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At least 37 records · Page 2Linked to original sources

High-throughput screening of historic collections: observations on file size, biological targets, and file diversity.

At Pfizer Central Research, high-throughput screening has been an important source of new leads for drug discovery for a decade. Our experience with over 150 high-throughput screens can address questions about necessary file size, how well particular biological targets fare (with particular reference to protein-protein interactions), and what file diversity means in practice.

Databases, Factual↗

X-File: a program for maintaining a radiographic teaching file.

Software designed for entry, retrieval, and maintenance of radiographic case-file data on a microcomputer offers considerable help in maintaining such records in a radiology department. The case files are based on the Index for Roentgen Diagnoses, published by the AmericanCollege of Radiology. The terms and code numbers of the index are included in the software, so that the user need only enter the diagnostic term desired; the code numbers and exact terminology are assigned automatically. The software is written for an IBM-compatible microcomputer. Residents and staff radiologists have been using the program for the past two years to store and find both confirmed cases and other interesting cases. The system's capacity exceeds 70,000 entries on a 20-megabyte had disk. The program has five features not found in previous similar programs and not attainable with manual methods.

Hospital Information Systems↗

A comparison of Flex-R files and K-type files for enlargement of severely curved molar root canals.

A double exposure radiographic technique is introduced and used to evaluate the magnitude of apical canal transportation that occurs during preparation procedures. The balanced force technique and a step-back method for cleaning and shaping root canals were evaluated in mesiobuccal root canals from 80 extracted human molar teeth with curvatures ranging from 30 to 73 degrees. Pre- and posttreatment file positions were examined from clinical and proximal radiographic views by computer digitization. Statistical analysis indicated significantly less apical transportation with the use of the balanced force technique when compared with a step-back technique in canals exhibiting both more and less than 45 degrees of curvature.

Dental Pulp Cavity↗

Analysis of the registry of toxic effects of chemical substances (RTECS) files and conversion of the data in these files for input to the environmental chemicals data and information network (ECDIN).

A data bank for environmental chemicals, ECDIN, is being developed at the Joint Research Centre of the European Communities in cooperation with universities and research institutes in the nine member states as a part of the Environmental Research Programme of the EC. During the pilot phase of the project, data from the Registry of Toxic Effects of Chemical Substances have been incorporated into the data bank. Conversions of the data into ECDIN input format was necessary before inclusion of the toxicity data in ECDIN, and the computer programs used for this format conversion have produced various statistics for the contents of the RTECS files. Analyses of the data in three editions of RTECS are presented.

Environmental Pollutants↗

Root canal transportation with a Ni-Ti rotary file system and stainless steel hand files in simulated root canals.

OBJECTIVE: The purpose of this study was to compare the root canal transportation of the crown-down technique performed with the Ni-Ti rotary ProFile system (Dentsply/Maillefer), with the step-back technique using stainless steel K-Flexofiles (Dentsply/Maillefer). METHOD AND MATERIALS: Thirty simulated root canals in resin blocks were equally divided into 2 groups. The first group was instrumented with the ProFile system in a crown-down technique and the second group with hand K-Flexofiles in a step-back technique. After instrumentation, resin blocks of both groups were scanned by a transparency scanner, and the derived images were superimposed with the scanned image of an uninstrumented block. Transportation was digitally calculated by a computer software, and results were statistically evaluated by Student t test. RESULTS: Statistically significant differences (P < .05) were found among the 2 groups at 1, 2, 4, 5, and 6 mm from the apical foramen. No statistically significant difference was detected at 3 mm from the apical foramen. CONCLUSION: ProFile caused less transportation at 1 and 2 mm from the apex, whereas at 3 mm, both instrumentation techniques caused the same transportation. Standard deviation was less in the ProFile group than in the hand file group, indicating a more standardized preparation.

Dental Alloys↗

Extended apical enlargement with hand files versus rotary NiTi files. Part II.

OBJECTIVE: The objective of this study was to compare 2 preparation techniques performed under simulated clinical conditions with extended apical enlargement following determination of the optimal apical preparation size (APS). STUDY DESIGN: After preflaring 240 root canals, APS was evaluated as outlined in Part I. The apical portion was shaped to APS either with rotary NiTi Lightspeed instruments (LS) or NiTi hand instruments (HA) using the balanced force technique in a phantom head. After sectioning the apical area at 3 levels, every cross section was analyzed microscopically for circumferential removal of canal wall dentine. Loss of working length, instrument separation, and perforation were additionally recorded. RESULTS: In 70% (LS) and 69% (HA) of the root canals, 2 of 3 levels demonstrated that the root canal dentin was cut circumferentially. Neither loss of working length nor perforation occurred in both groups. Four LS instruments separated. CONCLUSIONS: APS frequently results in a nearly complete apical preparation regardless of the preparation techniques. In a few cases apical enlargement to APS does not achieve complete cutting of the canal walls. There was a rather slight risk of serious procedural errors.

Algorithms↗