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PubMed1991

Psychobiology of the near-miss in fruit machine gambling.

Explanations involving the etiology of pathological gambling have tended to emphasize psychosocial factors. However, the possibility that psychobiological factors may be important in the development of pathological gambling behavior should not be ruled out. Psychobiological approaches are becoming ever more prominent with the three main lines of research being (a) a search for a physiological disposition and/or underlying biological substrate in pathological gamblers, (b) an examination of the role of arousal in gambling, and (c) speculation about endorphin-related explanations. The data from questionnaires and interviews with fruit machine gamblers suggest that both physiological and cognitive factors (e.g., the psychology of the near-miss) may be important in the explanation of excessive fruit machine gambling. Thus, if a gambler becomes physiologically aroused when he or she wins or nearly wins, it will stimulate further play, here termed the psychobiology of the near-miss.

Adolescent↗

PubMed1985

Psychobiological adaptation model for physical therapy practice.

This article describes the Psychobiological Adaptation Model for the practice of physical therapy. The focus of the model is optimal treatment outcome. Treatment outcome is a function of both psychobiological factors associated with the patient and clinical professional factors associated with the therapist. A second order of factors exerts its effect on treatment outcome indirectly. Psychosocial factors influence the psychobiological factors relating to the patient. Education and research professional factors influence the clinical professional factors and the quality of the clinical skills provided by the therapist. Unlike some other health professions, physical therapy does not have a well-developed conceptual model of practice. This discussion of the advantages of a model of practice focuses on the development of an integrated, programmatic approach to the advancement of physical therapy in the following three areas: service, education, and research.

Adaptation, Psychological↗

PubMed1993

The psychobiology of childhood stress.

Recent psychobiologic research has provided new insights into the interplay between constitutional and environmental etiologies in stress-induced childhood illness. Individual differences in both psychobiologic reactivity and physiologic self-regulation may substantially influence a child's internal stress responses. In addition, the physiologic consequences of a given environmental stressor may depend critically on the developmental stage in which the stressor occurs. Behavioral changes associated with early exposures to stressors may be linked to alterations in central nervous system monoamine production and metabolism. Evidence for developmental and psychobiologic changes in response to very early, even prenatal, stressors suggests that environmental and genetic contributions to stress response profiles may ultimately be difficult to disentangle.

Animals↗

PubMed2006

Psychobiological subtypes of ulcerative colitis: pANCA status moderates the relationship between disease activity and psychological distress.

INTRODUCTION: Studies of psychological factors in ulcerative colitis (UC) have produced inconsistent findings. This study sought to determine whether perinuclear antineutrophil cytoplasmic antibody (pANCA) demarcates subtypes which differ with respect to psychobiological interactions. METHODS: In 148 outpatients with UC, the strength of the relationship between current UC disease activity and psychological distress was assessed. pANCA was determined by ELISA and immunofluorescence, disease activity was determined by symptoms, physical examination, and endoscopy using the St. Mark's index, and depressive symptoms and health anxiety were measured with self-report scales. Pearson correlations between disease activity and depressive symptoms and between disease activity and health anxiety were calculated. RESULTS: In 74 pANCA negative subjects, the relationship between disease activity and measures of psychological distress was significant for disease activity-depression (partial correlation = 0.48, p < 0.001) and for disease activity-health anxiety (partial correlation = 0.64, p < 0.001), whereas in 74 pANCA positive subjects, no relationships were found (disease activity-depression: partial correlation = 0.18, p= 0.14; disease activity-health anxiety: partial correlation = 0.20, p= 0.09). The differences in the strength of correlation between pANCA positive and pANCA negative subjects were statistically significant for both disease activity-depression (z = 2.0, p= 0.02) and activity-health anxiety (z = 3.3, p < 0.001). CONCLUSIONS: pANCA status demarcates psychobiologically distinct subtypes of UC, such that the absence of pANCA is associated with greater psychobiological interaction. These findings have implications for clinical care and understanding the pathophysiology of intestinal inflammation.

