Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “Newborn”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed1988

Objective characterization and differentiation of sleep states in healthy newborns and newborns-at-risk by spectral analysis of heart rate and respiration rhythms.

Best parameters of power and coherence spectra of heart rate fluctuations (HR) and respiration rhythms (RR) were established to differentiate sleep states in healthy newborns and newborns-at-risk by means of multivariate variance and discriminant analysis. Nine healthy newborns and 20 newborns with low risk features were examined polygraphically. Long-term-variability of both HR and RR and coherence between HR and RR in the frequency range of 0.26-0.97 Hz, corresponding to Respiratory Sinus Arrhythmia, allow the best differentiation of neonatal sleep states S 1 and S2. Differentiation of healthy newborns and newborns-at-risk by these parameters was not possible. Thus, in studies dealing with low risk features in newborns sleep states must be previously classified. State 1 and 2 represent different autonomic organisations. State 1 is a neuro-vegetative, relatively stable state. State 2 shows cyclic increases of coherence between HR and RR within the frequency range of Respiratory Sinus Arrhythmia. These properties are related to autonomic brain stem functions and were absent in 6 out of the 20 newborns-at-risk.

Heart Rate↗
PubMed1990

The association of fetal and newborn metabolic acidosis with severe periventricular leukomalacia in the preterm newborn.

One hundred twenty preterm newborns less than 34 weeks' gestational age have been studied prospectively to determine the frequency of fetal and newborn metabolic acidosis and to examine the relationship of metabolic acidosis to periventricular leukomalacia as demonstrated by serial newborn ultrasonographic examinations. Fetal metabolic acidosis, based on an umbilical artery buffer base less than 34 mmol/L at delivery, occurred in three cases (2%), one of which had evidence of periventricular leukomalacia. Newborn metabolic acidosis that is based on a buffer base less than 34 mmol/L during the 4 days after delivery occurred in 12 cases (10%), five of which had evidence of periventricular leukomalacia. There is a significant relationship between the degree and duration of newborn metabolic acidosis and the occurrence of periventricular leukomalacia. This study indicates that systemic metabolic acidosis is an important pathophysiologic marker of periventricular leukomalacia. Intrapartum fetal asphyxia with metabolic acidosis, although an infrequent occurrence in the preterm newborn, may account for a few cases of periventricular leukomalacia, while the more common newborn metabolic acidosis, when of sufficient degree and duration, carries a high risk of periventricular leukomalacia.

Acidosis↗
PubMed1987

Differentiation of healthy newborns and newborns-at-risk by spectral analysis of heart rate fluctuations and respiratory movements.

Neonatal heart rate and its interaction with respiration were computerized by spectral and coherence analysis (FFT) to differentiate healthy newborns (n = 9) from newborns with mild neonatal risk (n = 20). An increased mean heart rate and decreased total variability have been found in newborns-at-risk. Respiratory Sinus Arrhythmia is diminished in newborns-at-risk possibly caused by an impairment of autonomic brain stem function. Furthermore, Respiratory Sinus Arrhythmia holds a central position in differentiating healthy newborns and newborns-at-risk with and without neurological abnormalities during the first year of life. Respiratory Sinus Arrhythmia is diminished in newborns-at-risk showing these abnormalities. None of the parameters discriminates between the two groups of risk infants. The final prognostic value of our results must be confirmed in further clinical follow-up examinations.

Arrhythmia, Sinus↗
PubMed1983

Glycolipids of fetal, newborn, and adult erythrocytes: glycolipid pattern and structural study of H3-glycolipid from newborn erythrocytes.

The glycolipids of blood group type O adult, newborn, and fetal erythrocytes were compared. The total amount of glycolipids was indistinguishable between adult and newborn erythrocytes. However, glycolipids with long and neutral carbohydrates and the H determinant were greatly reduced in newborn cells. On the other hand, the amount of sialylated glycolipids (gangliosides) was significantly higher in newborn cells, suggesting that during erythropoiesis sialyltransferases are more active in fetuses than in adults. The amount of each core structure, lacto-N-tetraosyl, linear lacto-N-hexaosyl, and branched lacto-N-octaosyl, was compared between adult and newborn erythrocytes. It was found that branched lacto-series glycolipids were reduced in newborn cells compared with adult cells. Thus, development from fetal to adult human erythrocytes is associated with an increase of branching and a decrease of sialylation of N-acetyllactosaminyl carbohydrate chains. The study indicates that glycolipids are quantitatively different between adult and newborn or fetus.

