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Results for “Contingent Negative Variation”

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PubMed1990

Contingent Negative Variation in migraine.

The Contingent Negative Variation (CNV) is an event-related slow potential. It was recorded in healthy volunteers (n = 8) and in patients suffering from migraine without (n = 12) or with (n = 5) aura, during one (CNV1) and three second (CNV3) foreperiods in a forewarned reaction time task. CNV1 was recorded at the vertex while CNV3 was recorded at multiple electrode sites to assess topographical differences. Seven out of twelve migraine patients without aura had increased CNV1 amplitudes. CNV3 amplitudes were increased as well, but only at electrode positions C3 and C4 and not at Fz. CNV3, which allows for analysis of both an early and a late CNV component, could improve the discrimination of migraine without aura beyond that of CNV1. In migraine with aura all CNV parameters were at control levels, confirming previous results. The data obtained are discussed in terms of arousal, activation and stress and the "biobehavioral model of migraine" (Welch, 1986).

Adult↗
PubMed1976

Brain wave components of the contingent negative variation in humans.

In a contingent negative variation paradigm with two stimuli paired at an interstimulus interval of 4 seconds, two distinct waveforms having functional and topographic differences are observed. An early wave is maximal over the frontal cortex and is elicited by the warning stimulus. A later wave, maximal over the motor cortex, precedes the imperative stimulus and is identified with preparation for motor response.

Brain↗
PubMed2004

Brain activity relating to the contingent negative variation: an fMRI investigation.

The contingent negative variation (CNV) is a long-latency electroencephalography (EEG) surface negative potential with cognitive and motor components, observed during response anticipation. CNV is an index of cortical arousal during orienting and attention, yet its functional neuroanatomical basis is poorly understood. We used functional magnetic resonance imaging (fMRI) with simultaneous EEG and recording of galvanic skin response (GSR) to investigate CNV-related central neural activity and its relationship to peripheral autonomic arousal. In a group analysis, blood oxygenation level dependent (BOLD) activity during the period of CNV generation was enhanced in thalamus, somatomotor cortex, bilateral midcingulate, supplementary motor, and insular cortices. Enhancement of CNV-related activity in anterior and midcingulate, SMA, and insular cortices was associated with decreases in peripheral sympathetic arousal. In a subset of subjects in whom we acquired simultaneous EEG and fMRI data, we observed activity in bilateral thalamus, anterior cingulate, and supplementary motor cortex that was modulated by trial-by-trial amplitude of CNV. These findings provide a likely functional neuroanatomical substrate for the CNV and demonstrate modulation of components of this neural circuitry by peripheral autonomic arousal. Moreover, these data suggest a mechanistic model whereby thalamocortical interactions regulate CNV amplitude.

Adult↗
PubMed2001

Contingent negative variation and personality in depression.

Contingent negative variation (CNV) has been applied in depression with controversial results. A major source for these controversial results could result from the diversity of depressed patients included in the different studies. Supporting this assumption, impulsivity, blunted affect and suicidal behavior significantly influence CNV amplitude. However, no data are available on the possible influences of personality of depressed patients on CNV. Since personality is related to CNV in normal subjects, the aim of the present study was to investigate the relationship between CNV and personality as assessed by the Temperament and Character Inventory (TCI) in 52 depressed patients. A group of 76 healthy volunteers was included in the study. Among depressed patients, the main results of the study shows that CNV amplitude is positively correlated with self-transcendence dimension. In healthy volunteers, results show that CNV amplitude is negatively correlated with novelty seeking and persistence dimensions. The other dimensions are not related to CNV amplitude either in depressed patients or in healthy volunteers. The findings among depressed subjects suggest that lower CNV amplitude may be associated with psychotic traits (high self-transcendence scores), and those observed in healthy subjects are consistent with previous studies and support energetical models of slow potentials. However, the preliminary nature of the present results with respect to the weak statistical significance should be underlined.

Adult↗
PubMed1993

[Psycho-physiological study by contingent negative variation (CNV) in otolaryngological diseases].

