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PubMed1989

Subclavian perivascular block: influence of location of paresthesia.

Subclavian perivascular block of the brachial plexus was used in 156 adult patients undergoing orthopedic hand and forearm surgery. The location of the elicited paresthesia prior to deposition of 30 ml of a solution containing 1% mepivacaine, 0.2% tetracaine and 1.200,000 epinephrine was recorded. Twenty minutes later the quality of the block in the distribution of the superior, middle and inferior trunks of the brachial plexus was evaluated. Anesthesia in each of the three trunks was compared with the three sites where the paresthesia was elicited (superior, middle, or inferior trunk). A middle trunk paresthesia was the most successful in producing surgical anesthesia of all three trunks. A superior trunk paresthesia was the paresthesia most often elicited. It resulted in a significantly lower incidence of inferior trunk anesthesia than did a middle or inferior trunk paresthesia. Complications included arterial puncture (25.6%), Horner's syndrome (64.1%), and recurrent laryngeal nerve block (1.3%), with no instances of symptomatic phrenic block or symptomatic pneumothorax.

Adult↗
PubMed1995

A 21 year retrospective study of reports of paresthesia following local anesthetic administration.

A retrospective study of paresthesia following the injection of local anesthetic in dentistry was conducted by examining every report of paresthesia recorded by Ontario's Professional Liability Program from 1973 to 1993, inclusive. Only those cases where surgery was not conducted were considered in this study. The parameters examined included patient age and gender, needle gauge, site of injection, area affected, report of pain or any additional symptoms, and the type of local anesthetic used. From 1973 to 1993, there were 143 reports of paresthesia not associated with surgery. There were no significant differences found with respect to patient age, patient gender, or needle gauge. All reports involved anesthesia of the mandibular arch, with the tongue most frequently reported to be symptomatic, followed by the lip. Pain was reported in 22 per cent of the cases. Paresthesia was reported most often following the injection of articaine and prilocaine. In 1993 alone, there were 14 reports of paresthesia not associated with surgery. This can be projected to an incidence of 1:785,000 injections. Articaine was administered in 10 of these cases or prilocaine in the other four. The observed frequencies of paresthesia following the administration of articaine (p < 0.002) or prilocaine (p < 0.025) were significantly greater than the expected frequencies for these agents, based on the distribution of local anesthetic use in Ontario in 1993. These results are consistent with the suggestion that local anesthetic formulations may have the potential for mild neurotoxicity. Further studies are needed to investigate the mechanisms for this, and to determine whether similar findings would be found elsewhere.

Adult↗
PubMed2005

Distribution of paresthesias in Carpal Tunnel Syndrome reflects the degree of nerve damage at wrist.

OBJECTIVE: To verify whether the distribution of paresthesias in patients with Carpal Tunnel Syndrome (CTS) is related to the degree of the neurophysiological involvement. METHODS: We performed a cross-sectional study and retrospectively evaluated 163 patients who referred to our electromyography lab and to which a clinical and electrophysiological diagnosis of CTS was made. We divided the patients into two groups: (1) patients complaining of paresthesias at the hand as a whole and (2) patients with paresthesias in the territory of the median nerve. We referred to the distribution of paresthesias at the hand as GLOVE and to the distribution in the territory of the median nerve as MEDIAN. We compared the neurophysiological impairment in GLOVE and MEDIAN distributions. Moreover, we performed multiple regression analysis to evaluate which clinical-neurophysiological variables determined GLOVE and MEDIAN distribution. RESULTS: In our sample, 70.4% of patients had GLOVE distribution and 29.6% of patients MEDIAN distribution. The risk of presenting MEDIAN distribution increases about twice (OR = 2.07; 95% IC: 1.51-2.83) for each unitary increment of neurophysiological class. CONCLUSIONS: The distribution of paresthesias reflects the degree of nerve damage at wrist; patients suffering of SEV/EXT CTS present MEDIAN distribution. SIGNIFICANCE: Our data have important clinical implications because they strongly suggest that we have to consider the possibility of a severe neurophysiological involvement of the median nerve at wrist in patients complaining of MEDIAN distribution.

Adult↗
PubMed2005

Epidural catheter-induced paresthesia accompanied by changes in skin color and temperature in an obstetric patient.

