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Electrophysiological analysis of the registration, storage and retrieval of information in delayed matching from samples.

Brain processes of registration, storage in working memory and retrieval of different kinds of information were studied by analysis of EEG and ERP activity recorded during two delayed matches from sample tasks: (1) matching the digits in two series of six numbers, and (2) matching the sums of the same two series of six numbers. each trial was composed of six intervals continuing six equally spaced visual stimuli: (1) control--observing a series of six fixation points, P1, on a computer monitor; (2) priming--viewing a series, S1, of six numbers; (3) delay--observing a second series of six fixation points, P2; (4) matching--viewing a second series, S2, of six numbers; (5) response selection--selecting the left button to press if S1 contained all the items in S2 or the right button if any item appeared only in S2, while observing six fixation points; (6) feedback--six color coded fixation points indicate correct or error. Each interval was 4 s in duration and 20 trials were presented in each task. During each interval the visual field flickered at a tracer frequency of 1.5/s, whether numbers or fixation points were on the monitor screen. Very narrow band power spectra (VNB), ERPs elicited by presentation of S1 or S2 information items, and non-contingent probes (NCP) elicited by presentation of fixation points were used to trace the processing of information by neural populations activated by the visual stimulation. Global field power maxima identified latencies at which functional landscapes were analyzed. VNB, ERP, NCP and landscape differences were found between digits and sums. However, though these differences were highly significant within each subject (p < 0.001), no consistency was found across individuals for the electrophysiological changes during the tasks. This suggests that utilization of brain resources in cognition varies greatly with individual cognitive styles and strategies.

Alpha Rhythm↗

MEDINFO--a medical information system.

The MEDINFO (MEDical INFOrmation) system is a general purpose computer-based information storage, retrieval, and analysis system. It is designed for a time sharing, on-line computer system for the rapid and easy creation, maintenance, and analysis of general data files. A wide variety of types of information may be used. These include numeric, categoric, text, date, and multiple-response. The file structure allows several sets of data, including date-orientated data, to be used. MEDINFO permits a study to be created, a description of the data made, data to be entered and updated into records, and for the data to be displayed or analyzed by the investigator without programmer intervention.

Computers↗

The Johns Hopkins radiology reporting system.

Radiologists can comprehensively report diagnostic radiographs by computer with a speed approaching that of dictation. This is the main mode of radiographic reporting used at the Johns Hopkins Hospital. Support functions include information storage, retrieval, statistics, and billing. Costs are comparable to stenography. The system can be run from a large time-sharing computer or dedicated minicomputer. A commercial stand-alone version will soon be available.

Costs and Cost Analysis↗

Computational tools for the study of allergens.

Allergy is a major cause of morbidity worldwide. The number of characterized allergens and related information is increasing rapidly creating demands for advanced information storage, retrieval and analysis. Bioinformatics provides useful tools for analysing allergens and these are complementary to traditional laboratory techniques for the study of allergens. Specific applications include structural analysis of allergens, identification of B- and T-cell epitopes, assessment of allergenicity and cross-reactivity, and genome analysis. In this paper, the most important bioinformatic tools and methods with relevance to the study of allergy have been reviewed.

Allergens↗

Informatics in the care of patients: ten notable challenges.

What is medical informatics, and why should practicing physicians care about it? Medical informatics is the study of the concepts and conceptual relationships within biomedical information and how they can be harnessed for practical applications. In the past decade, the field has exploded as health professionals recognize the importance of strategic information management and the inadequacies of traditional tools for information storage, retrieval, and analysis. At the same time that medical informatics has established a presence within many academic and industrial research facilities, its goals and methods have become less clear to practicing physicians. In this article, I outline 10 challenges in medical informatics that provide a framework for understanding developments in the field. These challenges have been divided into those relating to infrastructure, specific performance, and evaluation. The primary goals of medical informatics, as for any other branch of biomedical research, are to improve the overall health of patients by combining basic scientific and engineering insights with the useful application of these insights to important problems.

California↗

Structuring strain data for storage and retrieval of information on fungi and yeasts in MINE, the Microbial Information Network Europe.

A distributed Microbial Information Network Europe (MINE) is being constructed by a number of major microbial culture collections in countries of the European Community, with the support of the Biotechnology Action Programme (BAP) of the Commission of the European Community. The representatives of the collections participating in MINE have agreed to adopt a general format for the computer storage and retrieval of strain data. This uniform format will facilitate the electronic combination and exchange of data from different collections in order to produce integrated catalogues and the use of identical commands to search the different databases. It is recommended to other collections who may wish to contribute data to the MINE network or between themselves. Three kinds of records can be linked to the leading 'species records': strain records, synonym records, and alternative morphonym records. A minimum data set of 30 fields (similar to the fields used for producing catalogues) is defined that facilitates the exchange of data between the national nodes and serves as a directory to strains available at other nodes. It is suggested that the full strain record comprise 99 fields, grouped in 12 blocks: internal administration--name--strain administration--status--environment and history--biological interactions--sexuality--properties (cytology, biomolecular data)--genotype and genetics--growth conditions--chemistry and enzymes--practical applications. Several fields are divided into subfields of different ranks. Delimiters are used either to separate a range of entries that have to be indexed or to divide an entry from the reference to its source or remarks that should not be indexed. The contents and structure of the fields proposed for filamentous fungi and yeasts are described and in some cases illustrated by examples. Uniformity of input is essential for indexed fields and desirable for non-indexed fields. Seven thesaurus files are envisaged to ensure consistency.

Data Collection↗

A microcomputer based program for the storage and retrieval of experimental animal information.

A microcomputer based program for the storage and selective retrieval of experimental animal information has been developed for use on any system which runs under CP/M system software. The program has been designed to be completely conversational, to communicate with the user in French, English, or Spanish, and to allow the user to define the data format and the alphanumeric coding scheme.

Animals↗

Pupillary changes during encoding, storage, and retrieval of information.

6 subjects were each auditorily presented six lists of 7-digit numbers for retention intervals of 0, 5, and 10 sec. Pupil size was recorded during stimulus presentation, retention, interval, and recall of items. Results indicated that pupil dilation occurred during encoding and retrieval of stimulus items. Pupillary constriction was found during the retention interval when rehearsal was presumed to occur.

Acoustic Stimulation↗