Adult↗

PubMed2005

Marital-role quality and stress-related psychobiological indicators.

BACKGROUND: The quality of one's marital relationship is gaining recognition as a potential stressor associated with negative health outcomes. PURPOSE: In this study, we estimated the relationship between marital-role quality and three psychobiological stress indicators (self-reported stress, cortisol levels, and ambulatory blood pressure). METHOD: Participants were 105 middle-age adults (67 men, 38 women) who had previously taken part in the Whitehall psychobiology study. Ambulatory monitoring and saliva sampling were carried out over a working day, and marital relationships were assessed with the Marital/Partner Role Quality scales. RESULTS: We found that marital-role concerns (but not marital-role rewards) were related to all three psychobiological stress indicators; results did not vary by gender. Specifically, participants with more marital concerns reported greater stress throughout the day (p=.014), showed an attenuated cortisol increase following waking (p=.042) and a flatter cortisol slope over the day (p=.010), and had elevated ambulatory diastolic blood pressure over the middle of the workday (p=.004), with a similar trend in systolic pressure (p=.069). CONCLUSIONS: The results suggest that in addition to the carryover of work stress into domestic life that has been evident for many years, there are also influences of domestic strain on biological function over the working day and evening. Previous research suggests that a possible mechanism linking troubled marriages to health outcomes is depressed immune functioning. This study suggests a second mechanism-poorer stress-related biological response.

Blood Pressure↗

PubMed2002

Psychobiological and evolutionary perspectives on coping and health characteristics following loss: a twin study.

An analysis of coping, grief and health characteristics is reported for a bereaved monozygotic (MZ) and dizygotic (DZ) same-sex twin sample. The data were examined with reference to psychobiological and evolutionary perspectives on behavior. A Coping Scale, included as part of a comprehensive Twin Loss Survey (TLS), assessed coping with daily responsibilities and activities 1-2 months before the co-twin's death, 1-2 months following the co-twin's death and currently. A Grief Intensity Scale obtained judgments of grief 1-2 months following the loss, and currently. Information on physical symptoms was available from the Somatization Scale of the Grief Experience Inventory. Psychobiological and evolutionary perspectives specified hypotheses for two twin groups: one model was specified to reflect bereavement experiences immediately following loss of the co-twin (retrospective twin group); a second model represented present bereavement response (current twin group). Consistent with psychobiological theory, twins' social closeness showed a positive association with grief intensity which, in turn, affected somatic symptoms and coping efficacy in predicted directions. With respect to evolutionary psychological theory, the effect of zygosity on current grief implicated correlates of genetic relatedness as factors in the bereavement process.

Activities of Daily Living↗

PubMed1997

Psychobiology of HIV infection.

This review surveys evidence relevant to the proposition that psychobiologic factors may influence the progress of infection with human immunodeficiency virus Type 1 (HIV-1). Little research has directly examined the influence of psychobiologic factors on the pathogenetic mechanisms underlying HIV progression. However, basic research in neuroimmune interactions indicates that activation of the sympathetic nervous system and hypothalamic-pituitary-adrenal axis can influence several immunologic processes relevant to HIV pathogenesis and the body's ability to resist the progress of infection. A small number of observational natural history studies indicate that certain psychosocial characteristics may be associated with differential disease progression (e.g., subjective responses to highly threatening events, and inhibited psychosocial characteristics). We address some of the methodologic and conceptual issues critical to the interpretation of current results as evidence that psychobiologic processes influence HIV progression, and we conclude by highlighting promising areas for future inquiry.

Acquired Immunodeficiency Syndrome↗

PubMed2006

Exercise and psychobiological processes: implications for the primary prevention of coronary heart disease.