ABO Blood-Group System↗
PubMed1982

The effect of moderate hypoxaemia on cardiac performance in the newborn during anaesthesia and surgery - experimental studies in newborn and two-week-old piglets.

Circulatory adaptation to hypoxaemia was studied under anaesthetic and surgical conditions in 10 newborn (age 8-42 h, weight 850-1800 g) and 8 two-week-old piglets (12-16 days, 1400-3600 g). Arterial PO2 was lowered from 60-100 mmHg to 30-40 mmHg by reducing FiO2 (concentration of oxygen during inspiration) at otherwise constant conditions; control studies were performed under the same standard conditions maintaining normoxaemia during the whole experiment in 8 newborn and 8 two-week-old piglets of comparable weight. In both hypoxic groups a prompt compensatory, statistically significant increase of cardiac performance defined by aortic blood pressure, cardiac output, peak aortic flow, stroke volume and cardiac power appeared within a few minutes of hypoxaemia, reaching a maximum half an hour later. Thereafter cardiac performance decreased steadily leading to cardiac failure. Newborns survived 197 +/- 96 min and two-week-old animals 172 +/- 128 min. Peripheral vascular resistance decreased significantly at the time of compensatory increase of cardiac performance, but increased subsequently to a maximum shortly before cardiac failure. Compensatory increase of cardiac performance was more distinct in newborn than in two-week-old piglets. Heart rate increased steadily during exposure to hypoxaemia in both groups reaching a maximum 110 min later and falling back to pre-experimental levels at the end of study. The newborn normoxic controls tolerated the experimental model significantly longer (461 +/- 167 min; P less than 0.001) than the newborn hypoxic piglets. Their response pattern, however, was basically similar. Increase of cardiac performance reached its maximum not before 130 min after the end of the pre-experimental period with subsequent fatal decrease of cardiac performance leading to cardiac failure. Two-week-old normoxic control animals responded qualitatively identically compared with the two-week-old hypoxic animals. Despite normoxaemia their average survival time did not differ significantly (209 +/- 86 min). In all four groups severe metabolic acidosis appeared in most instances during the study, irrespective of hypoxaemia or normoxaemia. Failure of stress tolerance depended on the decrease of pH per hour. This relation was more distinct in normoxic animals. In both hypoxic groups survival time correlated well with the increase of heart rate during hypoxaemia (R = 0.71 in newborn, P less than 0.05; R = 0.86 in two-week-old piglets, P less than 0.01, respectively). This correlation could not be found in the normoxic piglets.

Adaptation, Physiological↗
PubMed1985

The effects of indomethacin administration during pregnancy on women's and newborns' T-suppressor lymphocyte activity and on HLA class II expression by newborns' leukocytes.

It has been previously shown that T lymphocytes from human newborns and pregnant women exert a suppressive activity when assayed on the PWM-induced B cell maturation. The mechanisms of the suppression have remained entirely unknown. Prostaglandin E2, known to trigger T-cell mediated suppressive activity, may be involved. We took advantage of the treatment of pregnant women with indomethacin, because of premature labor or hydramnios, to investigate the role of prostaglandins in the activation of T suppressor (TS) activity. Administration of indomethacin (250 mg/day for 1-7 weeks, then 150 mg/day for 3-12 weeks) during the third trimester of pregnancy, abrogated the TS activity in the nine women and the three newborns tested. Abrogation of TS activity by indomethacin therapy led to normal PWM-induced B cell maturation in pregnant women but not in newborns. Moreover, the low expression of HLA class II antigens observed on normal newborn B lymphocytes and monocytes was corrected in newborns from indomethacin-treated mothers. Our results strongly suggest that prostaglandins may play a role in induction of TS activity observed in normal pregnant women and newborns and in the decreased expression of HLA class II antigens on newborns' leucocytes. Both phenomena could play a role in immunological interactions between mother and fetus.

