ketamine-xylazine in combination at 35 and 5 mg/kg body weight, respectively, produced 45-60 minutes of surgical plane anesthesia. Anesthesia was induced in approximately 10 minutes. The average initial blood pressure drop was complete in 10 minutes and was 30%. Heart and respiratory rates dropped 19% and 77%, respectively, in the same time span. An additional blood pressure drop of 6-7% occurred as consciousness was regained. Blood pressure recovery was nearly complete (normal) about 6 hours following injection of the drug combination.

Anesthesia↗

Baseline body temperatures, heart rates, and respiratory rates of moose in Alaska.

Baseline body temperatures (BT), heart rates (HR) and respiratory rates (RR) were obtained from Alaskan moose (Alces alces gigas Miller) at the Moose Research Center (MRC), Alaska. Excitability, seasons and drugs influenced the values to varying degrees. Excitability was the most influential factor. Safe expected ranges were: BT 38.4 to 38.9 C, HR 70 to 91 beats/min (b/min), and RR 13 to 40 respirations/min (r/min). These ranges incorporated all seasons, a central nervous system depressant drug and a paralyzing drug. Values which may be considered critical and an indication that corrective action should be taken include: BT 40.2 C, HR 102 b/min, and RR 40 r/min. It is recommended that persons trained in monitoring vital signs be on hand during moose capture and immobilization procedures.

Alaska↗

Palliative performance status, heart rate and respiratory rate as predictive factors of survival time in terminally ill cancer patients.

To determine which symptoms, signs, and characteristics that define the patient's functional status predict the survival time in terminally ill cancer patients, a prospective longitudinal study was conducted with terminally ill cancer patients followed by a Home Care Support Team. Patients were followed up with at least weekly visits until death, collecting variables at each visit. A Cox multivariate regression analysis took into account all the follow-ups in the same patient. Ninety-eight patients were studied, and 250 evaluations were done. The mean age was 72 years. The median survival was 32 days. In the multivariate analysis, three independent variables were identified: Palliative Performance Score of 50 or under, heart rate of 100/minute or more, and respiratory rate of 24/minute or more. The variables that were found to be prognostic in our study are objective, easy, and quick to measure, and do not require that the professional have special training or experience. The prediction of survival time may be improved by considering these variables.

Activities of Daily Living↗

Effect of dynorphin-(1-13) and related peptides on respiratory rate and morphine-induced respiratory rate depression.

Previous studies from our laboratory have shown that the opioid peptide dynorphin-(1-13), although not analgesic when given by itself, can inhibit morphine-induced analgesia in naive mice and potentiate it in morphine tolerant mice. In the present study, we examined the effect of dynorphin-(1-13) with two other dynorphin-like peptides, alpha-neoendorphin and dynorphin-(1-10) amide, on respiration. Our results show that none of the peptides studied had any significant activity on the respiratory rate in mice when given alone. However, in the presence of morphine, dynorphin-(1-13) antagonized the morphine-induced respiratory rate depression in morphine-tolerant animals; alpha-neoendorphin enhanced the morphine-induced respiratory rate depression in naive but had no effect in morphine-tolerant animals and dynorphin-(1-10) amide had no modulatory effect on the morphine-induced respiratory rate depression in either group of animals.

Animals↗

Determination of the relationships between psychological stress levels and blood pressure, pulse and respiratory rates, weight and cigarette consumption.

Stress has often been invoked as the intervening variable between various patterns of environmental and psychological stimulation, and various physiological and non-physiological responses. In an attempt to document this, 71 subjects completed the Staats Stress-Vector Analysis Questionnaire yielding measures on environmental, psychogenic and somatogenic stress dimensions, as well as on an overall net stress measure. These were then correlated against the blood pressure, pulse rate, respiratory rate, weight and smoking indices of the respondents, measured under controlled circumstances. No linear correlation was apparent. The respiratory rate tended to be raised in the environmentally and overall stressed individuals as a class, while similar findings relating to weight and pulse rate applied to the psychologically stressed. Reasons are extended for these findings.

Adult↗