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PubMed2006

International control of alcohol: alternative paths forward.

Alcohol was the first psychoactive substance to be subject to international control, but these agreements between colonial powers have long since fallen away. In the wake of the entry into force of the Framework Convention on Tobacco Control (FCTC), paths forward for international control of alcohol are considered. The choices embedded in the FCTC are discussed, and the justifications for a parallel convention for alcohol considered. An alternative would be scheduling alcohol under one or more of the international drug conventions, most probably the 1971 convention, although the convention would have to be amended to allow use outside 'medical and scientific purposes' and without a prescription regime. In considering potential contents of an alcohol convention, it is noted that both the FCTC and the drug conventions are concerned at least as much with domestic markets as with international trade.

Alcohol Drinking↗
PubMed2004

Harmonization, regulation, and trade: interactions in the pharmaceutical field.

This article aims to draw attention to the process of harmonization of requirements for drug registration (the so-called ICH process) and to examine how it may affect access to medicines in developing countries. The ICH process, especially when seen in conjunction with the World Trade Organization's Agreement on Technical Barriers to Trade, may create additional barriers to would-be entrants on the global pharmaceutical market, notably large generic manufacturers in developing countries-the very companies that can create credible price competition for the innovative industry and, thus, increase access to medicines. These barriers could help maintain the status quo by insulating well-established companies from competition, thereby forming a further obstacle to lower drug prices and to access to medicines, especially in developing countries. Developing countries should therefore carefully consider the implications of the positioning of ICH standards as global standards, and be vigilant with regard to their possible incorporation, whether explicitly or not, in international trade agreements.

Commerce↗
PubMed1998

World trade: bringing health into the picture.

What implications do the new multilateral trade agreements have for health and well-being? The relationship needs to be understood in order to put trade and health objectives into proper perspective. This introductory article looks at some of the areas in which international trade and public health interact.

Commerce↗
PubMed1994

Opium and infant-sedation in 19th century England.

Infant cordials containing opium were commonly used in Victorian England to quieten babies and young children. The cordials were freely available and sold under a variety of brand names. JANET BRIAN describes the slow progress towards legislative control of the sale of opium and its use in infant cordials, in which opposition from the pharmacy lobby and government reluctance to lose income from the lucrative opium trade played a major part.

Drug Industry↗
PubMed2000

Sozodont powder dentifrice and Mrs. Winslow's Soothing Syrup: dental nostrums.

The Great Patent Medicine Era (1865-1907) was the golden age of secret remedies--quack, non-prescription medicinal products, sold over-the-counter. Making outrageous and unsubstantiated claims, the makers of dental nostrums purported to effectively treat stained teeth, bad breath, diseased gums, toothache and teething discomfort. No proof was required to substantiate the safety and effectiveness of these concoctions. Advertisements for patent medicines were widespread, appearing in newspapers, almanacs, magazines, trade cards and multiple other media forms. Many dental patent medicines contained acids, abrasive substances, alcohol and/or narcotics, such as heroin, cocaine and morphine. Sozodont Tooth Powder, the most widely promoted and successful dentifrice of this era, claimed to "harden and invigorate the gums, purify and perfume the breath and beautify and preserve the teeth from youth to old age." Early dental researchers found that this remedy contained harsh ingredients (such as acid, sharp abrasives and astringents) which could destroy tooth substance. Mrs. Winslow's Soothing Syrup, an extremely popular dental nostrum, was intended to quiet a fretful child during the teething process. However, it contained generous levels of alcohol and morphine sulfate which could cause coma, addiction or death in an infant. Although somewhat chemically altered, these two products were eventually removed from the market in the 1930s.

Analgesics, Opioid↗
PubMedDate not supplied

[Analysis of potassium permanganate as addictive drug "precursor"].

Potassium permanganate is used for the production of cocaine and methylcathinone. The third convention of the UN against narcotic drugs (1988) contains a list of so-called precursors, substances commonly used for the production of narcotic drugs. The control of the precursors can be a very important step to prevent the illicit production of narcotic substances. A chemical characterization of a seized product may contribute to determine the origin of the producing company and the trade channels and to prevent further illicit deliveries. 31 samples of permanganate (19 authentic and 12 seized samples) have been analyzed for 9 metallic elements. Detailed procedures for the emission spectrography and ICP-analysis are given and the range of concentrations is tabulated. It was surprising that no significant concentrations of metals like chromium, nickel or cobalt were present. Nor was the difference between the technical and analytically pure products sufficient to make a differentiation according to origin. This is probably attributable to the technical manufacture of permanganate by electrolysis. All the statistical analyses of the results performed on the available data do not allow conclusions as to the country of origin or manufacturer, as production batches of one and the same manufacturer may also show differences. Only the morphology of the product (crystals, powder or "free flowing") allows a certain characterization. Nevertheless it seems necessary to analyze all seized samples for impurities and to establish a table of "impurity profiling" in the future in order to receive more information and to find correlations in selected cases.