B-Lymphocytes↗
PubMed2004

Programmed obesity in intrauterine growth-restricted newborns: modulation by newborn nutrition.

The degree of nutrient enhancement during the newborn period may modulate programming of appetite-regulating hormones, body composition, and propensity to adult obesity in intrauterine growth-restricted (IUGR) newborns. Pregnant rats received, from day 10 to term gestation and throughout lactation, ad libitum food (AdLib) or 50% food restriction (FR) to produce IUGR newborns. AdLib vs. FR offspring were studied at day 1, and, to create two distinct groups of newborn catch-up growth (immediate, delayed) among the IUGR newborns, cross-fostering techniques were employed. The four groups of pups at 3 wk were IUGR immediate catch-up growth (FR/AdLib), IUGR delayed catch-up growth (FR/FR), control (AdLib/AdLib), and lactation FR control (AdLib/FR). From 3 wk to 9 mo, all offspring had AdLib rat chow. Maternal FR during pregnancy resulted in IUGR pups (6.0 +/- 0.3 vs. 7.1 +/- 0.3 g, P < 0.01) with decreased leptin (0.66 +/- 0.03 vs. 1.63 +/- 0.12 ng/ml, P < 0.001) and increased ghrelin (0.43 +/- 0.03 vs. 0.26 +/- 0.02 ng/ml, P < 0.001). Maternal FR during lactation (FR/FR) further impaired IUGR offspring growth at 3 wk. However, by 9 mo, these pups attained normal body weight, percent body fat, and plasma leptin levels. Conversely, IUGR offspring nursed by AdLib dams (FR/AdLib) exhibited rapid catch-up growth at 3 wk and continued accelerated growth, resulting in increased weight, percent body fat, and plasma leptin levels. Thus the degree of newborn nutrient enhancement and timing of IUGR newborn catch-up growth may determine the programming of orexigenic hormones and offspring obesity.

Animals↗
PubMed1989

Role of the newborn's sex in mixed maternal-newborn lymphocyte culture reactivity.

One-way-stimulated mixed mother-newborn lymphocyte cultures (MMNLC) from male and female newborns were evaluated and compared shortly after delivery. Newborn sex-correlated differences were observed in the strength of the MMNLC reactivity with responding maternal as well as newborn cells. The reactivity of MMNLC with responding maternal cells from male as compared to female newborns was significantly less inhibited in maternal and newborn serum. The inhibitory effect of maternal serum on maternal and male newborn lymphocytes in MMNLC seems to be correlated to the sex of the previous child delivered and was significantly lower when the present as well as the previous baby were of the same sex, e.g. 2 boys. The results suggest that fetal-male-specific Y-chromosome-correlated histocompatibility antigens may specifically influence the maternal immune response to her fetus.

Female↗
PubMed2004

Newborn screening for cystic fibrosis: evaluation of benefits and risks and recommendations for state newborn screening programs.

In November 2003, CDC and the Cystic Fibrosis Foundation cosponsored a workshop to review the benefits and risks associated with newborn screening for cystic fibrosis (CF). This report describes new research findings and outlines the recommendations of the workshop. The peer-reviewed evidence presented at the workshop supports the clinical utility of newborn screening for CF. Demonstrated long-term benefits from early nutritional treatment as a result of newborn screening for CF include improved growth and, in one study, cognitive development. Other benefits might include reduced hospitalizations and improved survival. Mixed evidence has been reported for pulmonary outcomes. Newborn screening in the United States is associated with diagnosis of CF a median of 1 year earlier than symptomatic detection, which might reduce the expense and anxiety associated with workup for failure to thrive or other symptoms. Certain psychosocial risks for carrier children and their families (e.g., anxiety and misunderstanding) are associated with newborn screening. Exposure of young children to infectious agents through person-to-person transmission in clinical settings, although not an inherent risk of newborn screening, is a potential cause of harm from early detection. Involving specialists in CF care and infection control, genetic counseling, and communication can minimize these potential harms. Although screening decisions depend on a state's individual resources and priorities, on the basis of evidence of moderate benefits and low risk of harm, CDC believes that newborn screening for CF is justified. States should consider the magnitude of benefits and costs and the need to minimize risks through careful planning and implementation, including ongoing collection and evaluation of outcome data.

