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PubMedDate not supplied

Correlation between maxillary central incisor form and face form in 4 racial groups.

OBJECTIVES: The purpose of this study was to evaluate the correlation between central incisor form and face form in 4 racial groups and to investigate if there was agreement among experts in categorizing the central incisor forms. METHOD AND MATERIALS: A total of 160 subjects (40 whites, 40 mulattos, 40 blacks, and 40 Asians) ranging from 18 to 33 years of age were selected. Digital photographic records were made, 1 full-face and 1 intraoral view of the maxillary right central incisor. The outline tracings of the tooth and face images were obtained using Adobe Photoshop 5.0 software. The outline tracings were printed in distinct transparencies, and 3 prosthodontists determined if there was correspondence between the tooth and the face forms by superimposition of the transparencies. If there was disagreement among the prosthodontists' evaluations, the prevalent decision was considered. The experts also classified the central incisor forms into square, ovoid, tapering, or combination at 2 different sessions. At the first session, no instructions were given. At the second session, the prosthodontists were instructed to follow Williams' method of classification. RESULTS: A correspondence between tooth and face forms was found in 23.75% of all cases. Agreement on the tooth form classifications among the prosthodontists occurred in 30.62% of all cases at the first session and 24.37% at the second session. CONCLUSION: There is not a highly defined correlation between central incisor form and face form in any racial group studied. In addition, the experts were not in fair agreement in categorizing tooth forms.

Adolescent↗
PubMed1980

Sensitivity to penicillin of gonococci in different racial groups.

The distribution of the sensitivity to penicillin of gonococci isolated from 631 men and 290 women was analysed in relation to the racial origin of the patients and the type of source contact alleged by the men. No difference in the sensitivity patterns was found between strains from white patients from the United Kingdom and those from immigrants from the Caribbean area. Asian men harboured significantly more insensitive strains than men of other racial groups. Men of Caribbean stock who had been born in this country had significantly more infections due to fully sensitive strains. The reasons for these variations are not known, but one contributory factor may be differences within the racial groups in the proportions of infections contracted from prostitutes.

Ethnicity↗
PubMed1992

Mapping the human liver/islet glucose transporter (GLUT2) gene within a genetic linkage map of chromosome 3q using a (CA)n dinucleotide repeat polymorphism and characterization of the polymorphism in three racial groups.

The human liver/islet glucose transporter (GLUT2), a candidate gene for diabetes, has been incorporated into a genetic linkage map for chromosome 3q using a (CA)n dinucleotide repeat polymorphism adjacent to the 3'-end of exon 4a. We have found a total of nine alleles ranging in length from 153 to 169 nucleotides in three racial groups and have determined the precise structure of the variable region for four of the alleles by DNA sequencing. Five alleles were found to be common to the American Black, Caucasian, and Pima Indian racial groups studied. One allele (169 bp) was unique to American Blacks, and another rare allele (153 bp) was found only in the Caucasian population studied. Observed heterozygosity of the polymorphism in the Caucasian (CEPH) reference pedigree collection is 60%, for American Blacks 71%, and for Pima Indians 53%. An independent study recently identified the same dinucleotide repeat and found six alleles in a Caucasian population (Froguel et al., 1991), a result that we confirm; however, our sequencing data indicate a different molecular structure for the polymorphism for some of the alleles. We have constructed a new genetic linkage map of chromosome 3q uniquely placing the GLUT2 gene between flanking markers D3S26 and D3S43. The genetic map consists of 23 loci (25 RFLPs and 2 (CA)n dinucleotide repeat markers) with 14 markers uniquely localized with odds of at least 1000:1. Three genes (FTHL4, TF, GLUT2) are integrated into the map, which spans a sex-average distance of 147.3 cM, 103.8 cM in males and 227.0 cM in females.(ABSTRACT TRUNCATED AT 250 WORDS)

Alleles↗
PubMed1999

Allelic distribution of the glycoprotein Ia (alpha2-integrin) C807T/G873A dimorphisms among caucasian venous thrombosis patients and six racial groups.

Two linked silent dimorphisms, 807 C --> T (Phe224) and 873 G --> A (Thr246) within the glycoprotein Ia (GPIa) gene have been correlated with low and high platelet receptor density, respectively, and associated with vascular disease. A multiplexed allele-specific PCR assay was used to determine the GPIa 807T/873A allele frequency among 331 Caucasian venous thrombosis patients and 3571 unrelated individuals belonging to six different racial groups. The 807T/873A allele frequencies were 54%, 51%, 39%, 39%, 38%, 34% and 30% among Native Americans, Hispanics, Caucasians, Caucasian venous thrombosis patients, Asian Indians, African-Americans, and Koreans, respectively. Significant differences in the GPIa allele frequency among racial groups were revealed which emphasized the need for appropriate controls in studies evaluating the association of GPIa genotype to vascular disease.