Interventions that reduce the magnitude of psychobiological responses are justified, at least in part, by the notion that exaggerated responses to stress can have detrimental effects on health. The biological processes underlying the association between stress and coronary heart disease (CHD) are thought to involve haemodynamic, neuroendocrine, inflammatory and haemostatic pathways. One of the many recognised benefits of exercise is in buffering physiological responses to psychosocial stressors, which is thought to be partly mediated by sympatho-inhibitory mechanisms, although other potentially important psychobiological processes such as inflammatory, neuroendocrine and haemostatic pathways have gained little attention. Thus, the present review focuses on the role of exercise in buffering psychobiological processes, particularly in relation to pathways that are directly relevant for reducing CHD risk. There are inconsistencies in the literature regarding the effects of exercise on cardiovascular responses to stressors, which may in part be accounted for by differences in experimental design, characteristics of participants, inadequate assessment of physical fitness, and the confounding effects of acute exercise. However, new emerging evidence suggests that exercise promotes an anti-inflammatory environment and increases tissue sensitivity to glucocorticoids, which may have implications for the effects of exercise on stress-induced inflammatory pathways. Future work should focus on the efficacy of exercise for promoting anti-inflammatory pathways in relation to psychosocial stress.

Coronary Disease↗

PubMed1986

[Psychotherapeutic effects of psychotropic drugs: principle considerations from the psychobiologic viewpoint].

The paper presents, from a psychobiological perspective, a critical and pragmatic discussion on fundamental questions related to the psychotherapeutic effects of psychopharmacological drugs. A series of definitions of the terms "psychopharmacological drugs", "cerebrotropic" and "psychotropic", "psychoactive and psychotherapeutic effects" and psychobiological" are initially given and set within a psychobiological framework of reference. The purpose of this is to reduce inherent contradictions of conventional definitions and to prove the heuristic value of the new concept. The epistemological basis of the presented reasoning is the psycho-physical identity theory that is based on the theories of systems and biological evolution. The author further discusses questions on the neurobiological and psychotherapeutical effects of psychopharmacological drugs, their locus and mechanism of action and other aspects related to the theme. Finally, the problem is raised as to how to separate from each other the multidimensional therapeutic factors, which alltogether result in the final psychotherapeutic effect of the drugs. Among these therapeutic factors, the so-called placebo is of prominent importance; the author presents a definition of placebo that fit the conceptual framework of the paper.

Brain↗

PubMed1977

The psychobiological model and multiple discriminant function analysis of high-calibre oarsmen.

Candidates for New Zealand rowing teams (N = 181) were given a battery of physiological, performance, anthropometric and psychological tests in order to test the psychobiological model for prediction of athletic success. A series of stepwise multiple discriminant function analyses were conducted on both separate sub-sets of variables and their combinations. The expectation that the model would not differentiate between the three age categories of oarsmen (Juniors, Colt and Senior) except for age-related factors was upheld. A more specific test of the model was an examination of the accuracy of discrimination within each age group between those who were selected for New Zealand teams and those who were not selected. The results indicated that such differentiation was best when the biological and psychological variables were used in concert. The major discriminators between selected and nonselected oarsmen on the psychobiological functions were certain anthropometric and psychological variables. Further support for the notion of the existence of a rowing stereotype was provided by testing the Senior discriminant function on the other two groups. It was concluded that the results were in accordance with the multidisciplinary psychobiological model.

Adolescent↗

PubMed1989

Psychobiological concomitants of history of suicide attempts among violent offenders and impulsive fire setters.

Psychobiological data on 58 violent offenders and impulsive fire setters were analyzed for associations with history of suicide attempts. Subjects with a history of suicide attempts serious enough to require an admission to a medical facility had significantly lower mean cerebrospinal fluid 5-hydroxyindoleacetic acid and 3-methoxy-4-hydroxyphenylglycol concentrations than subjects who had not made such attempts. A linear discriminant function analysis based on psychobiological and behavioral variables correctly classified 79% of the subjects according to the suicide attempt history positive and negative outcomes.

Adult↗

PubMed2000

Developmental psychobiology: a look back on 30 years.