Algorithms↗
PubMed2006

Neurological status of low-risk Vietnamese newborns: a comparison with a British newborn cohort.

A shortened version of the Dubowitz newborn neurological examination, recently reassessed in rural Thailand, was applied to a group of 58 Vietnamese newborns. The aim was to establish the neurological status of newborns in this population for use in further studies and to compare with groups previously studied. Compared to the original British cohort, the Vietnamese newborns showed significantly lower scores in 10 of 25 items, including several related to truncal tone. Evidence was sought of thiamine and long-chain fatty acid deficiency as a possible cause for these findings, but no correlation was found between the neurological status and the maternal or infant blood levels of these nutritional indicators. The findings suggest that the neurological status of low-risk Vietnamese newborns appears to lie between that of British newborns and those ethnic minority Karen newborns in refugee camps on the Thai-Burmese border tested previously. Although no specific nutritional cause has been identified in the study, the findings may still reflect sub-optimal intake of some important nutrients.

Adult↗
PubMed1998

[Serine protease inhibitors in newborns. IV. Levels of alpha-2-macroglobulin in serum of eutrophic and hypotrophic newborns and their mothers].

It is accepted that alpha-2-M may serve as an important factor for the regulation of homeostasis. For these reasons it is valuable to determine its concentration in some clinical conditions. We have found that the level of alpha-2-M is evidently higher in hypotrophic newborns than in neutrophic newborns. It is interesting to note that the mothers of hypotrophic newborns also exhibit increased concentration of alpha-2-M in comparison to the mothers of eutrophic newborns. No differences were observed in concentration of this inhibitor between mothers and this newborns in both groups. Taking under consideration these findings it seems there is an inverse relationship between cord serum alpha-2-M concentrations and birth weight of newborns. Probably the increase of this inhibitor may reflect in some extent its function as moderating factor high susceptibility hypotrophic newborns for infections since alpha-2-M plays so crucial role in inflammatory processes.

Adult↗
PubMed2005

Newborns and drug studies: the NICHD/FDA newborn drug development initiative.

BACKGROUND: Progress has been made in research on the effects of drug therapy on pediatric patients, but neonates are still an understudied population. Those most likely to receive drug therapy (eg, preterm infants) are least likely to be studied. OBJECTIVES: The purposes of this article are to summarize an initiative developed jointly by the National Institute of Child Health and Human Development (NICHD) and the US Food and Drug Administration (FDA) and to introduce a series of articles developed as a result of this initiative. METHODS: Information for this article was gathered from the proceedings of a workshop cosponsored by the NICHD and the FDA that took place March 29 and 30, 2004, in Rockville, Maryland. RESULTS: : Dosing based on use in adults and older children has resulted in adverse events among newborn infants, and may have long-term effects. Moreover, formulations appropriate for use in neonates are often unavailable, and compensatory efforts such as mixing crushed tablets into formula may interfere with accurate dose delivery. Under the Best Pharmaceuticals for Children Act of 2002, government agencies work with experts in pediatrics and pediatric research to develop and prioritize a list of off-patent drugs for which pediatric studies are urgently needed. Four such listings were published in the Federal Register from January 2003 through January 2005. The NICHD and FDA have also initiated the Newborn Drug Development Initiative (NDDI), a multiphase program to determine gaps in knowledge concerning neonatal pharmacology and clinical trial design and to explore novel study designs for use in newborns, with the ultimate goal of increasing our knowledge about the safety and efficacy of drugs used to treat newborns. CONCLUSIONS: Most drugs used to treat newborns still lack appropriate dosing, efficacy, and safety studies in this vulnerable population. The NICHD and FDA developed the NDDI as an ongoing process to identify and suggest strategies for addressing obstacles to conducting drug trials in the newborn.

Clinical Trials as Topic↗
PubMed2004

Prolonged T*2 values in newborn versus adult brain: Implications for fMRI studies of newborns.

