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PubMed1990

Heterogeneity in the familial aggregation of fasting plasma glucose in five North American populations: the Lipid Research Clinics Family Study.

Heterogeneity in the familial aggregation of plasma glucose in five samples of the Lipid Research Clinics Family Study (LRC) was investigated using path analysis. This study was deemed appropriate since recent investigations reported a wide range of estimates for genetic and cultural factors. The path model incorporated a measured index of the familial environment in order to separate the effects of genes and environments in the nuclear family design, genetic and environmental heritabilities, spouse resemblance, sibling environmental effects, and parental cultural transmission. The methodology was completely general in allowing sample-specific, as well as pooled-sample, estimation of all or any subset of the model parameters. Genetic heritability estimates were heterogeneous, ranging from zero to 33% across the clinics. Environmental heritability (7%), spouse resemblance, non-transmitted sibling environmental effects, and parental cultural transmission were homogeneous across samples. No support was found for specific maternal effects, nor for intergenerational differences in cultural or genetic heritability. We conclude that the genetic and environmental heritabilities for plasma glucose in the LRC are consistent with the diverse reports by earlier investigators. In addition, we were able to exclude methodological differences as a cause of this heterogeneity. Furthermore, formal hypothesis tests suggest that the aetiology of this heterogeneity is genetic (and not cultural), taking the form of two distinct homogeneous patterns (one for no genetic effect, and one for a moderate genetic effect). Only formal heterogeneity tests of the type described here can detect these effects, and allow pooling of separate studies in order to obtain more precise estimates of the parameters of interest.

Adult↗
PubMed1971

Fertility of Salmonella typhimurium crosses with Escherichia coli.

At least one factor that causes low fertility of Salmonella typhimurium LT2 strains in crosses with Escherichia coli K-12 Hfr's can be inhibited by growing the female strains in supplemented minimal salts medium rather than in nutrient broth and by incubating the female strains at 50 C immediately before mating with the Hfr. These pretreatments can enhance the recovery of prototrophic recombinants for markers injected early by the Hfr by a factor of as much as 10(4). The heat treatment is effective only on the female in intergeneric crosses and gradually loses (within 50 min) its effectiveness after return of heat-treated cells to 37 C. It is concluded that the restriction system of the female is heat-sensitive. Since markers injected late by the male enter females in which the heat-impaired restriction system has recovered, few recombinants for late markers are found. The presence of the leading end of an E. coli Hfr in an S. typhimurium-E. coli hybrid enhances by up to sevenfold the frequency of lac(+) recombinants in subsequent crosses with an E. coli Hfr if the E. coli segment is integrated into the chromosome of the hybrid; the effect is less marked if the E. coli segment is not integrated.

Antigens, Bacterial↗
PubMed1991

Inhibition of intergeneric coaggregation among oral bacteria by cetylpyridinium chloride, chlorhexidine digluconate and octenidine dihydrochloride.

The potential inhibitory effect of chlorhexidine digluconate on the intergeneric coaggregation of 11 pairs of Gram-positive organisms was compared to its ability to inhibit coaggregations of 14 pairs comprised of both a Gram-positive and a Gram-negative cell type. Dramatic differences in the inhibitory effectiveness of the antimicrobial compound on the two kinds of coaggregation pairs were found. Gram-positive pairs were not inhibited at a concentration of 0.25%, whereas the coaggregations involving a Gram-negative partner were usually completely blocked at concentrations as low as 0.01%. Similar effects to chlorhexidine digluconate were found with octenidine dihydrochloride and cetylpyridinium chloride, while sodium dodecylsulfate was inhibitory only at 10- to 50-fold higher concentrations. These results suggest that chlorhexidine digluconate, octenidine dihydrochloride, and cetylpyridinium chloride may be effective inhibitors of later microbial colonizers of dental plaque but may not disturb a normal healthy indigenous flora.

Actinomyces↗
PubMed1983

Intergenerational transfer of individual differences in hereditary monarchs: genetic, role-modeling, cohort, or sociocultural effects?

