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PubMed1998

H2O2 production of heart mitochondria and aging rate are slower in canaries and parakeets than in mice: sites of free radical generation and mechanisms involved.

Birds have a maximum longevity (MLSP) much higher than mammals of similar body size in spite of their high metabolic rates. In this study, State 4 and State 3 rates of H2O2 production were lower in canary (MLSP = 24 years) and parakeet (MLSP = 21 years) than in mouse (MLSP = 3.5 years) heart mitochondria. Studies using specific inhibitors of the respiratory chain indicate that free radical generation sites at Complexes I and III are responsible for these differences. Main mechanisms lowering H2O2 production in these birds are a low rate of mitochondrial oxygen consumption in the parakeet and a low mitochondrial free radical leak in the canary. Strong increases in H2O2 production during active respiration (State 3) released by addition of ADP to pyruvate/malate-supplemented mitochondria are avoided in three species because the free radical leak decreases during the transition from State 4 to State 3 respiration. These results, together with those previously obtained in pigeons and in various mammalian species, suggest that the rate of mitochondrial free radical production correlates better with the rate of aging and the MLSP than the metabolic rate. They also suggest that a low rate of mitochondrial H2O2 production is a general characteristic of birds, animals showing very slow aging rates.

Aging↗
PubMed1978

Frequency selectivity in the parakeet (Melopsittacus undulatus) studied with psychophysical tuning curves.

Seven parakeets were trained to avoid shock during pure-tone stimulation. A modified method of limits was used to measure detection thresholds of the pure tones. The intensity of masker tones, at numerous frequencies, was varied in order to measure the masked threshold of a probe-tone signal set at a fixed frequency and intensity. Masking curves were obtained for three probe tones (.63, 1.6, and 2.5 kHz) at each of five sensation levels (10, 20, 30, 40, and 50 dB). The masking curves from this procedure are frequently referred to as "psychophysical tuning curves" and provide an indication of frequency selectivity. The results are compared with analogous data in other species and suggest that frequency analysis in the parakeet ear is somewhat less accurate than in the mammalian ear.

Acoustic Stimulation↗
PubMed2000

Influences of graded dose of melatonin on the levels of blood glucose and adrenal catecholamines in male roseringed parakeets (Psittacula krameri ) under different photoperiods.

Effects of daily evening (just before the onset of darkness in a 24 h light dark cycle) administration of graded doses (25, 50, or 100 microg/100 g body wt./day for 30 days) of melatonin on the concentrations of blood glucose and adrenal catecholamines were studied in sexually active male roseringed parakeets under natural (NP; approximately 12L: 12D) and artificial long (LP; 16L: 8D) and short (SP; 8L: 16D) photoperiods. Blood samples and adrenal glands were collected from each bird during the mid-day on the following day of the last treatment. The concentrations of glucose in blood and epinephrine (E) and norepinephrine (NE) in the adrenals were measured. The results of the study indicated that exogenous melatonin induces hypo- or hyperglycemia depending on the dose of hormone administered as well as to the length of photoperiod to which birds were exposed. The levels of E and NE in the adrenals were shown also to vary in relation to photoperiod and the dose of melatonin administered. But the nature of the influence of melatonin becomes different under altered photoperiodic conditions. It appears that short photoperiods are more effective than long photoperiods as a modulator of glycemic and adrenal catecholaminergic responses to exogenous melatonin. A statistically significant correlation between the levels of blood glucose and that of E and NE in the adrenals was found in the control birds, but not in the melatonin treated birds. The results suggested that the responses of blood glucose and adrenal catecholamines to the treatment with melatonin in the roseringed parakeets may not be dependent on each other.

Adrenal Glands↗
PubMed2001

Imported parakeets harbor H9N2 influenza A viruses that are genetically closely related to those transmitted to humans in Hong Kong.

In 1997 and 1998, H9N2 influenza A viruses were isolated from the respiratory organs of Indian ring-necked parakeets (Psittacula Krameri manillensis) that had been imported from Pakistan to Japan. The two isolates were closely related to each other (>99% as determined by nucleotide analysis of eight RNA segments), indicating that H9N2 viruses of the same lineage were maintained in these birds for at least 1 year. The hemagglutinins and neuraminidases of both isolates showed >97% nucleotide identity with those of H9N2 viruses isolated from humans in Hong Kong in 1999, while the six genes encoding internal proteins were >99% identical to the corresponding genes of H5N1 viruses recovered during the 1997 outbreak in Hong Kong. These results suggest that the H9N2 parakeet viruses originating in Pakistan share an immediate ancestor with the H9N2 human viruses. Thus, influenza A viruses with the potential to be transmitted directly to humans may be circulating in captive birds worldwide.