The neonatal brain possesses higher water content, lower macromolecular concentration, and reduced synaptic density than is found in the brain of a 1-year-old child. Changes in MRI characteristics of brain such as relaxation times accompany rapid changes in brain during early postnatal development. It was hypothesized that T(*)(2) values found in newborns would be significantly higher than those found in 9-month-old children and adults as measured at 1.5 T. Spoiled gradient echo measurements of T(*)(2) within the brains of newborns, 9-month-olds, and adults confirmed this hypothesis. The results have implications with regard to functional MRI studies in newborns since, in general, BOLD signal optimization is achieved when echo times TE are set equal to the T(*)(2) values of the tissue of interest. Since significantly longer T(*)(2) values are found in newborns, it is suggested that the TE values employed for fMRI studies of newborns should be increased to maximize BOLD signal intensity changes and improve the overall reliability of fMRI results in newborns.

Adult↗
PubMed2004

Comprehensive description of newborn distress behavior in response to acute pain (newborn male circumcision).

One of the most difficult challenges still facing researchers and clinicians is assessing pain in the newborn. Behaviors provide one of the most promising avenues for deepening our fundamental understanding of complex phenomenon like newborn pain, and are key to developing descriptive-level knowledge to further newborn pain assessment efforts. In this ethologically based research, we report on the duration and frequency of neonatal distress behavior to seven distinct noxious and non-noxious but distress-provoking events including baseline (diaper change, post-diaper change, application of arm and leg restraints, post-application of arm and leg restraints, circumcision, post-circumcision) associated with newborn surgical pain. Approximately 67 min of videotaped data, involving four neonates who had undergone newborn male circumcision, were coded at 1-s intervals (4010 s in total). A reliably established coding scheme was used to code behaviors as they were observed on videotape for the duration of the seven designated events. This led to the identification of (1) 40 distress behaviors as they occurred along the continuum of distress, (2) eight distress behaviors specific to surgery, (3) 11 classes of behaviors occurring within the five sub-phases of circumcision, and (4) a description of 25 distinct post-distress behaviors. Findings support the ability to distinguish distress behaviors specific to pain and the ability to detect prolonged distress as well as individual differences in distress-related pain expression. Findings also justify ongoing use of ethological approaches to further newborn pain assessment and to investigate poorly understood topics such as infant self-regulation within the context of pain (pain recovery).

Circumcision, Male↗
PubMed2000

Role of maternal exposures and newborn genotypes on newborn chromosome aberration frequencies.

Maternal exposures may induce chromosome damage and birth defects in the fetus. Polymorphic variation in genes coding for enzymes involved in metabolic activation and detoxification of environmental procarcinogens may account for some of the differences in chromosome aberration frequencies in newborns. In this study, 40 mothers completed questionnaires regarding exposures they received during their pregnancy. Umbilical cord blood samples were analyzed for chromosome aberrations. An average of 1020 metaphase cell equivalents (equal to 1020 G-banded cells) were examined from each newborn. In 26 of the newborns, genotyping analysis was performed for genes functioning in metabolic activation and detoxification (cytochrome P450 genes: CYP2D6 and CYP1A1, and phase II genes: NAT1, NAT2, GSTT1, GSTM1, GSTP1, and epoxide hydrolase). A significant association between the CYP1A1 MspI polymorphism and chromosome aberration frequencies was observed in the newborns (p=0.02), with heterozygotes showing higher aberration frequencies than the wild type homozygotes. Some large differences in chromosome aberration frequencies for other genotypes were also noted, but these were not statistically significant. Exposure to tobacco smoke in utero also appeared to increase translocation frequencies. The mean frequency of translocations per 100 cell equivalents from newborns of mothers who smoked during pregnancy was significantly higher than that of newborns whose mothers did not smoke (0.21 vs. 0.11, respectively, p=0.045).

Acetyltransferases↗
PubMed2001

Experimental small bowel transplantation using newborn intestine in rats: III. Long-term cryopreservation of rat newborn intestine.