Placement of epidural catheters for labor analgesia is a common procedure that has become more popular in recent years. However, this procedure can often cause paresthesia, which is typically characterized as a transient and intense burning pain radiating to the hip or leg. In this case report, we describe a patient who had persistent paresthesia in her right foot caused by an indwelling epidural catheter, which was successfully relieved following a partial withdrawal of the epidural catheter. More interestingly, we also observed dramatic changes in skin color and temperature (cold and pale) on her right foot that was well correlated both in time and location with the epidural-induced paresthesia. This cold and pale skin on the right foot represents a localized sympathetic discharge associated with the epidural-induced paresthesia, a phenomenon that has not previously been described. Based on the location of the paresthesia and the pathway of the sympathetic nerve fibers, it is unlikely that this localized sympathetic discharge was due to a direct irritation of the preganglionic sympathetic fibers in the spinal nerve roots by the epidural catheter and thus, a spinal reflex was probably involved. This phenomenon provided us with additional clinical evidence of nerve root irritation, which prompted us to act quickly, and resulted in a favorable outcome.

Adult↗
PubMedDate not supplied

Influence of lumbar spine pathology on the incidence of paresthesia during spinal anesthesia.

BACKGROUND AND OBJECTIVES: Paresthesia occasionally occurs during dural puncture or injection of local anesthetic for spinal anesthesia. Although the incidence of neurologic complications after spinal anesthesia is extremely low, the significance of paresthesia is unknown. The influence of known lumbar spine pathology on the incidence of paresthesia during spinal anesthesia is studied. METHODS: Incidence of paresthesia with dural puncture (PP) or injection (PI) was studied in two groups of patients. Group 1 included patients for elective total joint replacement without known spine pathology or complaints. Group 2 included patients for elective lumbar spine surgery who received spinal anesthesia. RESULTS: Significantly more PP (20% vs 9%) and PI (16% vs 6%) occurred in the spine surgery group. There were no neurologic sequelae of spinal anesthesia. CONCLUSIONS: This information suggests that the incidence of paresthesia during the conduct of spinal anesthesia is higher in patients with lumbar spine pathology. Although there were no neurologic complications, the sample size is too small to exclude an increase in the neurologic risk of spinal anesthesia in patients with known intraspinal pathology.

Adrenergic Agonists↗
PubMed2000

Pyrethroid-induced paresthesia--a central or local toxic effect?

BACKGROUND: Pyrethroid-induced paresthesia is frequently seen after dermal exposure to pyrethroids. Affected individuals experience a sensation of burning, tingling, itching, or numbness, most commonly in the face. This occurs 1-2 hours after the beginning of exposure and resolves spontaneously. MECHANISMS: Paresthesia occurs as a result of a direct effect on intracutaneous nerve endings at very low pyrethroid doses. It is related to potency of the pyrethroid with pyrethroids without an alpha-cyano group generally showing the weakest effect. CONCLUSION: Doses sufficient to cause paresthesia are far lower than those causing central or systemic toxicity. Paresthesia is therefore considered to be a localized nuisance effect. The best advice to affected individuals is to prevent paresthesia from occurring through appropriate hygiene measures and personal protection.

Administration, Topical↗
PubMed2003

Paresthesia associated with endodontic treatment of mandibular premolars.

The objective of this retrospective study was to determine how often paresthesia occurs and to examine the role of the anatomy of the inferior alveolar nerve (IAN). The study took the form of a review of the records of the endodontic department at the Creighton University School of Dentistry, a literature review, and cadaver dissections. The result showed that of 6313 teeth treated during a 7-yr period, 832 were mandibular premolar teeth. The eight reported cases of paresthesia in that group reflected an incidence of 0.96%. Observations of dissected human-cadaver mandibles indicated that the paresthesias of the mandible could be related to the confinement of the IAN within the limits of the mandible. It was concluded that these paresthesias were related to the intrabony course of the IAN through the mandible, which contributed to the paresthesia symptoms.

Adult↗
PubMed1997

Effect of anode-cathode configuration on paresthesia coverage in spinal cord stimulation.