Alleles↗
PubMed2005

On the categorization of admired and disliked exemplars of admired and disliked racial groups.

The present work examined the influence of affective fit in the racial categorization process. Study 1 tested whether famous exemplars of stigmatized and nonstigmatized racial groups are categorized by race at differential rates, depending on whether they are admired or disliked. Using an inverted-face paradigm, Study 2 examined whether racial categorization accuracy differs for admired and disliked exemplars of these groups. Study 3 examined the influence of collective self-esteem on Whites' tendency to differentially categorize admired and disliked Black and White exemplars. Last, Study 4 replicated the pattern of results found in the previous studies for White participants, making use of unknown exemplars about whom participants learned either positive or negative information prior to categorizing them. Taken together, the results suggested that phenotypically irrelevant affective information regarding exemplars and their social group memberships influences the racial categorization process. Implications for prejudice and stereotyping are discussed.

Ethnicity↗
PubMedDate not supplied

Acetabular depth and race in young adults: a potential explanation of the differences in the prevalence of slipped capital femoral epiphysis between different racial groups?

Slipped capital femoral epiphysis (SCFE) is known to have a higher prevalence in blacks and Polynesians. It has been postulated that a deeper acetabulum increases the shearing forces on the proximal femoral physis, resulting in a higher incidence of SCFE. It was the purpose of this study to investigate acetabular depth in the normal adult population as a function of race. Anteroposterior pelvis radiographs from young polytrauma adults (<35 years) were identified. Race was classified according as white, black, Amerindian (Hispanic and Native American), and Asian. Acetabular depth was measured by Visser's modification of the center-edge (CE) angle and Sharp's angle. All measurements were made by one observer with the same goniometer and Mose circle. There were 167 patients with an average age of 24 +/- 4 years; there were 65 female (39%) and 102 male (61%) patients. There were 57 (34%) Amerindian, 50 (30%) white, 47 (28%) black, and 13 (8%) Asian people. The CE angle was 30.6 +/- 4.8 degrees for the Asian, 28.7 +/- 5.7 degrees for the black, 30.3 +/- 5.1 degrees for the Amerindian, and 28.0 +/- 4.3 degrees for the white racial groups. Sharp's angle was 39.8 +/- 3.0 degrees for the Asian, 39.9 +/- 3.6 degrees for the black, 37.4 +/- 3.4 degrees for the Amerindian, and 39.2 +/- 3.2 degrees for the white racial groups. These differences by race were statistically significant for both Sharp's and Visser's angles. If racial variation in acetabular depth is an explanation for the racial variability of SCFE, then the CE and Sharp's angle should vary by race. In this study of healthy adults without any underlying hip pathology, racial variability in the CE or Sharp's angle did not follow the racial prevalence of SCFE.

Acetabulum↗
PubMed1995

Expression of PAI-1, t-PA and u-PA in cultured human umbilical vein endothelial cells derived from racial groups.

To determine whether inherent fibrinolytic differences may exist in racial groups (black americans, BA vs. white americans, WA), 55 different individual racially-derived human umbilical vein endothelial cell (HUVEC) cultures (35 BA and 20 WA) were analyzed in terms of their fibrinolytic protein (t-PA, u-PA and PAI-1) antigen and mRNA levels. Values (mean +/- SD) for measured fibrinolytic component levels include: cell-associated t-PA antigen (ELISA), 1.14 +/- 0.82 ng/ml/8.6 x 10(5) cells/24 hr in BA and 0.70 +/- 0.85 ng/ml in WA (p = 0.0624); secreted t-PA antigen, 18.65 +/- 17.06 ng/ml in BA and 10.37 +/- 6.38 ng/ml in WA (p = 0.0422); t-PA/cyclophilin mRNA ratios (Northern blot analysis), 1.90 +/- 1.34 in BA and 1.32 +/- 0.70 in WA (p = 0.0776); cell-associated PAI-1 antigen, 71.10 +/- 30.16 ng/ml/8.6 x 10(5) cells/24 hr in BA and 108.85 +/- 56.89 ng/ml in WA (p = 0.0022); secreted PAI-1 antigen, 1,582.13 +/- 612.67 ng/ml in BA and 1,992.17 +/- 711.50 ng/ml in WA (p = 0.0285); 2.4 kb PAI-1/cyclophilin mRNA ratios, 0.59 +/- 0.39 in BA and 0.79 +/- 0.31 in WA (p = 0.1085); 3.4 kb PAI-1/cyclophilin mRNA ratios, 0.70 +/- 0.47 in BA and 0.77 +/- 0.54 in WA (p = 0.6322). These combined data suggest that cultured HUVECs from BA express significantly higher levels of t-PA, lower levels of PAI-1 and approximately 1.72-fold lower molar ratio of PAI-1/t-PA antigen (183.99 +/- 168.81 vs. 315.92 +/- 164.99) (p < 0.05) than cultured HUVECs from WA, presumably reflecting an apparent inherent increased fibrinolytic potential in cultured HUVEC derived from BA.

