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At least 37 records · Page 2Linked to original sources
PubMed2000

[Antihypertensive substance in the leaves of kumis kucing (Orthosiphon aristatus) in Java Island].

The water decoction of leaves of kumis kucing, Orthosiphon aristatus (BL.) MIQ (Lamiaceae) which has been prescribed in Javanese traditional medicine (jamu) for the treatment of hypertension etc., was partitioned into a mixture of chloroform and water. The chloroform-soluble portion showed an inhibitory effect on the contractile responses on rat thoracic aorta smooth muscle stimulated with KCl beforehand, while the water-soluble portion showed no effect. The chloroform-soluble portion was separated to afford a new benzochromene [orthochromene A (7)], two new isopimarane-type diterpenes [orthosiphonone A (10), orthosiphonone B (11)], and two novel migrated pimarane-type diterpenes [neoorthosiphol A (12), neoorthosiphol B (13)], together with eight known compounds (1-6, 8, 9). Among those thirteen substances, it was found that a major constituent in the water decoction of leaves, methylripariochromene A (5), exhibited a continuous decrease in systolic blood pressure after subcutaneous administration in conscious stroke-prone spontaneously hypertensive rats (SHRSP).

Animals↗
PubMed2001

A long-term study on the efficacy of a herbal plant, Orthosiphon grandiflorus, and sodium potassium citrate in renal calculi treatment.

The study was performed to compare the efficacy of a herbal plant, Orthosiphon grandiflorus (OG), and the drug sodium potassium citrate (SPC) in treatment of renal calculi. Forty-eight rural stone formers identified by ultrasonography were recruited and randomly assigned to two treatment groups (G1 and G2). For a period up to 18 months, subjects in G1 received 2 cups of OG tea daily, each tea cup made from an OG tea bag (contained 2.5 g dry wt), and G2 received 5-10 g of granular SPC in solution divided into three times a day. Once every 5 to 7 weeks, subjects were interviewed, given an additional drug supply, administered a kidney ultrasound and had spot urine samples collected for relevant biochemical analysis. From the recorded ultrasound images, rates of stone size reduction per year (ROSRPY) were calculated. The mean ROSRPY was 28.6+/-16.0% and 33.8+/-23.6% for G1 and G2, respectively. These two means were not significantly different. ROSRPY values of G1 and G2 were combined and divided into three levels: Level A (ROSRPY > mean + 0.5 SD), Level M (ROSRPY = mean +/- 0.5 SD) and Level B (ROSRPY < mean - 0.5 SD). Dissolution of stones was least in Level B which was related to higher excretions of Ca and uric acid in the urine. After treatment, 90% of the initial clinical symptoms (ie back pain, headaches and joint pain) were relieved. Fatigue and loss of appetite were observed in 26.3% of G2 subjects. Our study indicates that treatment of renal calculi with OG tea is an alternative means of management. Further investigation is needed to improve dissolution of stones with a low ROSRPY.

Adult↗
PubMed1989

[Adsorbed plant extracts, use of extracts of dried seeds of Orthosiphon stamineus benth].

The work presented is related to the elaboration and the control of spray dried vegetable extracts of Orthosiphon Stamineus Benth. From these studies, it feasibility of the spray dried extracts. The best result concerning a pulverulent structure and the stability under moisture conditions is obtained using Aerosil 200. Pharmacological studies on rats have shown a diuretic activity under our experimental conditions with alcoholic and water extracts.

Diuretics↗
PubMed1992

Diuretic action of aqueous Orthosiphon extract in rats.

An aqueous extract of Orthosiphonis folium, given orally, enhances considerably ion excretion in rat to a level comparable to that obtained with furosemide. No aqueretic action is observed. The increased ion excretion is not due to the potassium content of the starting material.

Animals↗
PubMed1991

Effects of Folia orthosiphonis on urinary stone promoters and inhibitors.

Yaa-Knuatmaeo or Folia orthosiphonis showed both favourable and non favourable effects of stone prevention. Uric acid and uric acid containing stone may be prevented by the increased alkalinity of the urine after drinking Orthosiphon tea. The unfavourable effect of orthosiphon being the excretion of oxalate in the urine may result in higher risk of stone formation. However, this study may or may not apply to the stone patients since it has been done only on healthy persons and all parameters were within normal limits. We feel that Orthosiphon tea may be beneficial in prevention of uric acid stone formation. This study was supported by a grant from the Medicinal Herbs Development Fund, Mahidol University.

Drug Evaluation↗
PubMed2006

Inhibitory effects of selected Thai medicinal plants on Na+,K+-ATPase.

Extracts of ten Thai indigenous medicinal plants having ethnomedical application in the treatment of dysuria were tested for their Na(+),K(+)-ATPase inhibitory activity. The hexane extracts of Cyperus rotundus and Orthosiphon aristatus showed high potent inhibitory activity on crude enzyme Na(+),K(+)-ATPase from rat brain.

Animals↗
PubMed1989

Screening of Taiwanese crude drugs for antibacterial activity against Streptococcus mutans.

Preliminary antibacterial screening of local crude drugs was carried out using the cariogenic bacterium, Streptococcus mutans. Of 79 aqueous extracts tested, 6 crude drugs were shown to have significant antibacterial activity with minimal inhibitory concentration equal to or lower than 7.8 mg/ml (expressed in terms of dry starting material). Of these effective crude drugs, Morus australis, Ludwigia octovalvis and Thuja orientalis were very effective in inhibiting the growth of serotypes c and d of S. mutans (MIC less than or equal to 2.0-7.8 mg/ml). Elephantopus scaber, Artemisia vulgaris, Mosla chinensis and Orthosiphon aristatus also exhibited considerable antibacterial activity (MIC = 7.8-23.4 mg/ml) against both serotypes. In the presence of 5% sucrose, the antibacterial potency of the majority of the extracts did not change for type c, while the potency decreased about one-half for type d.

Anti-Bacterial Agents↗
PubMed2003

In vitro TGF-beta1 antagonistic activity of ursolic and oleanolic acids isolated from Clerodendranthus spicatus.

The mechanism of action of the aerial parts of Clerodendranthus spicatus (Thunb.) C.Y. Wu, [syn. Orthosiphon aristatus (Blume) Miq,] a medicinal plant used in China to treat human renal disease, was investigated. The aqueous and methanol crude extracts exhibited dose-dependent inhibitory activity on 125I-TGF-beta1 binding to its receptor in Balb/c 3T3 cells. Subsequent bioassay-guided fractionation led to identification of two known triterpenoidal constituents, ursolic and oleanolic acids. Ursolic and oleanolic acids inhibited the binding of 125I-TGF-beta1 to its receptor with IC 50 values of 6.9 +/- 0.8 and 21.0 +/- 2.3 microM, respectively. The results suggest that TGF-beta1 antagonistic activity is responsible, at least in part, for the therapeutic efficacy of this plant to treat humans with renal disease.

3T3 Cells↗