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PubMed1998

Functional imaging: heterogeneity in task strategy and functional anatomy and the case for individual analysis.

To learn more about the functional anatomy of language, the authors used [99mTc]HMPAO single photon emission computed tomography (SPECT) functional imaging to study nonword rhyming, lexical-semantics and syntax. The authors did not find any task-related differences in cerebral blood flow using region-by-region analysis of variance. This led them to examine individual subject's task-related patterns of cerebral blood flow. This analysis revealed regions of interest with little or no change but also regions with changes as great as 30%. There was marked subject-to-subject variability in the pattern of blood flow, which precluded statistically significant results using analysis of variance. An alternative analytic strategy based on numbers of subjects exceeding a minimum threshold task-related change in cerebral blood flow was tested and shows promise in identifying commonalities and differences in individual task-related blood flow patterns. The authors conclude that the complex and difficult to interpret pattern of blood flow changes observed in this study reflect in considerable part the combined effects of variability in task strategy, owing in part to insufficiently constrained task performance, and variability in functional anatomy. The authors also tested the differences in results achieved with simple normalization and analysis of covariance approaches and found them to be insignificant.

Adult↗
PubMed1979

Normal functional anatomy of the facial artery.

The functional anatomy of the facial artery consists of a group of constant arterial pedicles nourishing a specific territory and supplied by a variable facial trunk. There is a hemodynamic balance with other variable connecting trunks such as the transverse facial and internal maxillary arteries. Every type of variant, irrespective of its origin, may be understood based on the constant relationships and anastomoses involved. Knowledge of this functional anatomical system is crucial to an understanding of the blood supply to the face.

Angiography↗
PubMed2005

Functional anatomy of the prostate: implications for treatment planning.

PURPOSE: To summarize the functional anatomy relevant to prostate cancer treatment planning. METHODS AND MATERIALS: Coronal, axial, and sagittal T2 magnetic resonance imaging (MRI) and MRI angiography were fused by mutual information and registered with computed tomography (CT) scan data sets to improve definition of zonal anatomy of the prostate and critical adjacent structures. RESULTS: The three major prostate zones (inner, outer, and anterior fibromuscular) are visible by T2 MRI imaging. The bladder, bladder neck, and internal (preprostatic) sphincter are a continuous muscular structure and clear definition of the preprostatic sphincter is difficult by MRI. Transition zone hypertrophy may efface the bladder neck and internal sphincter. The external "lower" sphincter is clearly visible by T2 MRI with wide variations in length. The critical erectile structures are the internal pudendal artery (defined by MRI angiogram or T2 MRI), corpus cavernosum, and neurovascular bundle. The neurovascular bundle is visible along the posterior lateral surface of the prostate on CT and MRI, but its terminal branches (cavernosal nerves) are not visible and must be defined by their relationship to the urethra within the genitourinary diaphragm. Visualization of the ejaculatory ducts within the prostate is possible on sagittal MRI. The anatomy of the prostate-rectum interface is clarified by MRI, as is the potentially important distinction of rectal muscle and rectal mucosa. CONCLUSION: Improved understanding of functional anatomy and imaging of the prostate and critical adjacent structures will improve prostate radiation therapy by improvement of dose and toxicity correlation, limitation of dose to critical structures, and potential improvement in post therapy quality of life.

Ejaculation↗
PubMed1993

The functional anatomy of the elbow complex.

The functional anatomy of the elbow joint complex is unique in orientation and configuration. Three bones, the ulna, radius, and humerus, articulate to form four articulations: the humeroulnar, humeroradial, superior radioulnar, and inferior radioulnar joints. This unique osseous structure provides the elbow excellent static stabilization, which is enhanced by the ulnar collateral ligament, the lateral collateral ligament, and the elbow joint capsule. Twenty-three muscles are directly associated with the elbow joint and can be classified into four main groups: the elbow flexors and extensors and the flexor-pronator and extensor-supinator groups. These muscles provide dynamic stabilization to the elbow and enable the hand to perform skilled, precise motions. The purpose of this review article is to provide the clinician with an understanding of the unique anatomy at the elbow joint and to enhance the clinician's knowledge of the biomechanics, clinical examination, and rehabilitation of the elbow complex.

Elbow Joint↗
PubMed1991

Functional anatomy: a challenge for the decade of the brain.

