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At least 37 records · Page 2Linked to original sources
PubMed1999

Effect of an aluminum hydroxide-magnesium hydroxide combination drug on adhesion, IL-8 inducibility, and expression of HSP60 by Helicobacter pylori.

BACKGROUND: Co-magaldrox (Maalox) is used world-wide as an antacid and as a cytoprotective agent for gastritis and peptic ulcer diseases. We examined the effects of co-magaldrox on Helicobacter pylori. METHODS: Adhesion of H. pylori to human gastric epithelial cells (MKN45) was evaluated by flow cytometry. Morphologic changes in H. pylori caused by co-magaldrox were determined by scanning electron microscopy. Induction of interleukin-8 (IL-8) from MKN45 cells was examined with enzyme-linked immunosorbent assay, and the intracellular and extracellular expression of heat-shock protein 60 (HSP60) was analyzed with sodium dodecyl sulphate-polyacrylamide gel electrophoresis and flow cytometry. RESULTS: Adhesion of H. pylori to MKN 45 cells was significantly inhibited by 1.25%-5% comagaldrox. H. pylori aggregated with co-magaldrox according to an electron microscopic examination. IL-8 secretion from MKN45 cells after H. pylori infection was also inhibited by co-magaldrox. Extracellular expression of HSP60 on the surface of H. pylori was decreased after treatment with comagaldrox, whereas the intracellular synthesis of HSP60 was not. HSP60-induced IL-8 secretion was significantly inhibited by co-magaldrox in a dose-dependent manner. CONCLUSIONS: These results show that co-magaldrox suppressed the expression of the following virulence factors: adhesion, IL-8 inducibility, and expression of extracellular HSP60. Therefore, co-magaldrox is a potent anti-H. pylori and cytoprotective drug.

Aluminum Hydroxide↗
PubMed1989

[Drug interactions during storage of mixtures of the antacid group. III. Effect of relative humidity on structural changes in mixtures aluminum hydroxide gel and magnesium hydroxide in the solid phase].

Mixtures of A1(OH)3 gel and Mg(OH)2 were stored for 14 months in the solid phase in chambers with relative air humidity of 35%, 55%, 76% and 92%. IR spectra of the stored mixtures were measured. In mixtures stored at relative air humidity of 35% there were found no changes in IR spectra, while the mixtures stored at relative air humidity of 92% proved to exhibit IR spectra characteristic for hydrotalcite.

Aluminum Hydroxide↗
PubMed1998

Synthesis of Heteropolyoxometalate-Pillared Mg/Al, Mg/Ga, and Zn/Al Layered Double Hydroxides via LDH-Hydroxide Precursors.

We report the synthesis of acidic (Zn/Al-POM) and basic (Mg/Al-POM and Mg/Ga-POM) materials by a general route previously demonstrated only for basic LDH materials. In each case, H(2)W(12)O(40)(6)(-) or PW(11)O(39)(7)(-) pillared materials with significant BET surface areas were obtained. Stringent control over the M(2+):M(3+) ratio in the layers of the POM-pillared products was not possible, and loss of M(2+) was found to be the most severe for the Mg/Ga and Zn/Al materials. Infrared analysis indicated that complete exchange of adipate anions in the precursor material by POM anions was achieved except for the Zn/Al analogues. Removal of the residual adipate anions after washing the product with a dilute base solution was possible, but a concomitant decrease in surface area could not be avoided.

Journal Article↗