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Results for “METHOCARBAMOL”

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PubMed1981

A comparison of calcium gluconate and methocarbamol (Robaxin) in the treatment of Latrodectism (black widow spider envenomation).

Calcium gluconate and methocarbamol were compared by using an algorithmic treatment protocol on all cases of Latrodectus (black widow) envenomation seen over a period of 3 years. Six of 13 patients were effectively cured of their symptoms by calcium gluconate, while only one of 10 patients was relieved by methocarbamol. Calcium gluconate remains the drug of first choice for this syndrome. It was also noted that calcium gluconate was more effective in patients who presented 3 hours of more after they were bitten. Antivenom may be necessary in those who present with symptoms in less than 3 hours.

Adolescent↗
PubMedDate not supplied

Liquid chromatographic determination of methocarbamol in injection and tablet dosage forms: collaborative study.

A reverse phase liquid chromatographic method was developed for determining methocarbamol in injection and tablet dosage forms. The injections require dilution only; the tablets require a filtration step before introduction into the chromatograph. Response for methocarbamol was linear over the range 0-18 micrograms, using an ultraviolet detector at 274 nm. Recoveries by the author ranged from 96.1 to 101.9% for authentic injection formulations and 98.0 to 101.0% for authentic tablet formulations. A collaborative study of the method by 6 laboratories resulted in standard deviations of 1.70 and 2.22 for injection and tablet dosage forms, respectively. The method has been adopted official first action.

Chromatography, Liquid↗
PubMed1982

A fatal methocarbamol intoxication.

A fatal methocarbamol intoxication is presented. Significant toxicologic findings were blood concentrations of 525 mg/L methocarbamol and 140 mg/dL ethanol. Analysis was by thin-layer, gas-liquid, and high pressure liquid chromatography. Toxicology data relevant to the interpretation of case findings are discussed.

Adult↗
PubMedDate not supplied

Pharmacokinetics and bioavailability of methocarbamol in rats.

In a pharmacokinetic study, 15, 30, 60, and 150 mg kg-1 intravenous and oral doses of methocarbamol were administered to rats. Differences observed in plasma clearance values, i.e. 0.0203, 0.0156, 0.0123, and 0.0085 1 kg-1 min-1 for 15, 30, 60, and 150 mg kg-1, respectively, suggested a dose-dependent pharmacokinetic behaviour of the drug. Elimination according to a biocompartmental open model and Michaelis-Menten kinetics fits the plasma level data. Estimated Km and Vmax values were 38.49 +/- 3.71 mg l-1 and 1.24 +/- 0.06 mg l-1 min-1, respectively. After oral administration of 15, 30, and 60 mg kg-1 the peak plasma levels were reached earlier. The tmax values were 6, 6, and 10 min, respectively. After 150 mg kg-1 oral doses, peak plasma levels were reached later (tmax = 150 min). Estimated bioavailability ranged between 77 and 112 per cent.

Administration, Oral↗
PubMedDate not supplied

Pain reduction in breast augmentation using methocarbamol.

Submuscular placement of breast implants produces significant postoperative pain and discomfort. The standard use of narcotics alone does not optimize pain reduction. Methocarbamol was used intraoperatively and postoperatively in 62 patients undergoing manipulation of the pectoralis major associated with breast implant surgery. Significant pain relief was achieved.

Adult↗
PubMed2001

Simultaneous determination of paracetamol and methocarbamol in tablets by ratio spectra derivative spectrophotometry and LC.

The application of the ratio spectra derivative spectrophotometry and high-performance liquid chromatography (HPLC) to the simultaneous determination of paracetamol (PAR) and methocarbamol (MET) in combined pharmaceutical tablets is presented. The spectrophotometric procedure is based on the use of the first derivative of the ratio spectra obtained by dividing the absorbtion spectrum of the binary mixtures by a standard spectrum of one of the compounds. The first derivative amplitudes were measured at 243.0 and 230.3 nm for the assay of PAR and MET, respectively. Calibration graphs were established for 2-30 microg ml for PAR and 2-36 microg/ml for MET in binary mixture. The detection limits for PAR and MET were found 0.097 and 0.079 microg/ml, respectively; while the quantification limits were 0.573 microg/ml for PAR and 1.717 microg/ml for MET. For the HPLC procedure, a reversed-phase column with a mobile phase of methanol-water (60:40, v/v), was used to separate both compounds with a detection of 274.0 nm. Linearity was obtained in the concentration range of 2 300 and 1.5-375 microg/ml for PAR and MET, respectively. The detection and quantification limits were found to be 0.42 and 1.4 microg/ml for PAR and 0.36 and 1.2 microg/ml for MET, respectively. The relative standard deviations were found to be less than 0.52%, indicating reasonable repeatibility of both methods. The proposed methods were successfully applied to the determination of these drugs in commercial tablets.

Acetaminophen↗
PubMed1999

A new HPLC technique for the separation of methocarbamol enantiomers.

We have developed a stereoselective high-performance liquid chromatography technique for analytical separation of methocarbamol enantiomers. Precolumn derivatization was performed at room temperature using (-)-menthylchloroformate as a chiral reagent in the presence of pyridine as catalyst. The resulting diastereomers were separated on two Resolve C18 columns connected in series. The mobile phase was phosphate buffer (pH 7.5)-acetonitrile (50: 50, v/v) at a flow rate of 1 mL min(-1). UV detection was set at 274 nm. The optimum amount of reagent and the maximum peak intensity of the diastereomers were determined. The resolution of the diastereomers was satisfactory (alpha = 1.04) under the conditions used.

Chromatography, High Pressure Liquid↗
PubMed1975

The use of diazepam and methocarbamol in the treatment of toxaphene poisoning in a Bangal tiger.

A 12-year-old female Bengal tiger was presented with clinical signs of acute chlorinated hydrocarbon poisoning and a history of recent consumption of food contaminated with toxaphene. Hyperreflexia and periodic convulsions were controlled by initial intramuscular injections of 30 mg diazepam and 2 g methocarbamol, followed at 6-hour intervals with intramuscular injections of 30 mg diazepam each, for 2 additional treatments. Following the initial treatment, hyperreflexia and convulsions did not recur.

Animals↗
PubMed1990

[Determination of methocarbamol].

Method of determination of 3-(2-metoxyfenoxy)-1,3-propandiol (Methocarbamol) with Marquisa reagent was verified. New method of quantitative determination based on the coloured reaction with Ce (IV) ion was developed.

Calibration↗
PubMed1959

Use of methocarbamol in orthopedics.

A new skeletal muscle relaxant, methocarbamol, was used in the treatment of 38 patients with a variety of severe neurological disorders and skeletal muscle spasm states.Eighty-two per cent of the patients studied obtained a beneficial result ranging from excellent to fair. Mild side effects such as drowsiness were observed in five patients, mild weakness in three patients and excessive perspiration in one. In two of the five patients who complained of drowsiness, it disappeared upon reduction of dosage and did not reappear when original dosage was reinstituted.

Cardiovascular Agents↗