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PubMed1951

Mephenesin as a relaxing agent in the treatment of tetanus; clinical experience in 12 cases.

Maintenance of a patent airway in cases of tetanus is best accomplished by means of tracheotomy performed early in the course of the disease. This eliminates the possibility of upper respiratory obstruction and facilitates the elimination of irritating and obstructing secretions from the lower respiratory passages. In many cases the amount of sedation required is decidedly reduced following tracheotomy. The combination of phenobarbital and Tolserol(R) is very satisfactory in controlling the muscular rigidity and spasm in cases of moderately severe tetanus. In severe cases, response is not always satisfactory. Severe respiratory depression was observed in only one case in which phenobarbital and Tolserol(R) were used.

Mephenesin↗