Search PubMed⌕ Search

SEARCH · Search PubMed

Results for “EJACULATION”

Search indexed PubMed citations on genomics, clinical trials, systematic reviews and public health. Explore titles, authors and supplied subject terms, then open the PubMed record.

Quote a phrase for an exact phrase match. Source license links do not imply unrestricted reuse.

At least 37 records · Page 2Linked to original sources
PubMed2004

Penile vibratory stimulation in the marmoset monkey: a practical alternative to electro-ejaculation, yielding ejaculates of enhanced quality.

The availability of sufficient amounts of spermatozoa of high quality is one of the main limiting factors in reproductive research and development of reproductive technologies in marmoset monkeys (Callithrix jacchus). Penile vibrostimulation (PVS) has been successfully used in semen collection in the squirrel monkey but with poor success rate in the marmoset. We report here on an improved protocol for PVS with a success rate of almost 90%. Ejaculates obtained by PVS were of enhanced quality compared with those obtained by rectal probe electro-ejaculation (RPE). PVS ejaculates contained on average three to fourfold higher numbers of total and motile spermatozoa. Assessment of sperm kinematics using computer-assisted sperm analysis indicated that there are also functional differences between spermatozoa collected by PVS and RPE. Marmoset spermatozoa in samples obtained by RPE swim in a more convoluted manner compared with those obtained by PVS.

Analysis of Variance↗
PubMed1999

[Human ejaculation: physiology, surgical conservation of ejaculation].

OBJECTIVE: The most widely accepted theory to explain ejaculation consists of two phases: 1) A phase of accumulation of the various constituents of semen inside the prostatic urethra. 2) A phase of expulsion with opening of the striated sphincter, while the smooth sphincter of the bladder neck remains closed. The objective of this study was therefore to confirm or invalidate this hypothesis. MATERIAL AND METHODS: Eight volunteers were studied by continuous transrectal ultrasonography allowing dynamic analysis of ejaculation. Sixteen patients presenting with a bladder neck obstruction syndrome were treated by a technique preserving the last centimetre of supramontanal urethra. RESULTS: In the eight healthy subjects, we constantly and successively observed: filling of the ejaculatory ducts. prostatic contractions. Expulsion of the contents of the seminal vesicles into the inframontanal urethra, without prior ballooning of the prostatic urethra. In the 16 patients treated for bladder neck obstruction, we did not observe any case of retrograde ejaculation.

Adult↗
PubMedDate not supplied

On the brain monoaminergic systems relatint to ejaculation. II. Brain serotonin and ejaculation.

The effects of 5-HTP and pCPA on manually induced ejaculation in dogs and on brain monoamines in dogs and rats were investigated. From the results obtained in this study it was concluded that the serotonergic system in the brain is the mechanism which inhibits the occurrence of ejaculation. Considered together with the results obtained in our previous paper, it is though that ejaculation occurs with the reconciliation of the dopaminergic and serotonergic systems.

5-Hydroxytryptophan↗
PubMedDate not supplied

Changes in seminal parameters of ejaculates after repeated ejaculation.

Seminal fluid parameters of ejaculates collected via masturbation successively after sixty minute interval were compared. Volumes of semen were in most cases significantly lower in the second ejaculations as compared with the first. Sperm density was higher in the second specimen only in 32 patients (31% of the group). The percentage of motile spermatozoa was comparable in both specimens. The velocity was in the second specimens significantly lower. The percentage of morphologically defective forms of spermatozoa was found to be approximately the same in both specimens. The use of successive ejaculation will have hardly any greater clinical importance in the treatment of hypofertile men.

Adult↗
PubMed1979

Mechanism of liquefaction of the human ejaculate. I. Changes of the ejaculate proteins.

The spontaneous liquefaction of the human ejaculate in vitro was studied by macroscopic inspection, disc electrophoresis of the ejaculate proteins, free amino acid and nitrogen determinations and by electron microscopy. Liquefaction occurred in three phases. Phase 1 was characterized by the macroscopic solubilization of the gelatinous material and by disappearance of its granular ultrastructure. Zn++, Hg++ and Cu++ completely inhibited the first step of the liquefraction, which could be reversed by Na2EDTA. The factor(s) involved is most probably a proteolytic enzyme(s) which is tightly incorporated into the gelatinous material. In Phase 2 of liquefaction solubilized proteins were degraded to peptides and in Phase 3 these peptides were degraded to amino acids. Factor(s) responsible for these two steps of liquefaction could be removed by washing the gelatinous material.

Adult↗
PubMed1975

[The correlation of morphological and biochemical factors in human ejaculate in various andrological diagnoses. I. Relationship between ejaculate volume, number, motility and morphology of the spermatozoa with regard to age].

