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At least 37 records · Page 2Linked to original sources
PubMed1985

Lathyrism: mini-review and a comment on the lack of effect of protease inhibitors on osteolathyrism.

Lathyrism has been reviewed in respect to four overlapping phases: finding an animal model for neurolathyrism, characterizing osteolathyrism in respect to its possible use as an animal model for human diseases, such as Marfan's syndrome, idiopathic juvenile scoliosis, etc., use of beta-aminopropionitrile (BAPN) as a tool to study collagen, and use of BAPN as a therapeutic agent in man. Because it has been suggested that the lathyrogen, BAPN, may stimulate the release of proteases, the protease inhibitors Trasylol and epsilon-aminocaproic acid (EACA) were given alone or in combination to BAPN-treated rats. The protease inhibitors did not reduce the effects of BAPN as measured by exostosis formation or collagen extractability.

Aminocaproates↗
PubMed1977

[Chronic lathyrism. Protective effect of pyridinol carbamate on connective tissue lesions in the rat (author's transl)].

The use of lathyric toxins (BAPN) in low dosage (1 g/kg/day) for a period of 8 weeks caused in the rat simultaneous changes in the skin and aortic connective tissues. In the skin. collagen tissue was dislocated and broken in fragments, the elastic tissue disappeared, the fibroblasts were vacuolized and presented evidence of injury. These lesions were comparable to those observed in human skin during ageing. The addition of pyridinol carbamate (PDC) to BAPN prevents the formation of lesions of the elastic tissue and of fibroblasts. When given after the cessation of the lathyrogen treatment PDC arrested the formation of the lesions and accelerated their regression.

Aminopropionitrile↗
PubMed1987

Experimental lathyrism: exostoses and aneurysmal-like bone cysts of the mandible in the rat.

The effect of chronic lathyrism on the mandible of the rat was studied. Exostoses, thinning and discoloration of the cortical plates, intraosseous bleeding and hemorrhagic cyst were observed after six weeks of administration of beta-aminoproprionitrile fumarate. The exostoses consisted of homogeneous cellular fibrous tissue containing osteoid, hyalin-like material and abundant ground substance. The cysts were filled with erythrocytes and lined by spindle-shaped fibroblasts, collagen fibers or osteoblast-like cells. Between the cysts, bands and sheets of dense and cellular connective tissue presenting foci of hemorrhage, osteoid and metaplastic cartilage were found. Numerous mast cells were demonstrated with alcian and toluidine blue in the hematopoietic bone marrow, cancellous bone and around the capillary network surrounding the exostoses and cysts. Exostoses have already been studied and explained by the action of BAPN (lysyl oxidase). Hemorrhagic cysts could be explained by histamine release from the mast cells (hypervascularity, hyperemia, increased permeability, rupture and progressive confluence of these small hemorrhagic cysts). Histopathology of the experimental cysts had some points in common with the human aneurysmal bone cyst. Could the pathogenic mechanisms be similar for both lesions?

Aminopropionitrile↗
PubMed1967

An apparent relationship between locoism and lathyrism.

An apparent relationship between locoism and lathyrism was investigated. Similarities reported in the literature in botanical relationship, signs produced in affected animals, and chemical characteristics were noted. It was demonstrated that the known lathyrogens, aminoacetonitrile and alpha, gamma-diaminobutyric acid, as well as an extract from the loco plant (expected to contain lathyrogens if present in the plant) produced many of the abortive, teratogenic and neurologic effects and signs evident in animals in true locoism. Preliminary assay of extracts from the plant suggested the presence of lathyrogens in the loco plant.

Abortion, Veterinary↗
PubMed1969

Preliminary investigation of the relationship between bovine congenital lathyrism induced by aminoacetonitrile and the lupine induced crooked calf disease.

Maternal feeding of the lathyrogen aminoacetonitrile, the range plant Lupinus caudatus, and an extract of this plant - expected to contain lathyrogens if present in the plant - all produced clinically similar congenital defects in calves. The defects included excessive flexure, malpositioning, malalignment and rotation of the front limbs. The results suggest a possible relationship between lathyrism and lupine-induced crooked calf disease.

Animals↗
PubMed1976

[Influence of a lathyric agent and of hypercholesterolemic serum on cell cultures of fetal rabbit aorta].

Cell cultures of foetal rabbit aorta are cultivated with a lathyric agent (beta-amino-propio-nitrile) or with an hypercholesterolemic serum; if morphological features, in these two cases, correspond with modifications observed, in vivo, when adult rabbits are respectively submitted to the same treatment, enzymatic activities of collagen metabolism vary in opposite way. Therefore, the influence of different parameters to be studied on vascular cell functions become easier.

Aminopropionitrile↗