Contingent negative variations (CNV) were recorded in patients with tinnitus (N = 20), abnormal sensations of the pharynx and larynx (ASPL) (N = 26) and Meniere's disease (N = 19), and compared with those of healthy adults (N = 20) in order to investigate the characteristics of their information processing mechanisms in the brain. Patients were also subjected to psychological tests: Depression Score and the Cornell Medical Index test. CNV (an event-related potential) is a slow negative cortical potential shift and can be recorded during two stimuli presented at a constant interval under conditions in which the subjects are told to press a key as quickly as possible upon an imperative stimulus (S2) following a warning stimulus (S1). S1 was a 1kHz tone burst of 300 msec duration at a level of 85dB HL. S2 was a light flash. The interstimulus (S1-S2) interval was set at 2 seconds. The CNV can be divided into three components, early, middle, and late, according to latency. Statistical analysis of CNV amplitudes of the three components showed the following differences between groups. In tinnitus patients, the mean amplitudes of both the early and middle component were significantly greater than those in healthy adults (P < 0.05). In ASPL patients, the mean amplitudes of the middle component were significantly greater than those in healthy adults (P < 0.05). In Menière's disease, the mean amplitudes of both the middle and late component were significantly greater than those in healthy adults (P < 0.05).(ABSTRACT TRUNCATED AT 250 WORDS)

Adult↗
PubMed1993

Contingent negative variation--findings and perspectives in migraine.

Contingent negative variation (CNV) is a negative cerebral potential which is related to attention and arousal. CNV occurs during an experimental situation in which stimuli and responses are serially organized. Between attacks migraine patients have on average higher negative amplitudes compared to healthy controls or patients with tension-type headache. Successful treatment with beta-blocking agents decreases CNV amplitudes. In spite of encouraging findings in neurological disorders, CNV is not widely used. In this review some possible reasons for this are pointed out.

Brain↗
PubMed1985

Pain, anxiety, and contingent negative variation: a clinical and pharmacological study.

Contingent negative variation (CNV) behavior was studied in 16 volunteers who were suffering from spontaneous recurrent pain syndromes (idiopathic trigeminal neuralgia, classic migraine). The subjects were divided into two groups, "more anxious" and "less anxious," based on psychometric tests (MMPI and STAI X2). The CNV recordings were carried out, respectively, in basal resting state, during an episode of pain, while under anxiolytic treatment, and lastly, during an episode of pain while under anxiolytic therapy. CNV voltage decrease and frequent appearance of postimperative negative variation (PINV) were observed when pain was present during the recording session. These phenomena were more marked when the pain was accompanied by a greater degree of anxiety. Finally, our results suggest that this slow evoked potential is sensitive to various degrees of anxiety and to pain perception in man, making it useful in the investigation of pain as a complex sensation.

Adult↗
PubMed1978

Influences between the contingent negative variation and the preceding readiness potential.

Contingent negative variation (CNV) is a slow negative shift in the potential, developing in the period of association between the warning and the imperative stimulus. The readiness potential (RP) resembles the CNV in morphology and amplitude and appears before the performance of a voluntary action. When RP precedes the appearance of the warning stimulus, CNV amplitude reaches considerably lower values. This phenomenon could be explained with the assumptions about a common neuronal pool of McAdam (1971) and with the "ceiling" hypothesis of Hamilton et al. (1973). The aim of the present study is to examine the effect of time intervals with different duration between RP and CNV. A decrease in the amplitude of CNV following RP has been found, without statistically significant differences depending on the interval between them. A more significant influence is observed on CNV morphology: in addition to a decrease in the amplitude, there is also a transition from type B to type A CNV when it is preceded by RP. Under conditions of a more complicated task involving combination with CNV, the RP itself shows lower values compared with the case of independent generation. This gives grounds for the conclusion that the complexity and the complex requirements of the task determine the value of the negatively directed slow-potential changes.

Adult↗
PubMed1975

Reliability of the contingent negative variation and the auditory evoked potential.

Contingent negative variations (CNVs) composed of 32 trials had a median subject consistency of 0.68 in retests separated from 5 min to 7 days. Hand measurement of the CNV was highly reliable with a median reliability of 0.96. Subject consistencies for the amplitudes and latencies of N1 and P2 components of a auditory evoked potential (AEP) had a median of 0.59 when 265 trials were averaged. These consistencies for N1 and P3 components had a median of 0.45 when only 16 trials were averaged. Median measurement reliabilities for the AEP were 0.92 for amplitudes and 0.66 for latencies.

Adult↗
PubMed1994

[Contingent negative variation elicited by electrical taste stimulation].