Amino Acid Sequence↗
PubMed2002

Comparative anatomy of the paratympanic organ (vitali organ) in the middle ear of birds and non-avian vertebrates: focus on alligators, parakeets and armadillos.

The paratympanic organ (PTO) in the middle ear has been described in numerous bird species, but little is known about the distribution of this presumed lateral line remnant in other vertebrate classes. Here we provide evidence for a PTO in juvenile alligators, and make the first detailed description of its location and relation to ligaments in the reptilian middle ear. The alligator PTO measures about 450 micro m in diameter. The alligator PTO contains hair cells whose cilia extend into a mucous substance within the lumen. The PTO connects though a ligament to the ear drum, suggesting that pressure onto the tympanic membrane might induce fluid movement in the PTO. Labeling of innervating nerve fibers with the fluorescent dye, DiI, indicates that the alligator PTO is connected with the vestibular brainstem. Because all bird species examined possess a PTO except for owls and possibly parakeets, we verified the absence of a PTO in parakeets by examination of serial sections combined with GABA immunolabeling for potential hair cells. Bird species with significant upper beak movement lack a PTO, suggesting that PTO function is incompatible with upper beak movement. We also examined the middle ear of an armadillo, a mammal that has a very basal position within the eutherian phylogenetic tree. A small vesicle with ciliated cells was found, but did not label with a hair-cell specific marker, antibodies to myosin VIIa, and thus is not likely to represent a true PTO. Our evidence for a PTO in a non-avian species, the alligator, together with previous reports suggesting the presence of a PTO in some mammals, indicates that ancestral stem amniotes possessed a PTO, and that the PTO was not a de novo invention of birds.

Alligators and Crocodiles↗
PubMed1984

A morphological study of the ultimobranchial body in the grass parakeet.

As parafollicular cells can be stained by Grimelius' silver impregnation and by lead-hematoxylin, the ultimobranchial body cells, homologous to them, seem to also react positively to these methods. In the present study of the ultimobranchial body of the grass parakeet, mirror-image sections were stained by both methods and compared. While about 50% of the cells reacted positively to both Grimelius' silver impregnation and lead-hematoxylin staining, only about 20% were positive to the former and about 30% were positive to the latter only. This result indicating heterogeneity among the cells of the ultimobranchial body of the grass parakeet suggests a possible occurrence of cells secreting substances other than calcitonin.

Animals↗
PubMed2004

Stable individual differences on developmental tasks in young yellow-crowned parakeets, Cyanoramphus auriceps.

We report on stable individual differences in young yellow-crowned parakeets across 38 tasks of cognitive development on three scales involving object permanence, means-end relations, and spatial relations. Stable performance ranks on blocks of tasks emerged after 13 weeks in two groups of sibling parakeets, one hand-reared and the other parent-reared. Examination of subject characteristics, such as hatch order, sex, general activity level, avoidances, latencies, social status, and errors, showed no significant correlations with these performance ranks. Characteristic individual approaches to unstructured play activities (from a fourth scale) were consistent with individual behavioral differences seen on the structured cognitive tasks.

Age Factors↗
PubMed2004

Psittacine beak and feather disease virus in budgerigars and ring-neck parakeets in South Africa.

Psittacine beak and feather disease (PBFD) is a common disease of the psittacine species and is caused by the psittacine beak and feather disease virus (PBFDV). In this study the occurrence of the disease in ring-neck parakeets and budgerigars in South Africa suffering from feathering problems, using polymerase chain reaction as a diagnostic test was investigated. The genetic variation between viral isolates was also studied. Results indicate that PBFDV can be attributed to being the cause of feathering problems in some of the ring-neck parakeets and budgerigars in South Africa. Genetic variation of isolates occurs between species and individuals. A cheap and easy to use method of blood sample collection on filter paper for diagnostic purposes was also evaluated. It proved to be less stressful to the birds and did not inhibit further processes.

Animals↗
PubMed1999

Heart fatty acid unsaturation and lipid peroxidation, and aging rate, are lower in the canary and the parakeet than in the mouse.

Despite their high metabolic rates, birds have a much higher maximum longevity (MLSP) than mammals of similar body size, and thus represent ideal models for identifying longevity characteristics not linked to low metabolic rates. This study shows that the fatty acid double bond content of both canary (MLSP = 24 years) and parakeet (MLSP = 21 years) hearts is intrinsically lower than in mouse (MLSP = 3.5 years) heart. This is caused by a redistribution between types of unsaturated fatty acids, mainly due to a lower content of the most highly unsaturated docosahexaenoic acid (22:6n-3) in the two birds in relation to the mammal. The lower double bond content leads to a lower sensitivity to lipid peroxidation, and to a lower level of in vivo lipid peroxidation in the heart of parakeets and canaries than in that of mice. Similar results have been previously found comparing liver mitochondria of rats and pigeons and tissues of different mammalian species. All these results taken together suggest that a low degree of fatty acid unsaturation is a general characteristic of longevous homeothermic vertebrate animals, both when they have low metabolic rates (mammals of large body size) or high metabolic rates (the studied birds); this constitutive trait protects their tissues and organelles against free radical mediated lipid peroxidation, and can contribute to their slow aging rate.

