The enzymic synthesis of dihydrofolate from 2-amino-4-hydroxy-6-hydroxymethyldihydropteridine and p-aminobenzoylglutamate by extracts of Lactobacillus plantarum.
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Folic Acid↗
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Effect of antimetabolites on the growth of Entamoeba histolytica. IV. Folic acid analogues.
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Antimetabolites↗
The enhanced folic and folinic acid contents of erythrocytes infected with malaria parasites.
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Animals↗
Folic acid, its analogs and antagonists.
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Folic Acid↗
Carcinoma of the cervix treated with continuous intra-arterial methotrexate and intermittent intramuscular leucovorin.
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Carcinoma↗
Occurrence of independent systems for the cleavage of folic acid and citrovorum factor in rat liver.
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Biophysical Phenomena↗
Interaction of formaldehyde and tetrahydrofolic acid and its relation to the enzymic synthesis of serine.
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Biochemical Phenomena↗
Folinic acid requirment of strains of the genus Pedicoccus.
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Folic Acid↗
Enzymic conversion of tetrahydrofolic acid to folinic acid by plant protein.
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Folic Acid↗
The interconversion of serine and glycine; preparation and properties of catalytic derivatives of pteroylglutamic acid.
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Catalysis↗
The interconversion of serine and glycine; some further properties of the enzyme system.
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Coenzymes↗
The reaction of tetrahydropteroylglutamic acid and related hydropteridines with formaldehyde.
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Folic Acid↗
Spectrophotometric studies on the combination of formaldehyde with tetrahydropteroylglutamic acid and other hydropteridines.
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Folic Acid↗
Analogues of folic acid and the activity of dihydrofolic acids in the synthesis of methionine by Escherichia coli.
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Escherichia coli↗
Folinic acid and non-dialyzable materials in the nutrition of malaria parasites.
The extracellular survival of the malaria parasite Plasmodium lophurae was favored on the 4th day of incubation in vitro by the presence in the medium of added folinic acid at a concentration of about 5 microg. per ml. The development of the human malaria parasite P. falciparum intracellularly in suspensions of human erythrocytes was better in a medium with a high than in one with a low concentration of folic acid. In the early extracellular development of P. lophurae in vitro erythrocyte extract could be partially replaced by certain yeast protein preparations and by a non-dialyzable fraction, free from hemoglobin, prepared from duck erythrocyte extract by means of starch electrophoresis.
Animals↗
The synthesis of citrovorum factor by Leuconostoc mesenteroides P60.
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Folic Acid↗
Effect of citrovorum factor and peptones on mouse leukemia cells L-5178 in tissue culture.
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Animals↗
Sparing of folinic acid by thymidine.
Thymidine, which is inactive when added alone to Pediococcus cerevisiae (Leuconostoc citrovorum) 8081, was found to increase its growth in the presence of folinic acid. The addition of thymidine increased both the sensitivity of the folinic acid assay and the total growth yield. The mechanism of the synergistic effect of thymidine is briefly discussed.
Folic Acid↗