Methods of teaching - revisited: games and simulation.
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The health care administrator can use digital simulation as a quantitative decision-making technique. Understanding its conceptual framework will enable the administrator to work with a technical specialist to formulate and solve problems.
Six young trained chess players received 10 consecutive tasks comprising problematic play position at chess. Each subject was tested four times with drug orders balanced across subjects. Compared with saline placebo, physostigmine (20 microgram/kg i.v.) in the presence of peripheral muscarinic blockade (methylscopolamine 6 microgram/kg i.v.) impaired the performance of good players, but the amount of correct solutions was increased when the initial performance level was low. Scopolamine (6 microgram/kg i.v.) impaired the performance of all subjects, and saline placebo proved inactive. The effect of scopolamine together with physostigmine was about the average of the separate effects of these drugs. The subjects talked less, when mildly sedated, and felt nauseated after the physostigmine treatment. Antimuscarinics with and without physostigmine caused cycloplegia in all subjects.
Performances of retarded young adults on the Porteus Maze Test were compared with those of first- through fourth-grade nonretarded children. The retarded subjects, approximately matched on MA with the fourth-grade group, performed at the level of the first graders and were reliably poorer than the third and fourth graders. This MA lag of at least 2 years is consistent with the MA lag previously found on strategic games and puzzles. The retarded and first-grade groups spent more time completing mazes than did the other groups.
Decision theory's role in medicine will lie between the extremes of naive optimism ("a Rosetta stone") and unmitigated pessimism ("a computerized Ouija board"). Its application to public health policy, research, and administrative problem-solving is established; experience offers some guidelines for more limited use in clinical practice.
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The costly provision of public goods serves as a model problem for the evolution of cooperative behavior, presenting a social dilemma between the collective benefits of shared resources and the individual incentive to free-ride in resource production. The spatial structure of populations can also impact cooperation over public goods, as diffusion of public goods and intentional motion of individuals towards regions with greater resources can interact with population and public goods dynamics to produce heterogeneous patterns in the spatial distribution of strategies and resources. In this paper, we build off a model introduced by Young and Belmonte for the reaction dynamics of interacting individuals and an explicit public good, deriving a system of PDEs that describes the spatial profiles of strategies and the public good in the presence of both diffusive motion of individuals and resources and chemotaxis-like directed motion of individuals in response to gradients in the concentration of public goods. Through linear stability analysis, we show that spatial patterns in strategic and public goods profiles can emerge due to either Turing instability with high defector diffusivity or a directed-motion instability through strong sensitivity of cooperators towards increasing resource concentration. We further explore the emergent spatial patterns with a mix of weakly nonlinear stability analysis and numerical simulation, showing that, for a wide range of reaction parameters, diffusion-driven instability appears to increase cooperation and public goods across the spatial domain, while directed motion of cooperators towards public goods tends to decrease cooperation and environmental quality across the environment.
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The interaction between two self-organising systems, each possessing two hierarchical levels, is dealt with. The communication process is pursued as a bidirectional information transfer. The criterion for the selection of the intrasystem control algorithm(s) is based on the maximisation of the 'Joint Figure of Merit' related to the long-term average of an appropriately weighted sum of conflicting terms: Probabilities of homeostases versus adequate matching with the partner.
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A 3D chaos game is shown to be a useful way for encoding DNA sequences. Since matching subsequences in DNA converge in space in 3D chaos game encoding, a DNA sequence's 3D chaos game representation can be used to compare DNA sequences without prior alignment and without truncating or padding any of the sequences. Two proposed methods inspired by shape-similarity comparison techniques show that this form of encoding can perform as well as alignment-based techniques for building phylogenetic trees. The first method uses the volume overlap of intersecting spheres and the second uses shape signatures by summarizing the coordinates, oriented angles, and oriented distances of the 3D chaos game trajectory. The methods are tested using: (1) the first exon of the beta-globin gene for 11 species, (2) mitochondrial DNA from four groups of primates, and (3) a set of synthetic DNA sequences. Simulations show that the proposed methods produce distances that reflect the number of mutation events; additionally, on average, distances resulting from deletion mutations are comparable to those produced by substitution mutations.
Risk taking by 53 nurses and 22 non-nurses was investigated in nursing and nonnursing situations in a laboratory study to assess nurses' propensity to risk and to gain information about how nurses make decisions. Games involving loss and gain of money were used. Subjects received money won from the games, but debts incurred by subjects were canceled. The study indicated that unwillingness to accept risk is not characteristic of all nurses. A nurse's propensity to risk appeared to depend on the situation and on the nurse's educational level. Study findings, though restricted by the mode of investigation, have implications for practice and future research.