At the beginning of the "Decade of the Brain," a number of aims for epilepsy research can be identified. These range from fundamental questions about the mechanisms of seizure etiology to the ways that seizures disturb brain function and structure. Information from such research will help in the development of new treatment and rehabilitative strategies for patients with epilepsy. Current tools from molecular biology have greatly expanded the promise and challenges for epilepsy research. As these investigative efforts are undertaken, however, it is important to recall the biological environment in which epilepsy occurs. Three major axes can be identified: the organizational axis (spanning from molecules through synapses to neuronal circuits to behavior), the time axis (relating to the chronobiology of epilepsy and diversities of seizure expression as a function of age), and the functional-anatomy axis (relating to the rich heterogeneity of the brain). Focusing on functional anatomy, certain principles can be developed from work with experimental models of seizures in the hippocampus and related structures. Three levels of functional anatomy are examined--network, local circuit, and individual neuron. This information can serve as a basis for directing epilepsy research in the future.

Brain↗
PubMed2005

[Functional anatomy of lymphangion].

This paper reviews the results of the studies performed mainly by the Russian anatomists on the functional anatomy of lymphangion as a structural and functional unit of lymphatic vessel. One of the peculiar features of functional anatomy of lymphangion is the heterogeneity of its structures (myocytes, endothelium, blood supply and innervation). The functional heterogeneity of different lymphangions, which depends on the local differences in the combination of lymph flow factors, was demonstrated. The role of lymphatic vessels is discussed on the basis of significance of lymphangion in active lymph transport. This is demonstrated by the multiple correlations between lymphangion structure, rate and type of its contractions, length of thoracic duct lymphangions and contraction type (peristaltic, rhythmic), number of lymphangions of thoracic duct and its type (presence of collaterals), form of individual variability of thoracic duct and its myoarchitecture, body mass and lymphangion volume in various animals and at different stages of ontogenesis.

Animals↗
PubMed2006

Functional anatomy of headache.

Functional neuroimaging in headache patients has revolutionised our understanding of these syndromes and provided unique insights into some of the commonest maladies in man, suggesting that at least migraine and cluster headache are primarily driven from the brain. Repeated and independent findings reinforce the crucial role for the brain stem in acute and probably also in chronic migraine, and the hypothalamic grey in several trigemino- autonomic headaches. If further studies confirm these findings, a better understanding will be gained of where and how acute and preventative therapy can be targeted. Given the rapid advances in functional neuroimaging, in particular newer techniques, such as voxel-based morphometry and magnetic resonance spectrometry, functional imaging continues to play a significant role and opens new avenues in targeting the neural substrates in individual primary headache syndromes.

Brain↗
PubMed1999

Effects of lexicality, frequency, and spelling-to-sound consistency on the functional anatomy of reading.

Functional neuroimaging was used to investigate three factors that affect reading performance: first, whether a stimulus is a word or pronounceable non-word (lexicality), second, how often a word is encountered (frequency), and third, whether the pronunciation has a predictable spelling-to-sound correspondence (consistency). Comparisons between word naming (reading) and visual fixation scans revealed stimulus-related activation differences in seven regions. A left frontal region showed effects of consistency and lexicality, indicating a role in orthographic to phonological transformation. Motor cortex showed an effect of consistency bilaterally, suggesting that motoric processes beyond high-level representations of word phonology influence reading performance. Implications for the integration of these results into theoretical models of word reading are discussed.

Adult↗
PubMed2000

Animating functional anatomy for the web.

The instructor sometimes has a complex task in explaining the concepts of functional anatomy and embryology to health professional students. However, animations can easily illustrate functional anatomy, clinical procedures, or the developing embryo. Web animation increases the accessibility of this information and makes it much more useful for independent student learning. A modified version of the animation can also be used for patient education. This article defines animation, provides a brief history of animation, discusses the principles of animation, illustrates and evaluates some of the video-editing or movie-making computer software programs, and shows examples of two of the author's animations. These two animations are the inferior alveolar nerve block from the mandibular nerve anesthetics unit and normal temporomandibular joint (TMJ) function from the muscles of the mastication and the TMJ function unit. The software discussed are the industry leaders and have made the job of producing computer-based animations much easier. The programs are Adobe Premiere, Adobe After Effects, Apple QuickTime and Macromedia Flash .

Anatomy↗
PubMed1998

Functional anatomy, vascularisation and pathology of the human thalamus.