Individual differences may be transferred across generations through either genetic inheritance, identification with role models, cohort effects, or sociocultural influences. Each of these four possible mechanisms makes different predictions regarding what traits display intergenerational continuities, the pattern of relationships between an individual and his or her relatives, as well as the relative impact of same-sex and cross-sex relationships. A sample of 342 hereditary monarchs was drawn from 14 European nations. These rulers, along with their parents, grandparents, and predecessors, were then assessed on the variables of intelligence, morality, eminence, leadership, life span, and reign span. Theoretically significant interaction effects were also operationalized using such moderator variables as genetic relationship, years of overlap in lives, age difference, difference in reign midpoints, and sex. The intergenerational transfer of intelligence and life span appears to be best explained by genetics, whereas the transfer of morality and eminence seems to be governed by role-modeling processes. The remaining variables were either transferred by more complex mechanisms (viz. leadership) or not transferred at all from one generation to the next (viz. reign span). The results contradict both Woods's (1906) belief that morality is genetically inherited and Galton's (1869) argument that eminence can served as a nearly equivalent proxy variable for intellectual genius.

Female↗
PubMed1991

The effects of maternal working conditions and mastery on child behavior problems: studying the intergenerational transmission of social control.

We assess the impact of maternal sense of mastery and maternal working conditions on maternal perceptions of children's behavior problems as a means to study the transmission of social control across generations. We use a sample of 521 employed mothers and their four-to six-year-old children from the National Longitudinal Survey's Youth Cohort in 1986. Regarding working conditions, we consider mother's hourly wage, work hours, and job content including involvement with things (vs. people), the requisite level of physical activity, and occupational complexity. We also consider maternal and child background and current family characteristics, including marital status, family size, and home environment. Maternal mastery was related to fewer reported behavior problems among children. Lower involvement with people and higher involvement with things, as well as low physical activity, were related significantly to higher levels of perceived problems. In addition, recent changes in maternal marital status, including maternal marriage or remarriage, increased reports of problems; stronger home environments had the opposite effect. We interpret these findings as suggesting how maternal experiences of control in the workplace and personal resources of control can influence the internalization of control in children.

Adult↗
PubMed1992

Intergenerational studies of human birthweight from the 1958 birth cohort. 1. Evidence for a multigenerational effect.

OBJECTIVE: To investigate possible multigenerational influences on birthweight. DESIGN: Data from the longitudinal study of one week's births in 1958 up to the age of 23 years, the British National Child Development Study, were utilized. These provide socio-biological information on the parents of the cohort, on the cohort members from birth onwards, and on the pregnancies and the birthweight of any babies born to the cohort members. MAIN OUTCOME MEASURE: The main outcome was the birthweight of babies born to the cohort members, for whom complete intergenerational data were available for 1638 firstborn. Multiple regression modelling was used to investigate any associations between their birthweight and characteristics of their parents and grandparents. RESULTS: Significant positive associations were found between babies' birthweight and parental birthweight but not gestational age. For the babies born to female cohort members additional findings included associations between their birthweight and the height of the maternal grandmother and the social class of the maternal grandfather, even after adjustment for such strong predictors of birthweight as maternal weight, smoking habit in pregnancy and baby's sex and birth order. CONCLUSION: These results thus offer support for a multigenerational influence on birthweight passed through the maternal line.

Birth Weight↗
PubMed1982

The Clinical Lipid Research Clinic Family Study: familial determinants of plasma uric acid.

Commingling analysis of plasma uric acid levels in a random sample of 160 nuclear families supports the hypothesis that there is a mixture of three distributions. Assuming one, two, and three components in the underlying distribution, we obtained the corresponding p-values (for power transformation) as 0.059, 1.040, and 1.643, respectively. Path analysis with p = 0.059, 1.040, and 1.643 respectively. Path analysis with p = 0.059 gives genetic (h2) and cultural (c2) heritabilities as 0.256 and 0.199, without much support for intergenerational differences, assortative mating, or maternal effects. Complex segregation analysis with p = 0.059 supports multifactorial inheritance, consistent with the findings of Gulbrandsen et al. (1979) and Morton (1979) in other populations. This study also fails to support a major locus hypothesis, contrary to earlier reports.

