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Results for “Ear Cartilage”

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At least 37 records · Page 2Linked to original sources
PubMed1978

The velocity field of growing ear cartilage.

The velocity vector field of the growing rabbit ear cartilage has been investigated between 12 and 299 days. Empirical curves have been computed for path lines and for velocities between 12 and 87 days. The tissue movement has been found to behave as an irrotational flow of material. Stream lines and velocity equipotential lines have been calculated and provide akinematic description of the changes during growth. The importance of a knowledge of the velocity vector in physical descriptions of growth and morphological differentiation at the tissue and cellular levels is emphasized.

Animals↗
PubMed1986

Simplified harvesting of the ear cartilage graft.

A simplified technique of harvesting of the ear cartilage graft is described which (1) uses a postauricular incision to minimize the visible scars, (2) removes the whole floor of the conchal fossa to avoid the irregularities, and (3) uses a tie-over dressing to eliminate the need for a head dressing. This technique has been used on 88 patients with one visible and tender medial irregularity, and three minor palpable, but invisible irregularities.

Bandages↗
PubMed2004

[Repair of the rabbit ear cartilage defects with transforming growth factor-beta1 and allogenic chondrocyte/poly-DL-lactide higher porosity polymer].

OBJECTIVE: To study the repair of the rabbit ear cartilage defects with transforming growth factor-beta1 (TGF-beta1) and allogenic chondrocyte/poly-DL-lactide (PDLLA) higher porosity polymer. METHODS: A total of 18 rabbits were divided into the TGF-beta1 and chondrocytes/PDLLA graft group, the chondrocytes/PDLLA graft group, and the blank control group. Samples were taken out at 4, 12 and 18 weeks after implantation. The histological characteristics were investigated. RESULTS: After 18 weeks of the transplantation, the repaired effects of TGF-beta1 and allogenic chondrocytes/PDLLA graft group was better than the allogenic chondrocytes/PDLLA graft group not only on general sample but also histology, and the blank control group were repaired with fibrous tissue. CONCLUSIONS: The allogenic chondrocytes/PDLLA graft could repair the rabbit ear cartilage defects while TGF-beta1 could improve the quality of the rabbit ear cartilage defects.

Animals↗
PubMed2004

Rabbit ear cartilage regeneration with a small intestinal submucosa graft.

OBJECTIVES/HYPOTHESIS: The objective was to demonstrate that interpositional grafting with porcine small intestinal submucosa promotes cartilage regeneration following excision of rabbit auricular cartilage. STUDY DESIGN: Blinded, controlled study. METHODS: Eight New Zealand white rabbits underwent excision of auricular cartilage on two sites with and two sites without preservation of perichondrium. Porcine small intestinal submucosa was implanted into one site with and one site without intact perichondrium. Remaining sites served as control sites. Histological assessment was performed at 3 (n = 4) and 6 (n = 3) months and at 1 year (n = 1) after grafting. RESULTS: Histological evaluation showed cartilage regeneration accompanied by chronic inflammation in areas in which porcine small intestinal submucosa was implanted between layers of intact perichondrium. Other sites failed to show significant cartilage regeneration. CONCLUSION: The results of the study using porcine small intestinal submucosa as a bioscaffold for cartilage regeneration are promising and justify further animal and human studies.

Animals↗
PubMed1987

The effects of unilamellar perichondrial dissection on the growth of rabbit ear cartilage.

The effects of elevation of the perichondrium from a surface of growing ear cartilage were investigated in immature rabbits. Eight 21-day-old rabbits completed the study in which perichondrium was elevated from one cartilaginous surface of one ear and the nonoperated ear served as a control. By maturity, both ears had developed symmetrically and no statistically significant difference could be demonstrated in length and surface area. Although several ears demonstrated subtle shape changes, the overall growth and development of the surgically manipulated ear cartilages did not appear to be affected. These findings appear to contradict a widely held view that perichondrial dissection of developing cartilage has a high potential for subsequent growth disturbances. The corollary has been that cartilage manipulation, such as that required in the surgical repair of the cleft lip nose deformity, should be delayed until the growth of cartilage is complete. These data would support the findings of long-term clinical studies which demonstrate the efficacy of early limited perichondrial dissection in the correction of the cleft lip nose deformity.

Animals↗
PubMed1976

N6,O2'-dibutyryl adenosine 3', 5'-monophosphate-stimulated release of proteoglycans from cultured immature rabbit ear cartilage.

The stimulatory effects of N6, O2'-dibutyrl adenosine 3',5'-monphosphate on proteoglycan released from immature rabbit ear cartilage were studied in viltro. Cartilage incubayed in medium containing dibutyryl cyclic AMP resulted in a significant increase of proteoglycans released in concentrations above 0.5 mM. Theophylline (1 mM) which did not significantly stimulate proteoglycans released alone, was found to potentiate the action of this nucleotide. ATP, 5'-AMP and butyric acid in the presence of theophylline, did not stimulate proteolgycans released. The addition of protein or RNA synthesis inhibitors depressed proteoglycans released by dibutyryl cyclic AMP and theophylline. Gel chromatogrphic and chemical investigation of the proteoglycans released into the culture media in the presence of dibutylic cyclic AMP indicated a reduction in the proportion of protein associated with these complexes. This result, together with enzyme inhbitor studies, leads us to speculate that the observed action of dibutyryl cyclic AMP on rabbit ear cartilages may be mediated by the neutral proteases.