Contingent negative variation (CNV) was elicited using electrical taste stimulation as the warning stimulus. Stimuli were generated for 100 msec or 500 msec using a bipolar stainless steel electrode disc with the center portion acting as the anode and the outer portion as the cathode. The imperative stimulus was a pure tone of 1 kHz at 60 dB and the interstimulus interval of paired stimuli was 2000 msec. The electrode was gently held in contact with the tongue by a specially made fixture and electrical taste stimuli were presented at 5-sec intervals. The CNV was recorded in 10 normal subjects at the Cz site of the 10-20 International System, referred to linked earlobes with a forehead ground. The results from 20 presentations were averaged. The mean threshold measured by electrogustometry employing a monopolar electrode as the anode was -4.2 dB (0 dB = 8 microA), and the mean thresholds measured with the bipolar electrode at a stimulus duration of 100 msec and 500 msec were 0 dB and -1.4 dB, respectively. As the mean threshold obtained with a duration of 500 msec was closer to the electrogustometry findings than that obtained with a duration of 100 msec, a stimulus duration of 500 msec was useful for determining the CNV threshold. The CNV could be recorded in all 10 normal subjects, and the late component was conspicuous because of recording at the Cz site. In four subjects, the P300 could be recorded after the warning stimulus at an intensity of 40 microA.(ABSTRACT TRUNCATED AT 250 WORDS)

Acoustic Stimulation↗
PubMed1992

[Contingent negative variation (CNV) as presaccadic potential].

By recording contingent negative variation (CNV) with saccade as the response, EEGs were recorded before, during and after saccade. Light-emitting diodes (LEDs) were used as the warning stimulus (S1) and the imperative stimulus (S2), and a different electrode was placed on Cz according to the international 10-20 system. Evoked potentials were amplified by a D.C. amplifier and 16 responses were averaged. EOGs were recorded simultaneously. There were no remarkable changes in CNV according to the S1-S2 interval or angle of saccade. A positive wave of approximately 10 microV was observed prior to saccade, and was not believed to be the influence of either EOG or blinking. This positive wave may be similar to the spike potential in presaccadic potentials or may be a component of postimperative negative variation (PINV).

Adult↗
PubMed2006

Two phases of the contingent negative variation in humans: association with motor and mental functions.

The question of the relationship between contingent negative variation and the mechanisms controlling motor and mental functions has received inadequate study. The aims of the present work were to investigate the relationship between the early and late phases of contingent negative variation and the state of motor and mental functions in patients with Parkinson's disease and to study the effects of levodopa on contingent negative variation. Patients with Parkinson's disease showed significant decreases in the amplitudes and areas of both phases of contingent negative variation as compared with subjects of similar age. Correlation analysis demonstrated a negative relationship between the extent of impairment of coordinatory muscle interactions and the amplitudes of both phases of this variation (p < 0.01). There was a positive relationship between the magnitudes of both phases and the state of mental functions, particularly memory (p < 0.05). Treatment of patients with Parkinson's disease with levodopa was followed by a significant increase in the late phase (p < 0.05). The results obtained here provide evidence for the important role of structures supporting both direct motor control and mental functions in forming both phases of contingent negative variation. The greater effect of levodopa on the late phase of contingent negative variation suggests that the efferent system of the basal ganglia has a greater role in generating the late phase than in organizing the early phase of the variation.

Acoustic Stimulation↗
PubMed2003

Abnormal contingent negative variation in HIV patients receiving antiretroviral therapy.

The contingent negative variation, an event-related potential related to neural activity in the frontal lobe and basal ganglia, neuropsychological tests and structural MRI were used to examine CNS function and structure in HIV-positive patients receiving antiretroviral therapy. Relative to controls, HIV patients had smaller thalamic volume and reduced late contingent negative variation amplitude that correlated with caudal atrophy. Behaviorally, viremic patients were more impaired than virally suppressed patients and controls on neuropsychological measures of psychomotor speed, selective attention and mental flexibility. These results suggest that antiretroviral therapy may not be effective in protecting cortical and subcortical structures against HIV-related neuropathology, regardless of immune function. However, the benefits of antiretroviral therapy on immune function appear to facilitate neurocognitive performance.

Adult↗
PubMed1993

Contingent negative variation: methods and potential interest in headache.

Contingent negative variation (CNV) is an event-related slow cerebral potential which has been found abnormal in migraine. Its methodology is described. Contrary to other neurophysiological techniques, CNV needs special equipment and expertise. On average, CNV amplitude is increased and its habituation is lacking in migraine without aura between attacks, but not in migraine with aura. The sensitivity of CNV as a diagnostic tool is low, but its specificity is high. CNV amplitude normalizes after treatment with beta-blockers. The CNV abnormalities in migraine might be due to hyperreactivity of central catecholaminergic pathways.

Acoustic Stimulation↗
PubMed2005

Contingent negative variation elicited before jaw and tongue movements.