OBJECTIVE: To provide a theoretical basis for the selection of the anode-cathode configuration in spinal cord stimulation for the management pain when one percutaneous epidural electrode or two electrodes in parallel are used. METHODS: A computer model of spinal cord stimulation at T8-T9 was used to calculate the dorsal column areas recruited in stimulation by various configurations used in clinical practice. RESULTS: Tripolar (or bipolar) stimulation by a single electrode, symmetrically placed over the dorsal columns, recruits the largest area and will give the widest paresthesia coverage. Stimulation by two symmetrically placed electrodes connected in parallel to a single channel pulse generator may give similar results, because of their generally smaller distance from the spinal cord, but a "summation effect" does not exist. A smaller dorsal column area is activated when two offset electrodes are used. An electrode placed laterally or transverse bipolar stimulation results in unilateral, usually segmentary, paresthesia. CONCLUSIONS: The relative positions of cathodes and anodes and their distance from the spinal cord are the major determinants of dorsal column/dorsal root activation and paresthesia distribution. The large interpatient variability of the intraspinal geometry is the main cause of differences in paresthesia coverage among patients having optimally placed electrode(s). Changes of paresthesia coverage over time are more probable when multiple electrodes are used.

Computer Simulation↗
PubMed2005

Unexpected return of sensation following 4.5 years of paresthesia: case report.

Neural damage leads to a transient or persistent alteration, depending on the severity or type of injury sustained. During the last decade, many investigators reported on paresthesia related to dental implants. In this case report, the patient had presented repeatedly with swelling and suppuration, showing typical signs of peri-implantitis. In addition, the implant was placed in proximity to the mental foramen and possibly had traumatized the mental nerve because the patient had had an altered sensation on his left side for the past 4.5 years. After removal of the implant, a significant diminishing of the paresthesia had occurred, described by the patient as a 40% improvement. Further improvement occurred at 6 and 9 months. In this case report, the findings differ from the current literature in that the return of sensation occurred following a prolonged state of paresthesia. This report documents 2 unique findings. First, an area of persistent paresthesia significantly improved 50 months after the initial injury, upon the removal of the offending implant. Second, the placement of another implant in the same vicinity did not result in recurrent paresthesia.

Adult↗
PubMed1996

Focal paresthesias with cervical magnetic stimulation.

Subjects undergoing cervical magnetic stimulation with an appropriate coil report focal hand paresthesias in a dermatomal distribution, but the physiologic accuracy of such subjective experiences has been uncertain. In six subjects, we used a butterfly-shaped magnetic coil to stimulate positions on the back of the neck at 1-cm intervals, constant output, and random order, while the subject-estimated location and intensity of paresthesias and sensory nerve action potentials (SNAPs) were recorded from the thumb or index finger. Three subjects each also had recording of finger accelerometry or compound motor action potentials (CMAPs) in the hand and forearm. We found a consistent correlation between subjective paresthesias and SNAPs but an appropriate anatomic divergence between paresthesias and accelerometry or CMAPs. Focal paresthesias from cervical magnetic stimulation are reliable and anatomically accurate, strengthening the hypothesis that other magnetic sensory phenomena are valid as well.

Action Potentials↗
PubMed2006

Piperacillin/tazobactam-induced paresthesiae.

OBJECTIVE: To describe a case of a delayed-type hypersensitivity (DTH) reaction to piperacillin/tazobactam in which painful paresthesiae were a predominant feature. CASE SUMMARY: A 27-year-old man with a history of intravenous drug abuse was admitted for treatment of a pulmonary parenchymal abscess in the setting of lower-limb deep-venous thrombosis and methicillin-sensitive Staphylococcus aureus bacteremia. He was treated with intravenous piperacillin/tazobactam 4.5 g 3 times daily; however, after 2 weeks of therapy, he developed symptoms (eg, fever, chills) and laboratory abnormalities (eg, white blood cell count 2.1 x 10(3)/mm3, erythrocyte sedimentation rate 63 mm/h) suggestive of a DTH reaction. This was accompanied by infusion-related painful paresthesiae. The symptoms and laboratory abnormalities resolved within 48 hours of treatment being switched to flucloxacillin. DISCUSSION: Due to the close temporal association and the absence of any other obvious explanation, we believe these paresthesiae represent an additional feature of the DTH reaction to piperacillin/tazobactam in this patient. Use of the Naranjo probability scale indicated a probable relationship between the paresthesiae and administration of piperacillin/tazobactam. CONCLUSIONS: To our knowledge, as of March 24, 2006, this is the first case in which a DTH reaction to piperacillin/tazobactam manifesting as fever, neutropenia, and thrombocytopenia has been associated with paresthesiae.