Aging↗
PubMed1975

Salmonellosis in a human infant, a cat, and two parakeets in the same household.

Salmonellosis occurred in a human infant, cat, and 2 pet parakeets in the same household. Salmonella typhimurium var copenhagen was isolated from all 4 subjects; however, its original source was never determined. The parakeets subsequently died, and necropsy revealed enteritis, foci of hepatic necrosis, and leptomeningitis.

Animals↗
PubMed1990

[A papovavirus-like infection in parakeets].

Several potential causes of disease were detected in young as well as in full-fledged parakeets of several species in an outbreak of disease on a parakeet-breeding farm. Both papovavirus and Absidia sp. were isolated; the drinking water contained a toxic level of nitrates. The pathological findings are presented and the possible role of the various findings in the pathogenesis of the disease complex is discussed.

Animals↗
PubMedDate not supplied

Antibiotic aerosolization: tissue and plasma oxytetracycline concentrations in parakeets.

Oxytetracycline hydrochloride (OTC) was delivered to adult parakeets by aerosolization using a DeVilbiss model 65 ultrasonic nebulizer. Trachea, lung, and plasma concentrations were ascertained at 1, 2, 4, 6, and 8 hours postaerosolization (PA). An average of 284 ml of a solution containing 2 mg OTC/ml was aerosolized over a 1-hour period into a 0.0596 M3 chamber containing 10 parakeets. The trachea and lung concentrations were more than 10 micrograms/g at 1 and 2 hours PA, had decreased to approximately 3 micrograms/g by 4 hours PA, and were below 2 micrograms/g by 8 hours. The plasma concentration never exceeded 2.6 micrograms/ml and was at 1.6 micrograms/ml by 8 hours. This study demonstrates that it is possible to achieve therapeutic concentrations of OTC by aerosolization in lung and trachea, but treatment may need to be repeated every 4-6 hours. Since the plasma concentration never reached high levels, aerosolization under the conditions of this study is not an effective way to treat systemic infections outside the respiratory tract.

Aerosols↗
PubMed1978

Frequency selectivity in the parakeet (Melopsittacus undulatus) studied with narrow-band noise masking.

Narrow-band noise masking was studied in the parakeet (Melopsittacus undulatus) using a modified method of limits and an instrumental avoidance-conditioning procedure. Masked thresholds were obtained from five subjects at 10 frequencies between 0.5 and 5.0 kHz for each of four sensation levels (26, 46, 66, and 86 db) of a 1/3-octave band noise masker centered at 1.6 kHz. The amount of masking was found to be linearly related to noise level, and the shape of the masking curve was symmetrical on both sides of the center frequency of the masker. In all cases, the greatest threshold shift occurred at the center frequency of the masker. The relative symmetry of the parakeet narrow-band masking curves contrasts with masking results reported in mammals.

Acoustic Stimulation↗
PubMed2003

Bacterial sinusitis as a cause of beak deformity in an Antipodes Island parakeet (Cyanoramphus unicolor).

CASE HISTORY: From 26 days of age, an Antipodes Island parakeet (Cyanoramphus unicolor) was noted to have a severe beak deformity and reduced bodyweight gain compared to its nest mate. The bird was euthanised at 43 days of age. CLINICAL AND PATHOLOGICAL FINDINGS: The beak abnormality consisted of distortion of the right nares and severe shortening resulting in deviation of the upper maxilla to the right and cranially. On sectioning the head, copious mucoid material was found in the infraorbital sinus and the bony sinus architecture was disrupted. Histopathological examination of the infraorbital sinuses revealed a large focus of chronic but active inflammation, bony lysis on the right side and pockets of a mixed population of bacteria. DIAGNOSIS: Severe beak deformity, likely secondary to bacterial sinusitis. CLINICAL RELEVANCE: The case illustrates the need to look for underlying aetiologies to beak malformation, particularly in young parrots. KEYWORDS: Sinusitis, beak malformation, Antipodes Island parakeet, parrot, beak growth.

Journal Article↗
PubMed1989

Primary structure of the hemoglobin beta-chain of rose-ringed parakeet (Psittacula krameri).