Adolescent↗
PubMed1991

Ethical issues in manipulating the human germ line.

This essay examines the arguments for and against working towards the objective of human germ line engineering for medical purposes. Germ line changes which result as a secondary consequence of other well designed and ethically acceptable manipulations of somatic cells to cure an otherwise fatal disease can be seen as acceptable. More serious objections apply to intentional germ line interventions because of the unacceptability of using a person solely as a vehicle for creating uncertain genetic change in his descendants. It is also morally unacceptable to use the promise of future benefit to experiment on fetuses or embryos when other more effective technologies exist to help parents have healthy children. Using new genetic technologies to select desirable genotypes among gametes is less problematic and affords a promising new technique for avoiding intergenerational harms.

Double Effect Principle↗
PubMed1983

Family resemblance for fasting blood glucose in a population of Japanese Americans.

The pattern of inheritance of fasting blood glucose was examined in a Japanese cohort of 500 nuclear families living in Hawaii. A principal component of glucose was defined to improve the ranking of diabetics and individuals receiving treatment (medication and/or diet) for hyperglycemia, thereby allowing as well as possible for inability to determine untreated levels in patients. Results from path and segregation analysis show that family resemblance for glucose is low in this population. The additive variation can be explained by a cultural model of inheritance without introducing intergenerational differences, a maternal-paternal effect, or even genetic parameters. Heritability is approximately 0.125. Complex segregation analysis provides no convincing evidence for a major gene, with preliminary support based upon leptokurtic outliers in five families disappearing on further analysis by partial truncation. A claim by other workers of a major recessive gene for hyperglycemia may be due to their failure to allow for treatment, skewness, and multifactorial heritability. In future, the search for major loci acting on liability to hyperglycemia should use multiple determinations of fasting glucose or be addressed to more primary and repeatable variables than fasting blood glucose.

Adult↗
PubMed1986

Intergenerational solidarity: an examination of a theoretical model.

This study provided an empirical test of a widely cited proposed model of intergenerational solidarity. The model emphasizes that association, affect, and consensus are interdependent dimensions of solidarity and offers an explanatory rationale for parent-child solidarity. Path analysis techniques were used with a sample of 279 older rural-transitional parents. The results showed little support for the model, but the data indicated that residential propinquity and mutual helping behavior were strong predictors of intergenerational association. The importance of the indirect effect of sex linkage via mutual help to associational solidarity also received strong support. The results showed that the proposed model was useful in explaining objective solidarity (association) but not subjective solidarity (consensus and affection) and that these variables were not dimensions of one construct.

Adult↗
PubMed1991

Self-reports of "positive" childhood and adolescent sexual contacts with older persons: an exploratory study.

An exploratory, descriptive study of 37 male and 26 female subjects reporting childhood or adolescent intergenerational sexual contacts about which subjects maintained, at least in part, "positive" feelings is reported. An informal comparison group of 7 female victims of sexual abuse also participated. Subjects were administered a 21-page, 130-item questionnaire designed to explore and evaluate childhood functioning and development, the nature of the sexual experience, and its possible impact on adult life. Eight subjects also participated in subsequent in-depth telephone interviews. A wide range of characteristics and possible effects of the experiences were reported, suggesting that intergenerational sexual contacts may represent a continuum of experience rather than a unitary and discrete pathological phenomenon.

Adolescent↗
PubMed1991

Intergenerational Partners Project: a model linking elementary students with senior center volunteers.

Age-integrated programming has become an effective way to bring the young and old closer together. This paper describes a 9-month intergenerational program designed to establish a more intimate involvement between a group of 4th graders and elderly volunteers from Senior Neighbors. The format used to organize the project is presented, and ongoing activities and program benefits are identified. The goals of this project have been richly met, reducing students' fears and misconceptions about aging and providing a satisfying experience for the seniors.

Aged↗
PubMed1992

An extension of the acquaintanceship procedure in family studies of mental disorder.

