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PubMedDate not supplied

[Hemostatic disorders in a severe course of icterohemorrhagic leptospirosis (a clinico-morphological study)].

Morphologic studies were made on the brain tissue and internal organs of those deceased (n = 75) who had died of leptospirosis icterohemorrhagica during different periods of the condition, with the results obtained being compared to clinical and laboratory findings. It has been shown that realization of the pathogenic potential of the disease-producing germ is exercised both through direct generalized injury to the endothelium of microvessels, parenchymal cells (predominantly those of the liver and kidneys) by toxic substances of Leptospira and (to a larger degree) through disorders of hemostasis presented as thrombosis of vessels of the microcirculatory bed with subsequent development of hemorrhagic manifestations and alterative changes of hypoxic genesis in vital organs. Early haemocoagulatory disorders are characterized by marked and stable hypocoagulation, with direction of the processes of fibrin formation and fibrinolysis being different, which fact is consistent with diversity of structural formations originating from fibrin in the microcirculatory bed of the deceased. Prophylaxis of grave pathologic changes in the organism leading to lethal outcome consists in correction of hemostatic disorders during early phases of the disease course, which is to be pathogenetically substantiated and situational one because of the problem posed by verification of stages of that syndrome of disseminated intravascular coagulation in patients with grave course of leptospirosis icterohemorrhagica.

Acute Disease↗
PubMed1993

Buccal mucosa bleeding time is prolonged in canine models of primary hemostatic disorders.

Bleeding times are reported in many studies using canine models, with a variety of techniques employed to adapt these tests for dogs. We evaluated a canine model of template bleeding time, the buccal mucosa bleeding time (BMBT), by examining the test's sensitivity and specificity for defects of primary hemostasis. We examined thirty-five dogs having defined defects of either primary hemostasis (Types I, II, III von Willebrand's disease, thrombasthenia, thrombopathia) or secondary hemostasis (hemophilia A and B, Factor VII deficiency). Comparisons of BMBT and cuticle bleeding time were made in a subset of these dogs. All dogs having primary hemostatic disorders had long BMBT, and all factor deficient dogs had BMBT within normal range. The BMBT in canine models appears to be a specific and sensitive test of primary hemostasis; suitable for evaluating factors affecting template bleeding time and potential efficacy and thrombogenicity of treatment regimens.

Animals↗
PubMed1986

Early hemostatic disorders in patients with gynecologic tumors.

One hundred and seventeen female subjects were studied: 23 patients with cervical carcinoma; 25 with endometrial carcinoma; 29 with benign uterine diseases; 14 with ovarian carcinoma; 26 patients with benign ovarian tumors. These patients, together with 25 healthy female control subjects, underwent several coagulation tests including Beta-Thromboglobulin (Beta-TG) and Platelet Factor 4 (PF4) plasma levels. Among all Beta-TG and PF4 exhibited the most interesting results. They were increased in four groups of patients: those with malignant 92.2% (13/14) and benign 50% (13/26) ovarian tumors and those with endometrial 64% (16/25) and cervical carcinoma 69.5% (16/23). Our study showed a high incidence of abnormalities of Beta-TG and PF4, early signs of hemostatic disorders, in gynecological malignancies especially in ovarian carcinoma. These data suggest a possible value of these tests as tumor-markers and in order to detect the patients who develop thrombo-embolic accidents.

Adult↗
PubMedDate not supplied

Hemostatic disorders in feline immunodeficiency virus-seropositive cats.

The hemostatic function of 40 feline immunodeficiency virus (FIV) seropositive and 8 FIV and feline leukemia virus (FeLV) seropositive cats was evaluated and compared with reference values from 30 clinically healthy cats. The FIV-positive cats were divided into 3 groups: group I included asymptomatic carriers; group II comprised sick FIV-infected cats with illnesses not likely to influence the hemostatic system; and group III included FIV-positive cats with diseases potentially associated with coagulopathies. Platelet counts in FIV/FeLV-infected cats were significantly lower than in healthy cats (P < .003), whereas the differences in the 3 groups of FIV-positive cats were variable (group I, P = .009; II, P = .05; III, P = .09). Thrombocytopenia (< 145,000 platelets/microL) was present in 4 FIV-positive and 3 FIV/FeLV-positive cats. Platelet aggregation induced by collagen (0.5 and 0.25 micrograms/mL), adenosine diphosphate (ADP) (1 and 0.6 mumol/L), and thrombin (0.4 and 0.25 IU/mL) was not significantly different from that of healthy cats. The plasma coagulation system was evaluated by measuring one-stage prothrombin time (OSPT), activated partial thromboplastin time (APTT), thrombin time, fibrinogen concentration, coagulation factor assays, fibrinogen and fibrin degradation products (FDP), and plasma exchange test. The OSPT was similar in FIV-seropositive cats and in the healthy control group. Cats with FIV infection, however, had markedly shorter clotting times than healthy cats when using a modified test system (P < .05).(ABSTRACT TRUNCATED AT 250 WORDS)

Animals↗
PubMed1989

[Prevention and treatment of hemostatic disorders in patients with liver cirrhosis].

