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[The diagnosis and treatment of osteoarthrosis deformans in subjects in contact with fluorine compounds].

A comparative study is presented of 378 workers with osteoarthrosis deformans (OD) contacting with fluorine compounds and in 106 patients with primary OD. The diagnostic criteria in these two categories of patients coincided. But the pain syndrome in the joints in professional fluorosis (PF) was associated with ossalgias (85%), tenderness of the bones (50.1%) and in 100% by symmetric hyperostosis. OD in PF was accompanied by a more pronounced density, was not accompanied by formation of nodes, and secondary synovitis was 4 times frequent. In OD plus PF males prevailed (96.7 e), and were averagely 10 years younger. In OD+PF treatment diet, calcium agents, glutamic acid should be used that bind and excrete fluorine from the body.

Adult↗

[Lysozyme activity in the saliva of industrial workers exposed to fluorine compounds].

The authors performed investigations in Phosphoric Fertilizers Works in Gdańsk to find out whether or not the work environment contaminated by fluorine compounds affects the activity of lysozome--the protective enzyme of saliva. In some in vitro experiments lysozome activity in exposed workers' saliva was found to be significantly lowered, as opposed to that in unexposed workers. In vivo experiments did not indicate any effects of work conditions on the activity of this enzyme. The obtained results, in vivo and in vitro, do not demonstrate any clear effects of work environment in the Phosphoric Fertilizers Works in Gdańsk, upon lysozome activity in workers' saliva.

Adult↗

Long-term sequestration of fluorinated compounds in tissues after fluvoxamine or fluoxetine treatment: a fluorine magnetic resonance spectroscopy study in vivo.

Fluorine magnetic resonance spectroscopy (19F MRS), spectroscopic imaging (MRSI) and proton anatomical magnetic resonance imaging (1H MRI) were performed on brains and lower extremities of six subjects in vivo concurrently with HPLC of serum to investigate tissue and plasma drug localization and withdrawal kinetics in humans treated with fluvoxamine or fluoxetine. 19F MRS signal was unexpectedly detected in the lower extremities months after complete disappearance of signal from plasma and brain. MRSI suggested that the lower extremity fluvoxamine signal originated mainly from bone marrow. Results suggest long-term sequestration of these drugs or their metabolites mainly in bone marrow and possibly in surrounding tissue and demonstrate the usefulness of MRS to reveal drug-trapping compartments in the body.

Adult↗