Developmental Psychobiology publishes papers from the disciplines of psychology, biology, neuroscience, and medicine that contribute to an understanding of behavioral development. Research focuses on development in the embryo/fetus, neonate, juvenile, and adult as well as multidisciplinary research that relates behavioral development to anatomy, physiology, biochemistry, genetics, and evolution. The journal represents a broad phylogenetic perspective on behavioral development by including studies on invertebrates, fish, birds, non-human primates, and humans. This paper presents an analysis of empirical articles published since its first issue in 1968. This analysis covers number of authors, sex of first author; evidence of grant support, and participation of investigators from outside the US. Additionally, the analysis includes the topic of research, level of analysis, and subject of experimental study. Over its 32-year history, Developmental Psychobiology has published papers on a wide range of topics representing a broad phylogenetic perspective with a continued focus on behavioral investigation. This analysis revealed trends such as an increase in the number of studies at a physiology/anatomy level, an increase in studies with human subjects, and increases in contributions from investigators outside of the United States as well as women.

Animals↗

PubMed2007

Psychobiological effects observed in obese men experiencing body weight loss plateau.

Our objective was to investigate the psychobiological impact associated with resistance to further weight loss in obese men. Anthropometric and body composition measurements, resting metabolic rate (RMR) measurement, appetite sensation markers, and three questionnaires [Short Form-36 Health Survey (SF-36), Three-Factor Eating Questionnaire (TFEQ), and Beck Depression Inventory (BDI)] were assessed at baseline and after 1 month of body weight loss plateau induced by a supervised diet and exercise clinical intervention in 11 obese men. The weight loss plateau corresponded to 11.2% of initial body weight (93.9% from fat stores). However, this amount of weight loss induced a significant decrease in RMR (P <.05) and a significant increase in hunger (P <.05) and desire to eat (P <.05). Using the SF-36 Health Survey, physical and mental health were shown to be unchanged at plateau as compared to baseline. The TFEQ showed that cognitive dietary restraint increased (P <.001) compared to baseline. Finally, depression risk as measured by the BDI significantly increased at plateau (P <.01) compared to baseline. Weight loss until resistance to further weight loss may be detrimental for some psychobiological variables including depression, which emphasizes the relevance of caution and reasonable objectives when prescribing a weight reduction program for obese individuals.

Adult↗

PubMed1981

Psychobiology of experimental hypertension: evaluation of the Dahl rat lines.

The Dahl salt-sensitive (DS) and salt-resistant (DR) rat lines were selectively bred to show opposite genetically determined blood pressure responses to excess sodium chloride ingestion. These animals have provided significant anatomical, physiological, and biochemical data concerning the pathological mechanisms of experimental hypertension. Research is also being conducted to determine the relevance of psychobiological and behavioral variables in these two lines. The rationale for the selection and maintenance of the Dahl model and the physiological, biochemical, and behavioral characteristics which distinguish DS and DR rats are presented. Although originally developed for the study of salt-induced hypertension, special attention is given to the application of this animal model in behavior genetic research, stressing its inherent advantages and limitations. The use of the Dahl model in psychobiological studies and the utility of the model for future behavioral, genetic, and psychophysiological research are also detailed.

Animals↗

PubMed1993

Fetal experience revealed by rats: psychobiological insights.

Psychobiological studies of fetal ontogenesis in non-human species, particularly in laboratory rat, now have much to offer students of human development. Psychobiological approaches are 'ecologically' oriented which, for fetal research, implies consideration of the adaptive significance of behavior within the uterine habitat. Consistent with this orientation is a concern for the sensory capabilities of the fetus, especially in relation to the specific forms and levels of stimulation that occur within the uterine milieu. We describe recent advances in these areas, and the impressive range of fetal responses to naturally-occurring (often mother-induced) forms of sensory stimulation. To the psychobiologist, sensory-evoked responses of all kinds constitute the fetus' experience and much has been learned about the roles of such experience in regulating the rate, direction, and form of development. Indeed, experience can be considered a significant, if not neglected, mechanism of development. Finally, we briefly survey some contemporary analyses of the interrelations between developmental and evolutionary processes. We use onset of sensory function (which occurs in a stereotyped sequence in every vertebrate species for which there are data) as a developmental phenotype. Phylogenetic considerations of sensory development are discussed. By identifying and clarifying some of the intellectual questions that guide perinatal research with non-human species, we hope to improve the appreciation of novel insights and interpretive strategies that derive from different approaches. This is bound to enhance the study of human development and to improve the design and use of animal models.