Adult↗
PubMed1995

Paresthesia in envenomation by the scorpion Leiurus quinquestriatus.

We observed two patients with systemic paresthesia as the sole systemic manifestation of envenomation by L. quinquestriatus. A prospective study of the incidence of local and systemic paresthesia in 20 consecutive patients stung by this scorpion was done. Sixteen patients (80%) had only local complaints and 4/20 (20%) had mild systemic manifestations. Eleven patients (55%) had local paresthesia and in 2 patients (10%) systemic paresthesia was noted involving all four extremities in one patient and the perioral area in the other. The possible mechanism of paresthesia following a scorpion sting is discussed.

Adult↗
PubMed2004

[A variant of Guillain-Barré syndrome with prominent bilateral peripheral facial nerve palsy--facial diplegia and paresthesias].

A patient with Facial diplegia and paresthesias, a rare regional variant of Guillain-Barré syndrome (GBS), is described. A 37-year-old woman developed paresthesias in the distal limbs and subsequently bifacial weakness. She had had a preceding episode of laryngitis. Neurological examination showed severe facial diplegia with loss of taste sensation on the tip of the tongue. Limb muscle power was preserved. Deep tendon reflexes were generally absent. She complained of paresthesias in the distal limbs, but sensory examination was normal. Cerebrospinal fluid showed albuminocytological dissociation. Electrophysiological studies revealed severe facial nerve involvements and demyelinative findings in her limbs. Intravenous immunoglobulin rapidly improved the abnormal sensation in her limbs. Although facial diplegia gradually lessened after the therapy, mild residual weakness was noted 6 months after the neurological onset. To diagnose facial diplegia and paresthesias, it is important to clarify the findings common to typical GBS such as the antecedent illness, acute and monophasic course, distal paresthesias, areflexia, cerebrospinal fluid albuminocytological dissociation, and demyelinative conduction abnormalities in the limbs.

Adult↗
PubMed2001

Inferior alveolar nerve paresthesia caused by endodontic pathosis: a case report and review of the literature.

Sensory disturbances such as anesthesia, hypoesthesia, hyperesthesia, and paresthesia may be present in the oral cavity, stemming from many local and systemic factors. Paresthesia of the inferior alveolar nerve is quite rare because of the unique anatomy of this nerve. Among other effects, periapical lesions can damage the nerve, resulting in paresthesia of its innervated area. Only a few cases of paresthesia caused by these lesions are reported in the literature. In this report we present a case of paresthesia of the right inferior alveolar nerve; discuss the anatomy, pathobiology, and etiology; and suggest that a periapical lesion affecting the lower right second molar (No. 31) may have been the cause. The routine x-rays (intraoral and panorex) and the axial and cross-sectional tomographs of the mandible by means of computed tomography contribute to making this case a good example of nerve injury.

Cranial Nerve Diseases↗
PubMed2000

Mechanisms of paresthesias arising from healthy axons.

Paresthesias are common manifestations of central and peripheral pathological processes and are due to ectopic impulse activity in cutaneous afferents or their central projections. Cutaneous afferents are more excitable than motor axons, due to differences in their biophysical properties. These differences probably include more persistent Na(+) conductance and inward rectification on cutaneous afferents, properties which probably confer greater protection from impulse-dependent conduction failure but create a greater tendency to ectopic activity. Ectopic discharges can be induced in normal afferents by four maneuvers: hyperventilation, ischemia, release of ischemia, and prolonged tetanization. The alkaline shift produced by hyperventilation selectively increases the persistent Na(+) conductance, while the membrane depolarization produced by ischemia affects both transient and persistent Na(+) channels. Postischemic and posttetanic paresthesias occur when hyperpolarization by the Na(+)/K(+) pump is transiently prevented by raised extracellular K(+). The electrochemical gradient for K(+) is reversed, and inward K(+) currents trigger regenerative depolarization. These mechanisms of paresthesia generation can account for paresthesias in normal subjects and may be relevant in some peripheral nerve disorders.

Axons↗
PubMed1984

Ectopic sensory discharges and paresthesiae in patients with disorders of peripheral nerves, dorsal roots and dorsal columns.