This first report from a study conducted to determine correlations between morphological and biochemical parameters in human ejaculate presents the results based on the measurement of predominantly morphological criteria in patients of various clinical diagnosis groups. The allocation of the 525 patients, who were recruited into the study during the period 1972/73 in the Department of Andrology, Hamburg-Eppendorf, to the diagnosis groups normozoospermia (196), asthenozoospermia (92), oligozoospermia (181) and azoospermia (56) was performed in accordance with the Recommendations for Andrological Nomenclature (1970). The following data were evaluated for this report: height (cm), weight (kg), age (years), ejaculate volume (ml), number of spermatozoa (mill./ml), motility (percentage of highly motile, motile and non-motile spermatozoa), round cells (mill./ml), morphology (percentage of normal-shaped/pathological spermatozoa), changes to the head, middle and tail sections (percentage of the pathological spermatozoa). Relationships between a dependent biological variable (y) and a variable to be assumed independent (x) were obtained by adaptation of polynomials of the 3rd degree: y = b0 + b1 + b2x2 + b3x3. The coefficients (b) which did not differ significantly (p greater than 0.05) from zero were eliminated step by step in regression analyses with breakdown and the resulting mean curves within the ranges covered by the sample depicted graphically. For the time being, the relationships found are described only in the sense of a collection of material. The increased occurrence of pathological spermatozoa in advancing age together with lower values for highly motile spermatozoa could be regarded as a result of a lower organ effectiveness of testosterone, which is protein-bound to an increased extent with advancing age. At the present time there is no explanation for the larger numbers of spermatozoa found with increasing age. The positive correlation between higher sperm counts and high motility, and between high motility and a lower percentage of pathological forms corresponds to expectations from earlier studies. The number of changes to the head, middle and tail sections increase proportionally in keeping with an increasing percentage of pathological forms. When the changes to the head, middle and tail sections are placed in relationship to the diagnosis groups normozoospermia, asthenozoospermia and oligozoospermia a disproportional percental participation becomes noticeable.

Adolescent↗
PubMed1982

ATP and ADP content of human ejaculated spermatozoa. II. Time-dependent changes after ejaculation.

ATP and ADP content of ejaculated spermatozoa of 7 donors were measured by a bioluminescent method within 24 h. The semen samples were kept at room temperature and at prefixed time were tested for motility and viability and extracted for ATP and ADP measurement. ATP pattern in relation to the time was studied with a mathematical model and the resulting curve showed a very high significance (P less than 0.001). ADP decrease with time was not significant and was variable among our subjects. The relationship between ATP decrease (%) and the decrease (%) of viability and motility was not linear, and till now no mathematical model has been found to express this phenomenon.

Adenosine Diphosphate↗
PubMed2006

Topical eutectic mixture for premature ejaculation (TEMPE): a novel aerosol-delivery form of lidocaine-prilocaine for treating premature ejaculation.

OBJECTIVE: To evaluate, in a phase II study, the efficacy and safety of a topical eutectic mixture for premature ejaculation (TEMPE), a metered-dose aerosol spray containing a eutectic mixture of lidocaine and prilocaine, as a treatment for PE. PATIENTS AND METHODS: Men with PE (Diagnostic and Statistical Manual-IV definition) aged 18-75 years were randomized into a double-blind, placebo-controlled study in the UK and the Netherlands. Efficacy variables included the mean change in intravaginal ejaculatory latency time (IELT) from baseline and the proportion of patients who achieved an IELT of > or = 4, > or = 3 or > or = 2 min on two occasions, and the effect of TEMPE on the index of ejaculatory control (IEC) and sexual quality-of-life (SQoL) scores of patients and their partners. Safety and adverse event data were also collected. Fifty-four patients were randomized and received study treatment. RESULTS: The observed mean change in IELT from baseline to the end of the treatment period was 3.8 min in the TEMPE group and 0.7 min in the placebo group, and when adjusted for baseline and centre was 2.4 times higher in the TEMPE than the placebo group (P < 0.01). The efficacy of TEMPE in increasing IELT was further supported by positive trends in the other efficacy endpoints. The proportion of men who had an IELT time > or = 2, > or = 3 or > or = 4 min on two occasions after treatment was 11/20 (55%), 8/20 (40%) and 5/25 (20%) in the TEMPE group, and 8/23 (35%), 3/23 (13%) and 3/23 (13%) in the placebo group, respectively, although these differences were not statistically significant. Improvements in IEC and SQoL (male and female) scores also showed trends towards greater efficacy for TEMPE than placebo. In all, 35 of 42 (83%) patients considered the spray easy to use. Mild to moderate local numbness occurred in three (12%) of the TEMPE-treated patients but did not lead to discontinuation. CONCLUSION: Topical treatment with TEMPE produced a statistically and clinically significant increase in IELT compared with placebo, and resulted in positive trends in ejaculatory control and SQoL. TEMPE was considered easy to use and was well tolerated. The data support the conduct of further large-scale studies to establish the utility of TEMPE as a first-line treatment for PE.

Administration, Topical↗