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PubMed1975

Rational diagnostic evaluation of the child with mental deficiency.

Evaluation of a mentally deficient child should be individualized, using findings from an appropriate history and physical examination. Depending on these findings the patient may be assigned to one of four subcategories, as determined by clinical indications and the patient's age at onset of the problem. These categories are (1) prenatal problem of morphogenesis, (2) perinatal insult to brain, (3) postnatal onset of brain dysfunction, and (4) undecided age at onset. This subcategorization has revelance to the type of diagnostic studies that may be indicated. Using this approach, a retrospective study of the diagnostic evaluation of 98 mentally deficient children was performed. Ninety percent of these children were considered to have had "nonrational" laboratory tests, and of these, none contributed to elucidation of the basic diagnosis. The only tests that were valuable had been indicated by a specific historical or physical finding in addition to mental deficiency.

Amino Acids↗
PubMedDate not supplied

[Serum amine oxidase activity in children with mental deficiency].

Correlation between a degree of mental deficiency and an activity of amine oxidase in blood serum as well as therapeutic efficiency of encephabole were found in children with mental deficiency of various genesis. Nootropile decreased the blood serum amine oxidase activity in the patients as well as the drug lowered the monoamine oxidase activity in brain mitochondria of young rats with antenatal hypoxia.

Central Nervous System Stimulants↗
PubMed1984

[Influence of the educational course on the future of young persons thought to be mentally deficient].

A survey of mental deficiency among children was carried out in 1967 in the department of Haute-Vienne by the Centre International de l'Enfance and the Institut National de la Santé et de la Recherche Médicale. A representative sample of the children was examined, with data recorded under paediatric, social, and psychological (including an intelligence quotient test, the "WISC") criteria. This study was resumed in 1974 and 1978 in order to determine how the children--by then, between 20 and 26 years of age--had fared. Among the 325 studied, it appears that those educated in specialized facilities succeeded less well than those who followed a normal curriculum. Only 39% of the former vs 58% of the latter won a diploma; 27% vs 17% were fired from jobs; 23% vs 9% experienced adaptation difficulties at work. Even when the IQs and the socioprofessional category of the parents are the same, the differences concerning diplomas (particularly in general, as opposed to professional, education) persist, as do problems in the workplace.

Adult↗
PubMed1983

Sleep and mental deficiency.

The nocturnal sleep of 54 young, organic and functional, institutionalized mentally deficients was recorded and analyzed according to Rechtschaffen and Kales (1968) and compared to that of 17 normal subjects of the same age. The paradoxical sleep (PS) rate of mental deficients is significantly lower than that of normals, as is the number of PS phases. On the other hand, the rate of intermediary sleep (IS) is increased, as is the latency of the first PS phases. The analysis of intervals between consecutive horizontal eye movements showed that intervals less than 1 sec (I less than 1 sec) are shorter in mental deficients. The ratio between high frequency (I less than 1 sec) and low frequency intervals (I greater than or equal to 2 sec) increases with age in normals and remains at a constant low level in mental deficients.

Child↗
PubMed1990

[Sampling survey of mentally deficient people in Sichuan].

From first April to 15th May 1987, 145,201 people were investigated by using the ways of layer, equal probability and mass sampling. Two thousand three hundred and forty two of them were confirmed to be mentally deficient. The incidence was 16.13%. It was estimated that 1,665,000 people have mental deficiency in Sichuan. The estimated range of reliability of 95% was 1,528,000-1,801,000. One million and three hundred ninety three thousand of them only had mental deficiency, while 272,000 had other organic deficiency. Male:female ratio was 101.4:100. The incidence of 6-14 year-old was 38.14%, which was 3 times higher than that of other age groups. Mild mental deficiency was 16.4 times more than severe mental deficiency. The most common causes were hereditary diseases, encephalitis, malnutrition, cerebral trauma, pregnant diseases, etc. All of the causes belonged to preventable diseases.

Adolescent↗
PubMed1981

Caveat: hip fractures in the mentally deficient.

Some hip fractures in mentally deficient patients are days to weeks old, are not painful, and can be treated nonoperatively. Despite current emphasis on reduction an internal fixation of femoral neck fractures, displaced fractures (Garden IV) in this group should not be nailed. Impacted neck fractures (Garden I) should be pinned in situ and the patient should ambulate immediately. Hemiarthroplasty is the treatment of choice for displaced intracapsular fractures in those previously ambulatory. Late pain is not a clinical problem. Extracapsular fractures should be reduced and nailed with a sliding device in a valgus position without medial displacement, and the patient should ambulate immediately. Extended hospital stays for the purpose of physical therapy should be avoided. These people should be returned as soon as possible to their previous environment where graduated mobilization should be encouraged.

Aged↗
PubMed1986

Mental deficiency in pseudohypoparathyroidism type I is associated with Ns-protein deficiency.

Pseudohypoparathyroidism type I is a hereditary disorder characterized by resistance to parathyroid hormone and other hormones that work via cyclic adenosine 3', 5'-monophosphate (cAMP). Most patients with this disorder have generalized deficient activity of Ns-protein (type Ia), which couples stimulatory hormone receptors to catalytic adenylate cyclase. In patients with normal Ns-protein activity (type Ib), a decreased incidence of resistance to hormones other than parathyroid hormone exists. Mental deficiency of unknown cause occurs in 47% to 75% of all patients with pseudohypoparathyroidism type I. Because mutations in the adenylate cyclase-cAMP system may affect the learning ability of Drosophila flies, we assessed mental deficiency in 25 patients whose Ns-protein activity we had determined: 9 of 14 patients with type Ia disorder and 0 of 11 patients with type Ib disorder had mental deficiency. We suggest that Ns-protein deficiency, reduced cAMP levels, or both, are involved in the mental deficiency in these patients and probably in mental function in humans.

Adolescent↗
PubMed1991

[Epidemiology of mental deficiency. The Safor study (II): age at detection, person making the diagnosis, medical studies].

As part of an epidemiological study on Mental Deficiency which was carried out in an area of the region of Valencia, a study has been made of the age when Mental Deficiency can be detected, who made this discovery, and which children have been the object of a medical study. 12% of the cases were detected at birth, 16% before the age of 3, 7% at 3, and 64% after the age of 4. In 16% of the cases the deficiency was detected by the family, in 20% of the cases a doctor and a psychologist in 62% of the cases. A medical study to discovered the causes of the Mental Deficiency was only carried out in 44% of the cases.

Age Factors↗