Contingent negative variation (CNV) is a negative brain potential occurring between two successive stimuli when the first stimulus is a warning and the second stimulus requires a motor response. The CNV is interpreted as an expression of the cognitive processes in preparation for a response directed to a purpose. Using 19 electrodes we recorded CNVs for mouth opening, closing and lateral movements, tongue protrusion and hand extension in 10 healthy subjects. The aim of the study was to examine the motor control mechanism underlying jaw and tongue movements in a cognitive paradigm. The first stimulus (S1) served as a preparatory warning signal for the imperative stimulus (S2) 2 s after the S1. The subject performed the experimental tasks after the S2. The grand average CNVs for jaw and tongue movements showed a bilaterally widespread negativity with the maximum in the vertex region (Cz). The early CNV was identified about 400 ms after the S1 and its amplitude was highest at the midline-frontal area. The late CNV started approximately 1000 ms after the S1 with the maximum at Cz. The mean amplitude was significantly lower for hand extension than for the other tasks, and significantly higher for lateral movement than for mouth closing, suggesting that the CNV amplitude can be affected by the complexity of the task. The CNV recording may provide a means to study the neuronal activity necessary for the sensorimotor integration of jaw and tongue movements.

Adult↗
PubMed2000

Task related changes in contingent negative variation (CNV) response of endogenous evoked potentials.

Contingent negative variation (CNV) is a slow negative cortical potential shift, which occurs during a warned foreperiod reaction time paradigm. Most studies of evoked potentials have concentrated on components occurring during the first 300 msec, although there are important and recordable aspects of signal processing occurring well beyond 300 msec e.g. late negative slow wave. CNV has proven sensitive to a number of psychological variables, none of which can yet be singled out as a definitive or exclusive correlate. Changes are expected if measured after a rigorous mental exercise. CNV was measured in 20 normal male subjects aged between 18 and 20 years. CNV was recorded twice in each subject before and after the administration of a mental task. The auditory mental task comprised repeating in reverse order string of random digits read out to the subject at a uniform speed of 1 per second. The visual mental task comprised reading laterally inverted type written text. Each subject had to undergo 2 sessions in separate sittings. The latency and amplitude of waves N1, P3, orientation (O), expectancy (E), CNV, reaction time (RT) were recorded. These values recorded before and after the task were compared statistically using student's unpaired t-test. The significant latencies recorded before and after the auditory task were, N1: 88.00 +/- 11.96 and 100.00 +/- 21.52 msec, P3: 289.00 +/- 54.85 and 299.00 +/- 52.91 msec, reaction time (RT): 102 +/- 17.05 msec and 123 +/- 17.5 msec, and in case of visual task, N1: 88 +/- 13.16 msec and 99.00 +/- 16.51 msec, reaction time (RT): 107 +/- 11.74 msec and 127 +/- 13.42 msec respectively. All other CNV wave latencies and amplitude changes were insignificant. Hence task effects sensory perception as reflected by increased latency of the long latency response N1 and the cortical integrative processes resulting in increased reaction time.

Adolescent↗
PubMed1971

Attention-related increases in cortical responsivity dissociated from the contingent negative variation.

Certain tasks which increase attention to stimuli also elicit the contingent negative variation and increase the amplitude of the P300 component of the sensory evoked response. Therefore it appeared possible that the contingent negative variation and attention-related increases in P300 are either confounded by artifact or generated by common neural mechanisms. The fact that we have recorded attention-related increases in P300 amplitude independent of corresponding systematic changes in contingent negative variation indicates that neither of these possibilities is correct. The two phenomena are independently variable modulations of cortical activity.

Analysis of Variance↗
PubMed1993

Contingent negative variation in Gilles de la Tourette syndrome.

The Contingent Negative Variation (CNV) may measure arousal and attention, and is affected by various dopaminergic disorders. We recorded CNVs in 12 patients fulfilling diagnostic criteria of Gilles de la Tourette Syndrome (TS). Ten of 12 patients were male, 10 had attention deficit disorder (ADD), and 3 also had obsessions and compulsions (OCD). Medication had been stopped or TS treatment not yet started. TS patients had higher CNV amplitude and more frequent postimperative negative variation than controls. CNV2 was enhanced in all TS patients, while CNV1 was attenuated in TS patients with ADD or OCD. This suggests that CNV may be increased in TS, mostly because of CNV2 and perhaps due to dopaminergic excess. CNV2, considered to reflect adrenergic arousal mechanisms, may be effected by neurobehavioral concomitants of TS. Neurophysiological categorization of TS patients may be possible and valuable.

Adolescent↗