Acetylglucosaminidase↗
PubMedDate not supplied

The effects of resorbable plates on rabbit ear cartilage.

BACKGROUND: When performing septorhinoplasty, deviated segments of septal cartilage can be straightened using cartilage or bone as splinting grafts. In some cases, autologous material is not available without an additional surgical procedure to harvest cartilage or bone. It is possible that resorbable plates can be used to splint and straighten deviated cartilage. Experience using bioresorbable rigid fixation devices on cartilage has been limited. OBJECTIVE: To examine early histopathologic changes of rabbit ear cartilage and adjacent soft tissue following implantation with bioresorbable plates. DESIGN: Nonrandomized, placebo-controlled trial. SUBJECTS: Twelve adult New Zealand white rabbits. MATERIALS AND METHODS: Ten adult New Zealand white rabbits (20 ears) underwent stenting of intact ear cartilage with LactoSorb plates (Lorenz, Jacksonville, Fla). Rabbits were killed 28 days after implantation, and the soft tissue, plates, and cartilage were harvested and prepared for histological examination. As controls, 2 rabbits (4 ears) underwent dissection and closure without stenting. RESULTS: Six rabbits experienced superficial skin breakdown on the ventral surface of the ear caused by excessive wound tension of the implant. The cartilage-plate interface and the surrounding soft tissues stenting the dorsal side of the ear remained free of inflammation or necrosis for all animals. Simple elevation of the perichondrium revealed no differences in the appearance of the cartilage between the control and test rabbits. CONCLUSIONS: Resorbable plates have no deleterious effects on cartilage during the first month of implantation. While short-term studies have documented the safety and efficacy of using bioresorbable plates, further studies are recommended.

Absorbable Implants↗
PubMed2003

Grafting the nasal dorsum with tandem ear cartilage.

A technique for autogenous grafting of the nasal dorsum with ear cartilage is suggested based on the results of 25 consecutive cases. The technique involves (1) harvesting the entire cymba conchae and cavum conchae of the ear; (2) separating them and suturing them to each other in tandem fashion; (3) filling the underside concavity of the cymba conchae part of the graft with scraps of cartilage; (4) avoiding any bruising or crushing of the graft; and (5) filling any minor residual irregularities of the dorsum with soft tissue or cartilage from the cephalic trim of the lateral crus. The results suggest a consistent augmentation of the nasal dorsum for deficiencies from 3 to 6 mm in size. Four of the 25 cases did require secondary correction for dorsal convexity, inadequate augmentation, and surface irregularities. The technique, however, has been helpful in that ear cartilage is invariably available, allowing septum to be used for more important grafts. The procedure is easily performed under local anesthesia with no significant distortion to the donor site.

Adult↗
PubMedDate not supplied

Relapsing polychondritis. Electron microscopic study of ear cartilage.

Light microscopic and for the first time electron microscopic (EM) studies of involved elastic ear cartilage in a patient with relapsing polychondritis confirm the superficial location of the inflammatory reaction. EM studies of deep cartilage were identical to those on controls except for a rare necrotic cell. Superficial cartilage showed a finely granular electron-dense material. This material, which may be protein, possibly of enzyme or immunoglobulin origin, also surrounded some elastic fibrils. Findings of predominantly superficial changes and the multisystem disease in the present patient and in many others suggest that the cartilage destruction is part of a systemic inflammatory disease.

Cartilage↗
PubMed1983

Otoplasty: something old, something new. Reconstruction of the external ear using fresh cadaver homograft ear cartilage and a sternomastoid myocutaneous flap.

By combining the very old concept of using fresh cadaver homograft ear cartilage with the more modern idea of a musculo-cutaneous flap, a new ear has been constructed for a patient who was considered unsuitable for standard reconstructive procedures. The early cosmetic result appears satisfactory and the patient's hearing has been significantly improved.

Adult↗
PubMed1981

An ultrastructural study on the ear cartilage of rabbits after the administration of papain. Appearance of cross-striated collagen segments of an atypical FLS-type.

Crude papain was administered intravenously to young rabbits and the cartilage of the collapsed ear was examined electron-microscopically. Degeneration and recovery of chondrocytes, and decrease in and recovery of the electron-density of elastic fibers, were observed during the collapse and restoration of the ear. Some samples were stained with ruthenium red. In the collapsed ear, with a marked decrease of proteoglycan in the cartilage, loss of ruthenium red-positive granules was observed in the extracellular matrix. Collagen fibrils in the cartilage appeared to be somewhat increased in number, some of their diameters became slightly greater, and a part were assembled into bundles, occasionally accompanied by periodic cross-striation. Decrease of proteoglycan in the cartilage matrix probably brought about the unmasking and the assembly of collagen fibrils. In one of the experimental animals, collagen fibrous segments of an atypical fibrous long spacing (FLS-)type with symmetrical cross-striation were found around the chondrocytes in the ear cartilage, during the period of recovery. Some kind of the endogenous sulfated carbohydrate may have acted to affect the arrangement of type II collagen or procollagen molecules newly produced by the recovering chondrocytes.

Animals↗