The acquaintanceship procedure is a method for obtaining a control group matched to relatives of probands on demographic variables. Relatives are asked to name six acquaintances who are the same gender, and who are about the same age and social class as themselves. An acquaintance is randomly selected from this list and contacted for recruitment. Rates of mental disorder in this group are assumed to approximate general population rates in a group with these demographic characteristics. This report focuses on an extension of the acquaintanceship procedure in which "super-normal" controls are used in a family study design. Two questions were addressed: (1) Does the acquaintance group (n = 166), as a whole, show a higher rate of illness than the relatives of acquaintances with no mental disorder (n = 129)? (2) Is there a relationship between mental disorder in acquaintances and in providers of acquaintance names? The prevalence of mental illness was significantly greater among acquaintances compared to relatives of "never ill" acquaintances. There was no evidence of assortative selection. We concluded that using the relatives of well acquaintances is a cost-effective control selection methodology which maximizes the detection of intergenerational transmission in family studies of mental disorder.

Adult↗
PubMed1992

Young women's antisocial behavior and the later emotional and behavioral health of their children.

OBJECTIVES: Antisocial and criminal behavior are increasing among US youth, especially among females. Thus, questions arise concerning whether youthful female deviant behavior eventually will have negative behavioral and emotional consequences for the later children of these women. METHODS: Associations between the severity of early female antisocial behavior (including both drug-related and non-drug related offenses) and the later behavioral and emotional health of the children of these women were examined among 1425 mother-child pairs of the National Longitudinal Survey of Youth. RESULTS: Multiple linear regression procedures indicated a significant positive relationship between the severity of the mothers' early non-drug-related offenses and the later severity of the children's scores on the Antisocial, Hyperactive, Anxious/Depressed, Headstrong, Peer Conflict/Social Withdrawal, Immature Dependency, and Total Problem subscales of the Behavior Problem Index. CONCLUSIONS: This study demonstrated an association between the antisocial behavior of female youth and the later behavioral and emotional problems of the children of these women. Future research needs to determine the mechanisms underlying the intergenerational transmission of these types of problems so that effective preventive and therapeutic public health practices may be designed and implemented.

Adolescent↗
PubMed1980

[Intergeneric crossing: P1 phage transduction of the malB region in crosses between E. coli and S. typhimurium].

In the intergeneric crossing of E. coli and S. typhimurium, no effective transduction of the malB gene was observed. The absence of effective transduction suggests the low homology of the malB chromosomal areas in E. coli and S. typhimurium. To carry out the transduction of the MalB gene together with the lexA gene from E. coli to S. typhimurium, a hybrid having no restriction of phage P1 and incorporating the malB area of E. coli should be previously created.

Coliphages↗
PubMedDate not supplied

[Aging in one's occupation: occupational and life's perspectives of elderly male and female employees].

The consequences of social change for the workforce are discussed. In our society of the future we will have to deal with an aging industry as a result of the increasing number of older employees. Furthermore, we expect changes in relation to mandatory retirement in establishing the "Rentenreform 1992" (Retirement age policy). The necessity of intergenerational exchange to avoid "ageism" is explained. The impact of technology on life-long learning and qualifications of older workers is pointed out. Finally, we describe the pluralism of life courses as a characteristic of social change in relation to gender-effects.

Aged↗
PubMed1991

Do close parent-child relations reduce the mortality risk of older parents?

This analysis examines the association between affectional solidarity in older parent-child relationships, and the parents' length of survival over a 14-year interval. It is hypothesized that close intergenerational relations have the capacity to reduce pathogenic stress among elderly parents, thereby enhancing their ability to survive. Direct and buffering effects of affectional solidarity, as expressed by 439 elderly parents, are tested using data from the U.S.C. Longitudinal Study of Generations collected between 1971 and 1985. Buffering effects are examined in the context of social decline and social loss experienced by the older parent. Hazard regression models indicate that greater intergenerational affect increases survival time among parents who experienced a loss in their social network, particularly among those who were widowed less than five years. Neither a direct effect of affection nor a buffering effect in the presence of social decline were found. It is concluded that the mortal health risks associated with the stress of being widowed can be partially offset by affectionate relations with adult children.

Adolescent↗