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At least 37 records · Page 2Linked to original sources

Prediction of the potentially fertile period by urinary hormone measurements using a new home-use monitor: comparison with laboratory hormone analyses.

BACKGROUND: The study compared a new urinary hormone monitoring system, Clearview Primera Fertility Monitor (CPFM), with laboratory hormone analyses in the prediction of the potentially fertile period. METHODS: Thirty healthy female volunteers provided blood and early morning urine samples for one cycle. Serum oestradiol, progesterone and luteinizing hormone (LH), and urinary LH and oestrone-3-glucuronide (E3G) were measured. The fertility status of volunteers; Low, High or Peak, was collected from monitors and compared with the hormone measurements. RESULTS: There was agreement between the first day of peak fertility and the urinary LH peak day in 65.6% of cycles and detection 1 or 2 days before the urinary LH peak day in 24.1 and 6.9% of cycles respectively. In 58.6% of cycles the system detected up to 5 days of increased fertility prior to the urinary LH peak day. Warning days of the urinary LH peak were similarly determined using defined thresholds of E3G and oestradiol providing up to 5 days warning in 82.8 and 96.6% of cycles respectively. CONCLUSIONS: The system can provide couples attempting to conceive with information about the potentially fertile days in the cycle in order that they may time intercourse. It also has potential for use in evaluation and treatment of infertile couples.

Adult↗

[Correlation between indicators of the fertile period of the menstrual cycle and ultrasonically-determined ovulation].

The authors intend to verify the reliability of some indices set up for the assessment of the fertile period of the menstrual cycle in women. The patterns of the following indices were studied and related to the day of ovulation, as detected by pelvic ultrasonography, in 42 cycles in healty women: the urinary surge of luteinising hormone tested by radioimmunoassay (R.I.A.), urinary surges of estrone-3-glucuronide (E1-3-G) and pregnanediol-3 alpha-glucuronide (Pd-3-alpha-G) tested by chemiluminescence immunoassay, cervical mucus at the vulva and basal body temperature (B.B.T.) recorded by self-observation. The patterns of these parameters have shown a various temporal relationship and reliability for detection of the fertile days of the menstrual cycle.

Adolescent↗

Is the salivary "ferning" a reliable index of the fertile period?

We found that the fern leaf crystallisation of human saliva is a non-specific phenomenon, independent on the action of estrogenic hormones. Salivary ferning can be obtained in practice during the whole menstrual cycle and occurs in the saliva of postclimateric, pregnant and prepuberal women. Even the saliva of male subjects gives invariably the ferning reaction. In conclusion, salivary ferning does not seem a reliable method to establish woman fertile period.

Crystallization↗

Cervicovaginal peroxidases: markers of the fertile period.

The specific activity of guaiacol peroxidase was measured daily in human cervical mucus, vaginal fluids, and saliva during 45 cycles in 31 women. Also determined were basal body temperatures and serum hormones (luteinizing hormone [LH], estradiol, progesterone). The guaiacol peroxidase was extracted with 0.5 M CaCl2 and thus may be a different peroxidase from that obtained by noncalcium extraction procedures. The guaiacol peroxidase specific activity did not vary in the saliva during the cycle but fell sharply in the cervical mucus and vaginal fluid four to five days before the ovulation time, estimated by the LH peak, and rose again one to two days after ovulation. Anovulatory cycles did not show the midcycle drop in guaiacol peroxidase. Growth curve analysis gave excellent fitting of the guaiacol peroxidase data to a polynominal model. These data suggest that cervicovaginal guaiacol peroxidase may be clinically useful in detecting the fertile period for population control and for infertility treatment.

Adult↗

Evaluation of the Lady Free Biotester in determining the fertile period.

Small hand-held microscopes have been developed for self-observation of salivary ferning patterns to detect the fertile time of a woman's menstrual cycle. The purpose of this study was to evaluate one such microscope, the Lady Free Biotester, by comparing it with the self-observation of cervical-vaginal mucus and with the self-detection of luteinizing hormone (LH) in the urine. Twelve natural family planning teachers (average age 34.6 years) observed their cervical-vaginal mucus, tested their urine for LH, and observed salivary and cervical-vaginal mucus ferning patterns (with the Lady Free Biotester) for two menstrual cycles. Data indicated that there was a strong correlation between the LH in the urine and the peak in self-observed cervical-vaginal mucus ferning (r = 0.99, p < or = 0.001) and salivary ferning (r = 0.98, p < or = 0.001). However, it was difficult to assess the beginning and end of the fertile time based on the salivary ferning patterns. Further testing of salivary ferning patterns is recommended before widespread use of these devices for family planning.

Adult↗

Lifetime probability of additional births by age and parity for American women, 1935-1968: a new measurement of period fertility.

A new fertility measurement, probability that a woman of specified parity and age will bear a given number of births in her remaining lifetime, is proposed in this article. The measurement is a summary index of a set of age-parity-specific birth probabilities and in a particular case it is conceptually analogous to the total fertility by birth order but free from the influence of the parity distribution. Fertility of American women for the period 1935-1968 was studied by use of such lifetime probabilities. It appears that the trend of fertility of high birth orders has been parallel with that of low orders. Initiation of the recent decline in fertility depends on parity and age of woman.

Adolescent↗

Morphological studies on the surface and intracellular structures of the rat ovum during early post-fertilization period.

Rat ova in the early stage after fertilization were subjected to the double fixation with glutaraldehyde and osmium combined with critical point drying. Then they were observed by the scanning electron microscope. After that, they were soaked in QY-1 and embedded in epon. Ultrathin sections were prepared for them by means of MT-1 and observed by transmission electron microscopy. These sections were potentially available for scanning and transmission electron microscopy to observe peripheral changes and inner development of the ovum with the lapse of time in the early stage after fertilization.

Animals↗

Application of time-series analysis for the recognition of increases in urinary estrogens as markers for the beginning of the potentially fertile period.

Time-series analysis was applied to the urinary total estrogen data from 142 ovulatory menstrual cycles to determine the first statistically significant increase as a marker for the beginning of the potentially fertile phase. Application of the Trigg's tracking signal to each cycle detected an increase in urinary total estrogens above the baseline in every case, with a cumulative probability of > or = 95%. The distribution of first increase days ranged from 10 days before 3.5 days before the presumed day of ovulation with a mean of 6.5 +/- 1.4 days. The significant parameters in the calculation of the tracking signal are the smoothing constant (alpha) which is related to the number of baseline observations, the baseline mean for the cycle, and the variation of the baseline mean. The method allows a calculation of the tracking signal as the cycle unfolds and a statistical assessment can be given each day. The procedure is easily adaptable for computer calculation, and because it is applied to individual cycles avoids the use of population means with the loss of information inherently associated with the combination of data from many cycles. The Trigg's tracking signal is an appropriate method of analysis of menstrual cycle data and represents a satisfactory alternative to the more usual cumulative sum procedure. The distribution of the first increases constitutes a reference standard for urinary estrogen assays.

Adult↗