The thalamus is a nuclear complex situated in the diencephalon. Besides a neuro-anatomical description of the thalamus, this article reviews the current knowledge on the functional anatomy of the three functional classes of thalamic nuclei: specific, non-specific and association nuclei. As the majority of the pathology affecting the thalamus is of cerebrovascular origin, the vascularisation of the human thalamus will be reviewed as well. Finally, the knowledge of the functional anatomy and the vascularisation of the human thalamus will be integrated in the review of the semeiology of thalamic syndromes. Besides its function as a relay centre in subserving sensory and motor mechanisms, the thalamus participates in various neurocognitive processes such as memory and language. The current knowledge on these topics will be reviewed as well.

Cerebrovascular Disorders↗
PubMed1991

Functional anatomy of human hand sensorimotor cortex from spatiotemporal analysis of electrocorticography.

We measured chronic electrocorticography (ECoG) of sensorimotor cortex during contralateral median nerve stimulation in 6 patients with partial seizures evaluated for surgery. We analyzed the spatiotemporal structure of the somatosensory evoked response (SER) using multiple source modeling to investigate functional anatomy of its neuronal sources. Two dipole sources in postcentral gyrus explained the large majority of the first 60 msec of the SER, indicating a subregion of hand somatosensory cortex generating this activity. The source locations agreed with normal functional anatomy from cortical stimulations, intraoperative photographs, and postoperative neurological examinations after focal excisions. The time patterns of both sources were biphasic like the previously described N20-P30 and P25-N35 peaks. The spatiotemporal patterns of both sources overlapped. Spatiotemporal analysis with multiple dipole sources appears useful to determine the number, locations, and spatiotemporal field patterns of cortical regions active during peripheral somatosensory stimulation and reveals simplicity in the macroscopic functional anatomy of dynamic human sensorimotor cortex.

Adolescent↗
PubMed1996

Functional anatomy of the triangular fibrocartilage complex.

The functional anatomy of the triangular fibrocartilage complex (TFCC) was investigated in 20 fresh cadavers. Dynamic changes in the TFCC during rotation were also examined from both the proximal and distal aspects. In our analysis, the TFCC was separated into three components. The distal component was stable, functioning like a hammock to suspend the ulnar carpus. The proximal component was the fan-shaped triangular ligament, the true radioulnar ligament. This was found to originate from the fovea of the ulna in a vertical fashion and was easily twisted during rotation. The third component, the ulnar collateral ligament, also twisted during rotation. When analysed by coronal section, the internal portion of the TFCC was found to be loose, and probably serves as a cushion to absorb local deformities in the TFCC during rotation.

Adolescent↗
PubMedDate not supplied

Functional anatomy of the facial vasculature in pathologic conditions and its therapeutic application.

The authors describe the functional anatomy of the facial vascular system, using the anastomoses between the facial, maxillary, transverse facial, lingual, and ophthalmic systems to selectively identify the blood flow to a specific territory for embolization and posttreatment evaluation of hemangiomas. In three patients the specific vascular patterns are described and the usefulness of understanding the regional functional anatomy is illustrated for successful embolotherapy of these malformations.

Adolescent↗
PubMed1992

Human functional anatomy of visually guided finger movements.

The functional anatomy of visually guided movement was investigated in 18 normal subjects performing visuomotor tracking tasks during positron emission tomography imaging. Tracking a moving target with the index finger defined a network of focal responses of relative cerebral blood flow (relCBF) located in the primary motor cortex, dorsal parietal cortex, precuneate cortex, supplementary motor area (SMA) and ipsilateral anterior cerebellum relative to visual tracking alone. When the temporal complexity of the tracking task was altered by introducing a 'no go' contingency that allowed for greater time for movement preparation, there was a significant increase of relCBF in the SMA (P less than 0.0001). When the spatial complexity was augmented by adding a secondary target that provided directional cues for the primary target, there were additional significant increases of relCBF in bilateral dorsal parietal cortex (P less than 0.05) and precuneate cortex (P less than 0.05). Although the cued 'no go' task was subjectively easier, relCBF responses were similar to the uncued 'no go' task in motor areas. Performing the tracking task with different body parts produced somatotopically distributed responses in only the motor cortex. The findings are concordant with clinical reports of patients with brain lesions and physiological evidence that identifies this distributed network for performing visually guided movement. The results provide direct human evidence in the normal brain that the supplementary motor area contributes in part to the sequencing of movements and the medial and dorsal parietal cortex participates in the integration of spatial attributes during selection of movements.

