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Deficiency of uridine monophosphate synthase (DUMPS) and X-chromosome deletion in fetal mummification in cattle.

Ten mummified fetuses were tested for the deficiency of uridine monophosphate synthase (DUMPS), which is known to contribute to the embryonic and fetal mortality in cattle. Genomic DNAs of the mummified fetuses were extracted from tissue samples collected from the mummies and were amplified by GenomiPhi DNA amplification kit. UMPS gene of the mummies was amplified by polymerase chain reaction (PCR) with DUMPS primers. Out of ten mummies examined, two fetuses were heterozygous (carriers) for DUMPS as indicated by the presences of three bands of 89, 53 and 36 bp. Estimated stage of gestation when the death occurred in the two mummies was 3.5 and 2.5 months, respectively. The other fetuses exhibited only two bands of 53 and 36 bp on the polyacrylamide gel indicated that they were normal. On the other hand, all the mummies were sexed using AMX/Y primers. Specific regions of Y and X chromosomes were amplified by PCR using AMX/Y. The expected 280 bp fragment in the female sample and the 280 and 217 bp in the male sample were observed. Nine mummies had a normal X and Y chromosome bands; however, the other mummified fetus exhibited only Y chromosome band, while the constitutive X chromosome fragment was missing. The estimated stage of gestation when the death occurred in this mummified fetus was 100 days. This might be the first report of DUMPS and X-chromosome deletion at the amelogenin gene in bovine-mummified fetuses in Japan.

Animals↗

Artefact in forensic medicine: scrotal mummification.

Misinterpretation of postmortem artefacts in forensic medical practice may result in a misdiagnosis of criminal activity. Forensic physicians at the scene can liaise with forensic pathologists and visit the mortuary in the company of the crime scene investigators or scenes-of-crime officers to ensure all relevant facts are identified. In this case a postmortem change created by partial dessication of the scrotal skin was misinterpreted as a suspicious injury.

Journal Article↗

Mummification of fetal membranes in the bovine vagina: a case report.

Papyraceous, mummified fetal membranes were found in the vagina of a cow at the end of the fourth month after a normal delivery. The uterus and cervix were without any pathological changes. The cow conceived on Day 36 after removal of the mummified fetal membranes upon the second insemination. Apart from the uncommon nature of the case, it proves that after calving the bovine vagina can maintain a sterile environment and that the constrictive mechanism of the vagina can be strong enough to hinder for a long time the discharge of fetal membranes and access of microbes to the vagina.

Animals↗

Prolonged in utero retention and mummification of a Macaca mulatta fetus.

An intrauterine mummified fetus in a Macaca mulatta was delivered surgically 708 days after onset of the last menstrual flow. Supracervical hysterectomy and left salpingo-oophorectomy were done. The fetus consisted of a compressed but complete skeleton and hairy skin adherent to the intact, thin uterine wall. Placenta and umbilical cord could not be identified.

Abortion, Missed↗

Mummification of the infarcted myocardium by high dose corticosteroids.

There is evidence that glucocorticoids reduce infarct size but their use in myocardial infarction remains controversial because of their potential adverse effects on healing of the infarct. To investigate the healing process, rats received either four parenteral doses of 50 mg/kg of methylprednisolone (MP) or saline 5 min, 3,6 and 24 hr after coronary occlusion and their hearts were examined by light and electron microscopy 48 hr and seven days after occlusion. At 48 hr, in five untreated rats, only 12 +/- 7% of injured myocytes showed the persistence of striations and a relatively intact sarcolemma despite loss of nuclei and hence appeared "mummified" whereas in six MP-treated rats 72 +/- 8% of myocytes exhibited this appearance (P less than 0.001). In treated rats there were fewer phagocytes than in controls. At seven days, in seven MP-rats, mummified cells were still more prominent than in five untreated rats and there were fewer phagocytes and less collagen. In conclusion, high dose of MP delays the inflammatory process and retards the disintegration of necrotic myocytes, resulting in impaired healing.

Animals↗

Mourning, mummification and living with the dead.

Six cases are reported in which the bereaved kept the decreased's body for periods ranging from one week to ten years. Some relevant anthropological and psychoanalytical observations are discussed. This phenomenon does not appear to have been reported in the literature of Western psychiatry.

Aged↗

Fetal mummification associated with porcine parvovirus infection.

A crossbred gilt farrowed 2 mummified fetuses at term, but subsequently developed uterine inertia and became listless. The remaining 5 fetuses of the litter (4 mummified and 1 normal appearing) were collected by hysterectomy. Porcine parvovirus (PPV) was isolated from tissues of the mummified fetuses, and masses of viral antigen were detected throughout the same tissues when cryostat sections were examined by immunofluorescence microscopy. Serum from the normal-appearing fetus of this litter had a hemagglutination inhibition (HI) titer for PPV of 320. The finding of antibody (HI titer of 1,280) in serum collected from the gilt on the day of farrowing, but not in serum collected 67 days before, indicated initial exposure to PPV during gestation.

Animals↗