Austria↗
PubMed1994

Using mass media to reduce adolescent involvement in drug trafficking.

OBJECTIVE: Drug trafficking among adolescents is a newly recognized high-risk behavior that seems to be involving large numbers of youths. Strategies to prevent and/or alter this behavior must be developed and evaluated. In view of the high exposure of adolescents to the mass media, interventionists seeking to reduce adolescent risk behavior have increasingly employed the media in their efforts to reduce adolescent risk behaviors in general. However, not all risk behaviors may be amendable to change as a result of this approach. Therefore, before utilizing this approach to address adolescent drug trafficking, it is important to investigate previous efforts targeting related risk behaviors. RESULTS: Mass media campaigns against the use of drugs have been common in the US and seem to have played a role in reducing consumption of both legal and illegal drugs. The most effective messages seem to focus on the risks of drug use and the social disapproval that attends use. The mass media may increase the influence of these antidrug messages by changing the social climate surrounding drug use. CONCLUSIONS: The mass media may be a particularly effective way to reach adolescents and their parents in communities in which adolescent drug trafficking is prevalent and to unite the institutions that could influence adolescents against involvement in the drug trade. However, intervention efforts must also contend with the economic incentives of the drug trade in poor, central-city communities.

Adolescent↗
PubMed1985

Problems of substance abuse: exploitation and control.

The notion of substance abuse is highly problematic. There is considerable disagreement amongst 'experts' as to the relative hazards and addictive properties of both legally and illegally available substances. There are also widely divergent sub-cultural attitudes to the harmfulness or benefit of drug use. One can assume no social consensus as to the nature of the contemporary 'drug problem', nor about the most appropriate means of dealing with it. There is, however, considerable evidence that criminalization of drug use, and harsh penalties against users and suppliers, are ineffective and counter-productive. Other models of control need to be considered, and in particular the merits and de-merits of the medicalization of drug abuse require examination. However, this is only one aspect of the problem. On the other side are the national and international corporations and syndicates, both legitimate and criminal, that earn vast profits from trade in toxic substances. Tobacco is legally available in every country in the world, and the industry is rarely subject to strict control. Thus the issue of substance abuse and control should be seen in a global context, in which account is taken of both legitimate and underworld operations. In attempts to control international trade in toxic substances, the limited success and the problems of already existing legal controls should be acknowledged. Local awareness and regulation of trade in substances is essential, but not sufficient. Amongst other avenues to be explored is the possibility of diverting presently illicitly grown narcotics into indigenous pharmaceutical industries in the Third World. Some problems with this strategy are noted.(ABSTRACT TRUNCATED AT 250 WORDS)

Crime↗
PubMed1991

Effects of CO2 and N2 partial pressures on cognitive and psychomotor performance.

This study examined N2 and CO2 components of narcosis by comparing the effects of three levels of PETCO2 [low = 29 mmHg (SD = 4 mmHg), medium = 47 mmHg (SD = 1 mmHg), high = 57 mmHg (SD = 2 mmHg)] at 1 and 6 atm abs in 12 male volunteers. Cognitive and psychomotor performances were examined using a variety of tasks, including a modified Stroop test, an arithmetic test, number comparison, a figure copying test, and the Purdue pegboard test. Performance on all tasks demonstrated significant (P less than 0.05) decrements at 6 atm abs. High CO2 tensions significantly impaired cognitive and psychomotor performance at 1 atm abs and caused further decrements at 6 atm abs (P less than 0.05). However, no significant N2-CO2 interaction (P greater than 0.05) or global threshold for the onset of CO2 narcosis was indicated by the test scores. The pattern of intratest results were different for N2 and CO2. At high PETCO2, performance deficits were due to a slowing of performance rather than a disruption of the accuracy of processing. Nitrogen narcosis, conversely, produced significant impairment through both decreases in the speed and accuracy of processing on the majority of performance tests. It was concluded that within the PETCO2 ranges studied: a) PETCO2 and PIN2 are additive in their effects on impaired cognitive and psychomotor performance at depth; b) high PETCO2 and PIN2 induce distinctly different strategic responses on the speed accuracy trade-off function of the performance tests; c) decrements in cognitive and psychomotor performance under high PETCO2 do not conform to the predicted narcotic potency of CO2 according to the lipid solubility theory of narcosis.

Adult↗