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Results for “Cyclacillin”

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PubMed1976

[Studies on absorption and excretion of cyclacillin granules (vastcillin granules 'Takeda') (author's transl)].

Vastcillin granules 'Takeda', a cyclacillin (AC-PC) preparation for children were orally administered to nine children at a single dose of 10 mg/kg and its blood concentrations and urinary excretion were studied. From the results obtained, the following conclusions were obtained as to clinical dose and indications. (1) Absorption of AC-PC of Vastcillin granules is excellent . At 15 minutes after administration, 9.3 mcg/ml of AC-PC blood level was attained and its peak appeared 30 minutes after administration. The mean peak level was 17.6 mcg/ml.

Adolescent↗
PubMed1983

A new spectrophotometric method for the selective determination of ampicillin, amoxycillin and cyclacillin in the presence of polymers and other degradation products.

A rapid and convenient spectrophotometric method is described for the quantitative determination of ampicillin and other amino-penicillins. The method involves conversion of the penicillins to the corresponding piperazine-2,5-dione derivatives by heating in an alkaline sorbitol-zinc ion solution for 10 min at 60 degrees C and subsequent treatment of these derivatives with 1 M sodium hydroxide to give a highly absorbing product with lambda(max) at 322 nm. Since an intact beta-lactam moiety and a free amino group in the side-chain of the penicillin molecules are required for the piperazinedione formation, the method is highly selective. The method was found to be free of interference from polymerization and other degradation products and its application to assess the stability of the amino-penicillins was demonstrated.

Journal Article↗