The primary structure of Rose-ringed Parakeet hemoglobin beta-chain was established, completing the analysis of this hemoglobin. Comparison with other avian beta-chains show variations smaller than those for the corresponding alpha-chains. There are 11 amino acid exchanges in relationship to the only other characterized psittaciform beta-chain, and a total of 35 positions are affected by differences among all avian beta-chains analyzed (versus 61 for the alpha-chains). At three positions, the Psittacula beta-chain has residues unique to this species. Three alpha 1 beta 1 contacts are modified, by substitutions at positions beta 51, beta 116, and beta 125.

Amino Acid Sequence↗
PubMed1989

Sleep patterns in the parakeet Melopsittacus undulatus.

Electrophysiological and behavioral studies of vigilance states were performed on adult specimens of the parakeet Melopsittacus undulatus. Four states of vigilance were identified: Wakefulness, drownsiness, slow wave sleep and paradoxical sleep. During wakefulness, a low voltage fast EEG pattern was observed. This pattern was progressively increasing in amplitude and decreasing in frequency when passing from drowsiness to slow wave sleep. Sleep spindles were not present. Slow wave sleep was frequently interrupted by paradoxical sleep episodes of short duration (6.4 +/- 3.2 sec), characterized by an EEG pattern similar to that of waking state. During wakefulness there were body and eye movements. This motor activity decreased when animals went into drowsiness and slow wave sleep. Paradoxical sleep was characterized by slight motor automatisms, including sometimes ocular movements.

Animals↗
PubMed1999

Lithium-induced alterations in the testis of the male roseringed parakeet (Psittacula krameri) : evidence for significant structural changes and disruption in the spermatogenetic activity.

In this report, we have examined the effects of lithium on testicular morphology in a male subtropical wild avian species, the roseringed parakeet (Psittacula krameri). Adult male birds were collected during the months of February-March, a time when the testicular gametogenic activity in these seasonally breeding birds is at its peak. They were injected, intramuscularly, twice daily (07:00 and 19:00 h) with lithium chloride (Sigma Chemical Company) at a dosage of 0.5 mEq/Kg body weight either for 5 or 10 days. A significant decrease in both the absolute and relative testicular weights was evident in the lithium-treated birds as compared to those of the saline-injected control animals. Light microscopic studies of the testis in the lithium-treated animals showed a wide range of degenerative changes. These included a) a significant reduction in the diameter of seminiferous tubules; b) necrosis and exfoliation of most of the germ cells in the seminiferous tubular lumen with the exception of the spermatogonia; and c) a significant reduction in the number of mature spermatozoa in the tubular lumen. These degenerative changes were dependent on the duration of lithium treatment and were evident when the plasma lithium concentrations were well below the human therapeutic range. Leydig cell morphology was not affected by lithium however. Our results provide the first experimental evidence of lithium's adverse reproductive function in an avian species. These data provide further support to the view that lithium adversely affects the male reproductive system and that these effects extend beyond mammalian species.

Animals↗
PubMed1992

Acyclovir (Zovirax) pharmacokinetics in Quaker parakeets, Myiopsitta monachus.

The pharmacokinetics of intravenous (i.v.) and intramuscular (i.m.) single-dose administration of acyclovir were determined in Quaker parakeets. After i.v. injection at a dose of 20 mg/kg of acyclovir, elimination half-life was estimated at 0.65 h, volume of distribution at steady state was 627.65 ml/kg, and clearance was 11.22 ml/kg/min. The estimated pharmacokinetic values after i.m. injection at a dose of 40 mg/kg of acyclovir were an elimination half-life of 0.71 h and a bioavailability of 90.1%. The peak plasma acyclovir concentration occurred at 15 min when the drug was administered i.m. Plasma concentrations of acyclovir were undetectable 4-6 h after i.v. administration and 6-8 h after i.m. administration. Oral (capsules) and intravenous (sodium salt) formulations of acyclovir were given by gavage at 80 mg/kg. Peak concentrations with the sodium salt formulation were lower and developed more slowly than with the capsules. In studies designed to detect excessive drug accumulation or adverse side effects, acyclovir was administered i.m. at 40 mg/kg every 8 h for 7 days. Plasma concentrations were determined 15 min after (peak) and just prior to drug administration (trough). In another study acyclovir was gavaged at a dose of 80 mg/kg every 8 h for 4 days. Acyclovir plasma concentrations were determined just prior to and 2 h after drug administration. In both experiments, the birds maintained normal appetite and weight and did not exhibit excessive drug accumulation. Acyclovir plasma concentrations ranging from 2.07 +/- 1.09 micrograms/ml to 3.93 +/- 1.13 micrograms/ml were maintained for 4 days when acyclovir was administered in the feed and water (sole source of food and water).(ABSTRACT TRUNCATED AT 250 WORDS)

Acyclovir↗