Ectopically generated and antidromically conducted nerve impulses were recorded in 5 patients with tungsten microelectrodes inserted into skin nerve fascicles. All patients had mainly positive sensory symptoms and reported paresthesiae which could be provoked by different maneuvers which suggested increased mechanosensitivity of the primary sensory neurons at different anatomic levels. Ectopic multiunit nerve activity correlating in intensity and time course to the positive sensory symptoms was recorded: when Tinel's sign was elicited in a patient with entrapment of the ulnar nerve at the elbow, when paresthesiae were provoked by elevation of the arm in a patient with symptoms consistent with a thoracic outlet syndrome, when paresthesiae were evoked by straining during chin-chest maneuver in a patient with an S1 syndrome due to a herniated lumbar disc, when a painful Lasegue's sign occurred during the straight-leg raising test in a patient with an S1 syndrome due to root fibrosis, and when Lhermitte's sign was elicited by neck flexion in a patient with multiple sclerosis. The sites for the ectopic impulse generation in these cases are suggested to be peripheral nerve, brachial plexus, dorsal root or dorsal root ganglion and dorsal columns. The paresthesiae were non-painful except in the patient with Lasegue's sign and the ectopic impulses were probably recorded from large myelinated afferent fibers.

Adult↗
PubMedDate not supplied

The sensitivity of motor response to nerve stimulation and paresthesia for nerve localization as evaluated by ultrasound.

BACKGROUND AND OBJECTIVE: Seeking paresthesia and obtaining a motor response to an electrical stimulus are the two most common methods of nerve localization for the performance of peripheral-nerve blocks. However, these two endpoints do not always correlate, and the actual sensitivity and specificity of either method remains unknown. The objective of this study is to determine the sensitivity of paresthesia and motor response to electrical nerve stimulation as tools for nerve localization when a 22-gauge insulated needle is used for the performance of axillary-nerve block. METHODS: After IRB approval and informed consent, 103 patients were enrolled. Real-time ultrasonography was used as the reference test. After needle-to-nerve contact was confirmed by ultrasonography, the patient was requested to report the presence of paresthesia, and a nerve stimulator was used to seek a motor response, with a stimulating current of 0.5 mA or less. RESULTS: One patient was excluded from analysis because of protocol violation. Paresthesia was found to be 38.2% sensitive and motor response was 74.5% sensitive for detection of needle-to-nerve contact. CONCLUSION: The very different and relatively low sensitivity of either technique may explain, in part, the lack of correlation previously reported between the 2 endpoints.

Adult↗
PubMed2001

The lumbrical provocation test in subjects with median inclusive paresthesia.

OBJECTIVE: To investigate the value of the Lumbrical Provocation Test (LPT) in predicting carpal tunnel syndrome (CTS) among patients with symptoms suspicious for CTS. DESIGN: Prospective unigroup technique with blinded comparison of a clinical diagnostic test with 2 commonly used methods of diagnosing CTS: electrodiagnosis and a hand diagram. SETTING: Outpatient veterans referred by a heterogeneous group of specialists and generalists to a Veterans Affairs medical center electrodiagnostic laboratory. PATIENTS: Ninety-six consecutive patients who were referred to the electrodiagnostic laboratory with median inclusive paresthesia were evaluated. INTERVENTIONS: LPT: hold hand as fist for 1 minute (to evaluate changes in paresthesia); electrodiagnostic evaluations: median and ulnar mixed nerve, antidromic sensory, and motor latencies; and hand symptom diagram to describe pain. MAIN OUTCOME MEASURES: Evaluation of symptoms of paresthesia (with or without pain) inclusive of the median nerve distribution distal to the wrist. Prevalence sensitivity, specificity, and positive and negative predictive value of LPT, and electrodiagnosis, and hand diagram tests. RESULTS: Compared with the findings obtained with electrodiagnosis, the sensitivity of the LPT was.37; specificity,.71; positive predictive value,.59; and negative predictive value,.50. Compared with the findings obtained with the use of the hand diagram as a clinical measure, the sensitivity of the LPT was.43, specificity,.71, positive predictive value,.59, and negative predictive value,.56. CONCLUSION: The LPT has minimal use in predicting CTS in patients with median inclusive paresthesia compared with 2 commonly used methods of diagnosing CTS.

Carpal Tunnel Syndrome↗