Black People↗
PubMed1978

alpha1-Antitrypsin variants in different racial groups in Malaysia.

In a study of Malaysians of different racial groups, 1,510 sera (908 from Malays, 371 from Chinese and 231 from Indians) were identified for their protease inhibitor (Pi) types. The gene frequencies for the alleles PiM, PiS and PiX in Malays were, respectively, 0.979, 0.015, and 0.007. In Chinese, the frequencies were 0.981, 0.019 and 0.000, and in Indians they were 0.976, 0.24, and 0.000. It is interesting that the usually rare PiX type is found in appreciable frequency in the Malays. Two different types with unusual behavior and obscure origin were also found.

Alleles↗
PubMed2006

Fairness is not validity or cultural bias in racial-group assessment: a quantitative perspective.

When test scores that differ by racial groups are used for assessment purposes, resulting decisions regarding members of the lower scoring group are potentially unfair. Fairness is defined as the removal from test scores of systematic variance attributable to experiences of racial or cultural socialization, and it is differentiated from test-score validity and cultural bias. Two fairness models for identifying, quantifying, and removing from test scores construct-irrelevant variance attributable to racial or cultural psychological attributes are presented. ((c) 2006 APA, all rights reserved).

Attitude↗
PubMedDate not supplied

Nasal width as a guide for the selection of maxillary complete denture anterior teeth in four racial groups.

PURPOSE: Selecting artificial teeth for edentulous patients is difficult when pre-extraction records are not available. Various guidelines have been suggested for determining the width of the maxillary anterior denture teeth. This study was undertaken to evaluate the use of the nasal width as a guide for the selection of proper width maxillary anterior denture teeth in four racial groups of the Brazilian population. MATERIALS AND METHODS: One hundred and sixty subjects (40 Whites, 40 Mulattos, 40 Blacks, and 40 Asians) were selected. Using a sliding caliper, the nasal width and the intercanine distance were measured. The Pearson product-moment correlation coefficient was used to determine the relationship between the above measurements. A prediction was made of the percentage of subjects of the White, Mulatto, Black, and Asian populations in which the selection error due to the clinical application of the method of the nasal width would be within 0 to 2 mm, within 2 to 4 mm, and greater than 4 mm. RESULTS: The four racial groups showed a weak correlation between the intercanine distance and the nasal width. In 39.7% of the White, 55.7% of the Mulatto, 81.9% of the Black, and 48.2% of the Asian populations, errors greater than 4 mm would be present with the use of the nasal width. CONCLUSIONS: The correlation found between the intercanine distance and the nasal width was not high enough to be used as a predictive factor. The relationship between natural tooth width and artificial tooth width as predicted by the nasal width showed that the nasal width method is not accurate for all the studied groups.

Adolescent↗
PubMed2005

Carotid plaque composition differs between ethno-racial groups: an MRI pilot study comparing mainland Chinese and American Caucasian patients.

OBJECTIVE: Ethnicity-based research may identify new clues to the pathogenesis of atherosclerotic disease. Therefore, we sought to determine whether carotid lesions differ between 20 Chinese and 20 Caucasian Americans by MRI. METHODS AND RESULTS: Inclusion criteria were >50% stenosis as measured by duplex ultrasound and recent symptoms attributed to carotid artery disease. The patients were imaged in 2 centers (Beijing, China and Seattle, Wash) using a standardized protocol. Both carotid arteries were reviewed quantitatively (lumen, wall, outer wall, tissue components) and morphologically (lesion types, fibrous cap status). Significant differences between the Chinese and Americans were found for the mean size of the lipid/necrotic core (13.6 versus 7.8 mm2; P=0.002), percentage of slices with calcified type VII lesions (1.6 versus 12.4%; P=0.03), and percentage of slices with early type III lesions (19.3 versus 9.3%; P=0.02). Furthermore, the mean outer wall area in the common carotid artery was larger in the Chinese population (P=0.007). CONCLUSIONS: This pilot study suggests that composition and morphology of atherosclerotic lesions in symptomatic carotid disease differ between ethno-racial groups. Quantitative MRI-based review of carotid atherosclerosis comparing plaque morphology and composition between ethno-racial groups is feasible, and future MRI studies may improve our understanding of the pathophysiology of this disease.

