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[Computed tomography in the diagnosis of pathological states of the lumbar diaphragm. 2: diseases of the diaphragm].

CT potentialities in the diagnosis of diaphragmatic diseases were considered. CT provides valuable information in relaxations of the diaphragm and diaphragmitides, permitting the detection of infiltration of the diaphragm by a tumor, retroperitoneal fibrosis, diaphragmatic cysts, Bochdalek's hernia, and hernias of the esophageal opening. An algorithm for investigation of patients with suspected diaphragmatic pathological conditions was proposed.

Diaphragm↗
PubMed1971

Comparison of some metabolic parameters in the perfused and the incubated rat diaphragm muscle with diaphragm muscle in vivo.

1. A method is described for perfusing the rat diaphragm muscle. 2. The following parameters were compared in both perfused and non-perfused incubated preparations: water content, sorbitol space, rate of lactate production, and the concentrations of tissue glucose, pyruvate, lactate, hexose phosphate intermediates, ATP and AMP. No significant differences were found. 3. Significant differences, however, were found on comparison of the tissue kept in vitro with the tissue in vivo. Immediately after removal of the tissue from the animal, the concentrations of the hexose phosphates and ATP were found to be much higher than after incubation or perfusion, and the concentrations of free glucose and of AMP were much lower, possibly indicating that the capacity for oxidative phosphorylation of glucose is impaired in vitro because of hypoxia.

Adenosine Monophosphate↗
PubMed1989

Diaphragm VO2, diaphragm EMG, pressure-time product and calculated ventilation in newborn lambs during hypercapnic hyperpnoea.

We examined the relationship between diaphragmatic EMG (EMGdi) and pressure-time index (Pt'), and diaphragmatic oxygen consumption (VO2di) in 6 newborn lambs quietly breathing air and during 3 levels of hypercapnic hyperpnoea (PaCO2 was equal to 48, 53, or 60 Torr). We also determined minute ventilation (VI), whole body oxygen consumption (VO2), diaphragmatic oxygen consumption (VO2di), and respiratory muscle oxygen consumption (VO2resp). VO2 did not change significantly throughout the experiment. While breathing air VO2di was 0.46 +/- 0.03 ml.min-1, VO2resp was 1.40 +/- 0.22 ml.min-1, and VI was 1.98 +/- 0.11 L.min-1. These values increased significantly during hyperpnoea and reached 3.88 +/- 0.45 ml.min-1, 7.22 +/- 1.12 ml.min-1, and 6.99 +/- 1.03 L.min-1, respectively. EMGdi, and Pt' also increased significantly during hyperpnoea. A strong linear relationship was found between the normalized values of EMGdi and Pt' (r = 0.90), between VO2di and EMGdi (r = 0.88), and between VO2di and Pt' (r = 0.88). The relationship between both EMGdi and VI and PaCO2 was logarithmic. We found that (i) both EMGdi and Pt' correlate well with VO2di, and (ii) VI, VO2di, and EMGdi increased significantly when PaCO2 was greater than 48 Torr.

Animals↗