Disorders of the different links of the hemostatic system in patients with liver cirrhosis can be corrected by simultaneous prescription of minimal doses of heparin, vicasol and curantyl. As a result, treatment of liver cirrhosis, including cases with initial manifestations of the hemorrhagic syndrome, produced significant improvement of the hemostatic parameters and abatement of this syndrome. It is expedient to include this method in the combined treatment of this category of patients.

Blood Coagulation Disorders↗
PubMed2005

Abnormal uterine bleeding and underlying hemostatic disorders: report of a consensus process.

An ad hoc consensus group determined that the prevalence of von Willebrand's disease in females with heavy menstrual bleeding is approximately 13%, but the severity of the disorder varies and, consequently, the overall clinical impact remains unknown. Consensus recommendations are presented, which include [1] a structured history for screening females with heavy menstrual bleeding; [2] a collaborative, multidisciplinary evaluation, and [3] a strategy for future basic science and clinical investigation.

Blood Coagulation Disorders↗
PubMedDate not supplied

[Endotoxin aggression as a universal factor of pathogenesis of hemostatic disorders in children with urological pathology].

The role of the kidneys in development of endotoxin aggression and participation of the latter in impaired regulation of hemostasis was demonstrated basing on examination of 30 children with congenital urological pathology. In progressive decline of accumulative-excretory function of the kidneys, compensated chronic endotoxin aggression in children with urological diseases transforms into a subcompensated or uncompensated one with definite clinical manifestation: fever, aggravation of chronic pyelonephritis, marked DIC syndrome, macrohematuria.

Adolescent↗
PubMed1993

Laboratory evaluation of hemostatic disorders.

This article sketches a historical overview of milestones in diagnostic technologies to put into perspective a proposed role for laboratories in the diagnosis of coagulation disorders. Divided into five sections, the information presented in tables, illustrations, and appropriate vignettes for easy reference. The first section deals with the roles of coagulation testing in the management of bleeding and thrombotic disorders. Limitations of coagulation testing in defining the hemostatic state are discussed in the second section, and coagulation testing is reviewed in the third. In the fourth section interpretation of abnormal coagulation test results and the possible relationship to excessive bleeding and thrombosis are thoroughly discussed. The final section examines the contribution of gene analysis in establishing a diagnosis.

Blood Coagulation Disorders↗
PubMed1976

[Hemostatic disorders in septicemia. Apropos of 65 cases].

In the course of a restrospective study, some hemostatic parameters were studied in connection with 65 cases of septicaemia. From this study, it follows that coagulation troubles are more frequent in septicaemiae induced by negative Gram germs, but that this frequency is actually linked with circulatory troubles. Besides, as for the biological diagnosis of the disseminated intravascular coagulation syndrome in this instance, it is not possible to take strictly into account the fibrinogen values or the rate of thrombocytes.

Blood Coagulation Disorders↗
PubMed2001

[Prevention and therapy of hemostatic disorders in massive transfusion].

Adequate periop. analysis of hemostasis taking into account also disorders of primary hemostasis considerably contributes to prevention, early detection and appropriate treatment of hemostatic disturbances. Standard transfusion protocols are advisable in massive transfusion with respect to logistic problems. We describe an effective standard protocol based on the initial administration of blood components (red cells, plasma, platelets) in a certain fixed ratio which then is adapted according to the laboratory test results and the clinical situation of the patient. In addition, as soon as the hemostasis shows critical values, coagulation factor concentrates (prothrombin complex, fibrinogen, seldom single coagulation factors) are administered. Furthermore, desmopressin and antifibrinolytics can be successfully used in disorders of primary hemostasis, and additionally antifibrinolytics in hyperfibrinolysis or unclear diffuse bleeding.

Adult↗
PubMed1995

[Hemostatic disorders in severe forms of diphtheria and their correction with dicinon].

The presence of thrombohemorrhagic syndrome (THS) has been established in 28 patients with toxic severe diphtheria of oropharynx. In view of the leading role of platelet affection in progression of hemorrhagic disorders in diphtheria, dicinon treatment may be beneficial. THS implications in unfavourable outcome of the disease and prognostic significance of critical thrombocytopenia are considered.

Acute Disease↗
PubMed2006

[Complex clinical and laboratory characterization of hemostatic disorders in premature neonates with respiratory distress syndrome].

The pattern of time courses of changes in the basic parameters of homeostasis has been studied in premature neonates with respiratory disorders of varying severity in early neonatality. It is shown that in premature neonates with respiratory distress syndrome, all links of the hemostatic system occur and the activity of the major pool of anticoagulants (antithrombin III and protein C) decreases. The most informative indices are proposed for monitoring hemostatic parameters as determination of basic tests, the levels of protein C, D-dimer, and SFMC.

Hematologic Tests↗
PubMedDate not supplied

Hemostatic disorders in cats: a retrospective study and review of the literature.

Hemostasis profiles from 101 cats presented for medical or surgical evaluation to The Ohio State University Veterinary Teaching Hospital from 1986 through 1991 were reviewed retrospectively; 69% were abnormal. Commonly identified abnormalities included a mixed hemostatic defect compatible with disseminated intravascular coagulation, thrombocytopenia, isolated prolongation of the activated partial thromboplastin time (APTT), and prolongation of both the APTT and one-stage prothrombin time. The most common disorders associated with abnormal hemostasis profiles in this study were liver disease, neoplasia, and feline infectious peritonitis.

Animals↗