Aged↗
PubMed1979

Speech and language testing with distinct ethnic-racial groups: a survey of procedures for improving validity.

Several procedures are being used currently to improve the validity of speech and language evaluation for ethnic or racial groups from lower-income populations. Procedures mentioned in this article include: (1) developing a new test, (2) modifying test items or keyed responses on existing tests, and (3) developing new norms for existing tests. Examples are given for each procedure, and advantages and disadvantages are discussed.

Ethnicity↗
PubMed1987

The position of the mental foramen: a comparison between the southern (Hong Kong) Chinese and other ethnic and racial groups.

The anteroposterior position of the mental foramen in eighty-seven southern (Hong Kong) Chinese skulls was compared with that reported for other ethnic and racial groups. The average position was essentially in line with the longitudinal axis of the second premolar tooth, a result similar to that reported for other Mongoloid populations, just posterior to the position in Caucasoids and anterior to the position in Negroids. These observations do not support the statement made in the majority of textbooks on dental analgesia that the foramen is most commonly found between the apices of the premolar teeth.

Adolescent↗
PubMedDate not supplied

Are there beta-adrenergic receptor response differences between racial groups?

Beta-adrenergic receptor (BAR) agonists and antagonists are among the most widely used drugs in America today. This review highlights the importance of cross-racial studies in evaluating BAR effects because heterogeneity in pharmacologic response among humans exists. Clinicians and basic scientists in the drug development industry need to acknowledge racial differences in antihypertensive drug responses and prevent various racial groups from being underrepresented in clinical trials. This article reviews the influence of race on BAR responses with emphasis on blacks and whites. Information from patients with hypertension, healthy volunteers, and in vitro studies is presented.

Adrenergic beta-Antagonists↗
PubMedDate not supplied

Measurements of the lumbar spinal canal in 2 racial groups.

Direct measurements of 1,340 lumbar vertebrae in 275 skeletons in two racial groups are reported. The average figure, and the upper and lower limits of normal are reported for the anteroposterior diameter of the canal and for Spinal Index. Radiological studies have established a technique for defining the posterior margin of the spinal canal on plain X-ray films. It is formed by a line joining the apex of the superior to the inverted apex of the inferior articular facet. The Spinal Index is not a reliable factor. The anteroposterior diameter alone is the essential parameter in assessing spinal stenosis. The negroid canal is marginally less spatial than that of the caucasoid.

Black People↗
PubMed1979

Epidemiologic studies of gastric carcinoma: comparison between Iranians and two racial groups in the USA.

Gastric carcinoma in 226 cases from the two major racial groups--black and white--in Richmond, VA, USA, and in 75 cases from Shiraz, Iran, were studied. The age at onset and the ratio of intestinal to diffuse gastric carcinoma were compared with those for the high- and low-risk groups from Colombia. Poor socioeconomic conditions are directly related to intestinalization of the gastric mucosa and onset of carcinoma at a relatively young age. In Shiraz, the peak incidence of lymphoma, including intestinal lymphoma, is in the third decade of life; for esophageal carcinoma, it is in the fourth decade, and for gastric carcinoma, in the fifth. Comparison of this age distribution with induction times of neoplasia in immunosuppressed patients supports the suggestion of a common cocarcinogenic factor acting early in infancy. In Richmond, the ratio of intestinal to diffuse carcinoma for the black population is consistently higher than for the white. This difference has increased recently due to a more rapid decline in incidence of intestinal-type gastric carcinoma in the white population than in the black.

Aged↗
PubMed2005

A psychometric analysis of the Intolerance of Uncertainty Scale among four racial groups.

Recent psychometric analyses examining the cross-cultural validity of key anxiety measures have suggested that some, such as the Anxiety Sensitivity Index (ASI), may hold different psychometric characteristics among different racial or national groups. The Intolerance of Uncertainty Scale (IUS) is a self-report measure that, like the ASI, appears to assess a predispositional risk for developing some anxiety and mood disorders. Despite its validation in both a French and English version, the majority of the research conducted on the IUS has used predominantly Caucasian samples. Given this, the purpose of this research was to examine and compare the psychometric properties of the IUS among non-clinical participants of four racial groups: African American, Caucasian, Hispanic/Latino, and Southeast Asian. The data suggested generally strong, and highly similar, estimates of reliability and validity across the four racial groups. The factor structure of the IUS, however, was poorly interpretable among any of the groups. Implications for use of the IUS with different racial groups are discussed.

Adolescent↗