Adult↗
PubMed2003

[Dry eye disease as a complex dysregulation of the functional anatomy of the ocular surface. New concepts for understanding dry eye disease].

INTRODUCTION: Dry eye disease is a disorder of the tear film that results in epithelial damage and in a disruption of the normal homeostasis at the ocular surface. It is widespread and causes symptoms ranging from discomfort to blindness. METHODS: A review of the existing literature was used to compare different past and recent concepts for the understanding of dry eye disease with a focus on aspects of the integrating functional anatomy of the ocular surface. RESULTS: The understanding of the pathogenesis of dry eye disease has proceeded from the mere recognition of a lack of tears to a consideration of their quality and to the concept of wetting of the ocular surface. However, several other aspects as epithelial differentiation, innervation, hormonal status or immune protection contribute to the intact functional anatomy of the ocular surface. Recently it has been recognized that immunologically regulated mechanisms of inflammation represent a primary or secondary pathogenetic factor for dry eye disease. This is conceivably regulated by the cells of the physiological mucosal immune defence system, the eye-associated lymphoid tissue (EALT). Androgens represent an important trophic factor for the ocular surface and their deficiency predisposes to inflammation. CONCLUSION: Dry eye disease represents a complex dysregulation of the functional anatomy of the ocular surface that can start from different alterations (e.g. insufficient secretion, defects in wetting or innervation). Immune-based inflammation is able to interconnect and negatively reinforce these different pathomechanisms, resulting in a vicious circle.

Conjunctiva↗
PubMed1986

Functional anatomy of the lower limb.

To understand the functional anatomy of the lower limb, one must apply one's knowledge of the gross anatomy to the gait cycle. Gait analysis then leads to a better understanding of the function and dysfunction seen in the lower limb. Data from biochemical studies help one appreciate the forces the major joints are subjected to. These loads are three to five times body weight. The reason normal gait is so smooth is that there is minimal motion of the center of gravity located in the pelvis. Supple joints and good muscle strength are needed or gait disturbances result.

Ankle Joint↗
PubMedDate not supplied

Functional anatomy of pointing and grasping in humans.

The functional anatomy of reaching and grasping simple objects was determined in nine healthy subjects with positron emission tomography imaging of regional cerebral blood flow (rCBF). In a prehension (grasping) task, subjects reached and grasped illuminated cylindrical objects with their right hand. In a pointing task, subjects reached and pointed over the same targets. In a control condition subjects looked at the targets. Both movement tasks increased activity in a distributed set of cortical and subcortical sites: contralateral motor, premotor, ventral supplementary motor area (SMA), cingulate, superior parietal, and dorsal occipital cortex. Cortical areas including cuneate and dorsal occipital cortex were more extensively activated than ventral occipital or temporal pathways. The left parietal operculum (putative SII) was recruited during grasping but not pointing. Blood flow changes were individually localized with respect to local cortical anatomy using sulcal landmarks. Consistent anatomic landmarks from MRI scans could be identified to locate sensorimotor, ventral SMA, and SII blood flow increases. The time required to complete individual movements and the amount of movement made during imaging correlated positively with the magnitude of rCBF increases during grasping in the contralateral inferior sensorimotor, cingulate, and ipsilateral inferior temporal cortex, and bilateral anterior cerebellum. This functional-anatomic study defines a cortical system for "pragmatic' manipulation of simple neutral objects.

Adult↗
PubMedDate not supplied

Anterior cruciate ligament: functional anatomy of its bundles in rotatory instabilities.

The functional anatomy of tha anterior cruciate ligament was studied in 18 freshly amputated specimens. The cruciates were observed in the extremes of flexion and extension, and in midposition in simulated weight-bearing and nonweight-bearing conditions. Five femoral shafts were split longitudinally so that the femoral and tibial attachments of the ligament could be inspected. The findings indicated that (1) the anterior cruciate ligament is a secondary static stabilizer against rotatory instabilities of the knee; (2) the anteromedial bundle contributes to anterolateral stability; (3) the intermediate bundle adds to straight and anteromedial stability; and (4) the posterolateral bundle assists in posterolateral stability. Specific bundles and functions of bundles must be considered in reconstruction, substitution, or replacement of the anterior cruciate ligament.

Animals↗