BACKGROUND: If long-term organ cryopreservation can be attained, a significant achievement will have been made to address the problem for donor shortage. Fetal intestine has been known to revascularize naturally without vascular anastmosis. The authors have confirmed previously that the newborn intestine also could develop to maturity in the host omentum. Here, the authors examined whether the cryopreserved newborn intestine could revascularize in the syngeneic combination using the 2 different solutions and whether cryopreservation affect their antigenicity in the allogeneic combination. METHODS: Inbred rat strains of LEW (MHC haplotype; RT1(l)) and BN (RT1(n)) were used. LEW newborn intestinal grafts were stored in RPMI-1640 or University of Wisconsin solution with 10% DEMSO (n = 10 in each group). The grafts were placed into a cold (4 degrees C) preservation solution for 30 minutes and then placed into a freezing chamber and cooled to -80 degrees C at -1 degrees C/min after 12 hours quenched to -180 degrees C in liquid nitrogen for longer than 30 days. Then, the cryopreserved grafts under the 2 different solutions were transplanted syngenicaly (LEW to LEW). The cryopreserved BN grafts also were implanted into the LEW omentum pouch. The allotransplantation was received with a 14-day high-dose course of tacrolimus (0.64 mg/kg, intramuscularly). The grafts were evaluated histologically at 4 weeks after transplantation. Fresh newborn intestines implanted in this syngeneic and allogeneic combination were evaluated as each control group. RESULT: In the syngeneic combination, more than 90% of the mature intestine were obtained. There was no significant difference among the different solution and the fresh group. However, in the allogeneic combination, both fresh and cryopreserved grafts were histologically poor. CONCLUSIONS: This is the first report showing that long-term cryopreservation was not harmful for neovascularization of newborn intestine. Long-term cryopreservation did not reduce the antigenicity of the newborn intestine. J Pediatr Surg 36:602-604.

Animals↗
PubMed1994

[The improvement on the nursing procedure for pregnant women and newborns and the decrease of Staphylococcus aureus infections in newborns and infants in our hospital].

Knowing the importance of prevention of Staphylococcus aureus infections, especially that of Methicillin-resistant S. aureus (herein after abbreviated as MRSA) in the newborn room, we improved the nursing procedure in the room and examined subsequent changes in the onset condition of the above infection in newborns and infants less than 1-year-old. The infection was detected in 13 cases of stage 1 (stage according to the nursing procedure since the opening of our hospital): 6 cases (all MRSA) had their onset in the room. MRSA was detected in 11 cases, suspecting a hospital cross infection in relation to the period of birth and coagulase type. The infection was detected in 9 cases of stage 2 (stage of prevention of inter-newborn hospital cross infection through environmental purification within the newborn room, through hand and finger disinfection of medical workers, through improved bathing, etc.); 2 cases (1 of MRSA, 1 of Methicillin-sensitive S. aureus [hereinafter abbreviated as MSSA]) had an onset in the room. MRSA was detected in 5 cases, but hospital cross infection was thought difficult to be responsible. The MRSA infection was detected in 4 pregnant cases (0.8%) of stage 3 (stage of effortful prevention of MRSA from carrying into the ward following examination of possible intra-nasal MRSA establishment in pregnant women in addition to similar newborn nursing to stage 2), indicating pregnant women's possible carrying MRSA into the newborn room. S. aureus infection was detected in 9 cases; 2 cases (MSSA) had an onset in the above room.(ABSTRACT TRUNCATED AT 250 WORDS)

Cross Infection↗
PubMed1989

Renal function in the newborn. Newborn creatinine related to birth weight, maturity and maternal creatinine.

The maternal and newborn renal function in 84 normal pregnant women delivering at term was investigated. There was no difference between maternal and newborn plasma concentrations of urea (3.9 +/- 1.0 vs. 3.9 +/- 1.2 mmol/l) and creatinine (65.8 +/- 13.3 vs. 65.3 +/- 11.6 mumols/l). The plasma sodium and potassium concentrations were significantly higher in the newborn (139.6 +/- 4.1 vs. 136.8 +/- 5.1 mmol/l, p less than 0.001, and 5.1 +/- 1.3 vs. 4.2 +/- 0.9 mmol/l, p less than 0.001, respectively). Significant correlations were found between newborn sodium (p less than 0.02) and potassium (p = 0.0001) with maternal potassium concentrations, newborn urea with maternal urea concentrations (p = 0.0001), and newborn creatinine with maternal creatinine concentrations (p = 0.0001), gestation of delivery (p less than 0.05) and birth weight (p = 0.025).

Birth Weight↗