Animals↗

PubMed2004

Adaptive and maladaptive psychobiological responses to severe psychological stress: implications for the discovery of novel pharmacotherapy.

Post-traumatic stress disorder (PTSD) is one of the few DSM-IV diagnoses contingent upon a psychosocial stressor. In this context, there is an urgent need to acquire a better understanding of both the adaptive and maladaptive psychobiological responses to traumatic stress. Preclinical investigators have utilized a variety of animal models to identify the behavioral and neurobiological features of the organism's response to stress. However, given the complexity of the healthy and pathological human response to physiological and psychological stress, the extent to which the animal data is immediately transferable to human remains to be fully determined. This review draws upon preclinical and clinical literature to examine the transformation of an adaptive human stress response into a maladaptive and debilitating mental disorder. An integrative psychobiological model for PTSD is presented, linking psychological processes and behavioral patterns with current findings in neurocircuitry, neurochemistry and psychophysiology. The implications of this model for the discovery of novel pharmacological approaches to the treatment of severe psychological distress are discussed.

Adaptation, Physiological↗

PubMed2005

Psychobiological impact of a progressive weight loss program in obese men.

Psychobiological effects associated with a progressive body weight loss may help to improve the understanding of psychological barriers to weight loss. We hypothesized that a moderate body weight loss (about 10% of initial body weight) is accompanied with some negative psychological impact. Four questionnaires [SF-36 Health Survey, Three-Factor Eating Questionnaire (TFEQ), Beck Depression Inventory (BDI) and Pittsburgh Sleep Quality Index (PSQI)] were administered at each phase of a body weight loss program that consisted of a supervised diet and exercise clinical intervention to 11 obese men (mean BMI = 33.4 kg/m(2), mean age = 38 yr). The three phases investigated were: 1) at the beginning of the intervention (baseline); 2) after 5 +/- 1 kg body weight loss (Phase 1); and 3) after 10 +/- 1 kg body weight loss (Phase 2). Using the SF-36 Health Survey, physical and mental health were shown to be significantly improved at Phase 1 (p < 0.05). The TFEQ showed that cognitive dietary restraint increased (p < 0.001), and both disinhibition (p < 0.05) and susceptibility to hunger (p < 0.05) were significantly reduced at both Phase 1 and 2 compared to baseline. Depression as measured by the BDI significantly increased at Phase 2 (p < 0.05) compared to baseline and Phase 1. However, the mean BDI scores observed remained below the cut-off point for likely clinical significance. Finally, the PSQI showed that sleep quality was significantly improved at Phase 1 compared to baseline (p < 0.01). Altogether, these results suggest that a substantial improvement in the psychobiological profile occurs with a 5-kg weight loss (Phase 1) but that with additional weight loss (Phase 2) a small, but significant increase in depression occurred and seems to be associated with the increase in rigid restraint of eating. However, prospective studies with a larger sample are needed to confirm and deepen these results.

Adult↗

PubMed2005

Psychobiological perspectives on somatoform disorders.

Common physical symptoms such as abdominal pain, headache, back pain and dizziness play a major role for the health care system. Existing models for the development and maintenance of these symptoms emphasize a vicious circle with cognitive-perceptual, behavioral, and psychobiological components. In this manuscript, we present examples of psychobiological factors that might contribute to somatoform disorders. We emphasize that somatoform symptoms are not strictly mental events, but are associated with a diversity of biological processes. The possible role of the endocrine and immune system, amino acids and neurotransmitters, but also physiological activation and cerebral activity is exemplified. These approaches are categorized using a model of perception and filtering of bodily signals. Studies are needed that combine the investigation of different biological systems with assessments of psychological variables in longitudinal trials, but also experimental investigations in humans examining the interaction of behavior changes, biological variations, and body perception are still rare.

Animals↗